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    MODULAR INGESTIBLE DRUG DELIVERY CAPSULE
    11.
    发明申请
    MODULAR INGESTIBLE DRUG DELIVERY CAPSULE 有权
    模块不可食用药物输送胶囊

    公开(公告)号：US20120116358A1

    公开(公告)日：2012-05-10

    申请号：US13262841

    申请日：2010-04-02

    申请人： Johan Frederik Dijksman ,  Anke Pierik ,  Frits Tobi De Jongh ,  Jeff Shimizu ,  Hans Zou ,  Lucian Remus Albu ,  Olaf Weiner

    发明人： Johan Frederik Dijksman ,  Anke Pierik ,  Frits Tobi De Jongh ,  Jeff Shimizu ,  Hans Zou ,  Lucian Remus Albu ,  Olaf Weiner

    IPC分类号： A61M37/00

    CPC分类号： A61K9/4808 ,  A61K9/0009 ,  A61K9/0097 ,  A61M31/002

    摘要： An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).

    摘要翻译： 提供用于输送药物的可摄取胶囊（10），所述胶囊（10）包括第一模块（11）和第二模块（12）。 第一模块（11）具有至少一个用于包含一定量药物的药物隔室（13）。 药物隔室（13）由具有嵌入的导电加热丝（15）的箔（14）密封。 第二（12）模块包括用于向加热丝（15）提供电脉冲以便通过熔化箔（14）打开药物隔室（13）的电子器件（18）。 第一模块（11）和第二模块（12）包括用于将第一模块（11）固定到第二模块（12）的可互操作的连接装置（19），使得电热丝（15）电连接到电子装置 ）。

    Swallowable multi-nozzle dosing device for releasing medicines in the gastrointestinal tract
    12.
    发明授权
    Swallowable multi-nozzle dosing device for releasing medicines in the gastrointestinal tract 有权
    用于释放胃肠道药物的吞咽式多喷嘴给药装置

    公开(公告)号：US08597279B2

    公开(公告)日：2013-12-03

    申请号：US12447808

    申请日：2007-10-17

    申请人： Johan Frederik Dijksman ,  Anke Pierik ,  Judith Margreet Rensen ,  Jeff Shimizu ,  Hans Zou ,  Ivar Schram

    发明人： Johan Frederik Dijksman ,  Anke Pierik ,  Judith Margreet Rensen ,  Jeff Shimizu ,  Hans Zou ,  Ivar Schram

    IPC分类号： A61K9/22 ,  A61M31/00 ,  A61K9/52

    CPC分类号： A61B5/073 ,  A61B1/00016 ,  A61B1/041 ,  A61B5/4839 ,  A61M31/002

    摘要： A capsule and methodology for dispensing a medicament in the gastrointestinal tract of a mammal is disclosed, the gastrointestinal tract having tissue sites of interest. The capsule may include a medicament reservoir; medicament dispensing means such as a plurality of piezoelectric droplet jet nozzle dispensers; a power source; electronic control circuitry means and/or detecting means capable of communicating with a medicament dispensing means for regulating the amount and time interval for dispensing of the medicament into the gastrointestinal tract by the medicament dispensing means; and a non-digestible outer protective shell housing, e.g., the medicament reservoir, medicament dispensing means and electronic control circuitry means. A plurality of the nozzle dispensers of the medicament dispensing means can be positioned tangentially to a surface of the housing such that during release of a medicament, the capsule is caused to rotate and/or translate so as to discharge the medicament homogeneously onto tissue sites of interest. In addition, by using multiple nozzles and releasing medicament at high speed, this facilitates medicament absorption by the intestines in the gastrointestinal tract.

    摘要翻译： 公开了用于在哺乳动物的胃肠道中分配药物的胶囊和方法，所述胃肠道具有感兴趣的组织部位。 胶囊可以包括药物储存器; 药剂分配装置，例如多个压电滴喷嘴分配器; 电源; 电子控制电路装置和/或检测装置，其能够与药物分配装置通信，用于通过药物分配装置调节药物分配到胃肠道中的量和时间间隔; 以及不可消化的外部保护壳体外壳，例如药物储存器，药物分配装置和电子控制电路装置。 药物分配装置的多个喷嘴分配器可以与壳体的表面相切地定位，使得在释放药物期间，使胶囊旋转和/或平移以将药物均匀地排出到组织位置 利益。 此外，通过使用多个喷嘴和高速释放药物，这有利于胃肠道中肠道的药物吸收。

    DESIGN OF SWALLOWABLE MULTI-NOZZLE DOSING DEVICE FOR RELEASING MEDICINES IN THE GASTROINTESTINAL TRACT
    13.
    发明申请
    DESIGN OF SWALLOWABLE MULTI-NOZZLE DOSING DEVICE FOR RELEASING MEDICINES IN THE GASTROINTESTINAL TRACT 有权
    用于释放胃肠道诱导药物的易燃多喷射剂量装置的设计

    公开(公告)号：US20100049120A1

    公开(公告)日：2010-02-25

    申请号：US12447808

    申请日：2007-10-17

    申请人： Johan Frederik Dijksman ,  Anke Pierik ,  Judith Margreet Rensen ,  Jeff Shimizu ,  Hans Zou ,  Ivar Schram

    发明人： Johan Frederik Dijksman ,  Anke Pierik ,  Judith Margreet Rensen ,  Jeff Shimizu ,  Hans Zou ,  Ivar Schram

    IPC分类号： A61M31/00

    CPC分类号： A61B5/073 ,  A61B1/00016 ,  A61B1/041 ,  A61B5/4839 ,  A61M31/002

    摘要： A capsule and methodology for dispensing a medicament in the gastrointestinal tract of a mammal is disclosed, the gastrointestinal tract having tissue sites of interest. The capsule may include a medicament reservoir; medicament dispensing means such as a plurality of piezoelectric droplet jet nozzle dispensers; a power source; electronic control circuitry means and/or detecting means capable of communicating with a medicament dispensing means for regulating the amount and time interval for dispensing of the medicament into the gastrointestinal tract by the medicament dispensing means; and a non-digestible outer protective shell housing, e.g., the medicament reservoir, medicament dispensing means and electronic control circuitry means. A plurality of the nozzle dispensers of the medicament dispensing means can be positioned tangentially to a surface of the housing such that during release of a medicament, the capsule is caused to rotate and/or translate so as to discharge the medicament homogeneously onto tissue sites of interest. In addition, by using multiple nozzles and releasing medicament at high speed, this facilitates medicament absorption by the intestines in the gastrointestinal tract.

    摘要翻译： 公开了用于在哺乳动物的胃肠道中分配药物的胶囊和方法，所述胃肠道具有感兴趣的组织部位。 胶囊可以包括药物储存器; 药剂分配装置，例如多个压电滴喷嘴分配器; 电源; 电子控制电路装置和/或检测装置，其能够与药物分配装置通信，用于通过药物分配装置调节药物分配到胃肠道中的量和时间间隔; 以及不可消化的外部保护壳体外壳，例如药物储存器，药物分配装置和电子控制电路装置。 药物分配装置的多个喷嘴分配器可以与壳体的表面相切地定位，使得在释放药物期间，使胶囊旋转和/或平移以将药物均匀地排出到组织位置 利益。 此外，通过使用多个喷嘴和高速释放药物，这有利于胃肠道中肠道的药物吸收。

    Electronic pill comprising a medicine reservoir
    16.
    发明授权
    Electronic pill comprising a medicine reservoir 有权
    电子药丸包含药物储存器

    公开(公告)号：US08911425B2

    公开(公告)日：2014-12-16

    申请号：US12995817

    申请日：2009-07-03

    申请人： Johan Frederik Dijksman ,  Anke Pierik ,  Jeff Shimizu ,  Hans Zou

    发明人： Johan Frederik Dijksman ,  Anke Pierik ,  Jeff Shimizu ,  Hans Zou

    IPC分类号： A61K9/22 ,  A61K47/00 ,  A61K9/00 ,  A61K9/48 ,  A61M31/00

    CPC分类号： A61K9/4808 ,  A61K9/0009 ,  A61K47/00 ,  A61K47/38 ,  A61M31/002

    摘要： Electronic pill (1, 11) comprising at least one medicine reservoir (2, 12) with a solid powder or granulate medicine, a discharge opening (3, 13) and an actuator responsive to control circuitry for displacing medicine from the reservoir (2, 12) to the discharge opening (3, 13). The medicine comprises a dispersion of one or more active ingredients—e.g., solids in powder or granulate form—in an inert carrier matrix. Optionally, the active ingredients are dispersed using intestinal moisture absorbed into the pill via a semi-permeable wall section (14).

    摘要翻译： 包括具有固体粉末或颗粒药物的至少一个药物储存器（2,12）的电子药丸（1,11），排出口（3,13）和响应于控制电路的致动器，所述控制电路用于将药物从贮存器 12）到排出口（3,13）。 药物包含一种或多种活性成分的分散体，例如粉末或颗粒形式的固体 - 在惰性载体基质中。 任选地，活性成分通过经由半透壁部分（14）吸收到药丸中的肠水分散。

    Imprint lithography alignment method and apparatus
    18.
    发明授权
    Imprint lithography alignment method and apparatus 有权

    公开(公告)号：US10222693B2

    公开(公告)日：2019-03-05

    申请号：US13189145

    申请日：2011-07-22

    申请人： Johan Frederik Dijksman ,  Anke Pierik ,  Sander Frederik Wuister ,  Roelof Koole

    发明人： Johan Frederik Dijksman ,  Anke Pierik ,  Sander Frederik Wuister ,  Roelof Koole

    IPC分类号： G03F7/00 ,  B82Y10/00 ,  B82Y40/00

    摘要： A method of aligning a template and a substrate for imprint lithography involves using a mask pattern of the template and a luminescent marker pattern of the substrate, the method including aligning the template mask pattern and the substrate marker pattern using a radiation intensity measurement of radiation emitted by the luminescent marker pattern and having passed the template mask pattern. The mask pattern and the luminescent marker pattern may each be shaped to provide a turning point in the intensity of detected radiation emitted from the marker pattern, and passing through the mask pattern to a detector, as a function of relative displacement at the aligned position. The displacement of the template and substrate may be aligned by identifying the turning point in radiation intensity. The marker pattern may be fluorescent with the emitted radiation excited by a radiation source.