公开(公告)号：US08455239B2

公开(公告)日：2013-06-04

申请号：US12820505

申请日：2010-06-22

申请人： Reid M. Renny Feldman ,  Uvini Gunawardena ,  Jun Urano ,  Peter Meinhold ,  Aristos Aristidou ,  Catherine Asleson Dundon ,  Christopher Smith

发明人： Reid M. Renny Feldman ,  Uvini Gunawardena ,  Jun Urano ,  Peter Meinhold ,  Aristos Aristidou ,  Catherine Asleson Dundon ,  Christopher Smith

IPC分类号： C12P7/04 ,  C12P7/16 ,  C12N1/15 ,  C12N1/16 ,  C12N15/00 ,  C12N9/88

CPC分类号： C12P7/16 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1022 ,  C12N9/88 ,  C12N9/90 ,  C12N15/81 ,  C12Y101/01001 ,  C12Y101/01008 ,  C12Y101/01086 ,  C12Y101/05003 ,  C12Y202/01006 ,  C12Y401/01001 ,  C12Y401/01074 ,  C12Y402/01009 ,  Y02E50/10

摘要： The present invention provides recombinant mircoorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

摘要翻译： 本发明提供包含产生异丁醇的代谢途径的重组微生物和使用所述重组微生物产生异丁醇的方法。 在本发明的各个方面，重组微生物可以包含导致丙酮酸脱羧酶和/或甘油-3-磷酸脱氢酶活性降低的修饰。 在本文所述的各种实施方案中，重组微生物可以是酵母进化枝，Crabtree阴性酵母微生物，Crabtree阳性酵母微生物，WGD（全基因组复制）酵母微生物，WGD前（全基因组复制）酵母微生物 ，和非发酵酵母微生物。

公开(公告)号：US08440689B2

公开(公告)日：2013-05-14

申请号：US12972333

申请日：2010-12-17

申请人： Yasuyoshi Arikawa ,  Qing Dong ,  Victoria Feher ,  Benjamin Jones ,  Betty Lam ,  Zhe Nie ,  Christopher Smith ,  Masashi Takahashi

发明人： Yasuyoshi Arikawa ,  Qing Dong ,  Victoria Feher ,  Benjamin Jones ,  Betty Lam ,  Zhe Nie ,  Christopher Smith ,  Masashi Takahashi

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P11/06 ,  A61P19/02 ,  A61P17/06 ,  A61P35/00 ,  C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04 ,  A61K31/437 ,  A61K31/519 ,  A61K31/527 ,  A61K45/06 ,  C07D471/04 ,  C07D487/10 ,  C07D519/00

摘要： Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, L1, L2, R1, R2, R3, and R4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, pharmaceutical compositions containing them, and their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other disorders, diseases, and conditions for which inhibition of SYK is indicated.

公开(公告)号：US20130037038A1

公开(公告)日：2013-02-14

申请号：US13566183

申请日：2012-08-03

申请人： Christopher Smith

发明人： Christopher Smith

IPC分类号： A61C5/14 ,  A42B1/04

CPC分类号： A61H19/30 ,  A41D13/11 ,  A61H2201/1604 ,  A61H2201/165

摘要： The Present invention relates to children who have a problem expressing themselves. Boys tend to bottle things up inside. This invention will help them be more expressive in their daily lives. We make this toy by using mold gel alginate; it is placed over one of our models face. When it starts to gel we apply a second coat over the mouth. We, then remove and create airways. The invention comes in various colors.

摘要翻译： 本发明涉及表达自己的问题的儿童。 男孩往往把东西放在里面。 本发明将有助于他们在日常生活中更具表现力。 我们使用模具凝胶藻酸盐制造这个玩具; 它放在我们的一个模特脸上。 当它开始凝胶时，我们在口上涂上第二层衣服。 我们然后删除并创建航空公司。 本发明具有各种颜色。

公开(公告)号：US20120175962A1

公开(公告)日：2012-07-12

申请号：US13004297

申请日：2011-01-11

申请人： Changjiang Zhan ,  Andrew James Bullock ,  Christopher Smith ,  Allan David Crane

发明人： Changjiang Zhan ,  Andrew James Bullock ,  Christopher Smith ,  Allan David Crane

IPC分类号： H02J1/00

CPC分类号： H02J3/386 ,  H02J1/102 ,  H02M2001/0077 ,  Y02B10/72 ,  Y02E10/763 ,  Y10T307/707

摘要： A power collection and transmission system can be used with a plurality of energy devices such as off-shore wind turbines. The energy devices are grouped into two or more clusters. The system includes a dc collection network for each cluster. A primary DC/DC converter is located at each energy device and is connected to the dc collection network. First and second dc transmission lines are used to transmit any power generated by the energy devices to an on-shore converter station. A secondary DC/DC converter assembly is connected between the dc collection networks and the first and second dc transmission lines.

摘要翻译： 集电和传输系统可以与诸如离岸风力涡轮机的多个能量装置一起使用。 能量装置分为两个或更多个簇。 该系统包括每个集群的直流收集网络。 主要的DC / DC转换器位于每个能量装置上，并连接到直流采集网络。 第一和第二直流传输线用于将由能量设备产生的任何电力传送到岸上转换站。 二次DC / DC转换器组件连接在直流收集网络和第一和第二直流输电线路之间。

公开(公告)号：US08200713B2

公开(公告)日：2012-06-12

申请号：US12038859

申请日：2008-02-28

申请人： Michael Cacenco ,  Christopher Smith ,  Kenneth Wallis

发明人： Michael Cacenco ,  Christopher Smith ,  Kenneth Wallis

IPC分类号： G06F17/30 ,  G06F9/44

CPC分类号： G06F8/20

摘要： A method is disclosed for facilitating development of an application having access to a database data-source. The method comprises the following steps. At least one subroutine that is a candidate for potentially including hidden information is identified. A definition document for the subroutine is generated using information available from its available schema metadata. The subroutine is executed via the database data-source. A result set of the executed subroutine is analysed for exposing any hidden information. The analysis is used to supplement the definition document with additional schema information to describe a structure of the exposed information. The definition document can then be used in developing the application. A development tool and computer readable medium configured to implement the method are also disclosed.

摘要翻译： 公开了一种方便开发具有访问数据库数据源的应用的方法。 该方法包括以下步骤。 确定作为潜在地包含隐藏信息的候选者的至少一个子程序。 使用可用的模式元数据可用的信息生成子例程的定义文档。 子程序通过数据库数据源执行。 分析执行的子程序的结果集，以暴露任何隐藏的信息。 该分析用于用定义文件补充额外的模式信息来描述暴露信息的结构。 然后可以将定义文档用于开发应用程序。 还公开了一种被配置为实现该方法的开发工具和计算机可读介质。

公开(公告)号：US20120045809A1

公开(公告)日：2012-02-23

申请号：US13141648

申请日：2009-12-23

申请人： Thomas Buelter ,  Peter Meinhold ,  Christopher Smith ,  Aristos Aristidou ,  Catherine Asleson Dundon ,  Jun Urano

发明人： Thomas Buelter ,  Peter Meinhold ,  Christopher Smith ,  Aristos Aristidou ,  Catherine Asleson Dundon ,  Jun Urano

IPC分类号： C12P7/16 ,  C12N1/19

CPC分类号： C12P7/16 ,  C12N15/52 ,  C12N15/81 ,  Y02E50/10

摘要： The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms comprise isobutanol producing metabolic pathway with one or more isobutanol pathway enzymes localized in the mitochondria. In various embodiments described herein, the recombinant microorganisms may be Crabtree-negative yeast microorganisms, microorganisms of the Saccharomyces clade, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

摘要翻译： 本发明提供包含产生异丁醇的代谢途径的重组微生物和使用所述重组微生物产生异丁醇的方法。 在本发明的各个方面，重组微生物包含产生异丁醇的代谢途径与一种或多种位于线粒体中的异丁醇途径酶。 在本文所述的各种实施方案中，重组微生物可以是Crabtree阴性酵母微生物，酵母进化枝的微生物，Crabtree阳性酵母微生物，WGD（全基因组复制）酵母微生物，WGD前（全基因组复制）酵母微生物 ，和非发酵酵母微生物。

公开(公告)号：US20110318799A1

公开(公告)日：2011-12-29

申请号：US13229438

申请日：2011-09-09

申请人： Reid M. Renny Feldman ,  Uvini Gunawardena ,  Jun Urano ,  Peter Meinhold ,  Aristos A. Aristidou ,  Catherine Asleson Dundon ,  Christopher Smith

发明人： Reid M. Renny Feldman ,  Uvini Gunawardena ,  Jun Urano ,  Peter Meinhold ,  Aristos A. Aristidou ,  Catherine Asleson Dundon ,  Christopher Smith

IPC分类号： C12P7/16

CPC分类号： C12N9/88 ,  C12P7/16 ,  C12Y401/01001 ,  Y02E50/10

摘要： There is disclosed a method of producing isobutanol. In an embodiment, the method includes providing a microorganism transformed with an isobutanol producing pathway containing at least one exogenous gene. The microorganism is selected to produce isobutanol from a carbon source at a yield of at least 10 percent theoretical. The method includes cultivating the microorganism in a culture medium containing a feedstock providing the carbon source, until isobutanol is produced. The method includes recovering the isobutanol. In one embodiment, the microorganism is a yeast with a Crabtree-negative phenotype. In another embodiment, the microorganism is a yeast microorganism with a Crabtree-positive phenotype. There is disclosed a microorganism for producing isobutanol. In an embodiment, the microorganism includes an isobutanol producing pathway containing at least one exogenous gene, and is selected to produce a recoverable quantity of isobutanol from a carbon source at a yield of at least 10 percent theoretical.

摘要翻译： 公开了异丁醇的制造方法。 在一个实施方案中，该方法包括提供转化了含有至少一种外源基因的产生异丁醇的途径的微生物。 选择微生物以产生至少10％的理论值从碳源产生异丁醇。 该方法包括在含有提供碳源的原料的培养基中培养微生物，直到产生异丁醇。 该方法包括回收异丁醇。 在一个实施方案中，微生物是具有Crabtree-阴性表型的酵母。 在另一个实施方案中，微生物是具有Crabtree阳性表型的酵母微生物。 公开了用于生产异丁醇的微生物。 在一个实施方案中，微生物包括含有至少一种外源基因的异丁醇生产途径，并且选择其以至少10％理论值的产率从碳源产生可回收量的异丁醇。

公开(公告)号：US08024452B2

公开(公告)日：2011-09-20

申请号：US11415288

申请日：2006-05-02

申请人： Michael Shenfield ,  Christopher Smith

发明人： Michael Shenfield ,  Christopher Smith

IPC分类号： G06F15/173 ,  G06F15/16

CPC分类号： G06F17/30864 ,  H04L67/04 ,  H04L67/26 ,  H04L67/28 ,  H04L67/2847 ,  H04L67/2876 ,  H04L67/32 ,  H04L67/325 ,  H04W8/18

摘要： A dynamic syndicated content delivery system and method, the system having: a push proxy, the push proxy having: a deferred retrieval message store, the deferred retrieval message store adapted to storing deferred content for future delivery; a push agent, the push agent adapted to push content; and a push scheduler, the push schedule adapted to communicate with the push agent to schedule the pushing of content and further adapted to monitor a wireless network for network conditions; a push client, the push client having: a client push agent, the client push agent adapted to communicate with the push agent of the push proxy; a content pull broker, the content pull broker adapted to communicate with the deferred retrieval message store of the push proxy; a deferred retrieval manager, the deferred retrieval manager adapted to communicate with the content pull broker and the client push agent to pull content, the deferred retrieval manager further adapted to monitor a network and instruct the content pull broker to pull the content if the network conditions are favorable for receiving the deferred content; and a network status monitor adapted to monitor the status of the network; and the wireless network.

摘要翻译： 一种动态联合内容递送系统和方法，所述系统具有：推送代理，所述推送代理具有：延迟检索消息存储器，所述延迟检索消息存储器适于存储用于将来传送的延迟内容; 推动剂，推动剂适于推动内容物; 以及推送调度器，所述推送计划适于与所述推送代理进行通信以调度所述内容的推送，并且还适于监视无线网络以用于网络状况; 推送客户端，所述推送客户端具有：客户端推送代理，所述客户端推送代理适于与所述推送代理的推送代理进行通信; 内容提取代理，内容提取代理适于与推送代理的延迟检索消息存储进行通信; 延迟检索管理器，延迟检索管理器，适于与内容提取代理和客户端推送代理进行通信以提取内容，延迟检索管理器还适用于监视网络，并指示内容提取代理拉取内容，如果网络条件 有利于接收递延内容; 以及适于监视网络状态的网络状态监视器; 和无线网络。

公开(公告)号：US20110183392A1

公开(公告)日：2011-07-28

申请号：US12696645

申请日：2010-01-29

申请人： Reid M. Renny Feldman ,  Uvini Gunawardena ,  Jun Urano ,  Peter Meinhold ,  Aristos Aristidou ,  Catherine Asleson Dundon ,  Christopher Smith

发明人： Reid M. Renny Feldman ,  Uvini Gunawardena ,  Jun Urano ,  Peter Meinhold ,  Aristos Aristidou ,  Catherine Asleson Dundon ,  Christopher Smith

IPC分类号： C12P7/16 ,  C12N1/19

CPC分类号： C12N9/88 ,  C12P7/16 ,  C12Y401/01001 ,  Y02E50/10

摘要： There is disclosed a method of producing isobutanol. In an embodiment, the method includes providing a microorganism transformed with an isobutanol producing pathway containing at least one exogenous gene. The microorganism is selected to produce isobutanol from a carbon source at a yield of at least 10 percent theoretical. The method includes cultivating the microorganism in a culture medium containing a feedstock providing the carbon source, until isobutanol is produced. The method includes recovering the isobutanol. In one embodiment, the microorganism is a yeast with a Crabtree-negative phenotype. In another embodiment, the microorganism is a yeast microorganism with a Crabtree-positive phenotype. There is disclosed a microorganism for producing isobutanol. In an embodiment, the microorganism includes an isobutanol producing pathway containing at least one exogenous gene, and is selected to produce a recoverable quantity of isobutanol from a carbon source at a yield of at least 10 percent theoretical.

公开(公告)号：US20110058519A1

公开(公告)日：2011-03-10

申请号：US12946712

申请日：2010-11-15

申请人： Arun Munje ,  Christopher Smith

发明人： Arun Munje ,  Christopher Smith

IPC分类号： H04W40/00

CPC分类号： H04L41/0806 ,  H04W8/26 ,  H04W76/11

摘要： A method for provisioning a mobile communications device comprises sending a registration request for registration with a registration server, the registration request including a request for a personal information number; receiving a response from the registration server, the response including the personal information number; sending a provisioning request to a network node, the request including the personal information number and at least one device identifier associated with the mobile communications device; receiving a response from the network node, the response including a URL and a session ID based upon the personal information number and the at least one device identifier associated with the mobile communications device; and launching an application on the mobile communication device to establish a communication session between the mobile communication device and a provisioning system.

摘要翻译： 一种用于配置移动通信设备的方法包括：向注册服务器发送用于注册的注册请求，所述注册请求包括对个人信息号的请求; 从所述注册服务器接收响应，所述响应包括所述个人信息号码; 向所述网络节点发送供应请求，所述请求包括所述个人信息号码和与所述移动通信设备相关联的至少一个设备标识符; 基于所述个人信息号码和与所述移动通信设备相关联的所述至少一个设备标识符，从所述网络节点接收响应，所述响应包括URL和会话ID; 并且在所述移动通信设备上启动应用以在所述移动通信设备和配置系统之间建立通信会话。