公开(公告)号：US08353682B2

公开(公告)日：2013-01-15

申请号：US12274120

申请日：2008-11-19

申请人： Mihai Patrascu ,  Mercedes Crego Calama ,  Martijn Goedbloed ,  Koray Karakaya

发明人： Mihai Patrascu ,  Mercedes Crego Calama ,  Martijn Goedbloed ,  Koray Karakaya

IPC分类号： F04B17/00

CPC分类号： F04B43/043 ,  F04B43/046 ,  F04B43/06 ,  Y10T29/49002

摘要： A microfluidic device is described. The microfluidic device comprises at least one transport channel and at least one working chamber, wherein the at least one transport channel and the at least one working chamber are separated from each other by a common deformable wall. The at least one transport channel is for containing a transport fluid and the at least one working chamber is for containing a working fluid. The microfluidic device comprises at least one pair of electrodes for changing the pressure on the working fluid such that when the pressure on the working fluid is changed, the deformable wall deforms, resulting in a change of the cross-section of the at least one transport channel. The working chamber comprises a flexible wall different from the common deformable wall and at least one electrode of the at least one pair of electrodes is provided on the flexible wall.

摘要翻译： 描述微流体装置。 所述微流体装置包括至少一个输送通道和至少一个工作室，其中所述至少一个输送通道和所述至少一个工作室通过共同的可变形壁彼此分开。 所述至少一个输送通道用于容纳输送流体，并且所述至少一个工作室用于容纳工作流体。 微流体装置包括至少一对电极，用于改变工作流体上的压力，使得当工作流体上的压力改变时，可变形壁变形，导致至少一个输送器的横截面的变化 渠道。 工作室包括与公共可变形壁不同的柔性壁，并且至少一对电极的至少一个电极设置在柔性壁上。

公开(公告)号：US20110205543A1

公开(公告)日：2011-08-25

申请号：US13033180

申请日：2011-02-23

申请人： Peter Offermans ,  Sywert H. Brongersma ,  Mercedes Crego Calama ,  Gabriele Vecchi ,  Jaime Gomez Rivas

发明人： Peter Offermans ,  Sywert H. Brongersma ,  Mercedes Crego Calama ,  Gabriele Vecchi ,  Jaime Gomez Rivas

IPC分类号： G01N21/55

CPC分类号： G01N21/554 ,  G01N2201/0221

摘要： The present disclosure relates to a gas sensor including a first layer and a second layer superimposed on each other along an interface between the two layers. The first layer includes an array of nanoparticles along the interface, the nanoparticles provided so as to allow, upon illumination with electromagnetic radiation, long range diffractive coupling of surface plasmon resonances resulting in a surface lattice resonance condition. The second layer includes a material that, when exposed to at least one predetermined gas, detectably affects the surface lattice resonance condition. The material of the second layer preferably has a porosity of at least 10%.

摘要翻译： 本公开涉及一种气体传感器，其包括沿着两层之间的界面彼此重叠的第一层和第二层。 第一层包括沿着界面的纳米颗粒阵列，所述纳米颗粒被设置成允许在用电磁辐射照射时允许表面等离子体共振的远距离衍射耦合，导致表面晶格共振状态。 第二层包括当暴露于至少一个预定气体时可检测地影响表面晶格共振条件的材料。 第二层的材料优选具有至少10％的孔隙率。

公开(公告)号：US08535499B2

公开(公告)日：2013-09-17

申请号：US13024177

申请日：2011-02-09

申请人： Michiel Blauw ,  Javier Gonzalo Ruiz ,  Mercedes Crego Calama ,  Sywert H. Brongersma

发明人： Michiel Blauw ,  Javier Gonzalo Ruiz ,  Mercedes Crego Calama ,  Sywert H. Brongersma

IPC分类号： G01N27/26

CPC分类号： G01N27/401 ,  G01N27/301

摘要： Micromachined reference electrodes for use in miniaturized electrochemical sensors, and methods for fabricating such reference electrodes and electrochemical sensors, for example, as a part of a microfluidic system, are disclosed. Electrochemical measurements allow for inexpensive detection of a wide variety of (bio-)chemical compounds in solution. The reference electrode is one of the main parts of an electrochemical cell. The reference electrode, from which no current is drawn, has a stable, constant potential.

摘要翻译： 公开了用于微型电化学传感器的微加工参考电极以及用于制造这种参考电极和电化学传感器的方法，例如作为微流体系统的一部分。 电化学测量允许便宜地检测溶液中各种（生物）化合物。 参比电极是电化学电池的主要部分之一。 没有电流的参考电极具有稳定的恒定电位。

公开(公告)号：US20110192720A1

公开(公告)日：2011-08-11

申请号：US13024177

申请日：2011-02-09

申请人： Michiel Blauw ,  Javier Gonzalo Ruiz ,  Mercedes Crego Calama ,  Sywert H. Brongersma

发明人： Michiel Blauw ,  Javier Gonzalo Ruiz ,  Mercedes Crego Calama ,  Sywert H. Brongersma

IPC分类号： G01N27/30 ,  G01N27/333 ,  G01N27/416

CPC分类号： G01N27/401 ,  G01N27/301

摘要： Micromachined reference electrodes for use in miniaturized electrochemical sensors, and methods for fabricating such reference electrodes and electrochemical sensors, for example, as a part of a microfluidic system, are disclosed. Electrochemical measurements allow for inexpensive detection of a wide variety of (bio-)chemical compounds in solution. The reference electrode is one of the main parts of an electrochemical cell. The reference electrode, from which no current is drawn, has a stable, constant potential.

摘要翻译： 公开了用于微型电化学传感器的微加工参考电极以及用于制造这种参考电极和电化学传感器的方法，例如作为微流体系统的一部分。 电化学测量允许便宜地检测溶液中各种（生物）化合物。 参考电极是电化学电池的主要部分之一。 没有电流的参考电极具有稳定的恒定电位。

公开(公告)号：US20100176822A1

公开(公告)日：2010-07-15

申请号：US12604325

申请日：2009-10-22

申请人： Peter Offermans ,  Mercedes Crego Calama ,  Sywert H. Brongersma

发明人： Peter Offermans ,  Mercedes Crego Calama ,  Sywert H. Brongersma

IPC分类号： G01R27/26

CPC分类号： B82Y15/00 ,  B82Y30/00 ,  G01N27/4146 ,  H01L29/0665 ,  H01L29/0676

摘要： An analyte sensing device is disclosed. In one aspect, the device includes at least one sensing module on a substrate. The sensing module has at least one nanowire including a bottom, an intermediate part and a top, the bottom being closer to the substrate than the top. The module has a surrounding electrode surrounding the bottom and at least part of the intermediate part of each nanowire in height direction and being electrically isolated from the nanowire. There is a gap between each nanowire and the corresponding surrounding electrode allowing penetration of an analyte to be detected between the nanowire and the surrounding electrode. A measurement circuitry is electrically connected to each nanowire and the surrounding electrode for detecting a change in an electrical property as a result of the penetration of the analyte into the gap.

摘要翻译： 公开了分析物感测装置。 在一个方面中，该装置在衬底上包括至少一个感测模块。 感测模块​​具有至少一个纳米线，其包括底部，中间部分和顶部，底部比顶部更靠近基底。 该模块具有围绕底部的周围电极和每个纳米线的高度方向的中间部分的至少一部分并且与纳米线电隔离。 每个纳米线和相应的周围电极之间存在间隙，允许在纳米线和周围电极之间穿透待检测的分析物。 测量电路与每个纳米线和周围电极电连接，用于检测分析物渗透到间隙中的电性能的变化。

公开(公告)号：US08525129B2

公开(公告)日：2013-09-03

申请号：US12743909

申请日：2008-12-17

申请人： Peter Offermans ,  Mercedes Crego Calama

发明人： Peter Offermans ,  Mercedes Crego Calama

IPC分类号： G01N21/64 ,  G01N21/39

CPC分类号： B82Y15/00 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N21/554 ,  G01N21/648 ,  G01N21/6489 ,  G01N21/75 ,  G01N2021/7723 ,  G01N2021/7786

摘要： The present invention relates to a gas sensing device comprising a nanoparticle layer (1) and a quantum dot layer (3) separated from each other by a gas absorption layer (2) which has a thickness which changes upon absorption of a gas. The nanoparticle layer (1) is provided for generating a surface plasmon resonance within a plasmon resonance frequency range upon illumination with light within a light frequency range; the quantum dot layer (3) has an absorption spectrum overlapping with said plasmon resonance frequency range of said nanoparticle layer (1) and shows photoluminescence in a photoluminescence emission frequency range upon absorption of energy within its absorption spectrum. The present invention further relates to a method for fabricating such a gas sensing device and to a method of using such a gas sensing device.

摘要翻译： 本发明涉及一种气体感测装置，其包括通过气体吸收层（2）彼此分离的纳米颗粒层（1）和量子点层（3），所述气体吸收层具有随气体吸收而变化的厚度。 提供纳米颗粒层（1），用于在光频范围内的光照射时在等离子体共振频率范围内产生表面等离子体共振; 量子点层（3）具有与所述纳米颗粒层（1）的所述等离子体共振频率范围重叠的吸收光谱，并且在吸收光谱吸收能量时在光致发光发射频率范围内显示光致发光。 本发明还涉及一种用于制造这种气体感测装置的方法以及使用这种气体感测装置的方法。

公开(公告)号：US20100264333A1

公开(公告)日：2010-10-21

申请号：US12743909

申请日：2008-12-17

申请人： Peter Offermans ,  Mercedes Crego Calama

发明人： Peter Offermans ,  Mercedes Crego Calama

IPC分类号： G01J1/58 ,  H01L31/12 ,  H01L21/20 ,  G01N21/55

CPC分类号： B82Y15/00 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N21/554 ,  G01N21/648 ,  G01N21/6489 ,  G01N21/75 ,  G01N2021/7723 ,  G01N2021/7786

摘要： The present invention relates to a gas sensing device comprising a nanoparticle layer (1) and a quantum dot layer (3) separated from each other by a gas absorption layer (2) which has a thickness which changes upon absorption of a gas. The nanoparticle layer (1) is provided for generating a surface plasmon resonance within a plasmon resonance frequency range upon illumination with light within a light frequency range; the quantum dot layer (3) has an absorption spectrum overlapping with said plasmon resonance frequency range of said nanoparticle layer (1) and shows photoluminescence in a photoluminescence emission frequency range upon absorption of energy within its absorption spectrum. The present invention further relates to a method for fabricating such a gas sensing device and to a method of using such a gas sensing device.

摘要翻译： 本发明涉及一种气体感测装置，其包括通过气体吸收层（2）彼此分离的纳米颗粒层（1）和量子点层（3），所述气体吸收层具有随气体吸收而变化的厚度。 提供纳米颗粒层（1），用于在光频范围内的光照射时在等离子体共振频率范围内产生表面等离子体共振; 量子点层（3）具有与所述纳米颗粒层（1）的所述等离子体共振频率范围重叠的吸收光谱，并且在吸收光谱吸收能量时在光致发光发射频率范围内显示光致发光。 本发明还涉及一种用于制造这种气体感测装置的方法以及使用这种气体感测装置的方法。

公开(公告)号：US20090129952A1

公开(公告)日：2009-05-21

申请号：US12274120

申请日：2008-11-19

申请人： Mihai Patrascu ,  Mercedes Crego Calama ,  Martijn Goedbloed ,  Koray Karakaya

发明人： Mihai Patrascu ,  Mercedes Crego Calama ,  Martijn Goedbloed ,  Koray Karakaya

IPC分类号： B23P17/00 ,  F16K31/02 ,  F04B17/00

CPC分类号： F04B43/043 ,  F04B43/046 ,  F04B43/06 ,  Y10T29/49002

摘要： A microfluidic device is described. The microfluidic device comprises at least one transport channel and at least one working chamber, wherein the at least one transport channel and the at least one working chamber are separated from each other by a common deformable wall. The at least one transport channel is for containing a transport fluid and the at least one working chamber is for containing a working fluid. The microfluidic device comprises at least one pair of electrodes for changing the pressure on the working fluid such that when the pressure on the working fluid is changed, the deformable wall deforms, resulting in a change of the cross-section of the at least one transport channel. The working chamber comprises a flexible wall different from the common deformable wall and at least one electrode of the at least one pair of electrodes is provided on the flexible wall.

摘要翻译： 描述微流体装置。 所述微流体装置包括至少一个输送通道和至少一个工作室，其中所述至少一个输送通道和所述至少一个工作室通过共同的可变形壁彼此分开。 所述至少一个输送通道用于容纳输送流体，并且所述至少一个工作室用于容纳工作流体。 微流体装置包括至少一对电极，用于改变工作流体上的压力，使得当工作流体上的压力改变时，可变形壁变形，导致至少一个输送器的横截面的变化 渠道。 工作室包括与公共可变形壁不同的柔性壁，并且至少一对电极的至少一个电极设置在柔性壁上。