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30 条记录 (耗时 0.019 秒)

    Phosphonylureidobenzene derivatives and their medicinal use
    13.
    发明授权
    Phosphonylureidobenzene derivatives and their medicinal use 失效
    膦酰基脲衍生物及其药用

    公开(公告)号：US4247546A

    公开(公告)日：1981-01-27

    申请号：US967035

    申请日：1978-12-06

    申请人： Hartmund Wollweber ,  Herbert Thomas ,  Peter Andrews

    发明人： Hartmund Wollweber ,  Herbert Thomas ,  Peter Andrews

    IPC分类号： A61K9/00 ,  A61K31/66 ,  A61K31/665 ,  A61K31/67 ,  A61K31/675 ,  A61P33/10 ,  C07F9/24 ,  C07F9/572 ,  C07F9/6539 ,  C07F9/6571 ,  C07F9/6574 ,  C07F9/6578 ,  A01N57/32 ,  A01N57/22

    CPC分类号： C07F9/6539 ,  A61K31/66 ,  C07F9/2487 ,  C07F9/5727 ,  C07F9/657154

    摘要： The invention includes phosphonylureidobenzene compounds of the general formula ##STR1## or pharmaceutically acceptable salts in whichR.sup.1 and R.sup.2 are identical or different and represent an alkyl group, orR.sup.1 and R.sup.2 together represent a dimethylene group, a trimethylene group or a tetramethylene group,X and Y are identical or different and represent an oxygen atom or a sulphur atom andR.sup.3 and R.sup.4 are identical or different and represent an alkyl group, orR.sup.3 and R.sup.4 together represent a trimethylene group or a tetramethylene group, orR.sup.3 and R.sup.4, together with the carbon atom and nitrogen atom between them, form a thiazolidine ring system, which are used medicinally as parasiticides.The compounds are particularly effective in combatting helminths in carnivores.Also included in the invention are pharmaceutical compositions containing said phosphonylureidobenzene compounds and methods for the treatment of warm-blooded animals by administering said compounds or compositions.

    摘要翻译： 本发明包括通式为（I）的膦酰基脲基化合物或其中R 1和R 2相同或不同并且表示烷基的药学上可接受的盐，或者R 1和R 2一起表示二亚甲基，三亚甲基或四亚甲基 基，X和Y相同或不同，表示氧原子或硫原子，R3和R4相同或不同，表示烷基，或R3和R4一起表示三亚甲基或四亚甲基，或R 3和R 4 与它们之间的碳原子和氮原子一起形成噻唑烷环体系，它们在医药上用作杀寄生虫剂。 这些化合物特别有效地对抗食肉动物的蠕虫。 本发明还包括含有所述膦酰基脲基化合物的药物组合物和通过施用所述化合物或组合物治疗温血动物的方法。

    4-Acylaminophenylacetamidines and a method for their preparation
    14.
    发明授权
    4-Acylaminophenylacetamidines and a method for their preparation 失效
    4-酰氨基苯基乙酰胺及其制备方法

    公开(公告)号：US4015012A

    公开(公告)日：1977-03-29

    申请号：US579446

    申请日：1975-05-21

    申请人： Hartmund Wollweber ,  Ekkehard Niemers ,  Hans Peter Schulz ,  Herbert Thomas ,  Peter Andrews

    发明人： Hartmund Wollweber ,  Ekkehard Niemers ,  Hans Peter Schulz ,  Herbert Thomas ,  Peter Andrews

    IPC分类号： A61K31/155 ,  A61K31/165

    CPC分类号： A61K31/155

    摘要： New 4-acylaminophenylacetamidines of the formula: ##STR1## in which R is a straight or branched chain alkoxyalkyl having 3 to 8 carbon atoms or straight or branched chain alkenyloxyalkyl having 3 to 8 carbon atoms wherein the alkoxy moiety or alkenyloxy moiety may substituted by alkoxy or phenyl, and including the non-toxic pharmacologically acceptable salts thereof. The products have utility as parasiticides.The products are obtained by either of two methods: (1) via the reaction of an N'-(4-aminophenyl)-N,N-dimethylacetamidine with an acylating agent or (2) via the reaction of a 4-acylaminoaniline with an N,N-dimethylacetamide or N,N-dimethylthioacetamide.

    摘要翻译： 新的具有3-8个碳原子的直链或支链烷氧基烷基或具有3-8个碳原子的直链或支链链烯氧基烷基的4-氨基苯基乙酰胺，其中R是具有3-8个碳原子的直链或支链烷氧基烷基，其中烷氧基部分或烯氧基部分可被烷氧基取代 或苯基，并且包括其无毒的药理学上可接受的盐。 该产品具有作为杀寄生虫剂的作用。

    Substituted phenylisothioureas and processes for their preparation and use
    16.
    发明授权
    Substituted phenylisothioureas and processes for their preparation and use 失效
    取代苯基异硫脲及其制备和使用方法

    公开(公告)号：US4005123A

    公开(公告)日：1977-01-25

    申请号：US595040

    申请日：1975-07-11

    申请人： Heinrich Kolling ,  Herbert Thomas ,  Arno Widdig ,  Hartmund Wollweber

    发明人： Heinrich Kolling ,  Herbert Thomas ,  Arno Widdig ,  Hartmund Wollweber

    IPC分类号： A61K31/17 ,  A61K31/155 ,  C07C67/00 ,  C07C325/00 ,  C07C335/38 ,  C07C149/40

    CPC分类号： C07C335/38

    摘要： N-[2-(Substituted amido)phenyl]-N'-carbonyl-S-substituted isothioureas bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)-phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenoxyphenyl)-N'-carbomethoxy-S-methylthiourea is a typical example, are prepared through the reaction of S-substituted N-(mercaptohalomethylene)carbamic acid ester and an apropriately substituted 2-aminoanilide, or through alkylation of the corresponding S-unsubstituted thiourea.

    摘要翻译： 在2-（取代的酰胺基） - 苯并噻唑的4-或5-位上带有任选取代的苯氧基，苯硫基，苯基亚磺酰基或苯基磺酰基的N- [2-（取代的酰氨基）苯基] -N'-羰基-S-取代的异硫脲， 苯基是驱肠剂。 通过S-取代的N-（巯基甲基亚甲基）氨基甲酸酯和适当的反应制备N-（2-乙酰氨基-4-苯氧基苯基）-N'-甲酯基-S-甲基硫脲的化合物是典型的例子 取代的2-氨基苯胺，或通过相应的S-未取代的硫脲的烷基化。

    Cutter head
    17.
    发明授权
    Cutter head 失效
    刀头

    公开(公告)号：US06378578B2

    公开(公告)日：2002-04-30

    申请号：US09777075

    申请日：2001-02-05

    申请人： Herbert Thomas

    发明人： Herbert Thomas

    IPC分类号： B27C500

    CPC分类号： B27G13/04 ,  Y10T83/9464 ,  Y10T407/1908 ,  Y10T407/1914 ,  Y10T407/192 ,  Y10T407/1938

    摘要： Cutter head for wood working machines comprising a carrier with at least one receptacle for detachably receiving a cutter unit and a means for adjusting the flight circle of a cutting edge of the cutter unit, wherein in order to facilitate such a cutter head in view of the manufacture and installation thereof and to improve the resharpening ability of the cutter unit, the adjusting means comprises at least one spacer arranged between the cutting edge and the receptacle in an exchangeable manner and defining the distance between the cutting edge and a bearing surface of the receptacle.

    摘要翻译： 用于木工机的切割头包括具有至少一个用于可拆卸地接收切割器单元的插座的托架和用于调节切割器单元的切割边缘的飞行圆圈的装置，其中为了便于这样的切割头，考虑到 制造和安装它们，并且为了提高切割器单元的再磨锐能力，调节装置包括至少一个间隔件，该隔离件以可更换的方式布置在切割边缘和插座之间，并且限定切割边缘与插座的支承表面之间的距离 。

    2-Formamido phenylguanidines and processes for their preparation and use
    18.
    发明授权
    2-Formamido phenylguanidines and processes for their preparation and use 失效
    2-甲酰氨基苯胍及其制备和使用方法

    公开(公告)号：US4127670A

    公开(公告)日：1978-11-28

    申请号：US770389

    申请日：1977-02-22

    申请人： Hartmund Wollweber ,  Heinrich Kolling ,  Herbert Thomas

    发明人： Hartmund Wollweber ,  Heinrich Kolling ,  Herbert Thomas

    IPC分类号： C07C279/24 ,  C07C149/437 ,  A61K31/27

    CPC分类号： C07C279/24

    摘要： N-(2-formamidophenyl)-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(formamido)-phenyl group are anthelminetic agents. The compounds, of which N-(2-formamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoformanilide.

    摘要翻译： 在2-（甲酰氨基） - 苯基的4-或5-位带有任意取代的苯氧基，苯硫基，苯基亚磺酰基或苯基磺酰基的N-（2-甲酰氨基苯基）-N'，N“ - 双 - 羰基胍具有抗激动作用 代理商 其中N-（2-甲酰氨基-4-苯硫基苯基）-N'，N“ - 双 - 甲酯基胍的化合物是典型的例子，是通过异硫脲-S-烷基醚和适当取代的2- 氨基甲酰苯胺。

    Substituted phenylisothioureas and processes for their preparation and use
    20.
    发明授权
    Substituted phenylisothioureas and processes for their preparation and use 失效
    取代苯基异硫脲及其制备和使用方法

    公开(公告)号：US4021571A

    公开(公告)日：1977-05-03

    申请号：US693097

    申请日：1976-06-04

    申请人： Heinrich Kolling ,  Herbert Thomas ,  Arno Widdig ,  Hartmund Wollweber

    发明人： Heinrich Kolling ,  Herbert Thomas ,  Arno Widdig ,  Hartmund Wollweber

    IPC分类号： A61K31/17 ,  A61K31/155 ,  C07C67/00 ,  C07C325/00 ,  C07C335/38 ,  A01N9/12

    CPC分类号： C07C335/38

    摘要： N-[2-(Substituted amido)phenyl]-N'-carbonyl-S-substituted isothioureas bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)-phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenoxyphenyl)-N'-carbomethoxy-S-methylthiourea is a typical example, are prepared through the reaction of S-substituted N-(mercaptohalomethylene)carbamic acid ester and an appropriately substituted 2-aminoanilide, or through alkylation of the corresponding S-unsubstituted thiourea.

    摘要翻译： 在2-（取代的酰胺基） - 苯并噻唑的4-或5-位上带有任选取代的苯氧基，苯硫基，苯基亚磺酰基或苯基磺酰基的N- [2-（取代的酰氨基）苯基] -N'-羰基-S-取代的异硫脲， 苯基是驱肠剂。 通过S-取代的N-（巯基甲基亚甲基）氨基甲酸酯与合适的反应制备N-（2-乙酰氨基-4-苯氧基苯基）-N'-甲酯基-3-甲硫基脲的典型实例的化合物 取代的2-氨基苯胺，或通过相应的S-未取代的硫脲的烷基化。