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23 条记录 (耗时 0.04 秒)

    Method for processing a zirconium oxide composition in crystalline form
    2.
    发明授权
    Method for processing a zirconium oxide composition in crystalline form 有权
    处理结晶形式的氧化锆组合物的方法

    公开(公告)号：US07135156B2

    公开(公告)日：2006-11-14

    申请号：US10402105

    申请日：2003-03-28

    申请人： Ton That Hai ,  Mark Nordhaus ,  Paul Sanders ,  Cong Jiang ,  Sujatha Karoor

    发明人： Ton That Hai ,  Mark Nordhaus ,  Paul Sanders ,  Cong Jiang ,  Sujatha Karoor

    IPC分类号： C01G1/00 ,  C01G25/00

    CPC分类号： C01G25/02

    摘要： Methods of producing zirconium oxide compositions and using same are provided. The zirconium oxide compositions in crystalline form can be prepared by a synthetic process wherein the hydrolysis of zirconyl chloride and particle formation can be achieved simultaneously. Alternatively, the particle formation can occur first and then followed by hydrolysis with a base solution. The processes utilize a zirconyl salt solution that includes a zirconyl salt in isopropanol and water.

    摘要翻译： 提供了生产氧化锆组合物并使用它们的方法。 结晶形式的氧化锆组合物可以通过合成方法制备，其中可以同时实现氧化锆的水解和颗粒形成。 或者，可以首先发生颗粒形成，然后用碱溶液水解。 该方法利用在异丙醇和水中包含锆盐的锆盐溶液。

    (Polyalkoxy)sulfonate surface modifiers
    7.
    发明授权
    (Polyalkoxy)sulfonate surface modifiers 有权
    （聚烷氧基）磺酸盐表面改性剂

    公开(公告)号：US07776360B2

    公开(公告)日：2010-08-17

    申请号：US11304421

    申请日：2005-12-15

    申请人： James E. Kipp ,  Ton That Hai ,  Bennett P. Melnick

    发明人： James E. Kipp ,  Ton That Hai ,  Bennett P. Melnick

    IPC分类号： A61K9/14

    CPC分类号： C08G65/334 ,  A61K8/90 ,  A61K9/146 ,  A61K47/34 ,  A61Q19/00 ,  C08G65/326 ,  C08L71/02

    摘要： The present invention is directed to novel compounds, methods of manufacture and methods of use. The present invention is also directed to solid drug/active agent particles having one or more of the compounds of the present invention associated with the surface thereof.The compounds of the present invention are comprised of a non-polar polyether covalently linked to an anionic sulfonate group. The compounds have an amphipathic quality and preferably, are surface active. Such compounds are preferably useful as surface-active agents to coat and stabilize dispersions of particles in a continuous liquid medium. These surface-active agents may be applied in the stabilization of suspensions, emulsions, or liposome formulations intended for pharmaceutical, medical, cosmetic, or agricultural use.The particles that can be prepared by a variety of methods and will preferably comprise a pharmaceutical agent. Pharmaceutical compositions of the present invention can be used to treat a myriad of conditions and can be administered by many routes, including intravenous, intramuscular, subcutaneous, intrathecal, subdural, intracameral, intracerebral, intralesional, topical, oral, buccal, rectal, transcutaneous, pulmonary, and nasal.

    摘要翻译： 本发明涉及新化合物，制备方法和使用方法。 本发明还涉及具有一种或多种与其表面相关的本发明化合物的固体药物/活性剂颗粒。 本发明的化合物由与阴离子磺酸盐基团共价连接的非极性聚醚组成。 该化合物具有两性质量，优选表面活性。 这些化合物优选用作表面活性剂以涂覆和稳定颗粒在连续液体介质中的分散体。 这些表面活性剂可以用于稳定用于制药，医疗，化妆品或农业用途的悬浮液，乳剂或脂质体制剂。 可以通过多种方法制备并且优选包含药剂的颗粒。 本发明的药物组合物可用于治疗无数的病症，并且可以通过许多途径施用，包括静脉内，肌肉内，皮下，鞘内，硬膜下，阴道内，脑内，肠内，局部，口腔，口腔，直肠，经皮， 肺和鼻。

    Therapeutic hemoglobin composition having isotropically increased size
    10.
    发明授权
    Therapeutic hemoglobin composition having isotropically increased size 失效
    具有各向同性增加的大小的治疗性血红蛋白组合物

    公开(公告)号：US5981710A

    公开(公告)日：1999-11-09

    申请号：US896743

    申请日：1997-07-21

    申请人： Ton That Hai ,  David E. Pereira ,  Deanna J. Nelson

    发明人： Ton That Hai ,  David E. Pereira ,  Deanna J. Nelson

    IPC分类号： A61K38/16 ,  A61K38/00 ,  A61P7/00 ,  A61P43/00 ,  C07G3/00 ,  C07K14/805 ,  C08B37/00 ,  C08G63/48 ,  A61K35/14 ,  A01N43/04

    CPC分类号： C07K14/805 ,  A61K38/00

    摘要： Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may be synthesized as repeating disaccharide units, or may be derived by acid hydrolysis of naturally occurring polysaccharides. Such natural sources include chondroitins obtained from shark cartilage, or hyaluronic acid. The polyanionic sulfate groups contained in the sugar moieties impart negative charges which repel the molecules from the negatively charged wall of capillaries, to lengthen retention times of decorated drug molecules, such as crosslinked hemoglobin, in the peripheral circulation.

    摘要翻译： 公开了新型多糖化合物用于装饰生物分子表面以增加各向同性尺寸和掩蔽抗原性。 可以将寡糖作为重复二糖单元合成，或者可以通过天然存在的多糖的酸水解衍生。 这些天然来源包括从鲨鱼软骨获得的软骨素或透明质酸。 包含在糖部分中的聚阴离子硫酸盐基团赋予负电荷，其排斥毛细管的带负电荷的壁的分子，以延长外周循环中装饰的药物分子例如交联血红蛋白的保留时间。