公开(公告)号：US20110276285A1

公开(公告)日：2011-11-10

申请号：US13037939

申请日：2011-03-01

Applicant: Michael Alexander ,  James Brown ,  Bernard Clement ,  Kelly Berger ,  James Riling ,  Joseph Reutzel

Inventor： Michael Alexander ,  James Brown ,  Bernard Clement ,  Kelly Berger ,  James Riling ,  Joseph Reutzel

IPC: G06F19/00 ,  G01R31/02

CPC classification number: B61L5/1881 ,  B61L1/20

Abstract: A railroad monitoring apparatus includes first and second diverse vital processing units, first and second current sensors configured to measure the current being provided to one or more signaling elements of an item of wayside signaling equipment, and means for measuring voltage levels being supplied to each of the signaling elements. The first processing unit receives a first current measurement from the first current sensor and the measured voltage levels, and the second vital processing unit receives a second current measurement from the second current sensor and the measured voltage levels. The vital processing units are each programmed to determine based on one or more of the first current measurement, the second current measurement and the measured voltage levels: (i) the state of the item of railroad wayside signaling equipment, (ii) failures within the item of railroad wayside signaling equipment, and (iii) failures within the monitoring apparatus itself.

Abstract translation: 铁路监测装置包括第一和第二多样的重要处理单元，第一和第二电流传感器被配置为测量提供给路旁信号设备的一个或多个信令元件的电流，以及用于测量提供给每个 信号元素。 第一处理单元从第一电流传感器接收第一电流测量值和测量的电压电平，第二生物处理单元从第二电流传感器接收第二电流测量值和测量的电压电平。 重要的处理单元各自被编程为基于第一电流测量，第二电流测量和测量的电压电平中的一个或多个来确定：（i）铁路路边信号设备的项目的状态，（ii） 铁路路边信号设备项目，以及（iii）监控设备本身的故障。

公开(公告)号：US20110262207A1

公开(公告)日：2011-10-27

申请号：US13102973

申请日：2011-05-06

Applicant: Jack W. Kaufman ,  James Brown

Inventor： Jack W. Kaufman ,  James Brown

IPC: B05C17/00

CPC classification number: A61M35/006 ,  A61M35/003 ,  A61M2210/04 ,  B43M11/06

Abstract: The present invention relates to a hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region therebetween. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.

Abstract translation: 本发明涉及包括流体源，连接到流体源的易碎施用器尖端和连接到易碎施用器尖端的吸收构件的手持分配施用器。 当易碎的施用器尖端破裂时，流体从源流向吸收构件，由此将流体施加并扩散在表面上。 优选地，易碎施用器尖端包括永久地连接到流体源的支撑元件，从支撑元件向外延伸的相对刚性的舌元件以及它们之间的易碎区域。 优选地，舌元件包括用于加强舌元件以防止易碎区域的无意破坏的肋。 更优选地，施用器末端包括设置在易碎区域周围的半透性或不可渗透的盖，以控制吸收构件中的流体分散体的速度和方向。 自适应实施例允许生成适用于特定医疗目的的设计。

公开(公告)号：US07946065B2

公开(公告)日：2011-05-24

申请号：US12138219

申请日：2008-06-12

Applicant: Sherif Ali ,  Kim Canchola ,  Russell Smith ,  Tracy Tenpenny ,  Jeffrey Kerlin ,  Mike Erwin ,  James Brown

Inventor： Sherif Ali ,  Kim Canchola ,  Russell Smith ,  Tracy Tenpenny ,  Jeffrey Kerlin ,  Mike Erwin ,  James Brown

IPC: A44C5/00 ,  G09F3/14

CPC classification number: G09F3/005

Abstract: A closure mechanism receiving aperture presents a substantially contiguous, uninterrupted planar surface on a flexible medium, primarily for use with identification devices, i.e., wristbands. The aperture does not interrupt the printable area so that printer ink may be printed over the aperture without passing through. The inventive aperture also does not produce waster material or chads which can jam or foul-up a printer. An inventive wristband includes both snap closure and adhesive closure mechanisms that can be used at the same time.

Abstract translation: 闭合机构接收孔在柔性介质上呈现基本连续的不间断平面，主要用于识别装置即腕带。 光圈不会打印可打印区域，因此打印机墨水可能会打印在光圈上而不通过。 本发明的孔径也不会产生可能堵塞或弄脏打印机的废物或绷带。 本发明的腕带包括可以同时使用的卡扣闭合和粘合剂封闭机构。

公开(公告)号：US07872009B2

公开(公告)日：2011-01-18

申请号：US11600264

申请日：2006-11-14

Applicant: Brian K. Albrecht ,  Denise Lyn Andersen ,  Michael Bartberger ,  James Brown ,  Ryan Brown ,  Stuart C. Chaffee ,  Yuan Cheng ,  Michael Croghan ,  Russell Graceffa ,  Scott Harried ,  Stephen Hitchcock ,  Randall Hungate ,  Ted Judd ,  Matthew Kaller ,  Charles Kreiman ,  Daniel La ,  Patricia Lopez ,  Craig Masse ,  Holger Monenschein ,  Thomas Nguyen ,  Thomas Nixey ,  Vinod F. Patel ,  Lewis Pennington ,  Matthew Weiss ,  Qiufen Xue ,  Bryant Yang ,  Wenge Zhong

Inventor： Brian K. Albrecht ,  Denise Lyn Andersen ,  Michael Bartberger ,  James Brown ,  Ryan Brown ,  Stuart C. Chaffee ,  Yuan Cheng ,  Michael Croghan ,  Russell Graceffa ,  Scott Harried ,  Stephen Hitchcock ,  Randall Hungate ,  Ted Judd ,  Matthew Kaller ,  Charles Kreiman ,  Daniel La ,  Patricia Lopez ,  Craig Masse ,  Holger Monenschein ,  Thomas Nguyen ,  Thomas Nixey ,  Vinod F. Patel ,  Lewis Pennington ,  Matthew Weiss ,  Qiufen Xue ,  Bryant Yang ,  Wenge Zhong

IPC: A61K31/50

CPC classification number: C07D405/12 ,  C07D413/12

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Abstract translation: 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中A，B，R 3，R 4，R 5，i和j在本文中定义。 本发明还包括药物组合物，其包括一种或多种式I化合物，这些化合物的使用方法，包括治疗AD和相关疾病，通过给受试者施用式I化合物或包含它们的组合物。 本发明还包括式II和III的其它实施方案，可用于制备本发明化合物的中间体和方法。

公开(公告)号：USD611984S1

公开(公告)日：2010-03-16

申请号：US29331063

申请日：2009-01-19

Applicant: Sherif Ali ,  Kim Canchola ,  Russell Smith ,  Tracy Tenpenny ,  Jeffrey Kerlin ,  Mike Erwin ,  James Brown

Designer： Sherif Ali ,  Kim Canchola ,  Russell Smith ,  Tracy Tenpenny ,  Jeffrey Kerlin ,  Mike Erwin ,  James Brown

公开(公告)号：US20100040402A1

公开(公告)日：2010-02-18

申请号：US12579728

申请日：2009-10-15

Applicant: JACK W. KAUFMAN ,  James Brown

Inventor： JACK W. KAUFMAN ,  James Brown

IPC: B05C17/00

CPC classification number: A61M35/006 ,  A61M35/003 ,  A61M2210/04 ,  B43M11/06

Abstract: The present invention relates to a hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region therebetween. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.

Abstract translation: 本发明涉及包括流体源，连接到流体源的易碎施用器尖端和连接到易碎施用器尖端的吸收构件的手持分配施用器。 当易碎的施用器尖端破裂时，流体从源流向吸收构件，由此将流体施加并扩散在表面上。 优选地，易碎施用器尖端包括永久地连接到流体源的支撑元件，从支撑元件向外延伸的相对刚性的舌元件以及它们之间的易碎区域。 优选地，舌元件包括用于加强舌元件以防止易碎区域的无意破坏的肋。 更优选地，施用器末端包括设置在易碎区域周围的半透性或不可渗透的盖，以控制吸收构件中的流体分散体的速度和方向。 自适应实施例允许生成适用于特定医疗目的的设计。

公开(公告)号：US20090292681A1

公开(公告)日：2009-11-26

申请号：US12471433

申请日：2009-05-25

Applicant: MATTHEW SCOTT WOOD ,  Paal Tveit ,  Brian Edginton ,  Steve Shillingford ,  James Brown ,  Joseph H. Levy ,  Daniel M. Arnold

Inventor： MATTHEW SCOTT WOOD ,  Paal Tveit ,  Brian Edginton ,  Steve Shillingford ,  James Brown ,  Joseph H. Levy ,  Daniel M. Arnold

IPC: G06F17/30 ,  G06F3/048 ,  G06F7/00

CPC classification number: G06F7/00 ,  G06F17/30 ,  G06F17/30864 ,  H04L43/02 ,  H04L43/045

Abstract: A system and method of presentation of an extracted artifact based on an indexing technique are disclosed. In an embodiment, the method includes indexing a database of a captured network characteristic data using a processor and a memory to form an indexed capture data. The method includes enhancing a query response time with the indexed capture data. The method further includes searching the indexed capture data to generate a capture query result. The capture query result includes an extracted artifact. The method also includes graphically presenting the capture query result as at least one of an artifact list and an artifact image.

Abstract translation: 公开了一种基于索引技术呈现提取的伪影的系统和方法。 在一个实施例中，该方法包括使用处理器和存储器对捕获的网络特征数据的数据库进行索引以形成索引的捕获数据。 该方法包括使用索引的捕获数据增强查询响应时间。 该方法还包括搜索索引的捕获数据以产生捕获查询结果。 捕获查询结果包括提取的人工制品。 该方法还包括以图形方式呈现作为工件列表和工件图像中的至少一个的捕获查询结果。

公开(公告)号：US20090191243A9

公开(公告)日：2009-07-30

申请号：US10611775

申请日：2003-06-30

Applicant: John Hill ,  Robert Kleiman ,  James Brown ,  Sambasivarao Koritala

Inventor： John Hill ,  Robert Kleiman ,  James Brown ,  Sambasivarao Koritala

IPC: A61K7/075 ,  A61K7/08 ,  A61K35/78 ,  A61K35/60

CPC classification number: A61K36/185 ,  A61K8/042 ,  A61K8/361 ,  A61K8/922 ,  A61Q9/02 ,  A61Q19/00 ,  A61Q19/10

Abstract: Materials with high levels of unsaponifiable matter, such as extracts from plants, result in Hydrolysates with unique properties. It has been found that the application of a hydrolysis process to materials, particularly materials with a high level of unsaponifiables (e.g., at least 6% by total weight of the material) produces a product with properties significantly different from those products resulting from the conventional saponification of materials with less than 6% by weight of unsaponifiables. The resulting Hydrolysates from the practice of the present invention are substantive, resisting both physical and aqueous-based removal from skin and hair, exhibit a very unique surfactant property, and are not foaming agents with water. Addition of extra alkali metal hydroxides to these Hydrolysates according to the present invention may thus be used to neutralized acidic gelling agents and thereby providing a gel with enhanced the performance for cosmetics and pharmaceuticals.

Abstract translation: 具有高水平不皂化物质的物质，如植物提取物，导致具有独特性质的水解产物。 已经发现，将水解方法应用于材料，特别是具有高水平不可皂化物的材料（例如，材料的总重量至少为6％）产生具有与常规的那些产物显着不同的性能的产品 皂化不到6％（重量）的不皂化物的材料。 所得到的本发明实施例的水解产物是实质性的，抵抗从皮肤和毛发的物理和水性去除，表现出非常独特的表面活性剂性质，并且不是水的发泡剂。 因此，根据本发明的这些水解产物中加入额外的碱金属氢氧化物可用于中和酸性胶凝剂，从而提供增强化妆品和药物性能的凝胶。

公开(公告)号：US20090118395A1

公开(公告)日：2009-05-07

申请号：US12242579

申请日：2008-09-30

Applicant: Susanna Ho ,  Daryl MacLeod ,  James Brown ,  Lloyd Gee ,  Ludo Zanzotto

Inventor： Susanna Ho ,  Daryl MacLeod ,  James Brown ,  Lloyd Gee ,  Ludo Zanzotto

IPC: C08J3/22

CPC classification number: C08J3/226 ,  C08J2495/00 ,  C08L95/00

Abstract: A process of preparing a polymer modified asphalt (PMA) comprising mixing a predetermined amount of a polymer-asphalt master batch with a predetermined amount of an asphalt-cross linking agent blend. The polymer-asphalt master batch comprises at least one polymer and a first asphalt. The asphalt-cross linking agent blend comprises a second asphalt and at least one cross linking agent. A predetermined amount of the polymer-asphalt master batch is blended with a predetermined amount of the asphalt-cross linking agent blend to form a PMA blend. Mixing of the PMA blend is performed without substantial delay following blending of the polymer-asphalt master batch with the asphalt-cross linking agent blend.

Abstract translation: 一种制备聚合物改性沥青（PMA）的方法，包括将预定量的聚合物 - 沥青母料与预定量的沥青交联剂混合物混合。 聚合物 - 沥青母料包含至少一种聚合物和第一沥青。 沥青交联剂混合物包含第二沥青和至少一种交联剂。 将预定量的聚合物 - 沥青母料与预定量的沥青交联剂混合物共混以形成PMA共混物。 在混合聚合物 - 沥青母料与沥青交联剂混合物之后，PMA共混物的混合在没有实质延迟的情况下进行。

公开(公告)号：US20090013407A1

公开(公告)日：2009-01-08

申请号：US12031513

申请日：2008-02-14

Applicant: Brad Doctor ,  James Brown

Inventor： Brad Doctor ,  James Brown

IPC: G06F21/00

CPC classification number: H04L63/02 ,  H04L63/1408

Abstract: A traffic inspection and filtering system (100) monitors traffic across a protected interface. In the case of monitoring incoming traffic, the incoming packets (102) are directed via a mandatory path (104) to a packet capture process (106) associated with a kernel (110) of an operating system. The packets are then stored in shared memory (112) of the kernel (112) for access by a user space application (108) that makes a filtering decision without requiring copying of the packet to user space and back.

Abstract translation: 流量检查和过滤系统（100）监视受保护接口的流量。 在监视传入流量的情况下，输入分组（102）经由强制路径（104）被引导到与操作系统的内核（110）相关联的分组捕获进程（106）。 然后，分组被存储在内核（112）的共享存储器（112）中，以供由进行过滤决定的用户空间应用程序（108）访问，而不需要将数据包复制到用户空间并返回。