公开(公告)号：US09616248B2

公开(公告)日：2017-04-11

申请号：US13559518

申请日：2012-07-26

申请人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

发明人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

IPC分类号： A61B5/05 ,  A61N5/10

CPC分类号： A61N5/1039 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1051

摘要： An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy.

公开(公告)号：US08437449B2

公开(公告)日：2013-05-07

申请号：US11189431

申请日：2005-07-25

申请人： James K. Riley ,  Eric Meier ,  J. Nelson Wright ,  Steven C. Dimmer ,  Timothy P. Mate

发明人： James K. Riley ,  Eric Meier ,  J. Nelson Wright ,  Steven C. Dimmer ,  Timothy P. Mate

IPC分类号： A61N5/10 ,  A61B5/00

CPC分类号： A61N5/1038 ,  A61N5/103 ,  A61N5/1048

摘要： A facility for facilitating custom radiation treatment planning is described. During a distinguished radiation treatment session for a patient, the facility collects data indicating positioning of a predefined treatment site of the patient relative to a target treatment location throughout the distinguished radiation treatment session. The facility associates the collected positioning data with data describing one or more other aspects of the distinguished radiation treatment session. The facility provides the associated data to a treatment planning facility to determine a treatment plan for future radiation treatment sessions for the patient.

摘要翻译： 描述了一种便于定制辐射治疗计划的设施。 在针对患者的不同的辐射治疗期间，设施收集指示患者相对于目标治疗位置在整个识别的辐射治疗期间的定位的数据。 该设施将收集的定位数据与描述不同的辐射治疗会话的一个或多个其他方面的数据相关联。 该设施将相关数据提供给治疗计划设施，以确定患者将来的放射治疗期间的治疗计划。

公开(公告)号：US08239005B2

公开(公告)日：2012-08-07

申请号：US12684639

申请日：2010-01-08

申请人： J. Nelson Wright ,  Steven C. Dimmer

发明人： J. Nelson Wright ,  Steven C. Dimmer

IPC分类号： A61B5/05

CPC分类号： A61B5/06 ,  A61B5/055 ,  A61B6/12 ,  A61B8/0833 ,  A61B34/20 ,  A61B34/25 ,  A61B90/36 ,  A61B90/39 ,  A61B2034/2051 ,  A61B2034/252 ,  A61B2090/3908 ,  A61B2090/3954 ,  A61B2090/3958 ,  A61B2090/3995 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1051

摘要： Systems and methods for tracking targets in real time for radiation therapy and other applications. In one embodiment, a method includes collecting position information of a marker implanted within a patient at a site relative to the target at a time tn, and providing an objective output indicative of the location of the target based on the position information collected at time tn. The objective output is provided to a memory device, user interface, and/or radiation delivery machine within 1 ms to 2 seconds of the time tn when the position information was collected. This embodiment of the method can further include providing the objective output at a periodicity of 10-200 ms during at least a portion of a treatment procedure. For example, the method can further include generating a beam of ionizing radiation and directing the beam to a machine isocenter, and continuously repeating the collecting procedure and the providing procedure every 10-200 ms while irradiating the patient with the ionizing radiation beam.

摘要翻译： 用于实时跟踪靶向放射治疗和其他应用的系统和方法。 在一个实施例中，一种方法包括在时刻tn收集在相对于目标的位置处植入在患者体内的标记的位置信息，并且基于在时间tn收集的位置信息提供指示目标位置的客观输出 。 当收集位置信息时，在时间tn的1秒至2秒内，将目标输出提供给存储装置，用户界面和/或辐射递送机。 该方法的该实施例还可以包括在至少一部分治疗过程期间以10-200ms的周期提供目标输出。 例如，该方法可以进一步包括产生电离辐射束并将光束引导到机器等角点，并且在每隔10-200毫秒同时持续地重复采集过程和提供过程，同时用电离辐射束照射患者。

公开(公告)号：US08095203B2

公开(公告)日：2012-01-10

申请号：US11190205

申请日：2005-07-25

申请人： J. Nelson Wright ,  Steven C. Dimmer ,  Stephen C. Phillips ,  Ryan K. Seghers

发明人： J. Nelson Wright ,  Steven C. Dimmer ,  Stephen C. Phillips ,  Ryan K. Seghers

IPC分类号： A61B5/05

CPC分类号： A61N5/1049 ,  A61B2090/3958 ,  A61N5/107 ,  A61N2005/1051

摘要： A facility for processing data is described. The facility receives a stream of digital location indications, each location indication identifying a location of a patient while undergoing radiation therapy. In response to each location indication of the string, in substantially real-time relative to the receipt of the position indication, the facility performs an action responsive to the location indication.

摘要翻译： 描述处理数据的设施。 该设施接收数字位置指示流，每个位置指示在进行放射治疗时识别患者的位置。 响应于字符串的每个位置指示，基本上实时地相对于接收到位置指示，设施执行响应于位置指示的动作。

公开(公告)号：US20090306728A1

公开(公告)日：2009-12-10

申请号：US10585493

申请日：2005-01-12

申请人： J. Nelson Wright ,  Steven C. Dimmer

发明人： J. Nelson Wright ,  Steven C. Dimmer

IPC分类号： A61N1/36 ,  A61N1/08 ,  A61N1/05

CPC分类号： A61N1/0531 ,  A61B5/04001 ,  A61B5/4041 ,  A61B5/6864 ,  A61B2090/3958 ,  A61B2090/3975 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36082

摘要： Instruments and method of using instruments for implanting electrodes into a patient. The instrument can include a body configured to be implanted into a patient, an electrode contact carried by the body, and a marker carried by the body. The electrode contact has an electrically conductive surface exposed at a location along the body to sense electrical activity and/or deliver electrical stimulation to the target neural structure. The marker can include a transponder configured to be energized by a wirelessly transmitted excitation energy and to wirelessly transmit a location signal in response to the excitation energy. The instrument is tracked as it is implanted into the patient by time multiplexing the wirelessly transmitted excitation energy and the location signal such that the absolute location of the marker can be determined in real time.

摘要翻译： 用于将电极植入患者体内的仪器和方法。 仪器可以包括构造成植入病人的身体，由身体携带的电极接触件和由身体携带的标记物。 电极接触件具有暴露在沿着身体的位置处的导电表面以感测电活动和/或传递对目标神经结构的电刺激。 标记可以包括被配置为通过无线传输的激发能量激励并且响应于激发能量无线地发送位置信号的应答器。 通过对无线传输的激发能量和位置信号进行时间复用，将其仪器植入患者体内，使得可以实时确定标记的绝对位置。

公开(公告)号：US09623208B2

公开(公告)日：2017-04-18

申请号：US10585494

申请日：2005-01-12

申请人： J. Nelson Wright ,  Steven C. Dimmer

发明人： J. Nelson Wright ,  Steven C. Dimmer

IPC分类号： A61B5/05 ,  A61M25/01 ,  A61B5/06 ,  A61B90/00 ,  A61B34/20

CPC分类号： A61M25/0127 ,  A61B5/06 ,  A61B5/062 ,  A61B34/20 ,  A61B90/36 ,  A61B2034/2051 ,  A61B2034/2072

摘要： Instruments and methods for tracking such instruments in a human patient. One embodiment of an instrument in accordance with the invention comprises an elongated body, such as an elongated flexible member, which has a distal section configured to be passed through a vessel or other passageway in a human. The instrument can further include a lumen through the distal section and a magnetic marker having a transponder at the distal section. The transponder includes a circuit configured to be energized by a wirelessly transmitted magnetic excitation energy and to wirelessly transmit a magnetic location signal in response to the excitation energy. The magnetic marker, for example, can be attached to or otherwise integral with the instrument.

公开(公告)号：US20100317968A1

公开(公告)日：2010-12-16

申请号：US12684639

申请日：2010-01-08

申请人： J. Nelson Wright ,  Steven C. Dimmer

发明人： J. Nelson Wright ,  Steven C. Dimmer

IPC分类号： A61B6/00 ,  A61N5/00 ,  A61N5/10

CPC分类号： A61B5/06 ,  A61B5/055 ,  A61B6/12 ,  A61B8/0833 ,  A61B34/20 ,  A61B34/25 ,  A61B90/36 ,  A61B90/39 ,  A61B2034/2051 ,  A61B2034/252 ,  A61B2090/3908 ,  A61B2090/3954 ,  A61B2090/3958 ,  A61B2090/3995 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1051

摘要： Systems and methods for tracking targets in real time for radiation therapy and other applications. In one embodiment, a method includes collecting position information of a marker implanted within a patient at a site relative to the target at a time tn, and providing an objective output indicative of the location of the target based on the position information collected at time tn. The objective output is provided to a memory device, user interface, and/or radiation delivery machine within 1 ms to 2 seconds of the time tn when the position information was collected. This embodiment of the method can further include providing the objective output at a periodicity of 10-200 ms during at least a portion of a treatment procedure. For example, the method can further include generating a beam of ionizing radiation and directing the beam to a machine isocenter, and continuously repeating the collecting procedure and the providing procedure every 10-200 ms while irradiating the patient with the ionizing radiation beam.

摘要翻译： 用于实时跟踪靶向放射治疗和其他应用的系统和方法。 在一个实施例中，一种方法包括在时刻tn收集在相对于目标的位置处植入在患者体内的标记的位置信息，并且基于在时间tn收集的位置信息提供指示目标位置的客观输出 。 当收集位置信息时，在时间tn的1秒至2秒内，将目标输出提供给存储装置，用户界面和/或辐射递送机。 该方法的该实施例还可以包括在至少一部分治疗过程期间以10-200ms的周期提供目标输出。 例如，该方法可以进一步包括产生电离辐射束并将光束引导到机器等角点，并且在每隔10-200毫秒同时持续地重复采集过程和提供过程，同时用电离辐射束照射患者。

公开(公告)号：US09682253B2

公开(公告)日：2017-06-20

申请号：US11190193

申请日：2005-07-25

申请人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

发明人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

IPC分类号： A61B5/05 ,  A61N5/10

CPC分类号： A61N5/1039 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1051

摘要： An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy type to identify the marker that is different than the first energy type.

公开(公告)号：US20130172657A1

公开(公告)日：2013-07-04

申请号：US13559518

申请日：2012-07-26

申请人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

发明人： Eric Meier ,  Timothy P. Mate ,  J. Nelson Wright ,  Steven C. Dimmer ,  Lynn M. Purdy

IPC分类号： A61N5/10

CPC分类号： A61N5/1039 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1051

摘要： An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy.

摘要翻译： 综合放射治疗过程包括通过使用定位模式周期性地定位位于患者内的标记来获取与患者内的目标参数有关的第一目标目标数据。 该方法继续通过周期性地定位标记来获得与目标参数相关的第二目标目标数据。 第一目标数据可以在离开包含用于产生用于治疗患者的电离辐射束的辐射递送装置的第二区域的第一区域中获取。 第一和第二区域的定位方式可以相同。 在其他实施例中，可以使用使用第一能量类型来识别标记的第一定位模态来获取第一目标数据，并且可以使用使用第二能量的第二定位模态来获得第二目标数据。

公开(公告)号：US07696876B2

公开(公告)日：2010-04-13

申请号：US11627693

申请日：2007-01-26

申请人： Steven C. Dimmer ,  J. Nelson Wright ,  William T. Mayo

发明人： Steven C. Dimmer ,  J. Nelson Wright ,  William T. Mayo

IPC分类号： G08B13/14

CPC分类号： G08B13/2414 ,  A61B5/06 ,  A61B5/062 ,  A61B34/20 ,  A61B90/36 ,  A61B2017/00154 ,  A61B2017/00411 ,  A61B2034/2051 ,  A61B2090/3958 ,  A61B2090/3975 ,  A61N5/1049 ,  A61N2005/1051 ,  H01Q7/08

摘要： A system for generating a magnetic field for excitation of a leadless marker assembly. The system of at least one embodiment includes a source generator that generates a plurality of alternating electrical signals each having an independently adjustable phase. A plurality of excitation coils are configured to simultaneously receive a respective one of the alternating electrical signals at a selected phase to generate a magnetic field. The phase of the alternating electrical signal for each excitation coil is independently adjustable relative to the phase of the alternating electrical signal for the other excitation coils so as to adjust the magnetic field from the respective coil. The magnetic fields from the excitation coils combine to form a spatially adjustable excitation field for excitation of the remote leadless marker assembly.

摘要翻译： 一种用于产生用于无引线标记组件的激励的磁场的系统。 至少一个实施例的系统包括源发生器，其产生多个具有独立可调相位的交替电信号。 多个激励线圈被配置为在选定的相位处同时接收相应的一个交流电信号以产生磁场。 每个励磁线圈的交流电信号的相位相对于其他励磁线圈的交变电信号的相位可独立地调节，以便调整来自相应线圈的磁场。 来自激励线圈的磁场组合形成用于激发远程无引线标记组件的空间可调的激励场。