摘要:
The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc.The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.
摘要翻译:本发明涉及通式(I)的化合物:其中Ar1是任选取代的芳基或杂芳基; R 1是任选取代的低级烷基,低级烯基,低级炔基或环低级烷基,或者是任选具有取代基的芳基,芳烷基或杂芳基; R2是氢原子,低级烷基,低级烯基或低级炔基,或者是任选具有取代基的芳基,芳烷基或杂芳基; R3是氢原子或低级烷基; R4是氢原子,卤素原子,羟基,低级烷基或-N(R1k)R1m基团; T和U是氮原子或次甲基等。本发明的化合物具有优异的韦尔激酶抑制作用,因此可用于药物领域,特别是治疗各种癌症。
摘要:
A voltage controller has a control circuit and a heat radiating member attached to the circuit. The circuit controls a voltage of electric power generated in an alternator of a vehicle while generating heat. The member has a first surface and a second surface. The second surface of the member is formed in a smooth shape having no protrusions or hollows. A cooling wind flows on the second surface. The member receives the heat from the control circuit through the first surface and radiates the heat from the second surface to the wind.
摘要:
A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for obesity are provided.The invention relates to a compound of a formula (I): [wherein R1 and R2 represent a hydrogen, etc.; R3 represents a hydrogen atom, a halogen atom, etc.; R4 each independently represents a hydrogen atom, a lower alkyl group, etc.; Q represents a carbon atom, a nitrogen atom or a sulfur atom (the sulfur atom may be mono- or di-substituted with an oxo group); R5 and R6 each represent a hydrogen atom, a lower alkyl group, etc.; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; Z represents an oxygen atom, a sulfur atom or a nitrogen atom; Ar represents an aryl or heteroaryl group optionally mono to tri-substituted with a group selected from the substituent group β; ring A represents a 5- or 6-membered nitrogen-containing heteroaromatic group; m indicates an integer of from 1 to 6; n indicates an integer of from 0 to 3; p indicates an integer of from 0 to 2 (provided that at least two of X1 to X4 are carbon atoms); q indicates 0 or 1] or its pharmaceutically-acceptable salt, which has an effect of glucokinase activation and is useful as a treatment for diabetes.
摘要翻译:提供葡糖激酶活化剂; 提供糖尿病的治疗和/或预防,或治疗和/或预防糖尿病如视网膜病,肾病,神经症,缺血性心脏病,动脉硬化,以及进一步的治疗和/或预防肥胖症。 本发明涉及式(I)的化合物:其中R 1和R 2代表氢等; R 3表示氢原子,卤素原子等; R 4各自独立地表示氢原子,低级烷基等; Q表示碳原子,氮原子或硫原子(硫原子可以被氧代基单取代或二取代)。 R 5和R 6各自表示氢原子,低级烷基等; X 1,X 2,X 3和X 4各自独立地表示碳原子或氮原子; Z表示氧原子,硫原子或氮原子; Ar表示任选被选自取代基组β的基团单取代至三取代的芳基或杂芳基; 环A表示5-或6-元含氮杂芳基; m表示1〜6的整数, n表示0〜3的整数, p表示0〜2的整数(条件是X 1〜X 4中的至少2个为碳原子); q表示0或1]或其药学上可接受的盐,其具有葡糖激酶活化的作用,并且可用作糖尿病的治疗。
摘要:
An engine equipped with an air-intake device for a personal watercraft, includes a cylinder head cover attached to an upper surface of a cylinder head, a plug cap with ignition coil configured to protrude upward from an upper surface of the cylinder head cover; and an air box for the air-intake device that is disposed above the cylinder head cover and is provided on a lower surface thereof with an air inlet that opens to be opposite to the upper surface of the cylinder head cover. The air box is disposed in such a manner that the lower surface of the air box is opposite to the upper surface of the cylinder head cover and a gap is formed between the lower surface of the air box and the upper surface of the cylinder head cover so as to form an air flow in the vicinity of the plug cap with ignition coil that is directed to the air inlet of the air box.
摘要:
A personal watercraft is disclosed. The personal watercraft typically includes a body formed by a hull and a deck covering the hull from above and having an inner space defined by the hull and the deck, an engine accommodated in the inner space of the body, and an exhaust pipe accommodated in the inner space and configured to guide an exhaust gas emitted from the engine outside the body. The body is typically provided with a penetrating hole through which an inside of the body and an outside of the body communicate with each other. The exhaust pipe is typically configured to extend through the penetrating hole and mounted to the body by a mounting device in the vicinity of the penetrating hole, and the mounting device is removably mounted to the body from outside the body.
摘要:
Down-sizing of a pump for sucking two types of different fluids is realized. The pump is provided with a cylinder pump having a cylinder main body having a reciprocally movable piston, a first cylinder chamber partitioned at one side of the piston for being introduced with a first fluid, and a second cylinder chamber partitioned at the other side of the piston for being introduced with a second fluid, and piston driving means for reciprocally moving the piston of the cylinder pump.
摘要:
A test strip pick-up mechanism in an automated analyzer, which comprises: a bottle holder removably holding a test strip bottle containing a plurality of test strips and having a pierced groove formed in the peripheral direction and a test strip pick-up portion connected to the groove and formed in the longitudinal direction; a bottle turning motor connected to the bottle holder; a guide member extended from the inner part of the bottle holder in parallel to the central axis of the test strip bottle and having a L-shaped guide portion formed over the entire length of the guide member with suction holes for adsorbing the test strips being formed on the guide portion which is adjacent to the test strip pick-up portion; claws engaged with the groove of the bottle holder; an air chuck having suction holes for drawing out the test strips contained in the test strip bottle; a movable member on which the air chuck is mounted; a test strip drawing out motor connected to the movable member via a guide bar; depressing arms for pushing the air chuck downward; and an air chuck depressing motor connected to the depressing arms via a shaft.
摘要:
A test strip overturning mechanism in an automated analyzer for arranging test strips such that the right sides thereof may face in one direction, which comprises: an overturning device having an arm portion with suction holes being formed thereon; and a motor connected to the overturning device via a rotary shaft, wherein the suction holes formed on the arm portion are aligned in a straight line with suction holes formed on a transportation stage, arranged in the direction orthogonal to the direction that the test strips are moved; and a turntable is disposed at the position corresponding to the location of the arm portion when the overturning device is turned 180.degree. around the rotary shaft.
摘要:
The present invention relates to a compound of General Formula (I) below, among others. In the Formula, Ar1 is an optionally substituted aryl or heteroaryl group; R1 is a hydrogen atom, an optionally substituted C1-C6 alkyl group, or an optionally substituted aryl, aralkyl, or heteroaryl group; R2 is an optionally substituted aryl, aralkyl, or heteroaryl group; and R3 is a hydrogen atom or a C1-C6 alkyl group. A compound of the present invention has an excellent Wee1 kinase inhibiting effect, and is therefore useful in the filed of medicine, particularly in various types of cancer therapy.