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公开(公告)号：US5091381A
公开(公告)日：1992-02-25
申请号：US684715
申请日：1991-04-12
申请人： Sun H. Kim , John E. Taylor
发明人： Sun H. Kim , John E. Taylor
IPC分类号： C07D255/04 , C07D403/06 , C07D405/06 , C07D409/06
CPC分类号： C07D403/06 , C07D255/04 , C07D405/06 , C07D409/06
摘要： Peripheral benzodiazepines (BZDs) are useful in treating disorders caused by abnormal level of peripheral benzodiazepene receptor activity and having, in one aspect, the formula: ##STR1## wherein each X, X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5, X.sub.6, and X.sub.8, independently, is hydrogen, halogen (F, Cl, Br, I), C.sub.1 -C.sub.4 straight or branched alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, hydroxy, nitro, cyano, amino, or trifluoromethyl; R.sub.1 =H, C.sub.1 -C.sub.4 alkyl, cyclo C.sub.3 -C.sub.5 alkyl, C.sub.1 -C.sub.4 alkenyl, CH.sub.2 --CO.sub.2 H, or CH.sub.3 --C.dbd.O; R.sub.2 =a member of the group of the formula (Ia) ##STR2## wherein each R.sub.3, R.sub.4, R.sub.8, R.sub.9, R.sub.10 and R.sub.11, independently, can be any of the groups listed as possibilities for X.sub.1 -X.sub.8, and can be attached at any available ring carbon atom, said R.sub.2 group being bonded to (CH.sub.2) in via any available ring carbon atom; n=0 or 1; and m=an integer between 1 and 4 provided that m is at least 1 when n=0.
摘要翻译： 外周苯并二氮杂（BZD）可用于治疗由外周苯并二氮杂受体活性异常水平引起的疾病，并且在一方面，具有以下分子式：其中每个X，X1，X2，X3，X4，X5，X6 ，X8独立地是氢，卤素（F，Cl，Br，I），C1-C4直链或支链烷基，C1-C4烷氧基，C1-C4烷硫基，羟基，硝基，氰基，氨基或三氟甲基; R1 = H，C1-C4烷基，环C3-C5烷基，C1-C4烯基，CH2-CO2H或CH3-C = O; 其中每个R 3，R 4，R 8，R 9，R 10和R 11独立地可以是任何式（Ia）的组中的任何一个， 列举为X1-X8的可能性的基团，并且可以连接在任何可用的环碳原子上，所述R2基团通过任何可用的环碳原子键合到（CH 2）; n = 0或1; 并且m = 1和4之间的整数，条件是当n = 0时，m至少为1。
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公开(公告)号：US4969305A
公开(公告)日：1990-11-13
申请号：US401068
申请日：1989-08-31
申请人： George York , John E. Taylor
发明人： George York , John E. Taylor
CPC分类号： B65C9/1873 , B65C1/021 , Y10T156/171
摘要： Indicia such as tax stamps are applied to objects such as cigarette packs by driving a heated ram against the back of an indicia supply tape to cause the indicium to transfer from the tape to the object. If the object is contained in outer packaging such as cigarette carton packaging, that outer packaging is opened prior to applying the indicia to the objects. Then the outer packaging is reclosed. The indicia supply tapes are contained in cartridges which are easily removed for reloading and storage in a secure place. The cartridges are mounted on heads in the machine which are movable to facilitate applying indicia with various spacings and in various arrangements.
摘要翻译： 通过将标记供应带的背面驱动加热的压头以使标记从胶带转移到物体上，将诸如香烟包装的标记施加到诸如香烟包装物之类的物品上。 如果物品包含在诸如香烟纸包装的外包装中，则在将标记应用于物体之前打开该外包装。 然后将外包装重新关闭。 标记供应带被容纳在盒中，其容易地移除以便在安全的地方重新加载和储存。 盒被安装在机器的头部上，其可移动以便于以各种间隔和各种布置来施加标记。
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公开(公告)号：US09129476B2
公开(公告)日：2015-09-08
申请号：US12238849
申请日：2008-09-26
CPC分类号： G07F17/3244 , G07F17/32 , G07F17/3225 , G07F17/3237 , G07F17/3239 , G07F17/3255
摘要： A system and method is provided for incentivizing players to visit a gambling location. In one aspect, a qualified person is invited to play an electronic game which has a plurality of outcomes, at least one of which is a winning outcome. In one embodiment, the qualified person may be required to redeem the outcome at the gambling location. In another embodiment, the person may be required to redeem the outcome at a redemption location. In another aspect, a method is provided for permitting a person to take one or more actions within a gambling location and in response inviting the person to play an electronic game separate from the games offered in a gambling environment at the gambling location, where the game has a plurality of outcomes, at least one of which is a winning outcome, and if the person obtains a winning outcome, requiring the person to redeem the at least one outcome at the gambling location. In one embodiment, the method includes the acts of qualifying a person. Qualification may require specific acts, for example, referring another person, and/or providing an invitation to play an electronic game to another person. Various systems and method assist in tracking and maintaining such referrals. Additionally group gaming in and amongst referrals and/or designated groups may be performed, and in some embodiment required for qualification and/or redemption. Further, another aspect relates to providing special incentives, for example for referral of a new player, for providing casino affiliation or membership information, among others.
摘要翻译： 提供了一种系统和方法，用于激励玩家访问赌博场所。 一方面，合格的人被邀请玩具有多个结果的电子游戏，其中至少一个是获胜结果。 在一个实施例中，可能需要合格的人员在赌博地点兑换结果。 在另一个实施例中，该人可能被要求在兑换地点兑换结果。 在另一方面，提供了一种允许一个人在赌博位置内采取一个或多个动作的方法，并且作为响应邀请该人与在赌博地点的赌博环境中提供的游戏分开玩一个电子游戏，其中该游戏 具有多个结果，其中至少一个是获胜结果，并且如果该人获得获胜结果，则要求该人在该赌博地点兑换该至少一个结果。 在一个实施例中，该方法包括限定人员的行为。 资格可能需要特定的行为，例如引用另一个人，和/或提供向另一个人玩电子游戏的邀请。 各种系统和方法有助于跟踪和维护这种转介。 此外，可以执行在转介和/或指定群组内和之间的组游戏，并且在某些实施例中需要资格和/或兑换。 此外，另一方面涉及提供特别的激励，例如用于转介新玩家，用于提供赌场附属或会员信息等。
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公开(公告)号：US20100311496A1
公开(公告)日：2010-12-09
申请号：US12645578
申请日：2009-12-23
IPC分类号： A63F9/24
CPC分类号： G07F17/32 , A63F13/10 , A63F13/12 , A63F2300/55
摘要： According to one aspect, provided are systems and methods for generating unrestricted games (e.g. promotional games) that preserve predetermination and/or do not introduce chance elements into the games while at the same time reduce the overhead associated with generating and maintaining entries (i.e. tickets) into the games. As part of systems and methods for creating ticketed entries, values can be assigned to any of one or more of players, game machines, or games. These values can used as unique identifiers. Additionally, information already associated with any one or more of the players, game machines, or games can also be used to generate these values. The values can have static components and can be combined with dynamic components, that can be used individually, separately, or in combination. In one example a predetermined numeric value is used, stored as part of a record. In another, static information can be used to generate the numeric value, or a component of the value. Once the value, in some examples a seed, is obtained the value is used with a deterministic function to provide deterministically an output. The output permits retrieval of an outcome from for example a prize matrix of predetermined game outcomes. According to another aspect, the systems and methods provided permit deterministic ticket generation without having to generate and/or maintain the entries for any game.
摘要翻译： 根据一个方面，提供了用于生成不限制游戏（例如促销游戏）的系统和方法，其保持预定义和/或不将机会元素引入到游戏中，同时减少与生成和维护条目相关联的开销（即，票 ）进入游戏。 作为创建票据条目的系统和方法的一部分，值可以分配给一个或多个玩家，游戏机或游戏中的任何一个。 这些值可以用作唯一标识符。 另外，也可以使用与任何一个或多个玩家，游戏机或游戏相关联的信息来产生这些值。 这些值可以具有静态组件，并且可以与动态组件结合使用，可以单独使用，单独使用或组合使用。 在一个示例中，使用预定的数值作为记录的一部分存储。 另一方面，静态信息可用于生成数值或值的组成部分。 一旦在一些示例中获得了种子的值，则该值与确定性函数一起使用以提供确定性的输出。 输出允许从例如预定游戏结果的奖励矩阵检索结果。 根据另一方面，所提供的系统和方法允许确定性票据生成，而不必为任何游戏生成和/或维护条目。
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公开(公告)号：US6001801A
公开(公告)日：1999-12-14
申请号：US6348
申请日：1998-01-13
申请人： David H. Coy , John E. Taylor
发明人： David H. Coy , John E. Taylor
IPC分类号： C07K7/02 , A61K38/00 , C07K20060101 , C07K7/00 , C07K14/655 , A61K38/31 , A61K38/12
CPC分类号： C07K14/6555 , A61K38/00 , Y10S930/16
摘要： A cyclic peptide analog of somatostatin wherein a disulfide bond links the N-terminus residue and the C-terminus residue.
摘要翻译： 生长抑素的环肽类似物，其中二硫键连接N末端残基和C末端残基。
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公开(公告)号：US4793685A
公开(公告)日：1988-12-27
申请号：US125
申请日：1987-01-02
CPC分类号： G02B6/4434 , G02B6/4407
摘要： An elongate flexible core 1 especially suitable for use in an optical cable to be employed as an aerial cable has in its outer circumferential surface circumferentially spaced, longitudinally extending grooves 3 in which optical fibres 34 will be loosely housed and comprises extruded plastics material and a multiplicity of longitudinally stressed elongate flexible non-metallic reinforcing element each substantially encapsulated in the extruded plastics material, the multiplicity of non-metallic reinforcing elements being substantially evenly distributed throughout the cross-sectional area of the core. The non-metallic reinforcing elements preferably extend helically around the axis of the core a long length of lay and preferably constitute 60 to 70% by volume of the extruded plastics material. The non-metallic reinforcing elements are preferably made of an aromatic polyamide and the plastics material may be a thermoplastics material, a thermosetting material or a thermotropic liquid crystalline polymer. The core 1 may be a single elongate flexible body or it may comprise a plurality of elongate flexible bodies extending helically around the axis of the core.
摘要翻译： 特别适用于要用作架空电缆的光缆的细长柔性芯1在其外圆周表面周向间隔开的纵向延伸的槽3中，光纤34将被松动地容纳在其中，并且包括挤出的塑料材料和多重的 纵向应力细长的柔性非金属增强元件，各自基本上包封在挤出的塑料材料中，多个非金属增强元件基本上均匀分布在芯的横截面区域。 非金属增强元件优选地围绕芯的轴线螺旋地长度延伸，并且优选地构成挤出的塑料材料的60至70体积％。 非金属增强元件优选由芳族聚酰胺制成，并且塑料材料可以是热塑性材料，热固性材料或热致变液晶聚合物。 芯1可以是单个细长柔性体，或者其可以包括围绕芯的轴线螺旋地延伸的多个细长柔性体。
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公开(公告)号：US4630887A
公开(公告)日：1986-12-23
申请号：US620426
申请日：1984-06-14
申请人： John E. Taylor
发明人： John E. Taylor
CPC分类号： G02B6/448 , B29D11/00663 , G02B6/06 , G02B6/4403 , Y10T29/49801
摘要： An optical fibre ribbon structure suitable for use in an optical cable or other application where there is a risk that optical fibres will be subjected to a tensile force comprises a plurality of optical fibres and flexible reinforcing elements of resilient material arranged side by side and embedded in an elongate plastics body. Each resilient reinforcing element is set in such a form that the ribbon structure follows a path of smoothly curved undulations whose axes of curvature lie parallel to one another and normal to the longitudinal axis of the ribbon structure. When the undulting ribbon stucture is subjected to a tensile force, the ribbon structure straightens in a lengthwise direction against the action of the resilient reinforcing elements thereby reducing the tensile force otherwise applied to the optical fibres. When the tensile force is removed, the ribbon structure returns towards its original undulating form.
摘要翻译： 适用于光缆或其他应用中的光纤带结构，其中存在光纤将受到拉力的风险包括多个光纤和弹性材料的柔性增强元件并排布置并嵌入 细长的塑料体。 每个弹性增强元件被设置成使得带状结构沿着平滑弯曲的起伏的路径，其曲率轴线彼此平行并且垂直于带状结构的纵向轴线。 当未变形的带状结构受到张力时，带状结构抵抗弹性增强元件的作用沿长度方向拉直，从而降低另外施加到光纤上的张力。 当拉力被去除时，带状结构返回到其原始起伏的形式。
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公开(公告)号：US4109369A
公开(公告)日：1978-08-29
申请号：US551341
申请日：1975-02-20
申请人： John E. Taylor
发明人： John E. Taylor
CPC分类号： G02B6/3803 , G02B6/3801 , Y10T29/49901
摘要： In effecting a joint between two optical fibres an elongate gauge having a cross-sectional shape and size corresponding to that of each of the optical fibres to be jointed is laid on a substantially flat surface of a soft, substantially non-resilient metallic body, e.g. annealed copper, and is pressed into the surface to form in, and between two edges of, the surface a groove of a substantially complementary cross-sectional size. The gauge is removed and the two optical fibres are aligned in the groove so formed in such a way that neighboring ends of the optical fibres substantially abut. A second body having a flat surface is applied to the grooved surface in such a way that its flat surface is in interfacial contact with the grooved surface, and the two bodies are secured together.
摘要翻译： 在实现两根光纤之间的接头时，具有截面形状和尺寸对应于要接合的每根光纤的细长规格被放置在柔软的，基本上无弹性的金属体的基本上平坦的表面上， 退火的铜，并且被压入表面以在表面的两个边缘之间形成具有基本上互补的横截面尺寸的凹槽。 移除量规，使两根光纤在凹槽中对准，使得光纤的相邻端基本上邻接。 具有平坦表面的第二主体以这样的方式施加到开槽表面，使得其平坦表面与槽表面接触，并且两个主体固定在一起。
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19.发明授权Method for inhibiting inflammation and pre-inflammatory cytokine/chemokine expression using a ghrelin analogue 有权使用生长素释放肽类似物抑制炎症和炎症前细胞因子/趋化因子表达的方法公开(公告)号：US08871706B2
公开(公告)日：2014-10-28
申请号：US12672681
申请日：2008-08-07
CPC分类号： A61K38/22 , A61K38/05 , A61K38/06 , A61K38/25 , C07K7/06 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/463 , Y02A50/475 , Y02A50/481 , Y02A50/484
摘要： The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to the onset of inflammation, in a subject in need of treatment for such conditions, by administering select analogous of native hGhrelin.
摘要翻译： 本发明提供了一种在需要治疗这些病症的受试者中通过施用天然的选择类似物来改善炎症，抑制促炎细胞因子和/或趋化因子表达并且治疗与发作炎症相关的各种疾病和/或病症的方法 hGhrelin。
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公开(公告)号：US08029361B2
公开(公告)日：2011-10-04
申请号：US11840541
申请日：2007-08-17
CPC分类号： G07F17/32 , G07F17/3239 , G07F17/3255 , G07F17/329
摘要： A system and method is provided for incentivizing players to visit a gambling location. In one aspect, a qualified person is invited to play an electronic game which has a plurality of outcomes, at least one of which is a winning outcome. In one embodiment, the qualified person may be required to redeem the outcome at the gambling location. In another embodiment, the person may be required to redeem the outcome at a redemption location.
摘要翻译： 提供了一种系统和方法，用于激励玩家访问赌博场所。 一方面，合格的人被邀请玩具有多个结果的电子游戏，其中至少一个是获胜结果。 在一个实施例中，可能需要合格的人员在赌博地点兑换结果。 在另一个实施例中，该人可能被要求在兑换地点兑换结果。
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