公开(公告)号：US20170210684A1

公开(公告)日：2017-07-27

申请号：US15327738

申请日：2015-07-22

申请人： Joern Ilja Siepmann ,  Peng Bai ,  Michael Tsapatsis ,  Michael W. Deem

发明人： Joern Ilja Siepmann ,  Peng Bai ,  Michael Tsapatsis ,  Michael W. Deem

IPC分类号： C07C5/27 ,  B01J29/74

CPC分类号： C07C5/2775 ,  B01J29/74 ,  B01J29/7446 ,  B01J29/7461 ,  C01B39/00

摘要： A process is provided for the conversion of a hydrocarbon feedstock using catalyst system comprising one or more zeolites. The zeolites have been identified to be capable of selectively catalyzing the hydroisomerization reactions of linear or slightly branched long-chain hydrocarbons. Also provided is a method for the systematic discovery of zeolite framework types that are suitable for such conversion processes, according to a set of criteria: large affinity towards linear alkanes, high adsorption selectivity of linear over branched alkanes, and low adsorption selectivity of linear alkanes of different molecular weights.

公开(公告)号：US06640191B1

公开(公告)日：2003-10-28

申请号：US09474965

申请日：1999-12-30

申请人： Michael W. Deem ,  Marco Falcioni

发明人： Michael W. Deem ,  Marco Falcioni

IPC分类号： G01N3348

CPC分类号： C40B40/18 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00691 ,  B01J2219/007 ,  B01J2219/00745 ,  B01J2219/00747 ,  B82Y30/00 ,  C40B10/00 ,  C40B20/00 ,  C40B30/08 ,  C40B60/14 ,  G01N31/10

摘要： Methods for generating multiple rounds of combinatorial libraries, which use Monte Carlo methods to search the multi-dimensional composition and non-composition space of variables in combinatorial chemistry; the combinatorial libraries generated and screened by such Monte Carlo methods; and an apparatus for generating and screening such libraries robotically. The process involves preparing a first set of samples, then changing the composition and non-composition variables of the samples using Monte Carlo sampling methods, and accepting proposed new samples according to a detailed balance acceptance criterion.

摘要翻译： 用于生成多轮组合库的方法，其使用蒙特卡罗方法来搜索组合化学中变量的多维组成和非组成空间; 组合图书馆通过蒙特卡罗方法生成和筛选; 以及用于机器人生成和筛选这些库的装置。 该过程包括制备第一组样品，然后使用蒙特卡罗取样方法改变样品的组成和非组成变量，并根据详细的平衡接受标准接受提出的新样品。

公开(公告)号：US20120093864A1

公开(公告)日：2012-04-19

申请号：US13335655

申请日：2011-12-22

申请人： Michael W. Deem ,  Jeong-Man Park ,  Hao Zhou

发明人： Michael W. Deem ,  Jeong-Man Park ,  Hao Zhou

IPC分类号： A61K39/02 ,  A61K39/39 ,  A61K39/002 ,  A61P33/02 ,  C12Q1/02 ,  A61P37/04 ,  A61P31/04 ,  A61P33/00 ,  A61K39/00 ,  G01N33/566

CPC分类号： A61K39/00 ,  A61K39/12 ,  A61K2039/54 ,  A61K2039/545 ,  C12N2770/24134 ,  G01N33/6893 ,  G01N2800/26 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/491 ,  Y02A50/53 ,  Y02A50/60

摘要： The present invention relates to therapeutic and prophylactic methods for treating Or preventing an infectious disease in a subject by stimulating or enhancing an immune response against an infectious agent causing the disease. The methods comprise administering to the subject a plurality of compositions, each composition being administered to a different site Of the subject, wherein each site is, or substantially drains to, an anatomically distinct lymph node, a group of lymph nodes, a nonencapsulated cluster of lymphoid tissue, or the spleen. Each composition comprises at least one antigenic molecule having one or more epitopes of the same infectious agent or a strain thereof. The antigenic molecules of each composition comprise in aggregate a set of epitopes distinct from that of any other composition that is administered to the subject.

摘要翻译： 本发明涉及通过刺激或增强针对引起该疾病的感染因素的免疫应答来治疗或预防受试者的感染性疾病的治疗和预防方法。 所述方法包括向受试者施用多种组合物，每种组合物施用于受试者的不同部位，其中每个部位是或基本上排泄到解剖学上不同的淋巴结，一组淋巴结，非包封的 淋巴组织或脾。 每种组合物包含至少一种具有相同感染剂或其应变的一个或多个表位的抗原分子。 每种组合物的抗原性分子包含与施用于受试者的任何其它组合物不同的一组表位。

公开(公告)号：US08110196B2

公开(公告)日：2012-02-07

申请号：US11118917

申请日：2005-04-29

申请人： Michael W. Deem ,  Jeong-Man Park ,  Hao Zhou

发明人： Michael W. Deem ,  Jeong-Man Park ,  Hao Zhou

IPC分类号： A61K39/12 ,  A61K39/295 ,  A61K45/00 ,  A61K47/00

CPC分类号： A61K39/00 ,  A61K39/12 ,  A61K2039/54 ,  A61K2039/545 ,  C12N2770/24134 ,  G01N33/6893 ,  G01N2800/26 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/491 ,  Y02A50/53 ,  Y02A50/60

摘要： The present invention relates to therapeutic and prophylactic methods for treating or preventing an infectious disease in a subject by stimulating or enhancing an immune response against an infectious agent causing the disease. The methods comprise administering to the subject a plurality of compositions, each composition being administered to a different site of the subject, wherein each site is, or substantially drains to, an anatomically distinct lymph node, a group of lymph nodes, a nonencapsulated cluster of lymphoid tissue, or the spleen. Each composition comprises at least one antigenic molecule having one or more epitopes of the same infectious agent or a strain thereof. The antigenic molecules of each composition comprise in aggregate a set of epitopes distinct from that of any other composition that is administered to the subject.

摘要翻译： 本发明涉及通过刺激或增强针对引起该疾病的感染因素的免疫应答来治疗或预防受试者的感染性疾病的治疗和预防方法。 所述方法包括向受试者施用多种组合物，将每种组合物施用于受试者的不同部位，其中每个部位是或基本上排泄到解剖学上不同的淋巴结，一组淋巴结，非包封的 淋巴组织或脾。 每种组合物包含至少一种具有相同感染剂或其应变的一个或多个表位的抗原分子。 每种组合物的抗原性分子包含与施用于受试者的任何其它组合物不同的一组表位。

公开(公告)号：US5938904A

公开(公告)日：1999-08-17

申请号：US623346

申请日：1996-03-27

申请人： Joel S. Bader ,  Jonathan M. Rothberg ,  Michael W. Deem ,  Gregory T. Mulhern ,  Gregory T. Went

发明人： Joel S. Bader ,  Jonathan M. Rothberg ,  Michael W. Deem ,  Gregory T. Mulhern ,  Gregory T. Went

IPC分类号： B01D57/02 ,  G01N27/26 ,  G01N27/447

CPC分类号： B82Y30/00 ,  G01N27/44773

摘要： This invention relates to a method and device for separating charged particles according to their diffusivities in a separation medium by means of a spatially and temporarily varying electric potential. The method is particularly suited to sizing and separating DNA fragments, to generating DNA fragment length polymorphism patterns, and to sequencing DNA through the separation of DNA sequencing reaction products. The method takes advantage of the transport of charged particles subject to an electric potential that is cycled between an off-state (in which the potential is flat) and one or more on-states, in which the potential is preferably spatially periodic with a plurality of eccentrically shaped stationary potential wells. The potential wells are at constant spatial positions in the on-state. Differences in liquid-phase diffusivities lead to charged particle separation. A preferred embodiment of the device is microfabricated. A separation medium fills physically defined separation lanes in the device. Electrodes deposited substantially transverse to the lanes create the required electric potentials. Advantageously, injection ports allow sample loading, and special gating electrodes focus the sample prior to separation. The effects of thermal gradients are minimized by placing the device in contact with a thermal control module, preferably a plurality of Peltier-effect heat transfer devices. The small size of a microfabricated device permits rapid separation in a plurality of separation lanes.

摘要翻译： 本发明涉及一种通过空间和暂时变化的电位根据其在分离介质中的扩散性分离带电粒子的方法和装置。 该方法特别适用于分选DNA片段，产生DNA片段长度多态性模式，并通过分离DNA测序反应产物对DNA进行测序。 该方法利用带电粒子的传输，该带电粒子经历在关闭状态（其中电位为平坦）和一个或多个导通状态之间循环的电位，其中电位优选为空间周期性的多个 偏心固定势阱。 势阱在导通状态下处于恒定的空间位置。 液相扩散性的差异导致带电粒子分离。 装置的优选实施例是微制造的。 分离介质填充设备中物理定义的分离通道。 基本横向于通道沉积的电极产生所需的电位。 有利地，注射端口允许样品加载，并且特殊门电极在分离之前聚焦样品。 通过将设备与热控制模块（优选多个珀耳帖效应传热装置）接触来使热梯度的影响最小化。 微型加工装置的小尺寸允许在多个分离通道中快速分离。

公开(公告)号：US06193866B1

公开(公告)日：2001-02-27

申请号：US09212622

申请日：1998-12-16

申请人： Joel S. Bader ,  Jonathan M. Rothberg ,  Michael W. Deem ,  Gregory T. Mulhern ,  Gregory T. Went ,  John Simpson ,  Steven Henck

发明人： Joel S. Bader ,  Jonathan M. Rothberg ,  Michael W. Deem ,  Gregory T. Mulhern ,  Gregory T. Went ,  John Simpson ,  Steven Henck

IPC分类号： G01N2726

CPC分类号： B82Y30/00 ,  G01N27/44773

摘要： This invention relates to a method and device for separating charged particles according to their diffusivities in a separation medium by means of a spatially and temporally varying electric potential. The method is particularly suited to sizing and separating DNA fragments, to generating DNA fragment length polymorphism patterns, and to sequencing DNA through the separation of DNA sequencing reaction products. The method takes advantage of the transport of charged particles subject to an electric potential that is cycled between an off-state (in which the potential is flat) and one or more on-states, in which the potential is preferably spatially periodic with a plurality of eccentrically shaped stationary potential wells. The potential wells are at constant spatial positions in the on-state. Differences in liquid-phase diffusivities lead to charged particle separation. A preferred embodiment of the device is microfabricated. A separation medium fills physically defined separation lanes in the device. Electrodes deposited substantially transverse to the lanes create the required electric potentials. Advantageously, injection ports allow sample loading, and special gating electrodes focus the sample prior to separation. The effects of thermal gradients are minimized by placing the device in contact with a thermal control module, preferably a plurality of Peltier-effect heat transfer devices. The small size of a microfabricated device permits rapid separation in a plurality of separation lanes.

摘要翻译： 本发明涉及一种通过空间和时间上变化的电势根据其在分离介质中的扩散性分离带电粒子的方法和装置。 该方法特别适用于分选DNA片段，产生DNA片段长度多态性模式，并通过分离DNA测序反应产物对DNA进行测序。 该方法利用带电粒子的传输，该带电粒子经历在关闭状态（其中电位为平坦）和一个或多个导通状态之间循环的电位，其中电位优选为空间周期性的多个 偏心固定势阱。 势阱在导通状态下处于恒定的空间位置。 液相扩散性的差异导致带电粒子分离。 装置的优选实施例是微制造的。 分离介质填充设备中物理定义的分离通道。 基本横向于通道沉积的电极产生所需的电位。 有利地，注射端口允许样品加载，并且特殊门电极在分离之前聚焦样品。 通过将设备与热控制模块（优选多个珀耳帖效应传热装置）接触来使热梯度的影响最小化。 微型加工装置的小尺寸允许在多个分离通道中快速分离。