公开(公告)号：US20090299174A1

公开(公告)日：2009-12-03

申请号：US10585494

申请日：2005-01-12

申请人： J. Nelson Wright ,  Steven C. Dimmer

发明人： J. Nelson Wright ,  Steven C. Dimmer

IPC分类号： A61B5/05 ,  A61B6/12

CPC分类号： A61M25/0127 ,  A61B5/06 ,  A61B5/062 ,  A61B34/20 ,  A61B90/36 ,  A61B2034/2051 ,  A61B2034/2072

摘要： Instruments and methods for tracking such instruments in a human patient. One embodiment of an instrument in accordance with the invention comprises an elongated body, such as an elongated flexible member, which has a distal section configured to be passed through a vessel or other passageway in a human. The instrument can further include a lumen through the distal section and a magnetic marker having a transponder at the distal section. The transponder includes a circuit configured to be energized by a wirelessly transmitted magnetic excitation energy and to wirelessly transmit a magnetic location signal in response to the excitation energy. The magnetic marker, for example, can be attached to or otherwise integral with the instrument.

摘要翻译： 用于在人类患者中跟踪这些器械的仪器和方法。 根据本发明的器械的一个实施例包括细长主体，例如细长的柔性构件，其具有构造成穿过人体中的血管或其它通道的远侧部分。 仪器还可以包括通过远侧部分的内腔和在远侧部分具有应答器的磁性标记。 应答器包括被配置为由无线传输的磁激发能量激励并且响应于激发能量无线地发送磁位置信号的电路。 例如，磁性标记可以附着到仪器或以其他方式与仪器一体。

公开(公告)号：US20090209852A1

公开(公告)日：2009-08-20

申请号：US11817383

申请日：2006-03-02

申请人： Timothy P. Mate ,  Steven C. Dimmer ,  Laurence J. Newell ,  J. Nelson Wright

发明人： Timothy P. Mate ,  Steven C. Dimmer ,  Laurence J. Newell ,  J. Nelson Wright

IPC分类号： A61N5/00 ,  A61B19/00

CPC分类号： A61B90/16 ,  A61B34/20 ,  A61B34/25 ,  A61B90/14 ,  A61B90/39 ,  A61B2034/2051 ,  A61B2090/101 ,  A61B2090/363 ,  A61B2090/374 ,  A61B2090/3975 ,  A61B2090/3995

摘要： Systems and methods for locating and tracking a target, i.e., measuring the position and/or rotation of a target during setup and treatment of a patient in guided radiation therapy applications for the head and neck. One embodiment is directed toward a device having a body and markers, such as excitable transponders and/or radiographic fiducials, fixable in or on the body for localizing the body. For example, the body can be a mouthpiece body having a channel configured to receive a patient's teeth such that the mouthpiece is repeatedly and consistently placed in the same relative position in the patient when the patient bites down on the mouthpiece. The transponders can be alternating magnetic transponders and the fiducials can be gold seeds. Other embodiments include a device having a two-piece body, a first piece of the body having excitable transponders and a second piece of the body having radiographic fiducials.

摘要翻译： 用于定位和跟踪目标的系统和方法，即在用于头颈部的引导放射治疗应用中，在患者的建立和治疗期间测量目标的位置和/或旋转。 一个实施例涉及具有身体和标记的装置，例如可固定在身体中或身体上的可兴奋的应答器和/或射线照相基准体，用于使身体定位。 例如，身体可以是具有通道的接口管体，该通道被配置为接收患者的牙齿，使得当患者咬在嘴件上时，接口管被重复且一致地放置在患者的相同相对位置。 应答器可以是交替磁转发器，基准可以是金种子。 其他实施例包括具有两件式主体的装置，具有可兴奋的应答器的本体的第一部分和具有放射照相基准的本体的第二部分。

公开(公告)号：US10195464B2

公开(公告)日：2019-02-05

申请号：US11165843

申请日：2005-06-24

申请人： Edward J. Vertatschitsch ,  Steven C. Dimmer ,  Timothy P. Mate ,  Eric Meier ,  Keith Seiler ,  J. Nelson Wright

发明人： Edward J. Vertatschitsch ,  Steven C. Dimmer ,  Timothy P. Mate ,  Eric Meier ,  Keith Seiler ,  J. Nelson Wright

IPC分类号： A61B5/05 ,  A61N5/10 ,  A61B34/30 ,  A61B34/00 ,  A61B90/00

摘要： Systems and methods for treating a lung of a patient. One embodiment of a method comprises positioning a leadless marker in the lung of the patient relative to the target, and collecting position data of the marker. This method further comprises determining the location of the marker in an external reference frame outside of the patient based on the collected position data, and providing an objective output in the external reference frame that is responsive to movement of the marker. The objective output is provided at a frequency (i.e., periodicity) that results in a clinically acceptable tracking error. In addition, the objective output can also be provided at least substantially contemporaneously with collecting the position data used to determine the location of the marker.

公开(公告)号：US20090216113A1

公开(公告)日：2009-08-27

申请号：US12159554

申请日：2006-11-17

申请人： Eric Meier ,  Steven C. Dimmer ,  J. Nelson Wright ,  Rich Edelson

发明人： Eric Meier ,  Steven C. Dimmer ,  J. Nelson Wright ,  Rich Edelson

IPC分类号： A61B5/05

CPC分类号： A61B17/32 ,  A61B5/0002 ,  A61B5/062 ,  A61B5/4504 ,  A61B5/686 ,  A61B17/15 ,  A61B17/155 ,  A61B17/157 ,  A61B17/17 ,  A61B17/1757 ,  A61B90/39 ,  A61B2017/320052 ,  A61B2090/3958 ,  A61B2090/3966 ,  A61B2090/3975 ,  A61B2090/3991 ,  A61F2/32 ,  A61F2/38 ,  A61F2/441 ,  A61F2002/3067 ,  A61F2250/0002 ,  G06F19/00

摘要： Electromagnetic transponders as markers are used to localize and guide orthopedic procedures including: knee replacement, hip replacement, shoulder replacement, damaged bone reconstruction, and spine surgery, and more particularly, to guide orthopedic surgical navigation and alignment techniques and instruments. For example, the marker could further be used in any number of guides or templates that attach to the bony anatomy, such as a surgical guide, cutting guide, cutting jig, resection block and/or resurfacing guide. Further, the marker could be incorporated into an existing intramedullary guide rod for a femur and an extramedullary guide rod for a tibia in a knee replacement surgery; or into an external surgical guide system, or the marker could eliminate the need for an external template altogether. According to yet another anticipated use of the tracking system, the marker could be used in conjunction with or replace an optical alignment system.

摘要翻译： 电磁转发器作为标记用于定位和引导矫形手术，包括：膝关节置换，髋关节置换，肩关节置换，骨重建受损和脊柱手术，更具体地，指导骨科手术导航和对准技术和手段。 例如，标记可以进一步用于附着于骨骼解剖结构的任何数量的引导件或模板中，例如手术引导件，切割引导件，切割夹具，切除块和/或表面置换引导件。 此外，标记可以结合到膝关节置换手术中用于股骨的现有髓内导杆和用于胫骨的髓外导杆; 或进入外部手术引导系统，或者标记可以完全消除对外部模板的需要。 根据跟踪系统的另一预期使用，标记可以与光学对准系统结合使用或替代光学对准系统。

公开(公告)号：US08340742B2

公开(公告)日：2012-12-25

申请号：US11190196

申请日：2005-07-25

申请人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

发明人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

IPC分类号： A61B5/05

CPC分类号： A61N5/1039 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1051

摘要： An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy type to identify the marker that is different than the first energy type.

摘要翻译： 综合放射治疗过程包括通过使用定位模式周期性地定位位于患者内的标记来获取与患者内的目标参数有关的第一目标目标数据。 该方法继续通过周期性地定位标记来获得与目标参数相关的第二目标目标数据。 第一目标数据可以在离开包含用于产生用于治疗患者的电离辐射束的辐射递送装置的第二区域的第一区域中获取。 第一和第二区域的定位方式可以相同。 在其他实施例中，可以使用使用第一能量类型来识别标记的第一定位模态来获取第一目标目标数据，并且可以使用第二定位模式来获得第二目标数据，第二定位模式使用第二能量类型来识别 不同于第一种能量类型的标记。

公开(公告)号：US20120323062A1

公开(公告)日：2012-12-20

申请号：US13346569

申请日：2012-01-09

申请人： J. Nelson Wright ,  Steven C. Dimmer ,  Stephen C. Phillips ,  Ryan K. Seghers

发明人： J. Nelson Wright ,  Steven C. Dimmer ,  Stephen C. Phillips ,  Ryan K. Seghers

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61B2090/3958 ,  A61N5/107 ,  A61N2005/1051

摘要： A facility for processing data is described. The facility receives a stream of digital location indications, each location indication identifying a location of a patient while undergoing radiation therapy. In response to each location indication of the string, in substantially real-time relative to the receipt of the position indication, the facility performs an action responsive to the location indication.

摘要翻译： 描述处理数据的设施。 该设施接收数字位置指示流，每个位置指示在进行放射治疗时识别患者的位置。 响应于字符串的每个位置指示，基本上实时地相对于接收到位置指示，设施执行响应于位置指示的动作。

公开(公告)号：US08244330B2

公开(公告)日：2012-08-14

申请号：US11190195

申请日：2005-07-25

申请人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

发明人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

IPC分类号： A61B5/05

CPC分类号： A61N5/1039 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1051

摘要： An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy type to identify the marker that is different than the first energy type.

公开(公告)号：US07176798B2

公开(公告)日：2007-02-13

申请号：US10997080

申请日：2004-11-23

申请人： Steven C. Dimmer ,  J. Nelson Wright ,  William T. Mayo

发明人： Steven C. Dimmer ,  J. Nelson Wright ,  William T. Mayo

IPC分类号： G08B13/14

CPC分类号： G08B13/2414 ,  A61B5/06 ,  A61B5/062 ,  A61B34/20 ,  A61B90/36 ,  A61B2017/00154 ,  A61B2017/00411 ,  A61B2034/2051 ,  A61B2090/3958 ,  A61B2090/3975 ,  A61N5/1049 ,  A61N2005/1051 ,  H01Q7/08

摘要： A system for generating a magnetic field for excitation of a leadless marker assembly. The system of at least one embodiment includes a source generator that generates a plurality of alternating electrical signals each having an independently adjustable phase. A plurality of excitation coils are configured to simultaneously receive a respective one of the alternating electrical signals at a selected phase to generate a magnetic field. The phase of the alternating electrical signal for each excitation coil is independently adjustable relative to the phase of the alternating electrical signal for the other excitation coils so as to adjust the magnetic field from the respective coil. The magnetic fields from the excitation coils combine to form a spatially adjustable excitation field for excitation of the remote leadless marker assembly.

摘要翻译： 一种用于产生用于无引线标记组件的激励的磁场的系统。 至少一个实施例的系统包括源发生器，其产生多个具有独立可调相位的交替电信号。 多个激励线圈被配置为在选定的相位处同时接收相应的一个交流电信号以产生磁场。 每个励磁线圈的交流电信号的相位相对于其他励磁线圈的交变电信号的相位可独立地调节，以便调整来自相应线圈的磁场。 来自激励线圈的磁场组合形成用于激发远程无引线标记组件的空间可调的激励场。

公开(公告)号：US06822570B2

公开(公告)日：2004-11-23

申请号：US10213980

申请日：2002-08-07

申请人： Steven C. Dimmer ,  J. Nelson Wright ,  William T. Mayo

发明人： Steven C. Dimmer ,  J. Nelson Wright ,  William T. Mayo

IPC分类号： G08B1314

CPC分类号： G08B13/2414 ,  A61B5/06 ,  A61B5/062 ,  A61B34/20 ,  A61B90/36 ,  A61B2017/00154 ,  A61B2017/00411 ,  A61B2034/2051 ,  A61B2090/3958 ,  A61B2090/3975 ,  A61N5/1049 ,  A61N2005/1051 ,  H01Q7/08

摘要： A system for generating a magnetic field for excitation of a leadless marker assembly. The system of at least one embodiment includes a source generator that generates a plurality of alternating electrical signals each having an independently adjustable phase. A plurality of excitation coils are configured to simultaneously receive a respective one of the alternating electrical signals at a selected phase to generate a magnetic field. The phase of the alternating electrical signal for each excitation coil is independently adjustable relative to the phase of the alternating electrical signal for the other excitation coils so as to adjust the magnetic field from the respective coil. The magnetic fields from the excitation coils combine to form a spatially adjustable excitation field for excitation of the remote leadless marker assembly.

摘要翻译： 一种用于产生用于无引线标记组件的激励的磁场的系统。 至少一个实施例的系统包括源发生器，其产生多个具有独立可调相位的交替电信号。 多个激励线圈被配置为在选定的相位处同时接收相应的一个交流电信号以产生磁场。 每个励磁线圈的交流电信号的相位相对于其他励磁线圈的交变电信号的相位可独立地调节，以便调整来自相应线圈的磁场。 来自激励线圈的磁场组合形成用于激发远程无引线标记组件的空间可调的激励场。

公开(公告)号：US07684849B2

公开(公告)日：2010-03-23

申请号：US10750164

申请日：2003-12-31

申请人： J. Nelson Wright ,  Laurence J. Newell

发明人： J. Nelson Wright ,  Laurence J. Newell

IPC分类号： A61B5/05

CPC分类号： A61B5/06 ,  A61B5/062 ,  A61B2034/2051

摘要： A receiver for determining the location of a marker that is excited with an exciting waveform. A sensing array having coils is used to sense magnetic flux from the resonating marker. The coils provide inputs to the receiver. The receiver includes a correlation processor for analyzing the inputs in a coherent manner. Further, the receiver is synchronized to act on inputs that are gathered when a treatment radiation source is inactive.

摘要翻译： 用于确定用激发波形激发的标记的位置的接收器。 具有线圈的感测阵列用于感测来自谐振标记的磁通量。 线圈为接收器提供输入。 接收机包括用于以相干方式分析输入的相关处理器。 此外，接收器被同步以作用于当处理辐射源不活动时收集的输入。