利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

23 条记录 (耗时 0.028 秒)

    Carboxylic acid derivatives and drugs containing the same as the active ingredient
    13.
    发明授权
    Carboxylic acid derivatives and drugs containing the same as the active ingredient 失效
    羧酸衍生物和含有与活性成分相同的药物

    公开(公告)号：US06664281B1

    公开(公告)日：2003-12-16

    申请号：US09763575

    申请日：2001-02-26

    申请人： Hisao Tajima ,  Yoshisuke Nakayama ,  Daikichi Fukushima

    发明人： Hisao Tajima ,  Yoshisuke Nakayama ,  Daikichi Fukushima

    IPC分类号： C07D26332

    CPC分类号： C07D413/04 ,  C07D263/32 ,  C07D493/08

    摘要： A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.

    摘要翻译： 含有式（I）的羧酸衍生物（其中所有符号如本说明书中所定义），其无毒性酸或其水合物作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于具有调节PPAR的作用 ，式（I）化合物可用作降血糖药，降血脂药，与代谢紊乱相关疾病（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症等），高脂血症，动脉粥样硬化的预防和/或补救措施 高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂以及用于缓解糖尿病或综合征X危险因素的药物。

    Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient
    14.
    发明授权
    Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient 失效
    羧酸衍生物和含有该衍生物作为活性成分的药物组合物

    公开(公告)号：US07241784B2

    公开(公告)日：2007-07-10

    申请号：US10464459

    申请日：2003-06-19

    申请人： Hisao Tajima ,  Yoshisuke Nakayama ,  Daikichi Fukushima

    发明人： Hisao Tajima ,  Yoshisuke Nakayama ,  Daikichi Fukushima

    IPC分类号： A61K31/422 ,  C07D413/10

    CPC分类号： C07D413/04 ,  C07D263/32 ,  C07D493/08

    摘要： A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from, risk factors of diabetes or syndrome X.

    摘要翻译： 含有式（I）的羧酸衍生物（其中所有符号如说明书中所定义），其无毒性酸或其水合物作为活性成分的过氧化物酶体增殖物激活受体调节剂。 由于具有调节PPAR的作用，式（I）化合物可用作降血糖剂，​​降血脂药，用于代谢紊乱（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症）的疾病的预防和/或补救措施 等），高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食，冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解危险因素的药物 的糖尿病或综合症。

    Phenylacetic acid derivative, process for producing the same, and use
    15.
    发明申请
    Phenylacetic acid derivative, process for producing the same, and use 失效
    苯乙酸衍生物，其制备方法及用途

    公开(公告)号：US20070105868A1

    公开(公告)日：2007-05-10

    申请号：US10572937

    申请日：2004-09-21

    申请人： Shinya Kusuda ,  Yoshisuke Nakayama ,  Hisao Tajima ,  Takahiko Sakamoto

    发明人： Shinya Kusuda ,  Yoshisuke Nakayama ,  Hisao Tajima ,  Takahiko Sakamoto

    IPC分类号： A61K31/496 ,  A61K31/4709 ,  A61K31/454 ,  A61K31/427 ,  A61K31/426

    CPC分类号： C07D413/10 ,  A61K31/421 ,  A61K31/422 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/454

    摘要： The present invention relates to the compound represented by formula (I) (wherein R1 and R2 is hydrogen atom, C1-8 alkyl etc.; R3 is C1-8 alkyl which may be substituted with 1 to 3 halogen atom(s), phenyl; R4 is hydrogen atom etc.; R5 and R6 is hydrogen atom, C1-8 alkyl etc.; X is sulfur atom or oxygen atom etc.; ringA is cyclic group which may have a substituent(s).), or a salt thereof. Toxicity of the compound represented by formula (I) is very low, and it is safe enough to use as a pharmaceutical agent and since it has PPAR δ agonistic activity, it is useful as preventive and/or therapeutic agent for glucose.lipid metabolic disorder, hypertension, circulatory diseases etc.

    摘要翻译： 本发明涉及由式（I）表示的化合物（其中R 1和R 2是氢原子，C 1-8烷基等; R 3 可以被1至3个卤素原子取代的C 1-8烷基，苯基; R 4是氢原子等; R 5和 R 6是氢原子，C 1-8烷基等; X是硫原子或氧原子等;环A是可以具有取代基的环状基团）或其盐。 由式（I）表示的化合物的毒性非常低，并且作为药物使用是安全的，并且由于其具有PPARδ激动活性，因此它可用作葡萄糖脂代谢紊乱的预防和/或治疗剂 ，高血压，循环系统疾病等

    Carboxylic acid derivatives and drugs containing the same as the active ingredient
    17.
    发明授权
    Carboxylic acid derivatives and drugs containing the same as the active ingredient 失效
    羧酸衍生物和含有与活性成分相同的药物

    公开(公告)号：US06589969B1

    公开(公告)日：2003-07-08

    申请号：US09807305

    申请日：2001-04-11

    申请人： Hisao Tajima ,  Yoshisuke Nakayama ,  Daikichi Fukushima

    发明人： Hisao Tajima ,  Yoshisuke Nakayama ,  Daikichi Fukushima

    IPC分类号： C07D41314

    CPC分类号： C07D413/06 ,  C07D413/14 ,  C07D417/06

    摘要： A peroxisome proliferator activated receptor regulator containing a compound of formula (I) (wherein all symbols are as defined in the specification), or a salt thereof as active ingredient. Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diabetes or syndrome X.

    摘要翻译： 含有式（I）化合物（其中所有符号如说明书中所定义）或其盐作为活性成分的过氧化物酶体增殖物激活受体调节剂。由于具有调节PPAR的作用，式（I）化合物 可用作降血糖药物，降血脂药物，与代谢紊乱（糖尿病，肥胖症，综合征X，高胆固醇血症，高脂蛋白血症等）相关疾病，高脂血症，动脉粥样硬化，高血压，循环系统疾病，暴饮暴食的疾病的预防和/或补救措施， 冠心病等，HDL胆固醇升高剂，LDL胆固醇和/或VLDL胆固醇降低剂和用于缓解糖尿病或综合征X的危险因素的药物。

    Ethynylindole compounds
    20.
    发明授权
    Ethynylindole compounds 有权
    乙炔基吲哚化合物

    公开(公告)号：US08115014B2

    公开(公告)日：2012-02-14

    申请号：US12644378

    申请日：2009-12-22

    申请人： Kazuyuki Ohmoto ,  Satoshi Itadani ,  Yoshisuke Nakayama ,  Jun Takeuchi ,  Manabu Fujita

    发明人： Kazuyuki Ohmoto ,  Satoshi Itadani ,  Yoshisuke Nakayama ,  Jun Takeuchi ,  Manabu Fujita

    IPC分类号： C07D209/04 ,  A61K31/405 ,  A61K31/40

    CPC分类号： C07D209/18

    摘要： As a compound having a potent oral activity and a long-lasting cysLT1/cysLT2 receptor antagonistic activity, the compound of the formula (I): which exhibits potent antagonistic activity against the cysLT1/cysLT2 receptor, and have long-lasting effects even in case of oral administration, and therefore is useful as an oral agent for preventing and/or treating a variety of diseases, for example, respiratory disease (for example, asthma (bronchial asthma, etc.), chronic obstructive pulmonary disease (COPD), pulmonary emphysema, chronic bronchitis, pneumonia (interstitial pneumonia, etc.), severe acute respiratory syndrome (SARS), acute respiratory distress syndrome (ARDS), apnea syndrome, allergic rhinitis, sinusitis (acute sinusitis, chronic sinusitis, etc.), pulmonary fibrosis, coughing (chronic coughing, etc.), and the like) was developed.

    摘要翻译： 作为具有有效的口服活性和持久的cysLT1 / cysLT2受体拮抗活性的化合物，式（I）化合物：其对cysLT1 / cysLT2受体具有强的拮抗活性，并且即使在例如 因此可用作预防和/或治疗各种疾病的口服药物，例如呼吸系统疾病（例如哮喘（支气管哮喘等），慢性阻塞性肺病（COPD），肺部 肺气肿，慢性支气管炎，肺炎（间质性肺炎等），严重急性呼吸综合征（SARS），急性呼吸窘迫综合征（ARDS），呼吸暂停综合征，过敏性鼻炎，鼻窦炎（急性鼻窦炎，慢性鼻窦炎等），肺纤维化 ，咳嗽（慢性咳嗽等）等）。