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公开(公告)号：US20070191329A1
公开(公告)日：2007-08-16
申请号：US11524718
申请日：2006-09-20
申请人： Ethan Sternberg , David Dolphin , Julia Levy , Anna Richter , David Hunt , Ashok Jain , Elizabeth Waterfield , Ronald Boch , Andrew Tovey
发明人： Ethan Sternberg , David Dolphin , Julia Levy , Anna Richter , David Hunt , Ashok Jain , Elizabeth Waterfield , Ronald Boch , Andrew Tovey
IPC分类号： A61K31/555 , C07D487/22 , A61K31/409
CPC分类号： C07D487/22 , A61K41/0071 , G06Q50/22 , Y10S514/825 , Y10S514/885
摘要： New compounds useful in photodynamic therapy are of the formula and their 1,4-diene isomers and the metallated and/or labeled and/or conjugated forms thereof wherein each R1 is independently alkyl(1-6C); each n is independently an integer of 0-6; and R2 is vinyl or a derivative form thereof.
摘要翻译： 可用于光动力学治疗的新化合物具有下式及其1,4-二烯异构体及其金属化和/或标记和/或共轭形式，其中每个R 1独立地为烷基（1-6C） ; 每个n独立地为0-6的整数; R 2是乙烯基或其衍生形式。
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公开(公告)号：US07122569B2
公开(公告)日：2006-10-17
申请号：US10825270
申请日：2004-04-14
申请人： Ethan D. Sternberg , David Dolphin , Julia G. Levy , Anna M. Richter , David W. C. Hunt , Ashok Jain , Elizabeth M. Waterfield , Ronald E. Boch , Andrew Norman Tovey
发明人： Ethan D. Sternberg , David Dolphin , Julia G. Levy , Anna M. Richter , David W. C. Hunt , Ashok Jain , Elizabeth M. Waterfield , Ronald E. Boch , Andrew Norman Tovey
CPC分类号： C07D487/22 , A61K41/0071 , G06F19/00 , G06Q50/22 , Y10S514/825 , Y10S514/885
摘要： New compounds useful in photodynamic therapy are of the formula and their 1,4-diene isomers and the metallated and/or labeled and/or conjugated forms thereof wherein each R1 is independently alkyl (1–6C); each n is independently an integer of 0–6; and R2 is vinyl or a derivative form thereof.
摘要翻译： 可用于光动力学治疗的新化合物具有下式及其1,4-二烯异构体及其金属化和/或标记和/或共轭形式，其中每个R 1独立地为烷基（1-6C） ; 每个n独立地为0-6的整数; R 2是乙烯基或其衍生形式。
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公开(公告)号：US06825343B2
公开(公告)日：2004-11-30
申请号：US10622322
申请日：2003-07-17
IPC分类号： C07D48722
CPC分类号： C07D487/22 , A61K41/0071
摘要： Methods of modifying polypyrrolic macrocycles by use of a 1,3-dipolar cycloaddition is described. The methods may be used to produce compounds for further derivatization to produce photosensitizing agents of interest.
摘要翻译： 描述了通过使用1,3-偶极环加成改性聚吡咯大环的方法。 该方法可用于制备用于进一步衍生化的化合物以产生感兴趣的光敏剂。
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公开(公告)号：US06693093B2
公开(公告)日：2004-02-17
申请号：US09851641
申请日：2001-05-08
IPC分类号： A61K3100
CPC分类号： A61K9/0009 , A61K9/0019 , A61K9/10 , A61K9/1278 , A61K31/409 , A61K31/555 , A61K31/787 , A61K41/00 , A61K41/0057 , A61K41/0071
摘要： The invention is generally related to the field of photodynamic therapy by use of photosensitizers and stabilized formulations of the photosensitizers. These formulations may be used to deliver a photosensitizer as a pharmaceutical, agricultural, or industrial agent. The photosensitizer containing formulations and compositions of the invention comprise one or more block copolymers. Furthermore, the invention relates to processes for the production of, and application of, said formulations and compositions as photosensitizer drug delivery systems.
摘要翻译： 本发明通常通过使用光敏剂和光敏剂的稳定配方与光动力疗法领域相关。 这些制剂可用于递送光敏剂作为药物，农业或工业剂。 含有本发明制剂和组合物的光敏剂包含一种或多种嵌段共聚物。 此外，本发明涉及用于制备和应用所述制剂和组合物作为光敏药物递送系统的方法。
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15.发明授权Methods to prepare .beta..beta.'-dihydroxy meso-substituted chlorins, isobacteriochlorins and bacteriochlorins 失效制备ββ'-二羟基内消旋二ine素，异二氢卟酚和细菌二氢卟酚的方法
公开(公告)号：US5831088A
公开(公告)日：1998-11-03
申请号：US853115
申请日：1997-05-08
申请人： David Dolphin , Christian Bruckner
发明人： David Dolphin , Christian Bruckner
IPC分类号： A61K31/40 , A61K31/409 , A61K49/06 , A61K51/04 , A61P35/00 , C07D487/22 , C07F1/08 , C07F3/06 , C07F5/00 , C07F5/06 , C07F7/10 , C07F7/22 , C07F7/30 , C07F13/00 , C07F15/04
CPC分类号： A61K51/0485 , A61K49/06 , C07D487/22
摘要： A .beta.,.beta.'-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin compound having the formula (I) or (II): ##STR1## wherein M is a metal. A novel method for synthesizing the compound of formula (I) or (II) comprises the steps of: a. osmylating a .beta...beta.'-unsubstituted, meso-substituted porphyrin to form an osmate ester at the .beta.,.beta.'-position, and b. reducing the osmate ester to form the corresponding .beta.,.beta.'-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin of formula (I) or (II).
摘要翻译： 具有式（I）或（II）的β，β'-二羟基内消旋二氯卟酚，细菌二氢卟酚或异细菌二氢卟酚化合物：其中M是金属。 合成式（I）或（II）化合物的新方法包括以下步骤：a。 渗透一个beta。 β'取代的内消旋卟啉在β，β'位上形成锇酸酯，b。 减少锇酸酯以形成式（I）或（II）的相应的β，β'-二羟基内消旋二取代的二氢卟酚，细菌二氢卟酚或异细菌素。
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公开(公告)号：US5399583A
公开(公告)日：1995-03-21
申请号：US187307
申请日：1994-01-25
申请人： Julia G. Levy , David Dolphin , Jack J. Chow , Ethan Sternberg
发明人： Julia G. Levy , David Dolphin , Jack J. Chow , Ethan Sternberg
IPC分类号： A61K41/00 , A61K49/00 , A61K51/04 , A61K51/10 , C07D487/22 , C07D519/00 , A61K31/40
CPC分类号： A61K41/0071 , A61K49/0036 , A61K51/0485 , A61K51/1093 , C07D487/22 , C07D519/00 , A61K2121/00
摘要： A group of hydro-monobenzoporphyrins "green porphyrins" (Gp) having absorption maxima in the range of 670-780 nanometers is useful in treating disorders or conditions which are subject to hematoporphyrin derivative (HPD) treatment in the presence of light, or in treating virus, cells and tissues generally to destroy unwanted targets. The use of the Gp of the invention permits the irradiation for therapy to use wavelengths other than those absorbed by blood. The Gp of the invention may also be conjugated to ligands specific for receptor or to specific immunoglobulins or fragments thereof to target specific tissues or cells for the radiation treatment. Use of these materials permits lower levels of drug to be used, thus preventing side reactions which might destroy normal tissues.
摘要翻译： 具有吸收最大值在670-780纳米范围内的一组氢 - 单苯并卟啉“绿色卟啉”（Gp）可用于治疗在光存在下经受血卟啉衍生物（HPD）治疗的病症或病症，或治疗 病毒，细胞和组织通常会破坏不想要的靶。 使用本发明的Gp允许用于治疗的照射使用除了被血液吸收的波长以外的波长。 本发明的Gp还可以与受体特异性配体或特异性免疫球蛋白或其片段缀合以靶向用于放射治疗的特定组织或细胞。 使用这些材料允许使用较低水平的药物，从而防止可能破坏正常组织的副反应。
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公开(公告)号：US4883790A
公开(公告)日：1989-11-28
申请号：US41680
申请日：1987-04-23
申请人： Julia G. Levy , David Dolphin , Jack K. Chow
发明人： Julia G. Levy , David Dolphin , Jack K. Chow
IPC分类号： G01N33/53 , A61K31/40 , A61K38/22 , A61K39/395 , A61K41/00 , A61P35/00 , C07D487/22 , C07K14/00 , C07K14/575 , C07K14/61 , C07K16/00
CPC分类号： C07D487/22 , A61K41/0071 , A61K2121/00
摘要： A group of hydro-monobenzoporphyrins "green porphyrins" (Gp) having absorption maxima in the range of 670-720 nanometers is useful in treating disorders which are subject to hematoporphyrin derivative (HPD) treatment in the presence of light. The use of the Gp of the invention permits the irradiation to comprise wavelengths other than those absorbed by blood. The Gp of the invention may also be conjugated to receptor ligands or to specific immunoglobulins or fragments thereof to target specific tissues or cells for the radiation treatment. Use of these materials permits lower levels of drug to be used, thus preventing side reactions which might destroy normal tissues.
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公开(公告)号：US08968715B2
公开(公告)日：2015-03-03
申请号：US11601559
申请日：2006-11-17
IPC分类号： A61K31/00 , A61K9/14 , A61K31/555 , A61K31/40 , A61K9/00 , A61K9/10 , A61K9/127 , A61K31/409 , A61K31/787 , A61K41/00
CPC分类号： A61K9/0009 , A61K9/0019 , A61K9/10 , A61K9/1278 , A61K31/409 , A61K31/555 , A61K31/787 , A61K41/00 , A61K41/0057 , A61K41/0071
摘要： The invention is generally related to the field of photodynamic therapy by use of photosensitizers and stabilized formulations of the photosensitizers. These formulations may be used to deliver a photosensitizer as a pharmaceutical, agricultural, or industrial agent. The photosensitizer containing formulations and compositions of the invention comprise one or more block copolymers. Furthermore, the invention relates to processes for the production of, and application of, said formulations and compositions as photosensitizer drug delivery systems.
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公开(公告)号：USD661701S1
公开(公告)日：2012-06-12
申请号：US29364170
申请日：2010-06-18
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公开(公告)号：USD645221S1
公开(公告)日：2011-09-13
申请号：US29364110
申请日：2010-06-18
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