公开(公告)号：US06193866B1

公开(公告)日：2001-02-27

申请号：US09212622

申请日：1998-12-16

申请人： Joel S. Bader ,  Jonathan M. Rothberg ,  Michael W. Deem ,  Gregory T. Mulhern ,  Gregory T. Went ,  John Simpson ,  Steven Henck

发明人： Joel S. Bader ,  Jonathan M. Rothberg ,  Michael W. Deem ,  Gregory T. Mulhern ,  Gregory T. Went ,  John Simpson ,  Steven Henck

IPC分类号： G01N2726

CPC分类号： B82Y30/00 ,  G01N27/44773

摘要： This invention relates to a method and device for separating charged particles according to their diffusivities in a separation medium by means of a spatially and temporally varying electric potential. The method is particularly suited to sizing and separating DNA fragments, to generating DNA fragment length polymorphism patterns, and to sequencing DNA through the separation of DNA sequencing reaction products. The method takes advantage of the transport of charged particles subject to an electric potential that is cycled between an off-state (in which the potential is flat) and one or more on-states, in which the potential is preferably spatially periodic with a plurality of eccentrically shaped stationary potential wells. The potential wells are at constant spatial positions in the on-state. Differences in liquid-phase diffusivities lead to charged particle separation. A preferred embodiment of the device is microfabricated. A separation medium fills physically defined separation lanes in the device. Electrodes deposited substantially transverse to the lanes create the required electric potentials. Advantageously, injection ports allow sample loading, and special gating electrodes focus the sample prior to separation. The effects of thermal gradients are minimized by placing the device in contact with a thermal control module, preferably a plurality of Peltier-effect heat transfer devices. The small size of a microfabricated device permits rapid separation in a plurality of separation lanes.

摘要翻译： 本发明涉及一种通过空间和时间上变化的电势根据其在分离介质中的扩散性分离带电粒子的方法和装置。 该方法特别适用于分选DNA片段，产生DNA片段长度多态性模式，并通过分离DNA测序反应产物对DNA进行测序。 该方法利用带电粒子的传输，该带电粒子经历在关闭状态（其中电位为平坦）和一个或多个导通状态之间循环的电位，其中电位优选为空间周期性的多个 偏心固定势阱。 势阱在导通状态下处于恒定的空间位置。 液相扩散性的差异导致带电粒子分离。 装置的优选实施例是微制造的。 分离介质填充设备中物理定义的分离通道。 基本横向于通道沉积的电极产生所需的电位。 有利地，注射端口允许样品加载，并且特殊门电极在分离之前聚焦样品。 通过将设备与热控制模块（优选多个珀耳帖效应传热装置）接触来使热梯度的影响最小化。 微型加工装置的小尺寸允许在多个分离通道中快速分离。

公开(公告)号：US09587274B2

公开(公告)日：2017-03-07

申请号：US13608841

申请日：2012-09-10

申请人： Yi-Ju Chen ,  Keith McDade ,  John Simpson

发明人： Yi-Ju Chen ,  Keith McDade ,  John Simpson

IPC分类号： G06F19/20 ,  G06F15/00 ,  C12Q1/68 ,  G06F19/24 ,  G06F19/22

CPC分类号： C12Q1/6848 ,  C12Q1/6869 ,  G06F19/22 ,  G06F19/24 ,  C12Q2537/165

摘要： An embodiment of method for correcting an error associated with phasic synchrony of sequence data generated from a population of substantially identical copies of a template molecule is described that comprises (a) detecting a signal generated in response to an incorporation of one or more nucleotides in a sequencing reaction; (b) generating a value for the signal; and (c) correcting the value for the phasic synchrony error using a first parameter and a second carry forward parameter.

摘要翻译： 描述了用于校正与从模板分子的基本相同拷贝的群体产生的序列数据的相位同步相关联的错误的方法的实施方案，其包括（a）检测响应于在一个或多个核苷酸中的一个或多个核苷酸的引入而产生的信号 测序反应; （b）产生该信号的值; 和（c）使用第一参数和第二进位参数来校正所述相位同步误差的值。

公开(公告)号：US20120209112A2

公开(公告)日：2012-08-16

申请号：US13277167

申请日：2011-10-19

申请人： Himanshu Patel ,  John Simpson

发明人： Himanshu Patel ,  John Simpson

IPC分类号： A61B17/34 ,  A61B18/00 ,  A61B18/18 ,  A61M25/09 ,  A61B6/00

CPC分类号： A61B17/32002 ,  A61B17/22012 ,  A61B17/32075 ,  A61B17/320758 ,  A61B18/1492 ,  A61B18/24 ,  A61B2017/00336 ,  A61B2017/00398 ,  A61B2017/22094

摘要： A rotating cutting head catheter for passage through chronic total occlusions or other refractory atherosclerotic plaque from diseased arteries is disclosed. The catheter's rotating cutting head is designed to reside safely within an outer protective sheath when not in use. The outer protective sheath contains one or more helical grooves or slots, and the cutting head contains protruding blades or projections that fit into these helical grooves or slots. Application of torque to an inner catheter or wire attached to the cutting head applies spin to the cutting head, and the force of the sheath's helical grooves or slots against the cutting head's protruding blades or projections advances the cutting head outward from the protective sheath. Once extended, the cutting head may now rotate freely. The device may use a guidewire to direct the cutting head to the desired position.

公开(公告)号：US20070151650A1

公开(公告)日：2007-07-05

申请号：US11679701

申请日：2007-02-27

申请人： John Simpson ,  Jessie Delgado ,  Robert Alcantara ,  Jason Phillips

发明人： John Simpson ,  Jessie Delgado ,  Robert Alcantara ,  Jason Phillips

IPC分类号： B31B1/60

CPC分类号： A61M25/104 ,  A61M25/0023 ,  A61M25/0029 ,  A61M25/0045 ,  A61M25/005 ,  A61M2025/0034 ,  A61M2025/0039 ,  A61M2025/0183 ,  Y10T156/1026

摘要： A balloon catheter including an elongated shaft having an inflation lumen, a guidewire lumen, a proximal shaft section, and a distal shaft section with a balloon on the distal shaft section, the distal shaft section formed by an outer tubular member having an opening in a sidewall, and an inner tubular member having a distal portion in the outer tubular member and a proximal portion extending through the sidewall opening and along an outer surface of a portion of the outer tubular member located proximal to the sidewall opening, with polymeric filler material around the outer surface of at least the proximal portion of the inner tubular member. The inner tubular member preferably comprises a polymeric tube having a reinforcing coiled member embedded therein. Preferably, a crescent shaped portion of the inflation lumen extends along side the proximal portion of the inner tubular member.

摘要翻译： 一种气囊导管，其包括具有充气腔的细长轴，导丝管腔，近端轴部分和在所述远端轴部分上具有气囊的远侧轴部分，所述远端轴部分由外管状部件形成，所述远端轴部件具有在 侧壁和内管状构件，其在外管状构件中具有远端部分，以及近端部分，其延伸穿过侧壁开口并且沿着位于侧壁开口附近的外管状构件的一部分的外表面，聚合物填充材料围绕 至少内管状构件的近端部分的外表面。 内部管状构件优选地包括具有嵌入其中的加强盘绕构件的聚合物管。 优选地，充气腔的新月形部分沿着内管状构件的近端部分的侧面延伸。

公开(公告)号：US20060135982A1

公开(公告)日：2006-06-22

申请号：US11022494

申请日：2004-12-21

申请人： John Simpson

发明人： John Simpson

IPC分类号： A61M29/00

CPC分类号： A61M25/10 ,  A61M2025/1093 ,  Y10T156/10 ,  Y10T156/1005

摘要： The end cap is preferably formed of a relatively high durometer material with an inner surface on an outer surface of the shaft and on an outer surface of the balloon skirt section, and contacts a compression member on the balloon outer surface. The configuration prevents or inhibits failure at the balloon seals which otherwise results from the compression member moving or the balloon pulling off the shaft and out from under the compression member during inflation of the balloon. As a result, the balloon catheter of the invention has an improved consistent burst pressure and/or failure mode.

摘要翻译： 端帽优选地由相对高的硬度材料形成，其具有在轴的外表面上的内表面和球囊裙部的外表面上，并且与球囊外表面上的压缩构件接触。 该构造防止或抑制球囊密封件处的失效，否则气囊膨胀期间由压缩构件移动或气囊从轴承下拉并从压缩构件下方引起。 结果，本发明的气囊导管具有改进的一致的爆裂压力和/或失效模式。

公开(公告)号：US20060024508A1

公开(公告)日：2006-02-02

申请号：US10900249

申请日：2004-07-27

申请人： Brian D'Urso ,  John Simpson

发明人： Brian D'Urso ,  John Simpson

IPC分类号： B32B17/06 ,  B32B3/00

CPC分类号： C03C17/30 ,  B05D5/083 ,  B05D2350/35 ,  B08B17/06 ,  B08B17/065 ,  B82Y30/00 ,  C03C11/005 ,  C03C15/00 ,  C03C2217/77 ,  C23F1/02 ,  F01D5/286 ,  F01D5/288 ,  F05D2230/90 ,  F05D2300/512 ,  Y02T50/672 ,  Y10T428/24364 ,  Y10T428/2438 ,  Y10T428/24479 ,  Y10T428/249955 ,  Y10T428/24996 ,  Y10T428/25 ,  Y10T428/315

摘要： A hydrophobic disordered composite material having a protrusive surface feature includes a recessive phase and a protrusive phase, the recessive phase having a higher susceptibility to a preselected etchant than the protrusive phase, the composite material having an etched surface wherein the protrusive phase protrudes from the surface to form a protrusive surface feature, the protrusive feature being hydrophobic.

摘要翻译： 具有突出表面特征的疏水性无序复合材料包括隐性相和突出相，所述隐性相对于预选蚀刻剂比突出相具有更高的敏感性，所述复合材料具有蚀刻表面，其中所述突出相从所述表面突出 以形成突出表面特征，突出特征是疏水性的。

公开(公告)号：US20060024478A1

公开(公告)日：2006-02-02

申请号：US10900248

申请日：2004-07-27

申请人： Brian D'Urso ,  John Simpson

发明人： Brian D'Urso ,  John Simpson

IPC分类号： B32B3/00 ,  C23F1/00

CPC分类号： H01J9/025 ,  B01L3/0244 ,  B01L3/0255 ,  B01L2200/12 ,  B01L2300/0819 ,  B05D5/083 ,  B82Y30/00 ,  C03C4/00 ,  C03C15/00 ,  C03C2204/08 ,  G01N33/54393 ,  H01J1/3044 ,  Y10T428/24149 ,  Y10T428/24479 ,  Y10T428/3154 ,  Y10T428/31678

摘要： A composite material having sharp surface features includes a recessive phase and a protrusive phase, the recessive phase having a higher susceptibility to a preselected etchant than the protrusive phase, the composite material having an etched surface wherein the protrusive phase protrudes from the surface to form a sharp surface feature. The sharp surface features can be coated to make the surface super-hydrophobic.

公开(公告)号：US20050255317A1

公开(公告)日：2005-11-17

申请号：US11148058

申请日：2005-06-07

申请人： Vincent Bavaro ,  John Simpson ,  Peter D'Aquanni ,  Aaron Baldwin ,  Wayne Cornish

发明人： Vincent Bavaro ,  John Simpson ,  Peter D'Aquanni ,  Aaron Baldwin ,  Wayne Cornish

IPC分类号： A61B5/05 ,  A61B5/107 ,  A61B19/00 ,  A61F2/958 ,  A61K49/04 ,  A61L31/18 ,  A61M25/01

CPC分类号： A61L31/18 ,  A61B5/1076 ,  A61B90/39 ,  A61B2562/17 ,  A61F2250/0098 ,  A61K49/0409 ,  A61K49/0419 ,  A61M25/0108 ,  Y10T428/2933

摘要： High radiopacity is achieved in a polymeric marker by combining a polymeric resin, a powdered radiopaque agent having uniformly shaped particles of a specific particle size distribution, and a wetting agent. The method to produce the marker calls for the blending and pelletization of these materials followed by extrusion onto support beading. The resulting supported tubing is subsequently cut to length with the beading still in place. After ejection of the beading remnant the marker is slipped into place on the device to be marked and attached by melt bonding. Marking of a guide wire allows lesions to be measured while the marking of balloon catheters allow the balloon to be properly positioned relative to a lesion.

公开(公告)号：US20050209913A1

公开(公告)日：2005-09-22

申请号：US11128212

申请日：2005-05-13

申请人： William Wied ,  Clifford Isaacson ,  John Thomson ,  Brian Flint ,  Diane Dreher ,  Daniel Murray ,  Rick MacConnell ,  John Simpson

发明人： William Wied ,  Clifford Isaacson ,  John Thomson ,  Brian Flint ,  Diane Dreher ,  Daniel Murray ,  Rick MacConnell ,  John Simpson

IPC分类号： G06Q10/00 ,  G06F17/60

CPC分类号： G06Q10/08 ,  G06Q10/083

摘要： An internet based method of facilitating commerce between shippers and carriers includes the steps of capturing electronic shipment requests for available shipments, the shipment requests including shipment specific criteria and carrier access criteria, and storing the electronic shipment requests in a database. The electronic shipment requests are presented for action to the remote carriers meeting the carrier access criteria. These remote carriers may reply to the shipment requests with fulfillment offers, which are responsive to the presented shipment requests. Carrier fulfillment offers are received and presented to the remote shippers originating the electronic shipment requests. An Internet based system for implementing the method of the present invention is also disclosed.

摘要翻译： 基于互联网的促进托运人和运营商之间的商务的方法包括以下步骤：捕获可用货物的电子装运请求，装运请求，包括装运特定标准和承运人接入标准，以及将电子装运请求存储在数据库中。 电子出货请求被提交给符合运营商接入标准的远程运营商。 这些远程运营商可以回复具有履行报价的装运请求，其响应于所呈现的装运请求。 承运人履行报价被收到并提交给发送电子装运请求的远程货主。 还公开了一种用于实现本发明的方法的基于因特网的系统。

公开(公告)号：US20050070844A1

公开(公告)日：2005-03-31

申请号：US10676616

申请日：2003-09-30

申请人： Mina Chow ,  Barbara Stamberg ,  William Webler ,  John Simpson ,  August Yambao ,  Gabriel Asongwe ,  Jessica Chiu ,  Lili Liu ,  Dagmar Beyerlein

发明人： Mina Chow ,  Barbara Stamberg ,  William Webler ,  John Simpson ,  August Yambao ,  Gabriel Asongwe ,  Jessica Chiu ,  Lili Liu ,  Dagmar Beyerlein

IPC分类号： A61M25/00 ,  A61M25/01 ,  A61M31/00

CPC分类号： A61M25/0136 ,  A61M25/0012 ,  A61M25/0013 ,  A61M25/0029 ,  A61M25/005 ,  A61M25/0051 ,  A61M25/0054 ,  A61M25/0138 ,  A61M25/0147 ,  A61M25/0152 ,  A61M2025/004 ,  A61M2025/0063 ,  A61M2025/0089 ,  A61M2025/009 ,  A61M2025/0096 ,  A61M2025/015

摘要： A deflectable catheter assembly is disclosed. The assembly comprises a catheter shaft having a catheter proximal section and a catheter distal section, and at least one lumen extending therethrough. The catheter distal section is more flexible than the catheter proximal section. A tendon is disposed within a first lumen of said catheter shaft. The first lumen is approximately centrally located within the catheter shaft at the catheter proximal section. The first lumen is located off-center of the catheter shaft at the catheter distal section. The tendon is able to deflect the catheter distal section when being pulled on. A catheter handle is coupled to the catheter shaft at the catheter proximal section, the catheter handle includes a control mechanism to control the tendon.

摘要翻译： 公开了一种可偏转导管组件。 组件包括具有导管近端部分和导管远端部分的导管轴和延伸穿过其中的至少一个内腔。 导管远端部分比导管近端部分更灵活。 腱设置在所述导管轴的第一内腔内。 导管近端部分处的第一管腔大致位于导管轴的中心。 第一管腔位于导管远端部处的导管轴的中心。 当被拉扯时，肌腱能够使导管远端部分偏转。 导管手柄在导管近端部分处联接到导管轴，导管手柄包括用于控制腱的控制机构。