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    Catheter having a distal drug delivery unit and method of using same
    3.
    发明申请
    Catheter having a distal drug delivery unit and method of using same 失效
    具有远端药物递送单元的导管及其使用方法

    公开(公告)号：US20060200083A1

    公开(公告)日：2006-09-07

    申请号：US11070190

    申请日：2005-03-03

    申请人： Toby Freyman ,  Maria Palasis ,  Wendy Naimark ,  Timothy Mickley

    发明人： Toby Freyman ,  Maria Palasis ,  Wendy Naimark ,  Timothy Mickley

    IPC分类号： A61M5/00

    CPC分类号： A61M25/0082 ,  A61M5/14526 ,  A61M5/14593 ,  A61M5/148 ,  A61M5/1483 ,  A61M25/0074 ,  A61M25/0084 ,  A61M2025/0091

    摘要： A catheter having a drug delivery unit at the distal end thereof. The drug delivery unit includes an actuator capable of assuming an activated and an inactivated configuration. The drug delivery unit also includes a receptacle capable of accepting a therapeutic agent. The actuator and receptacle are in communication with each other such that the actuator transmits force to the receptacle and the receptacle accepts force from the actuator in an activated configuration of the actuator. Also provided is a method of delivering a therapeutic agent to a target site using the catheter of the present invention.

    摘要翻译： 一种在其远端具有药物输送单元的导管。 药物递送单元包括能够承受激活和非活化构型的致动器。 药物递送单元还包括能够接受治疗剂的容器。 致动器和容器彼此连通，使得致动器将力传递到插座，并且插座在致动器的激活配置中接受来自致动器的力。 还提供了使用本发明的导管将治疗剂递送到靶位点的方法。

    Medical device guidance from an anatomical reference
    4.
    发明申请
    Medical device guidance from an anatomical reference 有权
    医疗设备指导从解剖参考

    公开(公告)号：US20050080429A1

    公开(公告)日：2005-04-14

    申请号：US10680288

    申请日：2003-10-08

    申请人： Toby Freyman ,  Timothy Mickley

    发明人： Toby Freyman ,  Timothy Mickley

    IPC分类号： A61B1/00 ,  A61B5/05 ,  A61M25/01

    CPC分类号： A61M25/01 ,  A61B5/061 ,  A61M25/0105

    摘要： A system and method for simply and reliably determining the location and orientation of a medical device within a patient's body. A medical device, such as a catheter, has bending indicators on or imbedded in its wall, and passes through an anatomical reference of known orientation relative to a target site within the patient. Information from the tube bending indicators permits determination of the orientation of a feature, such as an orifice, at the distal end of the medical device relative to the anatomical reference. From the known orientation of the anatomical reference, and information on the location and orientation of the distal end of the medical device obtained from fluoroscopic imaging from a single direction, the physician may reliably determine the orientation of the distal feature relative to the target site, eliminating the need for imaging from multiple directions.

    摘要翻译： 一种用于简单且可靠地确定患者体内的医疗装置的位置和方向的系统和方法。 诸如导管的医疗装置在其壁上具有或嵌入其中的弯曲指示器，并且相对于患者内的目标部位通过已知取向的解剖参考。 来自管弯曲指示器的信息允许在医疗装置的远端处相对于解剖参考确定诸如孔的特征的取向。 从已知的解剖学参考方向，以及关于从单一方向从透视成像获得的医疗装置的远端的位置和方位的信息，医师可以可靠地确定远侧特征相对于目标部位的方向， 消除了从多个方向进行成像的需要。

    Medical device with drug delivery member
    5.
    发明申请
    Medical device with drug delivery member 失效
    医疗器械配药

    公开(公告)号：US20050043678A1

    公开(公告)日：2005-02-24

    申请号：US10645653

    申请日：2003-08-20

    申请人： Toby Freyman ,  Timothy Mickley ,  Maria Palasis ,  Wendy Naimark

    发明人： Toby Freyman ,  Timothy Mickley ,  Maria Palasis ,  Wendy Naimark

    IPC分类号： A61M25/00 ,  A61M29/00

    CPC分类号： A61M29/02 ,  A61M25/1029 ,  A61M2025/0057 ,  A61M2025/105

    摘要： The present invention generally relates to a medical device for delivering a therapeutic agent to an internal portion of a patient's body. The medical device includes a shaft and a self-expanding delivery member in operative communication with the shaft. The delivery member is shaped from a porous material that is capable of releasing a therapeutic agent to an internal portion of a patient's body. The medical device further includes a therapeutic agent delivery lumen in fluid communication with the delivery member to fluidly connect the delivery member with a therapeutic agent source. A retention member may also be provided to selectively collapse the delivery member.

    摘要翻译： 本发明一般涉及用于将治疗剂递送到患者身体的内部的医疗装置。 该医疗装置包括轴和与该轴可操作地连通的自扩张输送构件。 递送构件由能够将治疗剂释放到患者身体的内部的多孔材料成形。 医疗装置还包括与递送构件流体连通以将递送构件与治疗剂源流体连接的治疗剂递送腔。 还可以设置保持构件以选择性地折叠输送构件。

    VARIABLE STIFFNESS DIRECT INJECTION SYSTEM
    6.
    发明申请
    VARIABLE STIFFNESS DIRECT INJECTION SYSTEM 审中-公开
    可变刚度直接注射系统

    公开(公告)号：US20080065049A1

    公开(公告)日：2008-03-13

    申请号：US11851600

    申请日：2007-09-07

    申请人： Chad Harris ,  Timothy Mickley

    发明人： Chad Harris ,  Timothy Mickley

    IPC分类号： A61M25/01

    CPC分类号： A61M25/0105 ,  A61M25/0041 ,  A61M25/0152

    摘要： A direct injection system with a small diameter that can be easily placed at a desired treatment location is provided, where the system comprises an outer guide catheter having a predefined bend at the distal end. For example, the outer guide catheter may be no larger than a 7 Fr catheter. According to the invention, various mechanisms may be used to alter the curvature of the predefined bend in the catheter, allowing an operator to easily place the distal end of an injection catheter at a desired treatment location. Alternatively, the injection catheter itself has a predefined bend at the distal end, wherein the curvature can be adjusted by adjusting the position of the injection catheter within a guide catheter.

    摘要翻译： 提供了一种具有小直径的直接注射系统，其可以容易地放置在期望的治疗位置，其中系统包括在远端具有预定弯曲的外导向导管。 例如，外引导导管可以不大于7Fr导管。 根据本发明，可以使用各种机构来改变导管中的预定弯曲的曲率，从而允许操作者容易地将注射导管的远端放置在期望的治疗位置。 或者，注射导管本身在远端处具有预定的弯曲部，其中可以通过调节引导导管内的注射导管的位置来调节曲率。

    Biocompatible medical devices
    7.
    发明申请
    Biocompatible medical devices 有权
    生物相容性医疗器械

    公开(公告)号：US20070197980A1

    公开(公告)日：2007-08-23

    申请号：US11451634

    申请日：2006-06-12

    申请人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg

    发明人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg

    IPC分类号： A61M25/00

    CPC分类号： A61L29/085 ,  A61L29/103 ,  A61L29/106 ,  A61L31/10

    摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic or polymeric component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to the metallic or polymeric component that are effective to diminish such a substantial reduction in pharmaceutical effectiveness.

    摘要翻译： 描述了用于递送药物活性物质的改进的医疗装置。 本发明人已经发现许多常规医疗器械含有在使用过程中与药物活性物质接触的金属或聚合物组分，并且接触显着降低了药物活性物质的药物有效性。 本文描述的发明涉及对金属或聚合物组分的各种修饰，其有效地减少药物有效性的这种显着降低。

    Infusion device and method
    9.
    发明申请
    Infusion device and method 审中-公开
    输液装置及方法

    公开(公告)号：US20050261667A1

    公开(公告)日：2005-11-24

    申请号：US11191053

    申请日：2005-07-28

    申请人： Justin Crank ,  Scott Larson ,  Timothy Mickley

    发明人： Justin Crank ,  Scott Larson ,  Timothy Mickley

    IPC分类号： A61J1/00 ,  A61J1/14 ,  A61M5/46 ,  A61M25/00 ,  A61M25/01 ,  A61M25/06 ,  A61M25/098

    CPC分类号： A61M25/0068 ,  A61J1/1406 ,  A61M5/46 ,  A61M25/0074 ,  A61M25/0084 ,  A61M25/0108 ,  A61M25/0662 ,  A61M2025/0008 ,  A61M2025/0081 ,  A61M2025/0085 ,  A61M2025/0086 ,  A61M2025/0091 ,  A61M2205/19 ,  A61M2210/125

    摘要： Devices and methods for performing improved percutaneous myocardial revascularization (PMR) procedures. One device includes a preassembled PMR drug delivery catheter and a drug neutralizing vial. The vial assembly allows prepping the PMR catheter by flushing drug through distal needle, and into a vial cavity where the drug is neutralized by a neutralizing agent. One set of devices includes needles having protrusions secured to the distal regions of drug delivery tubes. One needle has outward protruding barbs engaging the inner tube wall while another needle has outward threads which can screw into the tube inner wall. Radiopaque marker bands are also included in the present invention which are asymmetrically distributed on the catheter shaft, allowing a treating physician to determine under fluoroscopy whether the catheter distal region is pointed away or toward the treating physician, as well as determining whether the catheter distal region is rotated toward or away from the treating physician. PMR devices include catheters having dual injection needles, for both injecting a drug into the heart wall and a radiopaque contrast media to mark the already treated sites. One PMR injection device has multiple stops for allowing controlled, variable needle depth penetration with a single distal needle tip.

    摘要翻译： 用于进行改善的经皮心肌血运重建（PMR）手术的装置和方法。 一个装置包括预组装的PMR药物递送导管和药物中和小瓶。 小瓶组件允许通过将药物通过远端针头冲洗并进入药物中和药物的小瓶腔中来准备PMR导管。 一组装置包括具有固定到药物输送管的远侧区域的突起的针。 一针具有与内管壁接合的向外突出的倒钩，而另一针具有能够拧入管内壁的外螺纹。 不透射线标记带也包括在本发明中，其不对称地分布在导管轴上，允许治疗医师在透视下确定导管远端区域是指尖的还是朝向治疗医师，以及确定导管远端区域 被转向或远离治疗医师。 PMR装置包括具有双注射针的导管，用于将药物注射到心脏壁中，以及不透射线造影剂以标记已经治疗的部位。 一个PMR注射装置具有多个止动件，用于允许用单个远端针尖进行可控的，可变的针深度穿透。

    Biocompatible medical devices
    10.
    发明授权
    Biocompatible medical devices 失效
    生物相容性医疗器械

    公开(公告)号：US06638259B1

    公开(公告)日：2003-10-28

    申请号：US09429178

    申请日：1999-10-28

    申请人： Maria Palasis ,  Louis Ellis ,  Timothy Mickley

    发明人： Maria Palasis ,  Louis Ellis ,  Timothy Mickley

    IPC分类号： A61M2500

    CPC分类号： A61L29/085 ,  A61L2/18 ,  A61L29/08 ,  A61L29/103 ,  A61L29/106 ,  A61L29/14 ,  A61L31/10 ,  A61L33/0076 ,  C23C22/50

    摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns numerous modifications to the metallic component that are effective to prevent such a substantial reduction in pharmaceutical effectiveness.

    摘要翻译： 描述了用于递送药物活性物质的改进的医疗装置。 本发明人已经发现许多常规医疗器械含有在使用期间与药物活性物质接触的金属成分，并且接触显着降低了药物活性物质的药物有效性。 本文描述的发明涉及对金属组分的许多修改，其有效地防止药物效力的显着降低。