公开(公告)号：US4156207A

公开(公告)日：1979-05-22

申请号：US803357

申请日：1977-06-03

Applicant: James P. Reilly

Inventor： James P. Reilly

IPC: H01S3/0979 ,  H01S3/02

CPC classification number: H01S3/0979

Abstract: An electric discharge gas laser has a turbulence generator inserted in the flow path of the gas upstream of the optical cavity. The turbulence generator is illustrated as a screen. The turbulence is also disclosed as resulting from a vortex-causing blade inserted in the gas conduit. The turbulence resulting in the gas flow provides energy and specie diffusion to the outer walls at a rate relatively faster than laminar (molecular) diffusion, thereby permitting stable operations of the diffuse electric discharge at relatively higher powers.

Abstract translation: 放电气体激光器具有插入在光腔上游的气体的流路中的湍流发生器。 湍流发生器被示为屏幕。 还公开了由插入在气体导管中的产生涡流的叶片引起的紊流。 导致气流的湍流以比层流（分子）扩散更快的速率向外壁提供能量和物质扩散，从而允许在较高功率下的漫射放电的稳定操作。

公开(公告)号：US06911182B2

公开(公告)日：2005-06-28

申请号：US10274247

申请日：2002-10-18

Applicant: Tony J. Tegeler ,  Yehia Mechref ,  Kirk S. Boraas ,  James P. Reilly ,  Milos V. Novotny

Inventor： Tony J. Tegeler ,  Yehia Mechref ,  Kirk S. Boraas ,  James P. Reilly ,  Milos V. Novotny

IPC: B01L3/02 ,  G01N30/84 ,  H01J49/04 ,  H01J49/16 ,  B01L11/00 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC classification number: B01L3/0268 ,  B01L2300/0812 ,  B01L2400/0487 ,  G01N30/84 ,  G01N2030/8417 ,  H01J49/00 ,  Y10T436/11 ,  Y10T436/110833 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A device for placement of effluent comprises a substrate positioner, a deposition conduit, and a conduit positioner. The substrate positioner supports and positions a substrate on which effluent exiting from the deposition conduit is to be deposited. The conduit positioner moves an exit end of the deposition conduit relative to the substrate.

Abstract translation: 用于放置流出物的装置包括基板定位器，沉积导管和导管定位器。 衬底定位器支撑并定位要沉积从沉积导管排出的流出物的衬底。 管道定位器相对于衬底移动沉积管道的出口端。

公开(公告)号：US06627879B2

公开(公告)日：2003-09-30

申请号：US10223424

申请日：2002-08-19

Applicant: James P. Reilly ,  Noah P. Christian

Inventor： James P. Reilly ,  Noah P. Christian

IPC: H01J4940

CPC classification number: H01J49/40 ,  H01J49/0009

Abstract: One illustrative embodiment of a voltage pulser circuit comprises a voltage source producing a first voltage, and a thyratron tube having an anode coupled to the output of the voltage source, a cathode connected to a reference potential and a grid responsive to a grid control voltage to electrically connect the anode to the cathode to thereby cause the first thyratron tube to switch the anode between the first voltage and the reference potential. A pulse-shaping circuit may be connected to the anode of the tube to effectuate desired rise and fall times of the voltage pulses produced by the voltage pulser circuit. Such a voltage pulser circuit is particularly suited for use in connection with the operation of pulsed spectrometer instruments, such as time-of-flight mass spectrometers and the like.

Abstract translation: 电压脉冲发生器电路的一个说明性实施例包括产生第一电压的电压源和具有耦合到电压源的输出的阳极的闸流管，连接到参考电位的阴极和响应于电网控制电压的电网 将阳极电连接到阴极，从而使第一闸流管在第一电压和参考电位之间切换阳极。 脉冲整形电路可以连接到管的阳极，以实现由电压脉冲发生器电路产生的电压脉冲的期望上升和下降时间。 这种电压脉冲发生器电路特别适用于脉冲光谱仪器的操作，例如飞行时间质谱仪等。

公开(公告)号：US06437325B1

公开(公告)日：2002-08-20

申请号：US09313923

申请日：1999-05-18

Applicant: James P. Reilly ,  Noah P. Christian

Inventor： James P. Reilly ,  Noah P. Christian

IPC: H01J4940

CPC classification number: H01J49/40 ,  H01J49/0009

Abstract: A time-of-flight mass spectra calibration technique uses time-of-flight mass spectrometer instrument operational parameters and known mass and measured time-of-flight data pairs to optimize values of chosen ones of the instrument operational parameters. Electrostatic time-of-flight calculations are conducted in conjunction with an iterative procedure, preferably a simplex optimization procedure, to thereby minimize a residual error between the electrostatic time-of-flight calculations and the measured time-of-flight data values for each of the known mass values. While conventional curve fitting mass calibration techniques are devoid of information that describe ion behavior, the mass calibration technique of the present invention, by contrast, takes into account all of the instrument operational parameters in arriving at a final calibration. Because the electrostatic TOF calculation is a description of ion behavior in an actual TOF mass spectrometer instrument rather than a polynomial representation of a curve, it is well behaved and does not contain any instabilities where unpredictable calibration errors might occur. Moreover, unlike conventional curve fitting mass calibration techniques, the mass calibration technique of the present invention maintains mass accuracy in extrapolated mass ranges.

Abstract translation: 飞行时间质谱校准技术使用飞行时间质谱仪仪器操作参数和已知质量和测量的飞行时间数据对来优化所选仪器操作参数的值。 静电飞行时间计算结合迭代程序，优选单纯形优化程序进行，从而最小化静电飞行时间计算之间的残余误差和测量的飞行时间数据值 已知的质量值。 虽然传统的曲线拟合质量校准技术没有描述离子行为的信息，但是相比之下，本发明的质量校准技术考虑到达到最终校准的所有仪器操作参数。 因为静电TOF计算是对实际TOF质谱仪器中的离子行为的描述，而不是曲线的多项式表示，因此它的行为良好，并且不包含可能发生不可预测的校准误差的任何不稳定性。 此外，与传统的曲线拟合质量校准技术不同，本发明的质量校准技术保持外推质量范围的质量精度。

公开(公告)号：US5905258A

公开(公告)日：1999-05-18

申请号：US867245

申请日：1997-06-02

Applicant: David E. Clemmer ,  James P. Reilly

Inventor： David E. Clemmer ,  James P. Reilly

IPC: G01N27/64 ,  H01J49/40 ,  H01J49/42

CPC classification number: G01N27/622 ,  H01J49/004 ,  H01J49/40 ,  H01J49/42

Abstract: A hybrid ion mobility and time-of-flight mass spectrometer includes an ion source region coupled to an ion mobility spectrometer (IMS) which feeds directly into an ion accelerating region of a time-of-flight mass spectrometer (TOFMS). In one embodiment, the TOFMS is positioned relative to the IMS so that the flight tube axis of the TOFMS is perpendicular to the drift tube axis of the IMS. In an alternate embodiment, the TOFMS is positioned relative to the IMS so that the flight tube axis of the TOFMS is non-perpendicular to the drift tube axis of the IMS. In the alternate embodiment, a known quadrupole ion trap is positioned between the IMS and the TOFMS to provide the capability of controlling the injection of ion packets into the TOFMS. The ion source may be a MALDI source, an electrospray ionization source, or an ion trap positioned between the IMS and any known ion source. In each case, the IMS, TOFMS and ion sources are preferably controlled by a computer.

Abstract translation: 混合离子迁移率和飞行时间质谱仪包括耦合到离子迁移谱仪（IMS）的离子源区域，其直接进料到飞行时间质谱仪（TOFMS）的离子加速区域。 在一个实施例中，TOFMS相对于IMS定位，使得TOFMS的飞行管轴线垂直于IMS的漂移管轴线。 在替代实施例中，TOFMS相对于IMS定位，使得TOFMS的飞行管轴线不与IMS的漂移管轴线垂直。 在替代实施例中，已知的四极离子阱位于IMS和TOFMS之间，以提供控制将离子包注入到TOFMS中的能力。 离子源可以是位于IMS和任何已知离子源之间的MALDI源，电喷雾离子源或离子阱。 在每种情况下，IMS，TOFMS和离子源优选地由计算机控制。

公开(公告)号：US5712479A

公开(公告)日：1998-01-27

申请号：US566140

申请日：1995-12-01

Applicant: James P. Reilly ,  Steven M. Colby ,  Timothy B. King

Inventor： James P. Reilly ,  Steven M. Colby ,  Timothy B. King

IPC: H01J49/40

CPC classification number: H01J49/0031 ,  H01J49/40

Abstract: An apparatus and method for minimizing ion peak width measurements in a time-of-flight mass spectrometer to thereby minimize the effects of initial ion position distributions and initial ion velocity distributions on the mass resolution of the spectrometer are provided. Where the ion source and ion generation geometries indicate a functional relationship between the initial ion position and initial ion velocity, this relationship is substituted into the time-of-flight equation and the instrument parameters are thereafter optimized to achieve minimization of ion peak width broadening. Experimental results using MALDI indicate reductions in ion peak widths of up to 96% over those observed with traditional MALDI techniques.

公开(公告)号：US5510613A

公开(公告)日：1996-04-23

申请号：US477198

申请日：1995-06-07

Applicant: James P. Reilly ,  Steven M. Colby ,  Timothy B. King

Inventor： James P. Reilly ,  Steven M. Colby ,  Timothy B. King

IPC: H01J49/40

CPC classification number: H01J49/0031 ,  H01J49/40

Abstract: An apparatus and method for minimizing ion peak width measurements in a time-of-flight mass spectrometer to thereby minimize the effects of initial ion position distributions and initial ion velocity distributions on the mass resolution of the spectrometer are provided. Where the ion source and ion generation geometries indicate a functional relationship between the initial ion position and initial ion velocity, this relationship is substituted into the time-of-flight equation and the instrument parameters are thereafter optimized to achieve minimization of ion peak width broadening. Experimental results using MALDI indicate reductions in ion peak widths of up to 96% over those observed with traditional MALDI techniques.

公开(公告)号：US10221084B1

公开(公告)日：2019-03-05

申请号：US13605382

申请日：2012-09-06

Applicant: James P. Reilly ,  Victoria Jelderks

Inventor： James P. Reilly ,  Victoria Jelderks

IPC: C02F3/02 ,  C02F1/00

Abstract: Embodiments of the invention describe a headworks and dewatering component coupled to an inlet and disposed above a base of the basin, the headworks and dewatering component to include a filtration element to define a flow restriction for solid materials, dewater the solid materials from the wastewater influent, and pass a remainder of the wastewater influent (e.g., to another compartment of a host WWTP container). In one embodiment, the headworks and dewatering component comprises a box shape (i.e., orthogonal polyhedral). In other embodiments, said component may comprise a circular or free-form shape. In one embodiment, the filtration element defines a flow restriction for solid materials based, at least in part, on dimensions of the solid materials. Said filtration element may comprise fabric netting, or metal mesh netting.

公开(公告)号：US10107820B2

公开(公告)日：2018-10-23

申请号：US13519255

申请日：2010-12-31

Applicant: James P. Reilly ,  Liangyi Zhang

Inventor： James P. Reilly ,  Liangyi Zhang

IPC: G01N27/62 ,  G01N33/68 ,  G06F19/18 ,  G06F19/24

Abstract: Methods of identifying polypeptides have been developed using a de novo sequencing technique. Methods use photodissociation and low-energy fragmentation and the spectra of peptide ions obtained therefrom, such as obtained by post-source decay (PSD), have been developed. The methods include photodissociation and the spectra therefrom obtainable from treating ions with predetermined wavelengths of radiation in the vacuum ultraviolet range of the electromagnetic spectrum. The confidence of amino acid assignments based on x-type ions is evaluated by observing complementary y-, v- and w-type ions that provide additional constraints to sequence identification.

公开(公告)号：US20120282641A1

公开(公告)日：2012-11-08

申请号：US13519255

申请日：2010-12-31

Applicant: James P. Reilly ,  Liangyi Zhang

Inventor： James P. Reilly ,  Liangyi Zhang

IPC: G01N27/62 ,  G01N33/483 ,  G06F19/00

CPC classification number: G01N33/6818 ,  G01N33/6848 ,  G06F19/18 ,  G06F19/24

Abstract: Methods of identifying polypeptides have been developed using a de novo sequencing technique. Methods use photodissociation and low-energy fragmentation and the spectra of peptide ions obtained therefrom, such as obtained by post-source decay (PSD), have been developed. The methods include photodissociation and the spectra therefrom obtainable from treating ions with predetermined wavelengths of radiation in the vacuum ultraviolet range of the electromagnetic spectrum. The confidence of amino acid assignments based on x-type ions is evaluated by observing complementary y-, v- and w-type ions that provide additional constraints to sequence identification.

Abstract translation: 使用从头测序技术开发了鉴定多肽的方法。 方法使用光解离和低能量断裂，并且由其获得的肽离子的光谱，例如通过后源衰变（PSD）获得的光谱。 这些方法包括光解离及其可从电磁光谱的真空紫外范围内用预定波长的辐射处理离子获得的光谱。 通过观察对序列鉴定提供额外约束的互补y-，v-和w-型离子来评估基于x型离子的氨基酸分配的置信度。