公开(公告)号：US06810875B2

公开(公告)日：2004-11-02

申请号：US10283418

申请日：2002-11-18

申请人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Iain Grierson McDerment

发明人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Iain Grierson McDerment

IPC分类号： B65D8306

CPC分类号： A61M15/0065 ,  A61M11/002 ,  A61M15/0021 ,  A61M2202/064 ,  A61M2206/14

摘要： Mouthpieces for particulate inhalers typically have either stationary particle deflectors or rotatable devices for changing the flow of particulate material through the mouthpiece. However, these mouthpieces do not prevent the build up of particulate drug on the walls of the mouthpiece. Thus, there is provided a mouthpiece (10) for use in an inhaler for particulate medicament, the mouthpiece having an inlet (12) and an outlet (13) for particulate medicament, a helical member (15) disposed between the inlet and the outlet for, in use, imparting a rotational movement to an air flow which is drawn through the mouthpiece and in which medicament is entrained, wherein the helical member (15) is, in use, axially movable between a first position and a second position such that it restricts the build up of medicament on the inside of the mouthpiece (10).

公开(公告)号：US08435567B2

公开(公告)日：2013-05-07

申请号：US13269025

申请日：2011-10-07

申请人： John Nicholas Staniforth ,  Haggis Harris ,  David Alexander Vodden Morton ,  Robin Bannister

发明人： John Nicholas Staniforth ,  Haggis Harris ,  David Alexander Vodden Morton ,  Robin Bannister

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/16

CPC分类号： A61K9/5115 ,  A61K9/0075 ,  A61K9/008 ,  A61K9/145 ,  A61K9/1617 ,  A61K9/167 ,  A61K9/50 ,  A61K9/501 ,  A61K9/5015 ,  A61K9/5089 ,  A61K31/137 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32

摘要： The invention provides microparticles for use in a pharmaceutical composition for Pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.

摘要翻译： 本发明提供了用于肺部给药的药物组合物中的微粒，每个微粒包含活性物质的颗粒，其表面上具有适于延迟活性物质溶解的疏水性材料的颗粒。 本发明还提供了制造微粒的方法。

公开(公告)号：US07736670B2

公开(公告)日：2010-06-15

申请号：US10433072

申请日：2001-11-30

申请人： John Nicholas Staniforth ,  Matthew Michael James Green ,  David Alexander Vodden Morton

发明人： John Nicholas Staniforth ,  Matthew Michael James Green ,  David Alexander Vodden Morton

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K47/00 ,  A61K47/06 ,  A61K47/12 ,  A61K47/14 ,  A61K47/42

CPC分类号： A61K9/5115 ,  A61K9/0075 ,  A61K9/008 ,  A61K9/145 ,  A61K9/1617 ,  A61K9/167 ,  A61K9/50 ,  A61K9/501 ,  A61K9/5015 ,  A61K9/5089 ,  A61K31/137 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32

摘要： The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.

摘要翻译： 本发明涉及一种用于制备用于肺部给药的药物组合物的复合活性颗粒的方法，所述方法包括研磨步骤，其中活性物质的颗粒在适于促进的添加剂材料的颗粒存在下研磨 在吸入器致动时复合活性颗粒的分散。 本发明还涉及通过该方法制备的用于吸入的组合物。

公开(公告)号：US08580306B2

公开(公告)日：2013-11-12

申请号：US10433135

申请日：2001-11-30

申请人： John Nicholas Staniforth ,  David Alexander Vodden Morton

发明人： John Nicholas Staniforth ,  David Alexander Vodden Morton

IPC分类号： A61K9/00 ,  A61K9/14

CPC分类号： A61K9/0075 ,  A61K9/14 ,  A61K9/145 ,  A61K9/1617 ,  A61K31/137

摘要： The invention provides a method of making a composition for inhalation which includes the step of mixing particles of additive material having a diameter of not more than 2 μm with active particles, wherein the additive material is suitable for promoting the dispersal of active particles upon aerolization of a dry, powder in a dry powder inhaler.

摘要翻译： 本发明提供一种制备吸入组合物的方法，其包括将具有不大于2μm直径的添加剂材料的颗粒与活性颗粒混合的步骤，其中添加剂材料适于促进活性颗粒在气溶胶化时的分散 干粉，干粉吸入器。

公开(公告)号：US08048451B2

公开(公告)日：2011-11-01

申请号：US10433185

申请日：2001-11-30

申请人： John Nicholas Staniforth ,  Haggis Harris ,  David Alexander Vodden Morton ,  Robin Bannister

发明人： John Nicholas Staniforth ,  Haggis Harris ,  David Alexander Vodden Morton ,  Robin Bannister

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/00

CPC分类号： A61K9/5115 ,  A61K9/0075 ,  A61K9/008 ,  A61K9/145 ,  A61K9/1617 ,  A61K9/167 ,  A61K9/50 ,  A61K9/501 ,  A61K9/5015 ,  A61K9/5089 ,  A61K31/137 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32

摘要： The invention provides microparticles for use in a pharmaceutical composition for pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.

摘要翻译： 本发明提供用于肺部给药的药物组合物中的微粒，每个微粒包含活性物质的颗粒，其表面上具有适于延迟活性物质溶解的疏水性材料的颗粒。 本发明还提供了制造微粒的方法。

公开(公告)号：US20100297030A1

公开(公告)日：2010-11-25

申请号：US12653179

申请日：2009-12-09

申请人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Michael Tobyn ,  Stephen Eason ,  Quentin Harmer ,  David Ganderton

发明人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Michael Tobyn ,  Stephen Eason ,  Quentin Harmer ,  David Ganderton

IPC分类号： A61K9/12 ,  A61K31/473 ,  A61P15/10 ,  A61P15/00

CPC分类号： A61K9/0075 ,  A61K9/14 ,  A61K9/145 ,  A61K31/4745

摘要： A composition, device, and method for treating sexual dysfunction via inhalation is provided which comprises inhaling a dose of apomorphine or pharmaceutically acceptable salt(s) or ester(s) thereof.

摘要翻译： 提供了通过吸入治疗性功能障碍的组合物，装置和方法，其包括吸入阿扑吗啡或其药学上可接受的盐或其酯的剂量。

公开(公告)号：US07744855B2

公开(公告)日：2010-06-29

申请号：US10312488

申请日：2001-06-27

申请人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Rosella Musa

发明人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Rosella Musa

IPC分类号： A61K9/12 ,  A61K9/14 ,  A61K9/72

CPC分类号： A61K9/1688 ,  A61K9/0075 ,  A61K9/145 ,  A61K9/1617 ,  A61K9/1623 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4468 ,  A61K31/4985 ,  A61K31/573 ,  A61K31/58 ,  Y10S514/958

摘要： A method for making composite excipient particles for use in a pharmaceutical composition comprises a milling step in which particles of an excipient material are milled in the presence of an additive material. The product particles are of small size and the milling requires relatively low input of time and energy. The composite particles are suitable for use in inhalable pharmaceutical compositions.

摘要翻译： 用于制备用于药物组合物的复合赋形剂颗粒的方法包括研磨步骤，其中在添加剂材料存在下研磨赋形剂材料的颗粒。 产品颗粒尺寸小，铣削时间和能量输入相对较低。 复合颗粒适用于可吸入药物组合物。

公开(公告)号：US06990974B2

公开(公告)日：2006-01-31

申请号：US10226295

申请日：2002-08-22

申请人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Iain Grierson McDerment

发明人： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Iain Grierson McDerment

IPC分类号： A61M11/00 ,  A61M13/00

CPC分类号： A61M15/0086 ,  A61M11/002 ,  A61M2202/064

摘要： A mouthpiece for use in an inhaler for a particulate medicament, the mouthpiece having: an inlet and an outlet for the particulate medicament; a number of abutments which extend across the mouthpiece and which are arranged in a staggered configuration such that, in use, medicament is caused to break up as the medicament passes through the mouthpiece; wherein the abutments are blades having an elongate cross section in the direction of travel of the medicament.

摘要翻译： 用于用于颗粒药物的吸入器的接口管，所述接口管具有：用于颗粒药物的入口和出口; 许多邻接部分延伸穿过接口管并且以交错构造布置，使得在使用中，药物通过接口管被引起分解; 其中所述基台是在药物行进方向上具有细长横截面的叶片。

公开(公告)号：US08920781B2

公开(公告)日：2014-12-30

申请号：US12748275

申请日：2010-03-26

申请人： John Nicholas Staniforth

发明人： John Nicholas Staniforth

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K31/195 ,  A61P11/00 ,  A61K9/12 ,  A61K31/7012 ,  A61K9/00

CPC分类号： A61K9/0075 ,  A61K9/12 ,  A61K9/145 ,  A61K31/7012 ,  Y10S514/951

摘要： A powder for use in a dry powder inhaler includes active particles and carrier particles for carrying the active particles. The powder further includes additive material on the surfaces of the carrier particles to promote the release of the active particles from the carrier particles on actuation of the inhaler. The powder is such that the active particles are not liable to be released from the carrier particles before actuation of the inhaler. The inclusion of additive material in the powder has been found to give an increased respirable fraction of the active material.

摘要翻译： 用于干粉吸入器的粉末包括用于携带活性颗粒的活性颗粒和载体颗粒。 该粉末还包括在载体颗粒表面上的添加剂材料，以促进吸入器致动时活性颗粒从载体颗粒中的释放。 粉末使得活性颗粒在致动吸入器之前不容易从载体颗粒中释放出来。 发现添加剂在粉末中的包含增加了活性材料的可吸入分数。

公开(公告)号：US08137657B2

公开(公告)日：2012-03-20

申请号：US10439820

申请日：2003-05-16

申请人： John Nicholas Staniforth

发明人： John Nicholas Staniforth

IPC分类号： A61K9/14 ,  A61K9/12 ,  A61K9/00

CPC分类号： A61K9/0075 ,  A61K9/145

摘要： In a method of producing particles suitable for use as carrier particles in dry powder inhalers, particles (1) of a size suitable for use as carrier particles in dry powder inhalers are treated so as to dislodge small grains from the surface of the particles, without substantially changing the size of the particles during the treatment. The treatment gives improved efficiency of redispersion of active particles from the surfaces of carrier particles.

摘要翻译： 在适合用作干粉吸入器中的载体颗粒的颗粒的生产方法中，处理适合用作干粉吸入器中的载体颗粒的尺寸的颗粒（1），从而从颗粒表面移除小颗粒，而没有 在处理期间实质上改变了颗粒的尺寸。 该处理提高了活性颗粒从载体颗粒表面再分散的效率。