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11.发明申请Synthesis of Phosphono-Substituted Porphyrin Compounds for Attachment to Metal Oxide Surfaces 失效用于附着到金属氧化物表面的膦酰取代的卟啉化合物的合成公开(公告)号：US20070055060A1
公开(公告)日：2007-03-08
申请号：US11553542
申请日：2006-10-27
IPC分类号： C07D487/22 , C07F9/547
CPC分类号： H01L51/0077 , C07F9/6524 , H01G9/2031 , H01L51/4226 , Y02E10/542 , Y02P70/521
摘要： A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.
摘要翻译： 制备膦酰取代的二吡咯甲烷的方法包括使具有至少一个被取代的膦酰基的醛或缩醛与吡咯反应以产生膦酰取代的二吡咯烷; 并且其中膦酰基选自二烷基膦酰基，二芳基膦酰基和二烷基芳基膦酰基。 还描述了其它方法，中间体和产物。
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12.发明申请Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces 失效合成膦酰取代的卟啉化合物用于附着到金属氧化物表面公开(公告)号：US20050096465A1
公开(公告)日：2005-05-05
申请号：US10698255
申请日：2003-10-31
IPC分类号： C07F9/547 , C07F9/6524 , H01G9/20 , H01L51/00 , H01L51/42
CPC分类号： H01L51/0077 , C07F9/6524 , H01G9/2031 , H01L51/4226 , Y02E10/542 , Y02P70/521
摘要： A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.
摘要翻译： 制备膦酰取代的二吡咯甲烷的方法包括使具有至少一个被取代的膦酰基的醛或缩醛与吡咯反应以产生膦酰取代的二吡咯烷; 并且其中膦酰基选自二烷基膦酰基，二芳基膦酰基和二烷基芳基膦酰基。 还描述了其它方法，中间体和产物。
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公开(公告)号：US08653131B2
公开(公告)日：2014-02-18
申请号：US12545406
申请日：2009-08-21
申请人： Guohan Yang , Ton That Hai , Bennett P. Melnick , Paul Sanders , Cong Jiang , Catherine Quinn , Jie Li , Arounaguiry Ambroise , Larry R. Brown
发明人： Guohan Yang , Ton That Hai , Bennett P. Melnick , Paul Sanders , Cong Jiang , Catherine Quinn , Jie Li , Arounaguiry Ambroise , Larry R. Brown
IPC分类号： C07D207/46 , C07C271/08 , C07C69/63 , C07C69/66 , A61K31/27
CPC分类号： A61K47/48215 , A61K31/405 , A61K47/60
摘要： The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
摘要翻译： 本发明涉及聚合物衍生物，其可以与含氨基的药物缀合以改善其体内特性。 随后可以释放聚合物衍生物以产生其天然形式的药物。 描述了制备和使用这些聚合物衍生物和药物偶联物的方法。
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公开(公告)号：US20100048483A1
公开(公告)日：2010-02-25
申请号：US12545406
申请日：2009-08-21
申请人： Guohan Yang , Ton T. Hai , Bennett Melnick , Paul Sanders , Cong Jiang , Catherine Quinn , Jie Li , Arounaguiry Ambroise , Larry R. Brown
发明人： Guohan Yang , Ton T. Hai , Bennett Melnick , Paul Sanders , Cong Jiang , Catherine Quinn , Jie Li , Arounaguiry Ambroise , Larry R. Brown
IPC分类号： A61K38/16 , C07D207/46 , C08F8/00 , C08B37/00 , C07H5/04 , C08B37/08 , C08B37/10 , C08B37/02 , C07K2/00 , C07K14/00 , C07K14/745 , C07K14/505 , C07K14/755 , C12N9/48 , A61K38/02 , C07C69/63 , C07C69/66 , A61P43/00
CPC分类号： A61K47/48215 , A61K31/405 , A61K47/60
摘要： The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
摘要翻译： 本发明涉及聚合物衍生物，其可以与含氨基的药物缀合以改善其体内特性。 随后可以释放聚合物衍生物以产生其天然形式的药物。 描述了制备和使用这些聚合物衍生物和药物偶联物的方法。
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公开(公告)号：US08129525B2
公开(公告)日：2012-03-06
申请号：US12489121
申请日：2009-06-22
IPC分类号： C07D413/06
CPC分类号： C09B23/10 , C07D207/02 , C09B23/105 , G01N33/582 , G01N33/66
摘要： Reactive fluorescent dyes compositions and methods of using same are disclosed. Nile Red nucleus dyes are disclosed having thiol-reactive groups. Nile Red nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. The Nile Red nucleus dyes are of the following formulae:
摘要翻译： 公开了活性荧光染料组合物及其使用方法。 公开了尼罗红核染料具有硫醇反应性基团。 公开了展现至少约575nm的荧光发射的尼罗河红核染料。 尼罗红色核染料具有下列公式：
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公开(公告)号：US20060280652A1
公开(公告)日：2006-12-14
申请号：US11131283
申请日：2005-05-18
申请人： J. Pitner , Douglas Sherman , Arounaguiry Ambroise , K. Thomas
发明人： J. Pitner , Douglas Sherman , Arounaguiry Ambroise , K. Thomas
IPC分类号： G01N33/48
CPC分类号： C09B23/10 , C07D207/02 , C09B23/105 , G01N33/582 , G01N33/66
摘要： Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.
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公开(公告)号：US20100003763A1
公开(公告)日：2010-01-07
申请号：US12489121
申请日：2009-06-22
IPC分类号： G01N21/76 , C07D265/34
CPC分类号： C09B23/10 , C07D207/02 , C09B23/105 , G01N33/582 , G01N33/66
摘要： Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.
摘要翻译： 公开了活性荧光染料组合物及其使用方法。 揭示了具有硫醇反应性基团的方钠核，尼罗红核，苯并恶唑核，香豆素核或氮杂香豆素核染料。 披露了方解子核，尼罗红核，苯并恶唑核，香豆素核或者aza香豆素核染料，其表现出至少约575nm的荧光发射。 公开了具有结合蛋白和方酸核，尼罗红核，苯并恶唑核，香豆素核或者aza香豆素核的生物传感器。
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公开(公告)号：US07563891B2
公开(公告)日：2009-07-21
申请号：US11131283
申请日：2005-05-18
IPC分类号： C07D413/06 , A61K31/538 , G01N33/48
CPC分类号： C09B23/10 , C07D207/02 , C09B23/105 , G01N33/582 , G01N33/66
摘要： Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence emission of at least about 575 nm. Biosensors are disclosed having a binding protein and a squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus.
摘要翻译： 公开了活性荧光染料组合物及其使用方法。 揭示了具有硫醇反应性基团的方钠核，尼罗红核，苯并恶唑核，香豆素核或氮杂香豆素核染料。 披露了方解子核，尼罗红核，苯并恶唑核，香豆素核或者aza香豆素核染料，其表现出至少约575nm的荧光发射。 公开了具有结合蛋白和方酸核，尼罗红核，苯并恶唑核，香豆素核或者aza香豆素核的生物传感器。
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