公开(公告)号：US20230035403A1

公开(公告)日：2023-02-02

申请号：US17366769

申请日：2021-07-02

Applicant: Janssen Biotech, Inc.

Inventor： Denis A. Smirnov ,  Yashoda Rani Rajpurohit ,  Vipul Bhargava ,  Patrick Wilkinson ,  Kai Fu ,  Manuel Alejandro Sepulveda

IPC: G01N33/50 ,  G01N33/574 ,  C12Q1/686 ,  C12Q1/6806 ,  A61K35/768 ,  C12N7/00

Abstract: Disclosed herein are methods of diagnosing and treating a subject with prostate cancer, as well as methods of monitoring the responsiveness of a subject having prostate cancer to a therapeutic agent.

公开(公告)号：US20230024133A1

公开(公告)日：2023-01-26

申请号：US17366545

申请日：2021-07-02

Applicant: Janssen Biotech, Inc.

Inventor： Jason Lee DeHart ,  Vipul Bhargava ,  Patrick Wilkinson ,  Manuel Alejandro Sepulveda

IPC: A61K39/12 ,  A61K39/00

Abstract: Disclosed herein are self-replicating RNA molecules encoding prostate neoantigens, vaccines, and method of treating and preventing prostate cancer using the self-replicating RNA molecules and vaccines.

公开(公告)号：US20220194999A1

公开(公告)日：2022-06-23

申请号：US17556019

申请日：2021-12-20

Applicant: Janssen Biotech, Inc.

Inventor： Vinod Krishna ,  Manuel Alejandro Sepulveda ,  Vipul Bhargava ,  Iqbal S. Grewal ,  Kurtis Bachman

IPC: C07K14/47 ,  C07K14/71 ,  C07K14/725 ,  C12N15/85 ,  C12N5/0783 ,  C12N5/00 ,  C12N9/14 ,  C12N9/16 ,  C12N9/12

Abstract: Disclosed herein are polypeptide fragments and polynucleotides based on mutant capicua transcriptional repressor (CIC), catenin beta 1 (CTNNB1), v-erb-b2 erythroblastic leukemia viral oncogene homolog B (ERBB2), kirsten rat sarcoma (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), phosphatase and tensin homolog (PTEN), splicing factor 3b subunit 1 (SF3B1), SRY-box transcription factor 17 (SOX17), tumor protein 53 (TP53), and cytomegalovirus (CMV) sequences, vectors, host cells, viruses, methods for generating CD8+ T-cells, and methods of treatment. Also disclosed herein are T-cell receptors (TCRs), polynucleotides, vectors and cells comprising the TCRs, and methods of treatment.

公开(公告)号：US20210315986A1

公开(公告)日：2021-10-14

申请号：US17228871

申请日：2021-04-13

Applicant: Janssen Biotech, Inc.

Inventor： Marco Gottardis ,  Selina Khan ,  Manuel Alejandro Sepulveda ,  Douglas H. Yamada ,  Roland Zahn ,  Brent Rupnow

IPC: A61K39/00 ,  A61K45/06 ,  C12N15/86 ,  A61P35/00

Abstract: Disclosed herein are PSMA and/or STEAP1 polynucleotides, polypeptides, vectors, viruses, vaccines, and vaccine combinations, and their uses.