公开(公告)号：US20070005011A1

公开(公告)日：2007-01-04

申请号：US11155603

申请日：2005-06-20

申请人： Toby Freyman ,  Maria Palasis ,  Timothy Mickley

发明人： Toby Freyman ,  Maria Palasis ,  Timothy Mickley

IPC分类号： A61M29/00

CPC分类号： A61M25/1006 ,  A61B17/12136 ,  A61B2017/22067 ,  A61M25/0032 ,  A61M25/0045 ,  A61M25/1002 ,  A61M2025/0004 ,  A61M2025/0034 ,  A61M2025/0076 ,  A61M2025/0175 ,  A61M2025/1015 ,  A61M2025/1052

摘要： A therapeutic delivery catheter system method or kit for delivery of therapeutic to a target location is provided. In various embodiments of the present invention the invention may include a catheter with a therapeutic delivery lumen and a therapeutic delivery orifice. The lumen and the orifice may be in fluid communication with each other and may be configured such that therapeutic delivered therethrough may be done at pressures mimicking pressures existing or otherwise normal at the target locations receiving the therapeutic. In some embodiments the catheter may be part of a kit that may include instructions regarding the proper manner of operation of the catheter. These instructions may include suggested target pressures for therapeutic delivery as well as delivery times, and suggested lengths of time for the device to reside at the target area after delivery to allow for proper uptake of the therapeutic.

摘要翻译： 提供了用于将治疗剂递送到目标位置的治疗性递送导管系统方法或试剂盒。 在本发明的各种实施例中，本发明可以包括具有治疗性输送腔和治疗性输送孔的导管。 管腔和孔可以彼此流体连通，并且可以被配置成使得通过其传递的治疗可以在模拟接收治疗剂的目标位置处存在或以其他方式正常的压力下进行。 在一些实施例中，导管可以是套件的一部分，其可以包括关于导管的适当操作方式的指令。 这些说明书可以包括用于治疗性递送以及递送时间的建议目标压力，以及设备在递送之后驻留在目标区域的建议时间长度，以允许治疗剂的适当摄取。

公开(公告)号：US20060058815A1

公开(公告)日：2006-03-16

申请号：US10942046

申请日：2004-09-16

申请人： Timothy Mickley ,  Maria Palasis ,  Toby Freyman

发明人： Timothy Mickley ,  Maria Palasis ,  Toby Freyman

IPC分类号： A61B17/32

CPC分类号： A61M25/104 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1072

摘要： The present invention provides methods, systems, and devices that deliver therapeutic to the inner lumens, chambers, cavities, and vessels of the body. In one embodiment, a therapeutic delivery device for delivery of therapeutic to a target site within the body of a patient is provided. This device may include a catheter, an expandable multi-port housing fluidly coupled to the catheter and a sheath. The multi-port housing in this device may be sized to travel within a lumen of a patient and may be adapted to expand from a first configuration to a second configuration. The multi-port housing may also contain at least two ejection ports coupled to an internal lumen of the multi-port housing. In some embodiments the multi-port housing is a bladder, while in others it is a frame or a group of outwardly extending arms. In each case, the device is configured to deliver therapeutic to a remote site in the body of a patient.

摘要翻译： 本发明提供了将治疗剂递送到身体的内腔，腔室，空腔和血管的方法，系统和装置。 在一个实施例中，提供了用于将治疗剂递送到患者体内的靶部位的治疗递送装置。 该装置可以包括导管，可流体地联接到导管的可扩展多端口壳体和护套。 该装置中的多端口壳体的尺寸可以设计成在患者的内腔内行进，并且可以适于从第一构型扩展到第二构造。 多端口壳体还可以包含联接到多端口壳体的内腔的至少两个喷射端口。 在一些实施例中，多端口壳体是膀胱，而在另一些实施例中，其是框架或一组向外延伸的臂。 在每种情况下，该装置被配置为将治疗剂递送到患者体内的远端位置。

公开(公告)号：US20050215945A1

公开(公告)日：2005-09-29

申请号：US11037342

申请日：2005-01-19

申请人： Chad Harris ,  Matthew Hawk ,  Timothy Mickley ,  Dorin Panescu ,  Maria Palasis ,  Jacob Rooney

发明人： Chad Harris ,  Matthew Hawk ,  Timothy Mickley ,  Dorin Panescu ,  Maria Palasis ,  Jacob Rooney

IPC分类号： A61B5/0408 ,  A61B5/042 ,  A61M25/00 ,  A61M31/00

CPC分类号： A61B5/4839 ,  A61B5/0422 ,  A61B5/0538 ,  A61B5/6885 ,  A61M25/0084

摘要： An apparatus and method for catheter-based sensing and injection at a target site within a patient's body. An injection catheter is equipped with a electrodes at its distal end which contact the surface of a target site, such as an AV node of the heart. Electrical signals detected at the target site by the electrodes are fed via leads to the proximal end of the catheter, where they are received by a monitor, such as an EKG monitor. If the electrical signals satisfy predetermined criteria, a needle within the catheter is extended into the target site, and a therapeutic agent is injected into the target site.

摘要翻译： 一种用于在患者体内的目标部位进行基于导管的感测和注射的装置和方法。 注射导管在其远端配备有电极，其接触目标部位的表面，例如心脏的AV节点。 通过电极在目标部位检测到的电信号通过引线馈送到导管的近端，在那里它们被诸如EKG监视器的监视器接收。 如果电信号满足预定标准，则导管内的针头延伸到目标部位，并将治疗剂注射到目标部位。

公开(公告)号：US20050080429A1

公开(公告)日：2005-04-14

申请号：US10680288

申请日：2003-10-08

申请人： Toby Freyman ,  Timothy Mickley

发明人： Toby Freyman ,  Timothy Mickley

IPC分类号： A61B1/00 ,  A61B5/05 ,  A61M25/01

CPC分类号： A61M25/01 ,  A61B5/061 ,  A61M25/0105

摘要： A system and method for simply and reliably determining the location and orientation of a medical device within a patient's body. A medical device, such as a catheter, has bending indicators on or imbedded in its wall, and passes through an anatomical reference of known orientation relative to a target site within the patient. Information from the tube bending indicators permits determination of the orientation of a feature, such as an orifice, at the distal end of the medical device relative to the anatomical reference. From the known orientation of the anatomical reference, and information on the location and orientation of the distal end of the medical device obtained from fluoroscopic imaging from a single direction, the physician may reliably determine the orientation of the distal feature relative to the target site, eliminating the need for imaging from multiple directions.

摘要翻译： 一种用于简单且可靠地确定患者体内的医疗装置的位置和方向的系统和方法。 诸如导管的医疗装置在其壁上具有或嵌入其中的弯曲指示器，并且相对于患者内的目标部位通过已知取向的解剖参考。 来自管弯曲指示器的信息允许在医疗装置的远端处相对于解剖参考确定诸如孔的特征的取向。 从已知的解剖学参考方向，以及关于从单一方向从透视成像获得的医疗装置的远端的位置和方位的信息，医师可以可靠地确定远侧特征相对于目标部位的方向， 消除了从多个方向进行成像的需要。

公开(公告)号：US20080065049A1

公开(公告)日：2008-03-13

申请号：US11851600

申请日：2007-09-07

申请人： Chad Harris ,  Timothy Mickley

发明人： Chad Harris ,  Timothy Mickley

IPC分类号： A61M25/01

CPC分类号： A61M25/0105 ,  A61M25/0041 ,  A61M25/0152

摘要： A direct injection system with a small diameter that can be easily placed at a desired treatment location is provided, where the system comprises an outer guide catheter having a predefined bend at the distal end. For example, the outer guide catheter may be no larger than a 7 Fr catheter. According to the invention, various mechanisms may be used to alter the curvature of the predefined bend in the catheter, allowing an operator to easily place the distal end of an injection catheter at a desired treatment location. Alternatively, the injection catheter itself has a predefined bend at the distal end, wherein the curvature can be adjusted by adjusting the position of the injection catheter within a guide catheter.

摘要翻译： 提供了一种具有小直径的直接注射系统，其可以容易地放置在期望的治疗位置，其中系统包括在远端具有预定弯曲的外导向导管。 例如，外引导导管可以不大于7Fr导管。 根据本发明，可以使用各种机构来改变导管中的预定弯曲的曲率，从而允许操作者容易地将注射导管的远端放置在期望的治疗位置。 或者，注射导管本身在远端处具有预定的弯曲部，其中可以通过调节引导导管内的注射导管的位置来调节曲率。

公开(公告)号：US20050261667A1

公开(公告)日：2005-11-24

申请号：US11191053

申请日：2005-07-28

申请人： Justin Crank ,  Scott Larson ,  Timothy Mickley

发明人： Justin Crank ,  Scott Larson ,  Timothy Mickley

IPC分类号： A61J1/00 ,  A61J1/14 ,  A61M5/46 ,  A61M25/00 ,  A61M25/01 ,  A61M25/06 ,  A61M25/098

CPC分类号： A61M25/0068 ,  A61J1/1406 ,  A61M5/46 ,  A61M25/0074 ,  A61M25/0084 ,  A61M25/0108 ,  A61M25/0662 ,  A61M2025/0008 ,  A61M2025/0081 ,  A61M2025/0085 ,  A61M2025/0086 ,  A61M2025/0091 ,  A61M2205/19 ,  A61M2210/125

摘要： Devices and methods for performing improved percutaneous myocardial revascularization (PMR) procedures. One device includes a preassembled PMR drug delivery catheter and a drug neutralizing vial. The vial assembly allows prepping the PMR catheter by flushing drug through distal needle, and into a vial cavity where the drug is neutralized by a neutralizing agent. One set of devices includes needles having protrusions secured to the distal regions of drug delivery tubes. One needle has outward protruding barbs engaging the inner tube wall while another needle has outward threads which can screw into the tube inner wall. Radiopaque marker bands are also included in the present invention which are asymmetrically distributed on the catheter shaft, allowing a treating physician to determine under fluoroscopy whether the catheter distal region is pointed away or toward the treating physician, as well as determining whether the catheter distal region is rotated toward or away from the treating physician. PMR devices include catheters having dual injection needles, for both injecting a drug into the heart wall and a radiopaque contrast media to mark the already treated sites. One PMR injection device has multiple stops for allowing controlled, variable needle depth penetration with a single distal needle tip.

摘要翻译： 用于进行改善的经皮心肌血运重建（PMR）手术的装置和方法。 一个装置包括预组装的PMR药物递送导管和药物中和小瓶。 小瓶组件允许通过将药物通过远端针头冲洗并进入药物中和药物的小瓶腔中来准备PMR导管。 一组装置包括具有固定到药物输送管的远侧区域的突起的针。 一针具有与内管壁接合的向外突出的倒钩，而另一针具有能够拧入管内壁的外螺纹。 不透射线标记带也包括在本发明中，其不对称地分布在导管轴上，允许治疗医师在透视下确定导管远端区域是指尖的还是朝向治疗医师，以及确定导管远端区域 被转向或远离治疗医师。 PMR装置包括具有双注射针的导管，用于将药物注射到心脏壁中，以及不透射线造影剂以标记已经治疗的部位。 一个PMR注射装置具有多个止动件，用于允许用单个远端针尖进行可控的，可变的针深度穿透。

公开(公告)号：US20070225610A1

公开(公告)日：2007-09-27

申请号：US11389060

申请日：2006-03-27

申请人： Timothy Mickley ,  N. Willis

发明人： Timothy Mickley ,  N. Willis

IPC分类号： A61B5/04

CPC分类号： A61B5/0422 ,  A61B17/3478 ,  A61M25/0084

摘要： A method and medical system to take electrical readings includes an electrocardiogram (ECG) monitor, an electrode coupled to the monitor via a first lead and a needle such as an injection needle. The needle has a proximal end coupled to the monitor, where the monitor is able to measure an electrical pattern between the electrode and a distal end of the needle. In one example, the medical system is used to detect the contact, penetration, health and perforation of tissue at a target site.

摘要翻译： 采用电读取的方法和医疗系统包括心电图（ECG）监测器，经由第一引线和针（例如注射针）耦合到监视器的电极。 针具有联接到监视器的近端，其中监视器能够测量电极和针的远端之间的电气图案。 在一个示例中，医疗系统用于检测目标部位的组织的接触，渗透，健康和穿孔。

公开(公告)号：US20060200126A1

公开(公告)日：2006-09-07

申请号：US11405553

申请日：2006-04-18

申请人： Timothy Mickley

发明人： Timothy Mickley

IPC分类号： A61F5/04

CPC分类号： A61M25/0136 ,  A61M25/0041 ,  A61M25/0084 ,  A61M25/0133 ,  A61M25/0662 ,  A61M2025/0089 ,  A61M2025/0681

摘要： Devices and methods for delivering therapeutic or diagnostic agents to a target tissue of a human body are disclosed. A catheter in accordance with the present invention includes an injection catheter assembly having a first elongated member with a proximal end, a distal end, an external surface, and an inside surface defining a first lumen. The catheter includes a second elongated member having a proximal region and a distal region. The second elongated member is positioned at least partially within the first elongated member. The second elongated member has a second helical member fixed to an end. The catheter also includes a third elongated member. The third elongated member defines a lumen along a portion of the length of the first elongated member. The third elongated member has a first helical member. The second helical member is longitudinally moveable within the lumen of the first helical member to move the second elongated member longitudinally.

公开(公告)号：US20060142697A1

公开(公告)日：2006-06-29

申请号：US11360764

申请日：2006-02-24

申请人： Matthew Hawk ,  Scott Larson ,  Timothy Mickley ,  Chad Harris

发明人： Matthew Hawk ,  Scott Larson ,  Timothy Mickley ,  Chad Harris

IPC分类号： A61M5/00 ,  A61M25/00

CPC分类号： A61M25/0069 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/22069 ,  A61B2017/22077 ,  A61B2017/348 ,  A61B2017/3488 ,  A61B2018/00392 ,  A61B2018/00738 ,  A61B2090/036 ,  A61B2218/002 ,  A61M25/10 ,  A61M2025/1093

摘要： An elongate medical device that may be used for performing medical procedures on a patient is provided. This elongate medical device may include a first member having a distal end, an outer surface, and a first lumen, where the first member may have an elongated configuration such that the length of the first member is at least ten times greater than the width of the first member. The elongate medical device may also have a second member positioned within the first member and a hood stop. The hood stop in this device may be positioned within the first member and may have a distal region and a shoulder region where the shoulder region may be configured to limit the travel of the first member or the second member past the hood stop.

公开(公告)号：US20050187519A1

公开(公告)日：2005-08-25

申请号：US10781775

申请日：2004-02-20

申请人： Chad Harris ,  Matthew Hawk ,  Timothy Mickley

发明人： Chad Harris ,  Matthew Hawk ,  Timothy Mickley

IPC分类号： A61M25/00 ,  A61M25/01 ,  A61M25/06 ,  A61M5/00

CPC分类号： A61M25/0606 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/0084 ,  A61M2025/0089

摘要： An apparatus for the injection of therapeutic and other agents at a target site within a patient's body. A catheter including a first elongated shaft having a distal end and a proximal end and a lumen extending therebetween. The catheter also including a second elongated shaft slidingly disposed in the first elongated shaft, the second elongated shaft having a distal end and a proximal and a lumen extending therebetween. The catheter further including a third elongated shaft disposed in and attached to the second elongate shaft, the third elongated shaft to move in a one-to-one relationship with the first elongated shaft and the second elongated shaft to maintain a predetermined needle deployment length as each are subjected to various bend configurations.

摘要翻译： 用于在患者体内的靶位置注射治疗剂和其它药剂的装置。 一种导管，其包括具有远端和近端的第一细长轴和在其间延伸的内腔。 导管还包括滑动地设置在第一细长轴中的第二细长轴，第二细长轴具有远端和近端以及在其间延伸的内腔。 所述导管还包括设置在所述第二细长轴中并连接到所述第二细长轴的第三细长轴，所述第三细长轴与所述第一细长轴和所述第二细长轴以一对一关系移动，以将预定的针展开长度保持为 每个都经受各种弯曲构造。