公开(公告)号：US11747238B2

公开(公告)日：2023-09-05

申请号：US17209434

申请日：2021-03-23

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: G01N1/10 ,  G01N1/34 ,  G01N1/40 ,  G01N1/14

CPC classification number: G01N1/10 ,  G01N1/14 ,  G01N1/34 ,  G01N1/4077 ,  G01N2001/4088

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.

公开(公告)号：US20220125333A1

公开(公告)日：2022-04-28

申请号：US17511487

申请日：2021-10-26

Applicant: INNOVAPREP LLC

Inventor： David S. Alburty ,  Andew E. Page ,  John D. Birkenholz ,  Kathleen Ruegsegger ,  Ann K. Packingham ,  Zachary A. Packingham ,  Alec D. Adolphson ,  Pamela S. Murowchick ,  Hugh Olsen ,  Bryan C. Long ,  Steven D. Graham

IPC: A61B5/097 ,  A61B5/00

Abstract: Devices and methods are described for using normal human breath to separately capture particles from inhaled and exhaled breath for analysis. This device can be constructed as a wearable device worn as a mask with separately removable filters on the inside and the outside of an efficient collection material.

公开(公告)号：US09593359B2

公开(公告)日：2017-03-14

申请号：US14084385

申请日：2013-11-19

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: C12Q1/24 ,  G01N1/40

CPC classification number: G01N1/4077 ,  B01L3/0275 ,  B01L2200/026 ,  B01L2200/0631 ,  B01L2300/0681 ,  B01L2300/161 ,  C12Q1/24 ,  G01N2001/4088

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.

Abstract translation: 公开了高效和快速的基于过滤的浓缩装置，系统和方法，其具有样品流体管线和封装在一次性尖端中的过滤器，其将从液体悬浮的稀释进料悬浮液中的生物颗粒进行浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 然后将浓缩物从一次性尖端中以一定体积的洗脱液分配。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 将一次性尖端附接到仪器的所有导管组合成尖端上端的单个连接点。

公开(公告)号：US20220397494A1

公开(公告)日：2022-12-15

申请号：US17841563

申请日：2022-06-15

Applicant: Boehringer Ingelheim Vetmedica GmbH ,  INNOVAPREP LLC

Inventor： Zachary A. Packingham ,  Steven D. Graham ,  Sidney J. Spry ,  Dale D. Polson

IPC: G01N1/22 ,  G01N1/24

Abstract: The present subject disclosure discloses devices, systems, and methods related to collection and recovery of Aerosols and Bioaerosols for analysis. The system includes an omni-directional inlet assembly that is easily removed for decontamination and can be replaced with an already clean inlet assembly or with directional inlets or other tools for collection from animal breathing zones, air ducts, air nearing moving vehicles and other sampling scenarios. Further, the system includes other features that enable the device to be lower in cost than other similar systems while providing improved usability and performance.

公开(公告)号：US10955316B2

公开(公告)日：2021-03-23

申请号：US15431655

申请日：2017-02-13

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: G01N1/10 ,  G01N1/34 ,  G01N1/40 ,  G01N1/14

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.

公开(公告)号：US20210077080A1

公开(公告)日：2021-03-18

申请号：US17103912

申请日：2020-11-24

Applicant: InnovaPrep LLC

Inventor： Alec D. Adolphson ,  Ann K. Packingham ,  Andrew E. Page ,  David S. Alburty ,  Zachary A. Packingham ,  John D. Birkenholz ,  Michael F. Fischer

IPC: A61B10/02 ,  A61B10/00

Abstract: Devices, systems and methods are disclosed which relate to using wet foam elution for removal of particles from swabs and wipes. This allow users to capture particles from surfaces and recover them by elution into small sample volumes for subsequent detection for human clinical, veterinary, food safety, pharmaceutical, outbreak investigations, forensics, biodefense and bioterrorism response, environmental monitoring, and other applications where collection of samples from surfaces and humans or animals is required. More specifically, the swabs or wipes are used to collect samples in the standard ways that commercially available swabs and wipes are in use today; from, for instance, food preparation surfaces in food plants, from production equipment in pharmaceutical facilities, for collection of dry powders during bioterrorism event response, and for collection of clinical samples such as nasal, throat, nasopharyngeal, and wounds.

公开(公告)号：US10544445B2

公开(公告)日：2020-01-28

申请号：US15681078

申请日：2017-08-18

Applicant: InnovaPrep LLC

Inventor： David S. Alburty ,  Andrew E. Page ,  Zachary A. Packingham ,  Daniel B. Marske

IPC: C12Q1/24 ,  G01N1/40 ,  C12Q1/04

Abstract: A rapid one-pass liquid filtration system efficiently concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. Additional concentration stages may be added in “cascade” fashion, in order to concentrate particles below the size cut of each preceding stage remaining in the separated fluid in a concentrated sample suspension. This process can also be used to create a “band-pass” concentration for concentration of a particular target size particle within a narrow range.

公开(公告)号：US20170369925A1

公开(公告)日：2017-12-28

申请号：US15681078

申请日：2017-08-18

Applicant: InnovaPrep LLC

Inventor： David S. Alburty ,  Andrew E. Page ,  Zachary A. Packingham ,  Daniel B. Marske

IPC: C12Q1/24 ,  C12Q1/04 ,  G01N1/40

CPC classification number: C12Q1/24 ,  C12Q1/04 ,  G01N1/4005 ,  G01N1/4077 ,  G01N2001/4088

Abstract: A rapid one-pass liquid filtration system efficiently concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. Additional concentration stages may be added in “cascade” fashion, in order to concentrate particles below the size cut of each preceding stage remaining in the separated fluid in a concentrated sample suspension. This process can also be used to create a “band-pass” concentration for concentration of a particular target size particle within a narrow range.

公开(公告)号：US20170184478A1

公开(公告)日：2017-06-29

申请号：US15456981

申请日：2017-03-13

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  Zachary A. Packingham ,  David Scott Alburty ,  Alec D. Adolphson

IPC: G01N1/40 ,  C12Q1/24

CPC classification number: G01N1/4077 ,  B01L3/0275 ,  B01L2200/026 ,  B01L2200/0631 ,  B01L2300/0681 ,  B01L2300/161 ,  C12Q1/24 ,  G01N2001/4088

Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.

公开(公告)号：US09534989B2

公开(公告)日：2017-01-03

申请号：US14084403

申请日：2013-11-19

Applicant: InnovaPrep LLC

Inventor： Andrew Edward Page ,  David Scott Alburty ,  Alec D. Adolphson ,  Pamela S. Murowchick ,  Zachary A. Packingham

IPC: G01N1/22 ,  G01N1/40

CPC classification number: G01N1/4077 ,  B01D46/0032 ,  B01D46/0067 ,  B01D46/543 ,  G01N1/2205 ,  G01N1/2273 ,  G01N2001/4088

Abstract: Devices, systems and methods are disclosed which relate to using a wet foam elution method for removal of particles from a flat filter. Particles are captured from the atmosphere onto the flat filter. The flat filter is then placed into an extractor which passes a stream of wet foam through the flat filter. Expansion of the foam works to efficiently remove captured particles. The foam flows from the filter along with the captured particles into a sample container. Once in the sample container, the foam quickly breaks down leaving an analysis ready liquid sample.

Abstract translation: 公开了涉及使用湿泡沫洗脱法从扁平过滤器去除颗粒的装置，系统和方法。 颗粒从大气中捕获到扁平过滤器上。 然后将扁平过滤器放入提取器中，该提取器将湿泡沫流通过扁平过滤器。 泡沫的膨胀用于有效去除捕获的颗粒。 泡沫从捕获的颗粒与过滤器一起流入样品容器。 一旦在样品容器中，泡沫快速分解，留下分析就绪的液体样品。