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    Method and apparatus for device controlled gene expression for cardiac protection
    11.
    发明申请
    Method and apparatus for device controlled gene expression for cardiac protection 有权
    心脏保护装置控制基因表达的方法和装置

    公开(公告)号：US20070054871A1

    公开(公告)日：2007-03-08

    申请号：US11220397

    申请日：2005-09-06

    申请人： Joseph Pastore ,  Jeffrey Ross ,  Tamara Baynham ,  Rodney Salo ,  Andrew Kramer ,  Julio Spinelli

    发明人： Joseph Pastore ,  Jeffrey Ross ,  Tamara Baynham ,  Rodney Salo ,  Andrew Kramer ,  Julio Spinelli

    IPC分类号： A61K48/00 ,  A61N1/00

    CPC分类号： A61N1/3627 ,  A61K48/0083 ,  A61N1/36514

    摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.

    摘要翻译： 基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。 生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。 在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。 基因调控信号直接或间接调控基因产物的基因表达。

    REDUCTION OF INTERACTION WITH TACHYARRHYTHMIA DETECTION BY NEGATIVE OFFSET PACING
    13.
    发明申请
    REDUCTION OF INTERACTION WITH TACHYARRHYTHMIA DETECTION BY NEGATIVE OFFSET PACING 有权
    减少与负面偏差相关的TACHYARRHYTHMIA检测

    公开(公告)号：US20060116728A1

    公开(公告)日：2006-06-01

    申请号：US11276031

    申请日：2006-02-10

    申请人： Jeffrey Stahmann ,  Andrew Kramer ,  Julio Spinelli

    发明人： Jeffrey Stahmann ,  Andrew Kramer ,  Julio Spinelli

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3622

    摘要： A device and method is disclosed for improving tachyarrhythmia detection when the ventricles are resynchronized by delivering paces to both ventricles separated by a specified negative offset interval. Timing of escape intervals and tachyarrhythmia detection is based upon senses from one of the ventricles designated as a rate ventricle. Techniques are presented for preventing tachyarrhythmia detection from being compromised when the rate ventricle is paced after the other ventricle.

    摘要翻译： 公开了一种用于改善心律失常检测的装置和方法，当通过将指定的负偏移间隔分开的两个心室递送步调来再同步时，心律失常检测。 逃避间隔和快速性心律失常检测的时间是基于指定为速率心室的心室之一的感觉。 提出技术用于在速率心室在另一脑室之后起搏时预防快速性心律失常检测受到损害。

    Cardiac rhythm management system with arrhythmia classification and electrode selection
    14.
    发明申请
    Cardiac rhythm management system with arrhythmia classification and electrode selection 失效
    具有心律失常分类和电极选择的心律管理系统

    公开(公告)号：US20050203581A1

    公开(公告)日：2005-09-15

    申请号：US11125501

    申请日：2005-05-10

    申请人： Julio Spinelli ,  Qingsheng Zhu ,  Jeffrey Stahmann ,  Andrew Kramer

    发明人： Julio Spinelli ,  Qingsheng Zhu ,  Jeffrey Stahmann ,  Andrew Kramer

    IPC分类号： A61N1/362 ,  A61N1/368

    CPC分类号： A61N1/3622 ,  A61N1/3684

    摘要： A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.

    摘要翻译： 系统，方法或装置根据在多个电极处接收与特定心脏收缩相关联的去极化波的时间顺序对心律失常进行分类。 一种或多种抗心律失常疗法被映射到每种心律失常分类。 当检测到特别分类的心律失常时，选择相应地映射的治疗列表并进行适当的抗心律失常治疗。 在一个示例中，响应于心律失常递送的特定治疗至少部分地取决于其在治疗该分类的心律失常方面的历史成功。

    RESYNCHRONIZATION METHOD AND APPARATUS BASED ON INTRINSIC ATRIAL RATE
    20.
    发明申请
    RESYNCHRONIZATION METHOD AND APPARATUS BASED ON INTRINSIC ATRIAL RATE 有权
    基于内在速率的再生方法和装置

    公开(公告)号：US20070208386A1

    公开(公告)日：2007-09-06

    申请号：US11676339

    申请日：2007-02-19

    申请人： Andrew Kramer ,  Veerichetty Kadhiresan ,  Jiang Ding ,  Lawrence Baumann ,  Scott Vanderlinde

    发明人： Andrew Kramer ,  Veerichetty Kadhiresan ,  Jiang Ding ,  Lawrence Baumann ,  Scott Vanderlinde

    IPC分类号： A61N1/05

    CPC分类号： A61N1/3627 ,  A61N1/3682

    摘要： A method and system for setting the operating parameters of a cardiac rhythm management device in which a plurality of parameter optimization algorithms are available. A measured feature of an electrophysiological signal such as QRS width has been shown to be useful in selecting among certain parameter optimization algorithms. In one embodiment, one or more resynchronization pacing parameters are set based on one or both of the feature extracted from an electrogram signal and the value of a resynchronization pacing parameter which tends to minimize the intrinsic atrial rate.

    摘要翻译： 一种用于设定多个参数优化算法可用的心律管理装置的操作参数的方法和系统。 电生理信号（如QRS宽度）的测量特征已被证明可用于某些参数优化算法中的选择。 在一个实施例中，基于从电描记信号提取的特征中的一个或两个以及倾向于使固有心房率最小化的再同步起搏参数的值来设置一个或多个再同步起搏参数。