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    BCL-G POLYPEPTIDES, ENCODING NUCLEIC ACIDS AND METHODS OF USE
    11.
    发明申请
    BCL-G POLYPEPTIDES, ENCODING NUCLEIC ACIDS AND METHODS OF USE 审中-公开
    BCL-G多肽，编码核酸和使用方法

    公开(公告)号：US20130224182A1

    公开(公告)日：2013-08-29

    申请号：US13247882

    申请日：2011-09-28

    申请人： John C. Reed ,  Adam Godzik

    发明人： John C. Reed ,  Adam Godzik

    IPC分类号： C07K7/08 ,  C07K7/06

    CPC分类号： C07K7/08 ,  C07K7/06 ,  C07K14/4747 ,  C07K2319/00

    摘要： The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors containing Bcl-G nucleic acids, host cells containing such vectors, Bcl-G anti-sense nucleic acids and related compositions. The invention additionally provides Bcl-G oligonucleotides that can be used to hybridize to or amplify a Bcl-G nucleic acid. Anti-Bcl-G specific antibodies are also provided. Further provided are kits containing Bcl-G nucleic acids or Bcl-G specific antibodies. Such kits and reagents can be used to diagnose cancer, monitor response to therapy, or predict the prognosis of a cancer patient. The invention additionally provides methods of modulating apoptosis using Bcl-G polypeptides, encoding nucleic acids, or compounds that modulate the activity or expression of Bcl-G polypeptides. The methods for modulating apoptosis can be used to treat diseases such as cancer.

    摘要翻译： 本发明提供了Bcl-G多肽和编码核酸。 Bcl-G多肽包括Bcl-GL和Bcl-GS。 本发明还提供了小鼠Bcl-G。 本发明还提供含有Bcl-G核酸的载体，含有这些载体的宿主细胞，Bcl-G反义核酸和相关组合物。 本发明另外提供可用于与Bcl-G核酸杂交或扩增的Bcl-G寡核苷酸。 还提供抗Bcl-G特异性抗体。 还提供了含有Bcl-G核酸或Bcl-G特异性抗体的试剂盒。 这样的试剂盒和试剂可用于诊断癌症，监测对治疗的反应或预测癌症患者的预后。 本发明另外提供了使用调节Bcl-G多肽的活性或表达的Bcl-G多肽，编码核酸或化合物来调节凋亡的方法。 调节凋亡的方法可用于治疗癌症等疾病。

    NOVEL CARD PROTEINS INVOLVED IN CELL DEATH REGULATION
    12.
    发明申请
    NOVEL CARD PROTEINS INVOLVED IN CELL DEATH REGULATION 审中-公开
    参与细胞死亡调控的新型卡片蛋白质

    公开(公告)号：US20110318362A1

    公开(公告)日：2011-12-29

    申请号：US13205566

    申请日：2011-08-08

    申请人： John C. Reed

    发明人： John C. Reed

    IPC分类号： A61K39/395 ,  C12N5/10 ,  C12N1/21 ,  C12N1/19 ,  A61K38/45 ,  A61P29/00 ,  C12N5/071 ,  G01N33/574 ,  C12N9/96 ,  C07K14/47 ,  C07K19/00 ,  A61P35/00 ,  C07K16/40 ,  G01N33/566

    CPC分类号： C07K14/4747 ,  A01K2217/05 ,  A61K38/00 ,  A61K2039/505 ,  C07K2319/00

    摘要： The present invention provides NB-ARC and CARD-containing proteins (NACs), nucleic acid molecules encoding NACs and antibodies specific for at least one NAC. The invention further provides chimeric NAC proteins. The invention also provides screening assays for identifying an agent that can effectively alter the association of a NAC with a NAC-associated protein. The invention further provides methods of modulating apoptosis in a cell by introducing into the cell a nucleic acid molecule encoding a NAC or an antisense nucleotide sequence. The invention also provides a method of using a reagent that can specifically bind to a NAC to diagnose a pathology that is characterized by an increased or decreased level of apoptosis in a cell.

    摘要翻译： 本发明提供NB-ARC和含CARD蛋白（NAC），编码NAC的核酸分子和对至少一种NAC特异的抗体。 本发明还提供了嵌合NAC蛋白。 本发明还提供用于鉴定可有效改变NAC与NAC相关蛋白的缔合的试剂的筛选试验。 本发明还提供了通过将编码NAC或反义核苷酸序列的核酸分子引入细胞来调节细胞凋亡的方法。 本发明还提供了使用可以特异性结合NAC的试剂来诊断细胞凋亡水平升高或降低的病理学的方法。

    Card proteins involved in cell death regulation
    13.
    发明授权
    Card proteins involved in cell death regulation 失效
    卡蛋白参与细胞死亡调节

    公开(公告)号：US07994282B2

    公开(公告)日：2011-08-09

    申请号：US11874139

    申请日：2007-10-17

    申请人： John C. Reed

    发明人： John C. Reed

    IPC分类号： C07K5/00

    CPC分类号： C07K14/4747 ,  A01K2217/05 ,  A61K38/00 ,  A61K2039/505 ,  C07K2319/00

    摘要： The present invention provides NB-ARC and CARD-containing proteins (NACs), nucleic acid molecules encoding NACs and antibodies specific for at least one NAC. The invention further provides chimeric NAC proteins. The invention also provides screening assays for identifying an agent that can effectively alter the association of a NAC with a NAC-associated protein. The invention further provides methods of modulating apoptosis in a cell by introducing into the cell a nucleic acid molecule encoding a NAC or an antisense nucleotide sequence. The invention also provides a method of using a reagent that can specifically bind to a NAC to diagnose a pathology that is characterized by an increased or decreased level of apoptosis in a cell.

    摘要翻译： 本发明提供NB-ARC和含CARD蛋白（NAC），编码NAC的核酸分子和对至少一种NAC特异的抗体。 本发明还提供了嵌合NAC蛋白。 本发明还提供用于鉴定可有效改变NAC与NAC相关蛋白的缔合的试剂的筛选试验。 本发明还提供了通过将编码NAC或反义核苷酸序列的核酸分子引入细胞来调节细胞凋亡的方法。 本发明还提供了使用可以特异性结合NAC的试剂来诊断细胞凋亡水平升高或降低的病理学的方法。

    Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto
    14.
    发明授权
    Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto 失效
    涉及蛋白质降解的核酸编码蛋白质，与其有关的产品和方法

    公开(公告)号：US07927832B2

    公开(公告)日：2011-04-19

    申请号：US12132565

    申请日：2008-06-03

    申请人： John C. Reed ,  Matsuzawa Shu-ichi

    发明人： John C. Reed ,  Matsuzawa Shu-ichi

    IPC分类号： C12P21/06 ,  C07H17/00 ,  C07K14/00

    CPC分类号： C07K14/47 ,  C07K14/00 ,  Y10T436/143333

    摘要： In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein.

    摘要翻译： 根据本发明，提供了新型的Siah介导的降解蛋白（SMDP）和/或SCF-复合蛋白（SCP）。 还公开了编码这种蛋白质的核酸序列和使用其的测定法。 本发明SMDP和/或SCP可以以各种方式使用，例如用于在治疗组合物中生产抗SMDP和/或SCP抗体，以及使用这种蛋白质和/或抗体用于药物筛选的方法， 功能基因组学等应用。 还提供了表达本发明蛋白质的转基因非人哺乳动物。

    CARD-DOMAIN CONTAINING POLYPEPTIDES, ENCODING NUCLEIC ACIDS, AND METHODS OF USE
    15.
    发明申请
    CARD-DOMAIN CONTAINING POLYPEPTIDES, ENCODING NUCLEIC ACIDS, AND METHODS OF USE 审中-公开
    含有多核苷酸的多核苷酸，编码核酸的方法和使用方法

    公开(公告)号：US20110071213A1

    公开(公告)日：2011-03-24

    申请号：US12917295

    申请日：2010-11-01

    申请人： Krzysztof Pawlowski ,  John C. Reed ,  Adam Godzik

    发明人： Krzysztof Pawlowski ,  John C. Reed ,  Adam Godzik

    IPC分类号： A61K31/7088 ,  C07H21/04 ,  C07H21/02 ,  C07K14/00 ,  C07K16/00 ,  C12N15/63 ,  C12N5/10 ,  C12P21/06 ,  C12N5/07 ,  G01N33/566 ,  C12N5/02

    CPC分类号： C07K14/4702 ,  A01K2217/05 ,  A01K2227/105 ,  A61K38/00

    摘要： The invention provides caspase recruitment domain (CARD)-containing polypeptides and functional fragments thereof, encoding nucleic acid molecules, and specific antibodies. Also provided are screening methods for identifying CARD-associated polypeptides (CAPs), and for identifying agents that alter the association of a CARD-containing polypeptide with itself or with a CAP. Further provided are methods of altering a biochemical process modulated by a CARD-containing polypeptide, and methods of diagnosing a pathology characterized by an increased or decreased level of a CARD-containing polypeptide.

    摘要翻译： 本发明提供了含有胱天蛋白酶募集区（CARD）的多肽及其功能片段，编码核酸分子和特异性抗体。 还提供了用于鉴定CARD相关多肽（CAP）的筛选方法，以及用于鉴定改变含CARD的多肽与其自身或与CAP的缔合的试剂。 还提供了改变由含CARD的多肽调节的生物化学过程的方法，以及诊断特征在于含CARD的多肽的水平升高或降低的病理学的方法。

    Methods of using BCL-2 for the therapeutic treatment and prevention of diseases
    16.
    发明授权
    Methods of using BCL-2 for the therapeutic treatment and prevention of diseases 有权
    使用BCL-2治疗和预防疾病的方法

    公开(公告)号：US07910370B2

    公开(公告)日：2011-03-22

    申请号：US11869634

    申请日：2007-10-09

    申请人： John C. Reed

    发明人： John C. Reed

    IPC分类号： C12N15/63 ,  C12N5/10 ,  A61K48/00

    CPC分类号： A01K67/0275 ,  A01K67/0271 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/025 ,  A01K2267/03 ,  A01K2267/0318 ,  A61K35/39 ,  A61K38/00 ,  C07K14/82 ,  C07K16/00 ,  C12N15/8509 ,  C12N2840/20 ,  C12N2840/203

    摘要： The invention provides a method of treating a disease or pathological condition resulting in apoptotic cell death. The method includes increasing the activity of Bcl-2 in cells affected by the disease or pathological condition. Diseases or pathological conditions can include, for example, neurodegenerative diseases, cancer and viral infections. Also provided is a method of prolonging the in vivo survival of transplanted cells for the treatment of a disease or pathological condition. The method includes increasing the activity of Bcl-2 in a population of cells and transplanting the population of cells having increased Bcl-2 activity into a subject. Diseases or pathological conditions can include, for example, neurodegenerative diseases, cancer and viral infections. A method to enhance the sensitivity of malignant cells to therapy is provided that includes decreasing the activity of Bcl-2 in the malignant cells. Methods to identify compounds that alter apoptotic cell death and to enhance monoclonal antibody production are also provided by the invention disclosed herein.

    摘要翻译： 本发明提供了治疗导致凋亡性细胞死亡的疾病或病理状况的方法。 该方法包括增加Bcl-2在受疾病或病理状况影响的细胞中的活性。 疾病或病理状况可包括例如神经变性疾病，癌症和病毒感染。 还提供了延长移植细胞的体内存活以治疗疾病或病理状况的方法。 该方法包括增加细胞群中Bcl-2的活性，并将具有增加的Bcl-2活性的细胞群体移植到受试者中。 疾病或病理状况可包括例如神经变性疾病，癌症和病毒感染。 提供了增强恶性细胞对治疗的敏感性的方法，其包括降低恶性细胞中Bcl-2的活性。 鉴定化合物的方法来鉴定改变凋亡细胞死亡和增强单克隆抗体产生的化合物也由本文公开的本发明提供。

    Use of Hepatitis B X-Interacting Protein (HBXIP) in Modulation of Apoptosis
    17.
    发明申请
    Use of Hepatitis B X-Interacting Protein (HBXIP) in Modulation of Apoptosis 审中-公开
    乙型肝炎X相互作用蛋白（HBXIP）在细胞凋亡调控中的应用

    公开(公告)号：US20100190195A1

    公开(公告)日：2010-07-29

    申请号：US12698918

    申请日：2010-02-02

    申请人： Ingo Tamm ,  John C. Reed

    发明人： Ingo Tamm ,  John C. Reed

    IPC分类号： C12Q1/37

    CPC分类号： A61K38/1709 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/73 ,  G01N2333/70503 ,  G01N2333/96466

    摘要： Novel methods of regulating cellular apoptosis by affecting the interaction of hepatitis B X-interacting protein (HBXIP) with Survivin are described. More specifically, these novel methods of enhancing apoptosis of neoplastic cells comprises inhibiting interaction of hepatitis B X-interacting protein (HBXIP) with Survivin using siRNA or antisense compounds.

    摘要翻译： 描述了通过影响乙型肝炎X相互作用蛋白（HBXIP）与存活蛋白相互作用来调节细胞凋亡的新方法。 更具体地，这些增强肿瘤细胞凋亡的新方法包括使用siRNA或反义化合物抑制乙型肝炎X相互作用蛋白（HBXIP）与存活蛋白的相互作用。

    NOVEL CARD PROTEINS INVOLVED IN CELL DEATH REGULATION
    18.
    发明申请
    NOVEL CARD PROTEINS INVOLVED IN CELL DEATH REGULATION 失效
    参与细胞死亡调控的新型卡片蛋白质

    公开(公告)号：US20100189720A1

    公开(公告)日：2010-07-29

    申请号：US11874139

    申请日：2007-10-17

    申请人： John C. Reed

    发明人： John C. Reed

    IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K14/435 ,  A61P29/00 ,  C12N5/07 ,  G01N33/53

    CPC分类号： C07K14/4747 ,  A01K2217/05 ,  A61K38/00 ,  A61K2039/505 ,  C07K2319/00

    摘要： The present invention provides NB-ARC and CARD-containing proteins (NACs), nucleic acid molecules encoding NACs and antibodies specific for at least one NAC. The invention further provides chimeric NAC proteins. The invention also provides screening assays for identifying an agent that can effectively alter the association of a NAC with a NAC-associated protein. The invention further provides methods of modulating apoptosis in a cell by introducing into the cell a nucleic acid molecule encoding a NAC or an antisense nucleotide sequence. The invention also provides a method of using a reagent that can specifically bind to a NAC to diagnose a pathology that is characterized by an increased or decreased level of apoptosis in a cell.

    摘要翻译： 本发明提供NB-ARC和含CARD蛋白（NAC），编码NAC的核酸分子和对至少一种NAC特异的抗体。 本发明还提供了嵌合NAC蛋白。 本发明还提供用于鉴定可有效改变NAC与NAC相关蛋白的缔合的试剂的筛选试验。 本发明还提供了通过将编码NAC或反义核苷酸序列的核酸分子引入细胞来调节细胞凋亡的方法。 本发明还提供了使用可以特异性结合NAC的试剂来诊断细胞凋亡水平升高或降低的病理学的方法。

    PAAD domain-containing polypeptides, encoding nucleic acids, and methods of use
    19.
    发明授权
    PAAD domain-containing polypeptides, encoding nucleic acids, and methods of use 失效
    含PAAD结构域的多肽，编码核酸和使用方法

    公开(公告)号：US07671183B2

    公开(公告)日：2010-03-02

    申请号：US11496017

    申请日：2006-07-27

    申请人： John C. Reed ,  Adam Godzik

    发明人： John C. Reed ,  Adam Godzik

    IPC分类号： C07H21/02

    CPC分类号： C07H21/04 ,  C07K14/4747 ,  Y10T436/143333

    摘要： The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NACHT domains and ARED domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that alter an association of a PAAD domain-containing polypeptides. Further provided are methods of identifying agents that modulate PAAD domain-mediated inhibition of NFKB activity, or modulate an activity of a NACHT domain of a PAAD domain-containing polypeptide. Also provided are methods of modulating NFKB transcriptional activity in a cell, and methods of altering expression of a PAAD domain-containing polypeptide in a cell.

    摘要翻译： 本发明提供编码含有PAAD结构域的多肽及其功能片段的分离的核酸分子，包括含有PAAD结构域，NACHT结构域和ARED结构域，编码多肽和抗体的片段。 还提供了鉴定与含PAAD结构域的多肽或其片段缔合的多肽和试剂的方法，或改变含PAAD结构域的多肽的缔合。 还提供了鉴定调节PAAD结构域介导的NFκB活性抑制或调节含有PAAD结构域的多肽的NACHT结构域的活性的试剂的方法。 还提供了调节细胞中NFκB转录活性的方法，以及改变细胞中含有PAAD结构域的多肽表达的方法。