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11.发明授权Method and apparatus for cardiac analysis using four-dimensional connectivity and image dilation 有权使用四维连接和图像扩张的心脏分析的方法和装置公开(公告)号：US06249693B1
公开(公告)日：2001-06-19
申请号：US09431953
申请日：1999-11-01
申请人： Harvey Ellis Cline , Siegwalt Ludke
发明人： Harvey Ellis Cline , Siegwalt Ludke
IPC分类号： A61B500
CPC分类号： G01R33/56 , G01R33/5608
摘要： An imaging system enables cardiac functioning within a particular cardiac chamber to be imaged. The system acquires imaging data that includes intensity values for four-dimensional voxels within a region of interest (ROI). A seed voxel is identified, and neighbor voxels to the seed voxel are also identified. The intensity values for each neighbor voxel are compared to a threshold to determine whether the voxel corresponds to blood or muscle tissue. For each neighbor voxel corresponding to blood, its neighbor voxels are identified and compared to the threshold, and this process is repeated until a pre-established spatial boundary is encountered or the number of new neighbor voxels indicates that processing is migrating into an adjacent cardiac chamber. At that point, the set of identified blood voxels represents a blood volume for the desired cardiac chamber. Voxels adjacent to the interior and exterior surface boundaries of the blood volume are added to the set. At that point, the set of voxels are counted into bins of cardiac phases, cardiac images for each phase are reconstructed, and parameters such as ejection fraction are calculated.
摘要翻译： 成像系统使得能够对特定心室内的心脏功能进行成像。 该系统获取包括感兴趣区域（ROI）内的四维体素的强度值的成像数据。 识别种子体素，并且还识别出种子体素的相邻体素。 将每个邻近体元的强度值与阈值进行比较，以确定体素是否对应于血液或肌肉组织。 对于对应于血液的每个邻近体素，其邻近体素被识别并与阈值进行比较，并且重复该过程直到遇到预先建立的空间边界或新邻居体素的数目表示该过程迁移到相邻心室 。 在这一点上，识别的血液体素的集合代表所需心室的血液体积。 与血液体积的内部和外部表面边界相邻的体素被添加到组中。 在这一点上，将这组体素计数到心脏相位的心脏区，重建每个阶段的心脏图像，并计算诸如射血分数的参数。
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12.发明授权Method and system for providing a maximum intensity projection of a non-planar image 有权提供非平面图像的最大强度投影的方法和系统公开(公告)号：US06211674B1
公开(公告)日：2001-04-03
申请号：US09311875
申请日：1999-05-14
IPC分类号： G01V300
CPC分类号： G01R33/4833 , G01R33/563
摘要： An imaging method and system generates images of non-planar portions of a three dimensional data point array wherein the non-planar portion corresponds to a non-planar object. The method includes selecting at least two different intermediate imaging planes, each selected plane including at least a portion of the object to be imaged, generating cross-sectional views perpendicular to each intermediate plane, selecting a viewing plane, projecting the cross-sectional views onto the viewing plane to generate transition value sets, and combining the transition value sets to generate values for each pixel in a display.
摘要翻译： 成像方法和系统生成三维数据点阵列的非平面部分的图像，其中非平面部分对应于非平面物体。 该方法包括选择至少两个不同的中间成像平面，每个选定平面包括待成像对象的至少一部分，产生垂直于每个中间平面的横截面视图，选择观察平面，将横截面视图投影到 观察平面以产生转换值集合，并且组合转换值集合以生成显示器中的每个像素的值。
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公开(公告)号：US6115048A
公开(公告)日：2000-09-05
申请号：US787526
申请日：1997-01-21
申请人： Harvey Ellis Cline , Siegwalt Ludke
发明人： Harvey Ellis Cline , Siegwalt Ludke
CPC分类号： G06T17/10
摘要： A system for displaying surfaces of volumetric data determines surface cubes by a simple method without interpolation. A central voxel is selected. The central voxel is tested against a threshold. If it is below the threshold, a different voxel is chosen as a central voxel. When one is found which is above the threshold, diagonal cubes, those at each of the corners of the central voxel, are tested against the threshold. When one is encountered with at least one voxel below the threshold, it is categorized as a surface voxel. The values of the adjacent voxels are then used to determine a vector normal to the surface at the central voxel. This is repeated for a number of central voxels to determine a surface. The surface then may be displayed. If anisotropic voxels are used, the elevation angle is converted to an effective elevation angle. The normal vectors to the surface are also adjusted to compensate for the anisotropic nature of the data. The voxels are then assumed to be isotropic being displayed with the effective elevation angle and using the adjusted surface normals.
摘要翻译： 用于显示体积数据表面的系统通过没有插值的简单方法来确定表面立方体。 选择中心体素。 中心体素针对阈值进行测试。 如果它低于阈值，则选择不同的体素作为中心体素。 当找到高于阈值的人时，针对阈值测试对角立方体，即中心体素的每个角落处的角立方体。 当遇到低于阈值的至少一个体素时，它被分类为表面体素。 然后使用相邻体素的值来确定在中心体素处垂直于表面的矢量。 对于许多中心体素重复这一点以确定表面。 然后可以显示表面。 如果使用各向异性体素，则将仰角转换为有效仰角。 还调整了表面的法向量以补偿数据的各向异性。 然后假设体素为具有有效仰角的各向同性，并使用调整的表面法线。
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14.发明授权System and method for co-registering multi-channel images of a tissue micro array 有权用于共同记录组织微阵列的多通道图像的系统和方法公开(公告)号：US08131476B2
公开(公告)日：2012-03-06
申请号：US11500028
申请日：2006-08-07
申请人： Harvey Ellis Cline , Ali Can
发明人： Harvey Ellis Cline , Ali Can
IPC分类号： G01N33/48
CPC分类号： G01N1/30 , G06T7/35 , G06T2207/30024 , G06T2207/30072
摘要： A system and methods for co-registering multi-channel images of a tissue micro array, comprising the steps of, providing a biological material on a substrate; applying one or more molecular probes, adapted to provide fluorescent molecular markers, to the biological material; obtaining a first digital image of the biological material and the fluorescent molecular markers; applying a morphological stain to the biological material; obtaining a second digital image of the biological material, computing information common to the first and second images; and co-registering the second image with the first image based on one or more registration metrics.
摘要翻译： 一种用于共同配准组织微阵列的多通道图像的系统和方法，包括以下步骤：在基底上提供生物材料; 将一种或多种适于提供荧光分子标记的分子探针应用于生物材料; 获得生物材料和荧光分子标记物的第一数字图像; 对生物材料施加形态染色; 获得生物材料的第二数字图像，计算第一和第二图像共同的信息; 以及基于一个或多个注册度量与所述第一图像共同配准所述第二图像。
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公开(公告)号：US07725157B2
公开(公告)日：2010-05-25
申请号：US11383608
申请日：2006-05-16
申请人： Charles Lucian Dumoulin , Richard Philip Mallozzi , Robert David Darrow , Harvey Ellis Cline , Renee Ann Guhde
发明人： Charles Lucian Dumoulin , Richard Philip Mallozzi , Robert David Darrow , Harvey Ellis Cline , Renee Ann Guhde
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/0402 , A61B5/042 , A61B5/06 , A61B5/743 , A61B6/503 , A61B6/504 , A61B8/0891 , A61B34/20 , A61B2034/2051 , A61B2090/364 , A61B2090/374 , G01R33/287
摘要： An imaging and interventional system and methods are provided. The system comprises an imaging device for acquiring volumetric image data for an anatomical region of interest, a catheter for acquiring electrophysiological (EP) measurements of the anatomical region of interest, the catheter having at least one tracking coil for detecting signals indicative of a position of the catheter, and, a processor coupled to the catheter for receiving the EP measurements and signals indicative of the position of the catheter. The position of the catheter and EP measurements are combined and superimposed on a resultant image. The method comprises acquiring volumetric image data for an anatomical region of interest, acquiring position data for a catheter inserted in the region of interest, obtaining electrophysiological (EP) measurements for the region of interest and combining the image data, position data and EP measurements into a resultant image for use in the interventional procedure.
摘要翻译： 提供了成像和介入系统和方法。 该系统包括用于获取感兴趣解剖区域的体积图像数据的成像装置，用于获取感兴趣解剖区域的电生理学（EP）测量值的导管，所述导管具有至少一个跟踪线圈，用于检测指示位置的信号 导管，以及耦合到导管的处理器，用于接收EP测量值和指示导管位置的信号。 将导管的位置和EP测量结合并叠加在合成的图像上。 该方法包括获取感兴趣的解剖区域的体积图像数据，获取插入在感兴趣区域中的导管的位置数据，获得感兴趣区域的电生理（EP）测量值，并将图像数据，位置数据和EP测量结合到 用于介入程序的结果图像。
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公开(公告)号：US06793496B2
公开(公告)日：2004-09-21
申请号：US10085726
申请日：2002-02-28
IPC分类号： G09B2328
CPC分类号： G09B23/28 , G06F19/00 , G06T11/006 , G06T13/20 , G06T19/20 , G06T2210/41 , G06T2211/412 , G06T2219/2016 , G06T2219/2021
摘要： The present invention provides a model and a method and apparatus for utilizing the model to simulate an imaging scenario. The model is mathematically defined by analytical basis objects and/or polygonal basis objects. Preferably, the model is a model of the human heart and thorax. Polygonal basis objects are only used to define structures in the model that experience torsion, such as certain structures in the heart that experience torsion during the cardiac cycle. The manner in which the basis objects comprising the model are transformed by scaling, translation and rotation is defined for each basis object. In the case where a basis object experiences torsion, the rotation of the basis object will change as a function of the length along the axis of the basis object about which rotation is occurring. During an imaging system simulation, the model is utilized by a forward projection routine, which integrates the linear attenuation coefficients associated with the rays emitted by a simulated x-ray source and collected by a simulated detector array to obtain line integrals corresponding to forward projection data. The forward projection data is then processed to take into account the physics of the imaging technology, the x-ray source and the detector array. The processed projection data is then processed and back-projected by a reconstruction modeling routine to produce a reconstructed representation of the model of the heart as a function of time.
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公开(公告)号：US06522786B1
公开(公告)日：2003-02-18
申请号：US09332393
申请日：1999-06-14
申请人： Harvey Ellis Cline
发明人： Harvey Ellis Cline
IPC分类号： G06T530
CPC分类号： G06T17/00 , G01R33/5608 , G06T5/002 , G06T5/30 , G06T2200/04 , G06T2207/10088 , G06T2207/20192 , G06T2207/30004
摘要： A method and apparatus for reducing noise in a three dimensional rectilinear parallelepiped data point array includes both erosion and dilation processes for each array point value. The erosion process includes the steps of determining gradients along all three axis which pass through a data point and modifying the point value as a function of the gradients to generate an updated point value. The dilation process includes the steps of using point values from the updated array, determining gradients along all three axis which pass through the point, and modifying the updated point value as a function of the gradients to generate a final and revised point value.
摘要翻译： 用于降低三维直线平行六面体平行六面体数据点阵列中的噪声的方法和装置包括针对每个阵列点值的侵蚀和扩张过程。 侵蚀过程包括以下步骤：沿着穿过数据点的所有三轴确定梯度并根据梯度修改点值以产生更新的点值。 膨胀过程包括以下步骤：使用来自更新的阵列的点值，沿着穿过该点的所有三轴确定梯度，以及根据梯度修改更新的点值以产生最终和修正的点值。
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公开(公告)号：US06298148B1
公开(公告)日：2001-10-02
申请号：US09274010
申请日：1999-03-22
IPC分类号： G06K900
摘要： A patient surface is registered with a model surface based on curvature by acquiring patient range data and determining the curvature of the patient surface based on the range data. The patient surface is generated and shaded based on the curvature. A model surface is generated from image data and processed to determine the curvature of the model surface. The model surface is shaded to represent the curvature. The shaded patient surface and the shaded model surface are aligned in registration with each other by manipulating the patient surface and/or the model surface until the curvature features coincide.
摘要翻译： 基于曲率，通过获取患者范围数据并根据范围数据确定患者表面的曲率，将患者表面与模型表面对齐。 基于曲率产生和遮蔽患者表面。 从图像数据生成模型表面，并对其进行处理，以确定模型曲面的曲率。 模型表面被遮蔽以表示曲率。 阴影的患者表面和阴影模型表面通过操纵患者表面和/或模型表面而彼此对准，直到曲率特征重合。
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19.发明授权
公开(公告)号：US6155978A
公开(公告)日：2000-12-05
申请号：US210706
申请日：1998-12-09
CPC分类号： G01S7/52034 , G01S15/8993 , G01S7/52026 , Y10S128/916
摘要： In three-dimensional imaging of ultrasound data, speckle artifact data are reduced before the acquired data from a volume of interest are projected onto an image plane. A master controller performs an algorithm that iteratively morphologically filters the pixel data in a volume of interest and then iteratively projects the morphologically filtered data onto a plurality of rotated image planes using a ray-casting technique. Morphological filtering is performed by stepping a seven-point kernel through a source data volume of pixel data. The kernel, made up of a central pixel value and the six pixel values adjacent to the central pixel value, is stepped through the entire source data volume. The morphological filtering operation includes at least one erosion step, which removes speckle, followed by an equal number of dilation steps, which restore the imaging data.
摘要翻译： 在超声数据的三维成像中，在将来自感兴趣体积的所获取的数据投影到图像平面上之前，斑点伪影数据被减少。 主控制器执行迭代地形态地过滤感兴趣体积中的像素数据的算法，然后使用射线投射技术将形态滤波的数据迭代地投影到多个旋转图像平面上。 通过对像素数据的源数据量进行七点内核进行形态滤波。 由中心像素值构成的内核和与中心像素值相邻的六个像素值，跨越整个源数据量。 形态学过滤操作包括至少一个侵蚀步骤，其消除斑点，随后是等量的扩张步骤，其恢复成像数据。
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公开(公告)号：US5821942A
公开(公告)日：1998-10-13
申请号：US622639
申请日：1996-03-27
摘要： A system for displaying sets of surface cubes with gradient vertex vectors first employs a pointer table constructed to order the surface cubes so as to generally cause a row by row and layer by layer ordering during model creation. During display, a viewpoint is selected and a scan controller causes cubes to be displayed according to this order of the pointer table. A test backprojection of cubes to image plane is performed to determine which pixels will be impinged by the cubes. For pixels which have not been updated, or pixels which have been updated by a less superficial cube than the current cube, projection rays are created through the center of impinged pixels in a direction opposite that of the backprojection. An intersection point of the ray with a surface within a current cube is determined. The data value and gradient vectors for the current cube are interpolated at this intersection point. These interpolated vector and value are then rendered to produce and image with less distortion and with less processing complexity.
摘要翻译： 用于显示具有渐变顶点向量的表面立方体的集合的系统首先采用构造成对表面立方体进行排序的指针表，以便在模型创建期间通常逐行并逐层排序。 在显示期间，选择视点，并且扫描控制器根据指针表的顺序使多维数据集显示。 执行立方体到图像平面的测试反投影以确定哪些像素将被立方体撞击。 对于尚未更新的像素，或者由比当前立方体更少的表面立方体更新的像素，通过与背投影相反的方向通过撞击像素的中心创建投影光线。 确定射线与当前立方体内的表面的交点。 在该交点处插入当前立方体的数据值和梯度向量。 然后渲染这些内插向量和值以产生和图像，具有较少的失真和较少的处理复杂度。
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