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公开(公告)号：US07592441B2
公开(公告)日：2009-09-22
申请号：US11418875
申请日：2006-05-04
申请人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
发明人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
CPC分类号： C12Q1/6886 , C07K14/4748 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178
摘要： Described herein are novel polynucleotides associated with liver cancer. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of liver cancer. Also described herein are methods that can be used to identify modulators of the disease-associated polynucleotides. Also described herein are methods and compositions for linear amplification and labeling of a targeted nucleic acid. The amplified targeted molecules may be used in hybridization techniques like Luminex and Microarray analysis.
摘要翻译： 本文描述的是与肝癌相关的新型多核苷酸。 多核苷酸是miRNA，miRNA前体和相关核酸。 描述了可用于肝癌诊断，预后和治疗的方法和组合物。 本文还描述了可用于鉴定疾病相关多核苷酸的调节剂的方法。 本文还描述了用于靶向核酸的线性扩增和标记的方法和组合物。 扩增的靶向分子可用于杂交技术，如Luminex和Microarray分析。
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公开(公告)号：US20070259352A1
公开(公告)日：2007-11-08
申请号：US11429720
申请日：2006-05-08
申请人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
发明人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
CPC分类号： C12Q1/6886 , C07K14/4748 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178
摘要： Described herein are novel polynucleotides associated with prostate cancer. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of prostate cancer. Also described herein are methods that can be used to identify modulators of the disease-associated polynucleotides. Also described herein are methods and compositions for linear amplification and labeling of a targeted nucleic acid. The amplified targeted molecules may be used in hybridization techniques like Luminex and Microarray analysis.
摘要翻译： 本文描述了与前列腺癌相关的新型多核苷酸。 多核苷酸是miRNA，miRNA前体和相关核酸。 描述了可用于诊断，预后和治疗前列腺癌的方法和组合物。 本文还描述了可用于鉴定疾病相关多核苷酸的调节剂的方法。 本文还描述了用于靶向核酸的线性扩增和标记的方法和组合物。 扩增的靶向分子可用于杂交技术，如Luminex和Microarray分析。
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公开(公告)号：US20070259349A1
公开(公告)日：2007-11-08
申请号：US11418718
申请日：2006-05-04
申请人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
发明人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178
摘要： Described herein are novel polynucleotides associated with bladder cancer. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of bladder cancer. Also described herein are methods that can be used to identify modulators of the disease-associated polynucleotides. Also described herein are methods and compositions for linear amplification and labeling of a targeted nucleic acid. The amplified targeted molecules may be used in hybridization techniques like Luminex and Microarray analysis.
摘要翻译： 本文描述的是与膀胱癌相关的新型多核苷酸。 多核苷酸是miRNA，miRNA前体和相关核酸。 描述了可用于膀胱癌的诊断，预后和治疗的方法和组合物。 本文还描述了可用于鉴定疾病相关多核苷酸的调节剂的方法。 本文还描述了用于靶向核酸的线性扩增和标记的方法和组合物。 扩增的靶向分子可用于杂交技术，如Luminex和Microarray分析。
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公开(公告)号：US20110189766A1
公开(公告)日：2011-08-04
申请号：US12800556
申请日：2010-02-08
申请人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
发明人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12N2330/10 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178
摘要： Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.
摘要翻译： 本文描述了与前列腺和肺癌相关的新型多核苷酸。 多核苷酸是miRNA和miRNA前体。 公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。 本文还描述了可用于鉴定前列腺和肺癌调节剂的方法。
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公开(公告)号：US07709616B2
公开(公告)日：2010-05-04
申请号：US11130645
申请日：2005-05-16
申请人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
发明人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
CPC分类号： C12N15/113 , A61K38/00 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2330/10 , C12Q1/6809 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , Y02A90/26
摘要： Described herein are polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.
摘要翻译： 本文描述的是与前列腺和肺癌相关的多核苷酸。 多核苷酸是miRNA和miRNA前体。 公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。 本文还描述了可用于鉴定前列腺和肺癌调节剂的方法。
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公开(公告)号：US20080182237A1
公开(公告)日：2008-07-31
申请号：US11418870
申请日：2006-05-04
申请人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
发明人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12N2330/10 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178
摘要： Described are polynucleotides associated with lung cancer. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of lung cancer. Also described are methods that can be used to identify modulators of the disease-associated polynucleotides. Also described are methods and compositions for linear amplification and labeling of a targeted nucleic acid. The amplified targeted molecules may be used in hybridization techniques like Luminex and Microarray analysis.
摘要翻译： 描述了与肺癌相关的多核苷酸。 多核苷酸是miRNA，miRNA前体和相关核酸。 描述了可用于诊断，预后和治疗肺癌的方法和组合物。 还描述了可用于鉴定疾病相关多核苷酸的调节剂的方法。 还描述了用于靶向核酸的线性扩增和标记的方法和组合物。 扩增的靶向分子可用于杂交技术，如Luminex和Microarray分析。
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公开(公告)号：US20070166724A1
公开(公告)日：2007-07-19
申请号：US11275628
申请日：2006-01-19
申请人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
发明人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/10 , C12N2330/10
摘要： Described herein are novel polynucleotides associated with disease. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of disease. Also described herein are methods that can be used to identify modulators of the disease-associated polynucleotides.
摘要翻译： 本文描述的是与疾病相关的新型多核苷酸。 多核苷酸是miRNA，miRNA前体和相关核酸。 描述了可用于诊断，预后和治疗疾病的方法和组合物。 本文还描述了可用于鉴定疾病相关多核苷酸的调节剂的方法。
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公开(公告)号：US20070050146A1
公开(公告)日：2007-03-01
申请号：US11130645
申请日：2005-05-16
申请人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
发明人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
CPC分类号： C12N15/113 , A61K38/00 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2330/10 , C12Q1/6809 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , Y02A90/26
摘要： Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.
摘要翻译： 本文描述了与前列腺和肺癌相关的新型多核苷酸。 多核苷酸是miRNA和miRNA前体。 公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。 本文还描述了可用于鉴定前列腺和肺癌调节剂的方法。
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公开(公告)号：US20070003575A1
公开(公告)日：2007-01-04
申请号：US11511035
申请日：2006-08-28
申请人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
发明人： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
CPC分类号： C12Q1/701 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2310/141 , C12N2320/10 , C12N2320/30 , C12N2330/10 , C12N2710/16222 , C12Q2600/136
摘要： Described herein are novel polynucleotides associated with viral infections. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of viral infections.
摘要翻译： 本文描述的是与病毒感染相关的新型多核苷酸。 多核苷酸是miRNA和miRNA前体。 公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。 本文还描述了可用于鉴定病毒感染调节剂的方法。
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公开(公告)号：US08481506B2
公开(公告)日：2013-07-09
申请号：US12517760
申请日：2007-12-05
申请人： Issac Bentwich , Amir Avniel , Ranit Aharonov , Yael Karov , Yonat Shemer-Avni , Asal Levy
发明人： Issac Bentwich , Amir Avniel , Ranit Aharonov , Yael Karov , Yonat Shemer-Avni , Asal Levy
CPC分类号： C12N15/1133 , A61K48/00 , C12N15/113 , C12N15/1131 , C12N15/1132 , C12N2310/141 , C12N2320/11 , C12N2330/10 , C12N2330/31 , C12N2710/16022 , C12N2760/16122 , C12N2760/18522
摘要： Provided herein are isolated viral and human nucleic acids associated with viral infection and various nucleic acid molecules relating thereto or derived therefrom. The nucleic acids may be useful for the prevention, treatment and diagnosis of viral infections.
摘要翻译： 本文提供了与病毒感染相关的分离的病毒和人核酸以及与其相关或由其衍生的各种核酸分子。 核酸可用于预防，治疗和诊断病毒感染。
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