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11.发明授权Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases 有权吡咯并哒嗪JAK3抑制剂及其用于治疗炎症和自身免疫疾病的用途公开(公告)号：US08921368B2
公开(公告)日：2014-12-30
申请号：US14005570
申请日：2012-03-16
申请人： Stephen T. Wrobleski , Gregory D. Brown , Lidia M. Doweyko , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
发明人： Stephen T. Wrobleski , Gregory D. Brown , Lidia M. Doweyko , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
IPC分类号： C07D487/04 , C07D471/04 , A01N43/58 , A61K31/50
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Disclosed are compounds of Formula (I), and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译： 公开了式（I）的化合物及其药学上可接受的盐。 式（I）化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎性和自身免疫性疾病。
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![8H-imidazo[4,5-D]thiazolo[4,5-B]pyridine based tricyclic compounds and pharmaceutical compositions comprising same](/abs-image/US/2006/06/15/US20060128741A1/abs.jpg.150x150.jpg)
12.发明申请8H-imidazo[4,5-D]thiazolo[4,5-B]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 有权8H-咪唑并[4,5-D]噻唑并[4,5-B]吡啶基三环化合物和包含它们的药物组合物公开(公告)号：US20060128741A1
公开(公告)日：2006-06-15
申请号：US11271598
申请日：2005-11-10
申请人： Jagabandhu Das , James Kempson , William Pitts , Steven Spergel
发明人： Jagabandhu Das , James Kempson , William Pitts , Steven Spergel
IPC分类号： A61K31/4745 , C07D498/14
CPC分类号： C07D513/14 , C07D513/16
摘要： The present invention provides for thiazolopyridine-based tricyclic compounds having the formula (I), wherein R1, R2, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的噻唑并吡啶类三环化合物，其中R 1，R 2，R 5和R 5， SUP> 6 如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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13.发明申请PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES 有权吡咯烷酮JAK3抑制剂及其用于治疗炎症和自发性疾病的用途公开(公告)号：US20140011795A1
公开(公告)日：2014-01-09
申请号：US14005570
申请日：2012-03-16
申请人： Stephen T. Wrobleski , Gregory D. Brown , Lidia M. Doweyko , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
发明人： Stephen T. Wrobleski , Gregory D. Brown , Lidia M. Doweyko , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Disclosed are compounds of Formula (I), and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译： 公开了式（I）的化合物及其药学上可接受的盐。 式（I）化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎性和自身免疫性疾病。
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14.发明申请1,6-Dihydro-1,3,5,6-Tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same 有权1,6-二氢-1,3,5,6-四氮杂 - 引入并三烯基三环化合物和包含它们的药物组合物公开(公告)号：US20060270654A1
公开(公告)日：2006-11-30
申请号：US11430215
申请日：2006-05-08
申请人： William Pitts , James Kempson , Junqing Guo , Jagabandhu Das , Charles Langevine , Steven Spergel , Scott Watterson
发明人： William Pitts , James Kempson , Junqing Guo , Jagabandhu Das , Charles Langevine , Steven Spergel , Scott Watterson
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/14
CPC分类号： C07D471/14
摘要： The present invention provides for tricyclic compounds having the formula (I), wherein R1, R2, R5, R6, R7, and R8 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的三环化合物，其中R 1，R 2，R 5，R 6， R＆lt; 7＆gt;和＆lt; 8＆gt;如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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公开(公告)号：US07109224B2
公开(公告)日：2006-09-19
申请号：US10702934
申请日：2003-11-06
申请人： James Kempson , William J. Pitts
发明人： James Kempson , William J. Pitts
IPC分类号： C07D263/30 , C07D277/20 , A61K31/155 , A61K31/421 , A61K31/427 , A61P19/02
CPC分类号： C07D277/56 , C07D417/12
摘要： Acyl guanidine compounds of the following Formula wherein R1, R2, R3, R4 and L are described herein, and pharmaceutical compositions thereof, are useful in treating leukocyte activation-associated disorders.
摘要翻译： 下式的酰基胍化合物其中R 1，R 2，R 3，R 4和L是 本文所述的药物组合物及其药物组合物可用于治疗白细胞活化相关疾病。
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![Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same](/abs-image/US/2006/09/28/US20060217412A1/abs.jpg.150x150.jpg)
16.发明申请Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 审中-公开咪唑并恶唑并[4,5-b]吡啶和咪唑并稠合的噻唑并[4,5-b]吡啶三环化合物和包含它们的药物组合物公开(公告)号：US20060217412A1
公开(公告)日：2006-09-28
申请号：US11444856
申请日：2006-06-01
申请人： William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , Fred Zusi
发明人： William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , Fred Zusi
IPC分类号： A61K31/4745 , C07D498/14 , C07D491/14
CPC分类号： C07D513/14
摘要： The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3，R 3， SUP> 4，R 5和R 6如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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![Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same](/abs-image/US/2006/05/18/US20060106051A1/abs.jpg.150x150.jpg)
17.发明申请Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 有权咪唑并恶唑并[4,5-b]吡啶和咪唑并稠合的噻唑并[4,5-b]吡啶三环化合物和包含它们的药物组合物公开(公告)号：US20060106051A1
公开(公告)日：2006-05-18
申请号：US11272401
申请日：2005-11-10
申请人： Alaric Dyckman , William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , F. Zusi
发明人： Alaric Dyckman , William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , F. Zusi
IPC分类号： A61K31/4745 , C07D498/14
CPC分类号： C07D513/14
摘要： The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3和R 3，R 如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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![Imidazo-fused oxazolo[4,5-beta]pyridine and imidazo-fused thiazolo[4,5-beta]pyridine based tricyclic compounds and pharmaceutical compositions comprising same](/abs-image/US/2005/05/12/US20050101626A1/abs.jpg.150x150.jpg)
18.发明申请Imidazo-fused oxazolo[4,5-beta]pyridine and imidazo-fused thiazolo[4,5-beta]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 有权咪唑并稠唑并[4,5-β]吡啶和咪唑并稠合噻唑并[4,5-β]吡啶三环化合物和包含它们的药物组合物公开(公告)号：US20050101626A1
公开(公告)日：2005-05-12
申请号：US10848412
申请日：2004-05-18
申请人： William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , Fred Zusi
发明人： William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , Fred Zusi
IPC分类号： A61K31/4353 , A61K31/4745 , C07D20060101 , C07D213/72 , C07D471/02 , C07D491/14 , C07D498/12 , C07D498/14 , C07D513/12 , C07D513/14
CPC分类号： C07D513/14
摘要： The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3，R 3， SUP> 4，R 5和R 6如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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