利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

41 条记录 (耗时 0.027 秒)

    Methods and Devices for Reducing Tissue Damage After Ischemic Injury
    12.
    发明申请
    Methods and Devices for Reducing Tissue Damage After Ischemic Injury 审中-公开
    缺血性损伤后减少组织损伤的方法和装置

    公开(公告)号：US20070269486A1

    公开(公告)日：2007-11-22

    申请号：US11696360

    申请日：2007-04-04

    申请人： Theodore Parker ,  Thai Nguyen ,  John Shanley ,  Frank Litvack

    发明人： Theodore Parker ,  Thai Nguyen ,  John Shanley ,  Frank Litvack

    IPC分类号： A61F2/06 ,  A61K31/337 ,  A61K31/4353 ,  A61K38/28 ,  A61P9/00

    CPC分类号： A61K31/337 ,  A61F2/91 ,  A61F2250/003 ,  A61F2250/0068 ,  A61K38/28 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/45

    摘要： Methods and devices are provided for the delivery of therapeutic agents which reduce myocardial tissue damage due to ischemia and anti-restenotic agents which inhibit restenosis following a cardiac procedure such as stent implantation. The anti-ischemia agents are delivered to the myocardial tissue over an administration period sufficient to achieve reduction in ischemic or reperfusion injury of the myocardial tissue. The anti-restenotic agents are delivered over an administration period sufficient to reduce the re-narrowing of a blood vessel following a cardiac procedure such as implantation of a device. Preferred anti-restenotic drugs are those that do not reduce the beneficial effects provided by the anti-ischemic drug, such as drugs that do not act on the mammalian target of rapamycin (mTOR).

    摘要翻译： 提供了用于递送治疗剂的方法和装置，其减少由于局部缺血引起的心肌组织损伤和在心脏手术如支架植入之后抑制再狭窄的抗再狭窄剂。 在足以实现心肌组织的缺血或再灌注损伤减少的给药期间将抗缺血剂递送至心肌组织。 抗再狭窄剂在足以减少心脏手术如植入装置后的血管再狭窄的给药期内递送。 优选的抗再狭窄药物是不减少由抗缺血药物提供的有益效果的那些，例如不作用于雷帕霉素哺乳动物靶标（mTOR）的药物。

    Implantable medical device with beneficial agent concentration gradient
    14.
    发明申请
    Implantable medical device with beneficial agent concentration gradient 有权

    公开(公告)号：US20060147489A1

    公开(公告)日：2006-07-06

    申请号：US11369592

    申请日：2006-03-07

    申请人： John Shanley ,  Theodore Parker ,  Kinam Park

    发明人： John Shanley ,  Theodore Parker ,  Kinam Park

    IPC分类号： A61F2/02 ,  A61F2/06

    CPC分类号： A61L31/08 ,  A61L31/041 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/60 ,  A61L2300/604

    摘要： The implantable medical devices are configured to release at least one therapeutic agent from a matrix affixed to the implantable body with a release profile which is programmable to the agent and treatment. The matrix is formed such that the concentration of the therapeutic agent in the matrix varies as a gradient relative to a surface of the implantable body. The change in the concentration gradient of the agent in the matrix directly controls the rate of elution of the agent from the matrix. The therapeutic agent matrix can be disposed in the stent or on surfaces of the stent in various configurations, including within volumes defined by the stent, such as openings, holes, or concave surfaces, as a reservoir of agent, and alternatively as a coating on all or a portion of the surfaces of the stent structure.

    Expandable medical device with openings for delivery of multiple beneficial agents
    15.
    发明申请
    Expandable medical device with openings for delivery of multiple beneficial agents 有权
    具有用于输送多种有益剂的开口的可扩展医疗装置

    公开(公告)号：US20060122697A1

    公开(公告)日：2006-06-08

    申请号：US11079967

    申请日：2005-03-14

    申请人： John Shanley ,  Frank Litvack ,  Theodore Parker ,  Thai Nguyen

    发明人： John Shanley ,  Frank Litvack ,  Theodore Parker ,  Thai Nguyen

    IPC分类号： A61F2/06

    CPC分类号： A61F2/856 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2250/0035 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/602

    摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. A plurality of different beneficial agents can be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different beneficial agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different beneficial agents may also be used to address different diseases, such as restenosis and acute myocardial infarction from the same drug delivery device.

    摘要翻译： 可扩张医疗装置包括多个细长的支柱，形成基本上圆柱形的装置，其可从具有第一直径的圆柱体扩展到具有第二直径的圆柱体。 多个不同的有益剂可以被装载到支柱内的不同的开口中以便递送到组织。 为了治疗诸如再狭窄的病症，将不同的有益药物装入装置的不同开口中以解决与再狭窄有关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。 不同的有益药物也可用于解决来自同一药物递送装置的不同疾病，例如再狭窄和急性心肌梗塞。

    Methods and systems for loading an implantable medical device with beneficial agent
    16.
    发明申请
    Methods and systems for loading an implantable medical device with beneficial agent 审中-公开
    用有益剂装载可植入医疗器械的方法和系统

    公开(公告)号：US20050287287A1

    公开(公告)日：2005-12-29

    申请号：US10876520

    申请日：2004-06-24

    申请人： Theodore Parker ,  John Shanley

    发明人： Theodore Parker ,  John Shanley

    IPC分类号： A61F2/00 ,  A61F2/82 ,  B05D1/00

    CPC分类号： A61F2/82 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0068

    摘要： An implantable medical device loading method is used to deposit layers into a plurality of holes in the implantable device in a stepwise manner to achieve extended and controllable delivery of drugs from the holes in the device. Each layer is deposited in a liquid form and is then solidified. The depositing and solidifying steps are repeated with the same or different solutions to achieve a controlled drug delivery matrix within the holes. To achieve increased uniformity of the initial layers improved wetting characteristics are desired. The selection and control of the surface energies of one or more of the surfaces within the holes and the surface tension of the filling solution allow the system to achieve the desired wetting characteristics.

    摘要翻译： 使用可植入医疗装置的加载方法，以逐步的方式将层沉积在可植入装置中的多个孔中，以实现药物从装置中的孔的延伸和可控输送。 每层以液体形式沉积，然后固化。 用相同或不同的溶液重复沉积和固化步骤以在孔内实现受控的药物递送基质。 为了提高初始层的均匀性，需要改进的润湿特性。 孔内的一个或多个表面的表面能的选择和控制以及填充溶液的表面张力允许系统达到所需的润湿特性。

    IMPLANTABLE MEDICAL DEVICE WITH BENEFICIAL AGENT CONCENTRATION GRADIENT
    18.
    发明申请
    IMPLANTABLE MEDICAL DEVICE WITH BENEFICIAL AGENT CONCENTRATION GRADIENT 审中-公开
    具有有益药剂浓度梯度的可植入医疗器械

    公开(公告)号：US20050010170A1

    公开(公告)日：2005-01-13

    申请号：US10777283

    申请日：2004-02-11

    申请人： John Shanley ,  Theodore Parker ,  Kinama Park

    发明人： John Shanley ,  Theodore Parker ,  Kinama Park

    IPC分类号： A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  A61M31/00 ,  A61M37/00

    CPC分类号： A61L31/06 ,  A61L31/048 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  A61L2300/608 ,  C08L39/06 ,  C08L67/04

    摘要： Abstract of the Disclosure The implantable medical devices are configured to release at least one therapeutic agent from a matrix affixed to the implantable body with a release profile which is programable to the agent and treatment. The matrix is formed such that the concentration of the therapeutic agent in the matrix varies as a gradient relative to a surface of the implantable body. The change in the concentration gradient of the agent in the matrix directly controls the rate of elution of the agent from the matrix. The therapeutic agent matrix can be disposed in the stent or on surfaces of the stent in various configurations, including within volumes defined by the stent, such as openings, holes, or concave surfaces, as a reservoir of agent, and alternatively as a coating on all or a portion of the surfaces of the stent structure.

    摘要翻译： 公开的摘要可植入医疗装置被配置为从固定到可植入物体的基质中释放至少一种治疗剂，释放特征可以对药剂和治疗进行编程。 基质被形成为使得基质中的治疗剂的浓度相对于可植入体的表面的梯度变化。 基质中药剂浓度梯度的变化直接控制药剂从基质中的洗脱速率。 治疗剂基质可以以各种构型设置在支架中或在支架的表面上，包括由支架限定的体积，例如开口，孔或凹面，作为药剂储库，或者作为涂层 支架结构的全部或一部分表面。

    Bifurcation stent with crushable end and method for delivery of a stent to a bifurcation
    19.
    发明申请
    Bifurcation stent with crushable end and method for delivery of a stent to a bifurcation 审中-公开
    具有可压溃端的分叉支架和用于将支架输送到分叉的方法

    公开(公告)号：US20060079956A1

    公开(公告)日：2006-04-13

    申请号：US11200765

    申请日：2005-08-10

    申请人： Neal Eigler ,  Frank Litvack ,  John Shanley ,  Stephen Diaz

    发明人： Neal Eigler ,  Frank Litvack ,  John Shanley ,  Stephen Diaz

    IPC分类号： A61F2/06

    CPC分类号： A61F2/856 ,  A61F2/852 ,  A61F2/91 ,  A61F2/915 ,  A61F2/954 ,  A61F2/958 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2250/0018 ,  A61F2250/0039 ,  A61F2250/0068

    摘要： A bifurcation stent includes a first end which is deformable or crushable at a lower force than a second end. The crushable first end and more rigid second end of the bifurcation stent allow one end of the stent to remain expanded in tissue supporting configuration in a side branch of a vessel bifurcation while the other end is easily crushed against the side wall of the main vessel into which it extends. A method of supporting a bifurcated body lumen with the bifurcation stent involves delivering the bifurcation stent in an unexpanded configuration to a bifurcation in a body lumen, positioning the bifurcation stent with the distal portion substantially within a side branch vessel of the bifurcation and the proximal crushable portion substantially within the main vessel, expanding the bifurcation stent, and expanding a main vessel stent along side the bifurcation stent and thereby crushing at least a portion of the crushable proximal portion of the bifurcation stent against the main vessel wall.

    摘要翻译： 分叉支架包括可在比第二端更低的力下变形或可压碎的第一端。 分叉支架的可破碎的第一端和更刚性的第二端允许支架的一端在血管分叉的侧支中的组织支撑构型中保持膨胀，而另一端容易被压在主血管的侧壁上 它扩展了。 使用分叉支架支撑分叉体腔的方法包括将未扩张构型中的分叉支架递送到体腔中的分叉，将分叉支架与远端部分基本上位于分叉的侧分支血管中并将近端可压溃 部分基本上在主容器内部，扩张分叉支架，并且使主血管支架沿着分叉支架一侧扩张，从而将分叉支架的可压溃近端部分的至少一部分压碎在主血管壁上。