摘要:
Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R8, R9 and R10, W, X, and Z are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
摘要:
Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9, and W are as defined in the specification. Such compounds are MEK inhibitors and are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, and inflammatory conditions in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative and inflammatory diseases in mammals and pharmaceutical compositions containing such compounds.
摘要:
A sensor provides an analog sensor output signal that is first converted by a A/D converter, followed by a digital signal processor having a digital signal output that is converted to an analog signal by way of a D/A converter so as to provide an analog information output signal indicative of a parameter quantity intended to be sensed. An analog dither signal and/or a digital dither signal is provided for modulating the A/D converter input signal and/or D/A converter input signal, respectively, separately, or in combination, to enhance dynamic range accuracy of the resultant analog information output signal representative of the quantity of the parameter intended to be sensed.
摘要:
A system and method for achieving, while using a laser and optical fibers, high signal-to-noise ratio. In particular, the system splits an incoming main light signal into two orthogonal polarization states, which then propagate through an optical circuit before recombining. The use of appropriate path differences ensures that the system is immune from the conversion of mode partition noise to intensity noise arising from the interference between parasitic light waves which traveled through the system in undesired polarization states.
摘要:
Peptides which bind to selected ligands are identified by screening peptide libraries which encode a random or controlled collection of amino acid sequences. A rapid and convenient iterative strategy is employed to determine the peptide sequences which bind to the ligand of interest. The peptides so identified can be used as diagnostic or therapeutic agents, or in the design of lead compounds for such uses.
摘要:
Peptides immunoreactive with antibodies to native proteins, and which have at least two cysteine residues that contribute to mimicking an epitope of the protein, are prepared with the cysteine thiol groups protected. When deprotected, the peptides have enhanced immunoreactivity. The peptides are particularly useful for detecting antibodies or antigens associated with retroviruses, including the clinically important lymphotropic retroviruses HIV-1, HIV-2, HTLV-I, and HTLV-II.
摘要:
Systems and methods according to these exemplary embodiments provide for methods and systems related to optical current sensors used to monitor standby power transformers, specifically fiber optical current and voltage sensors and, more particularly, to applications involving filters for use in such sensors, such as frequency tracking comb filters. According to one embodiment, a method for monitoring a connection condition of a stand by power transformer includes the steps of measuring a current flowing through a high voltage side of the standby power transformer using at least one optical current sensor disposed proximate to a current flow path of the high voltage side, using a comb filter to filter the measured current, determining whether the filtered, measured current is less than a predetermined threshold value; and generating an alarm indication that the high voltage side of the standby power transformer is unconnected.
摘要:
Disclosed are compounds of the Formula V and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, and inflammatory conditions in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases and inflammatory conditions in mammals and pharmaceutical compositions containing such compounds.
摘要:
Disclosed are methods of treating hyperproliferative disorders, method of treating inflammatory disorders, and methods of inhibiting MEK activity in a mammal, comprising administering an effective amount of one or more compounds of the Formula V or pharmaceutically acceptable salts thereof, wherein R1, R2, R7, R8, R9 and W are as defined in the specification.
摘要:
Compounds of Formula (I), and stereoisomers, geometric isomers, tautomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof, are useful for inhibiting receptor tyrosine kinases and for treating hyperproliferative disorders mediated thereby. Methods of using compounds of Formula (I), and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.