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公开(公告)号：US20240002417A1
公开(公告)日：2024-01-04
申请号：US17856041
申请日：2022-07-01
发明人： Anna C. IVASHKO , Carter W. ABNEY , Nicole M. HERB , Preeti KAMAKOTI , Aaron W. PETERS , Matthew T. KAPELEWSKI , Marc H. ANTHONIS , Roxana PEREZ VELEZ , Nadya A. HRYCENKO , Doron LEVIN , Tara L. REDDINGTON , Scott J. WEIGEL
CPC分类号： C07F13/005 , C07F3/02 , C01B39/00
摘要： Methods are provided for synthesizing metal organic framework compositions in an aqueous environment and/or in a mixed alcohol/water solvent. The methods can allow for formation of MOF-274 metal organic framework compositions, such as EMM-67 (a mixed metal MOF-274 metal organic framework composition). More generally, the methods can allow for formation of MOF structures that include disalicylate linkers in an aqueous environment and/or in a mixed alcohol/water solvent.
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公开(公告)号：US20180214479A1
公开(公告)日：2018-08-02
申请号：US15878120
申请日：2018-01-23
申请人： ZS PHARMA, INC.
IPC分类号： A61K33/24 , C01B33/20 , A61K45/06 , B01J39/02 , A61K33/00 , A61K9/14 , B01J19/00 , C07F7/02 , C01B39/00 , B01J39/14 , B01J19/18
CPC分类号： A61K33/24 , A61K9/10 , A61K9/14 , A61K9/143 , A61K33/00 , A61K45/06 , A61K2300/00 , B01J19/0013 , B01J19/006 , B01J19/18 , B01J39/02 , B01J39/14 , B01J2219/00063 , B01J2219/00094 , B01J2219/00768 , C01B33/20 , C01B39/00 , C07F7/025
摘要： The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred formulations are designed avoid increase in pH of urine in patients and/or avoid potential entry of particles into the bloodstream of the patient. Also disclosed is a method for preparing high purity crystals of ZS-9 exhibiting an enhanced level of potassium exchange capacity. These compositions are particularly useful in the therapeutic treatment of hyperkalemia.
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公开(公告)号：US09993811B2
公开(公告)日：2018-06-12
申请号：US14438566
申请日：2013-10-25
发明人： Lingping Zhou , Ziyang Liu , Jiexiao Zhang , Mingde Xu , Weilin Zhang , Huiping Tian , Yuxia Zhu
IPC分类号： C01B39/00 , B01J29/08 , B01J29/06 , C01B39/06 , B01J19/24 , C01B39/02 , C01B39/24 , B01J19/00 , B01J19/22 , B01J6/00 , B01J8/00
CPC分类号： B01J29/088 , B01J6/002 , B01J8/002 , B01J8/0055 , B01J19/006 , B01J19/22 , B01J19/2415 , B01J29/06 , B01J2029/081 , B01J2219/0077 , B01J2219/18 , B01J2219/187 , B01J2219/1943 , B01J2219/24 , B01J2229/16 , B01J2229/32 , C01B39/00 , C01B39/026 , C01B39/06 , C01B39/24
摘要： A process for preparing a catalytic cracking catalyst, which process comprises: a molecular sieve is introduced into a gas-phase ultra-stabilization reactor, the molecular sieve is moved without the conveying of carrier gas from a molecular sieve inlet of the gas-phase ultra-stabilization reactor to a molecular sieve outlet of the gas-phase ultra-stabilization reactor, and the molecular sieve is contacted and reacted with a gaseous SiCl4 in the gas-phase ultra-stabilization reactor, the molecular sieve resulting from the contacting and the reacting is optionally washed, then mixed with a matrix and water into slurry, and shaped into particles.
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公开(公告)号：US20180125884A1
公开(公告)日：2018-05-10
申请号：US15807352
申请日：2017-11-08
申请人： ZS PHARMA, INC.
IPC分类号： A61K33/24 , C01B39/00 , B01J39/14 , C01B33/20 , C01B39/46 , C07F7/02 , B01J19/18 , B01J19/00 , B01J39/02 , A61K9/14 , C01B39/02 , A61K45/06 , A61K33/00
CPC分类号： A61K33/24 , A61K9/14 , A61K9/143 , A61K33/00 , A61K45/06 , B01J19/0013 , B01J19/006 , B01J19/0066 , B01J19/18 , B01J39/02 , B01J39/14 , B01J2219/00063 , B01J2219/00094 , B01J2219/00768 , C01B33/20 , C01B39/00 , C01B39/02 , C01B39/46 , C01P2002/72 , C01P2002/82 , C01P2004/52 , C01P2004/61 , C07F7/025 , Y10T428/2982 , A61K2300/00
摘要： The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred formulations are designed avoid increase in pH of urine in patients and/or avoid potential entry of particles into the bloodstream of the patient. Also disclosed is a method for preparing high purity crystals of UZSi-9 exhibiting an enhanced level of potassium exchange capacity. These compositions are particularly useful in the therapeutic treatment of hyperkalemia.
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公开(公告)号：US09943637B2
公开(公告)日：2018-04-17
申请号：US13829415
申请日：2013-03-14
申请人： ZS Pharma, Inc.
CPC分类号： A61M1/3679 , B01J39/02 , B01J39/14 , C01B39/00 , Y10T428/2982
摘要： The present invention relates to novel microporous zirconium silicate compositions having a desired particle size distribution and methods of making those compositions. These compositions have an ideal particle size distribution for use ex vivo, for example in a dialysis exchange cartridge, yet retain many of the desirable properties of prior improved absorbers including high cation exchange capacity. Further, the new zirconium silicate molecular sieve absorbers can be manufactured using a technique that achieves the desired particle size distribution while eliminating the screening step that was previously necessary.
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公开(公告)号：US09896343B2
公开(公告)日：2018-02-20
申请号：US14527657
申请日：2014-10-29
发明人： Changjiu Xia , Bin Zhu , Min Lin , Xinxin Peng , Xingtian Shu , Chunfeng Shi
CPC分类号： C01B39/00 , C01B39/085 , C01P2004/90 , C01P2006/17
摘要： The present invention relates to a titanium silicalite molecular sieve, wherein the crystal grain of the titanium silicalite molecular sieve has a ratio of (surface Si/Ti ratio):(bulk Si/Ti ratio) being larger than 1.1 and less than 5.
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7.发明申请公开(公告)号：US20170081345A1
公开(公告)日：2017-03-23
申请号：US15126395
申请日：2015-03-17
发明人： Omar M. Yaghi , Felipe Gandara , Seungkyu Lee
CPC分类号： C07F5/069 , B01J20/22 , B01J20/226 , C01B3/0015 , C01B39/00 , C10L3/06 , F17C11/007 , F17C2221/033 , F17C2270/0168 , Y02E60/328
摘要： The disclosure provides for metal organic frameworks characterized by having a high number of linking moieties connected to metal clusters and a large number of adsorption sites per unit volume. The disclosure further provides for the use of these frameworks for gas separation, gas storage, catalysis, and drug delivery.
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公开(公告)号：US20170022066A1
公开(公告)日：2017-01-26
申请号：US15215657
申请日：2016-07-21
申请人： Chevron U.S.A. Inc.
发明人： Stacey Ian Zones
IPC分类号： C01B39/04 , C01B39/48 , C01B39/26 , B01J20/18 , B01J39/14 , B01J29/04 , B01J29/70 , B01J29/86 , B01J29/18 , C01B39/00 , B01J20/30
CPC分类号： C01B39/04 , B01J20/18 , B01J20/3057 , B01J29/041 , B01J29/047 , B01J29/18 , B01J29/70 , B01J29/86 , B01J39/14 , C01B37/02 , C01B39/00 , C01B39/12 , C01B39/265 , C01B39/48
摘要： Crystalline molecular sieves and their synthesis using quaternary N-methyl-diisoalkylammonium cations as organic structure directing agents are disclosed. The structure directing agent has the following structure (1): in which R1 is selected from hydrogen, a methyl group, an ethyl group, a propyl group, and a hydroxymethyl group; and R2, R3, R4 and R5 are independently selected from a methyl group, an ethyl group, and a propyl group.
摘要翻译： 其中R1选自氢，甲基，乙基，丙基和羟甲基; R2，R3，R4和R5独立地选自甲基，乙基和丙基。
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9.发明授权Film formed by secondary growth of seed crystals, three crystal axes of which had all been uniformly oriented on substrate 有权通过晶种的二次生长形成的膜，其三个晶轴全部在基底上均匀取向公开(公告)号：US09290859B2
公开(公告)日：2016-03-22
申请号：US13821813
申请日：2011-09-07
IPC分类号： C30B19/12 , C30B7/00 , C30B29/60 , C01B39/00 , B01D67/00 , B01D69/10 , B01D71/02 , C01B37/02 , C01B39/38 , C01B39/40
CPC分类号： C30B19/12 , B01D67/0051 , B01D69/10 , B01D71/028 , B01D2323/24 , C01B37/02 , C01B39/00 , C01B39/38 , C01B39/40 , C30B7/005 , C30B29/60 , Y10T428/24273 , Y10T428/24744
摘要： The present invention provides a method for preparing a thin or thick film, comprising the steps of: (1) arranging non-spherical seed crystals on a substrate such that all the a-, b- and c-axes of each seed crystal are oriented under a predetermined rule; and (2) forming and growing the film from the seed crystals through secondary growth by exposing the arranged seed crystals of step (1) to a seed crystal growth solution. The invention also provides a film prepared by the method. According to the invention, crystals or films larger than the seed crystals can be prepared.
摘要翻译： 本发明提供一种制备薄膜或厚膜的方法，包括以下步骤：（1）将非球形晶种布置在基板上，使得每个晶种的所有a-，b-和c-轴定向 根据预定规则 和（2）通过将步骤（1）中排列的晶种暴露于晶种生长溶液，通过二次生长从晶种形成和生长膜。 本发明还提供了通过该方法制备的膜。 根据本发明，可以制备大于晶种的晶体或膜。
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公开(公告)号：US20150196592A1
公开(公告)日：2015-07-16
申请号：US14659043
申请日：2015-03-31
申请人： ZS Pharma, Inc.
IPC分类号： A61K33/24
CPC分类号： A61K33/24 , A61K9/14 , A61K9/143 , A61K33/00 , A61K45/06 , B01J19/0013 , B01J19/006 , B01J19/0066 , B01J19/18 , B01J39/02 , B01J39/14 , B01J2219/00063 , B01J2219/00094 , B01J2219/00768 , C01B33/20 , C01B39/00 , C01B39/02 , C01B39/46 , C01P2002/72 , C01P2002/82 , C01P2004/52 , C01P2004/61 , C07F7/025 , Y10T428/2982 , A61K2300/00
摘要： The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred formulations are designed avoid increase in pH of urine in patients and/or avoid potential entry of particles into the bloodstream of the patent. Also disclosed is a method for preparing high purity crystals of UZSi-9 exhibiting an enhanced level of potassium exchange capacity. These compositions are particularly useful in the therapeutic treatment of hyperkalemia.
摘要翻译： 本发明涉及配制成去除毒素的新型微孔硅酸锆组合物，例如， 钾离子，来自胃肠道以升高的速率，而不引起不期望的副作用。 设计优选的制剂避免了患者尿液pH值的增加和/或避免了颗粒进入专利血液中的潜力。 还公开了一种制备显示增强的钾交换容量水平的UZSi-9的高纯度晶体的方法。 这些组合物特别可用于治疗高钾血症。
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