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    4-Acylaminophenylacetamidines and a method for their preparation
    3.
    发明授权
    4-Acylaminophenylacetamidines and a method for their preparation 失效
    4-酰氨基苯基乙酰胺及其制备方法

    公开(公告)号：US4015012A

    公开(公告)日：1977-03-29

    申请号：US579446

    申请日：1975-05-21

    申请人： Hartmund Wollweber ,  Ekkehard Niemers ,  Hans Peter Schulz ,  Herbert Thomas ,  Peter Andrews

    发明人： Hartmund Wollweber ,  Ekkehard Niemers ,  Hans Peter Schulz ,  Herbert Thomas ,  Peter Andrews

    IPC分类号： A61K31/155 ,  A61K31/165

    CPC分类号： A61K31/155

    摘要： New 4-acylaminophenylacetamidines of the formula: ##STR1## in which R is a straight or branched chain alkoxyalkyl having 3 to 8 carbon atoms or straight or branched chain alkenyloxyalkyl having 3 to 8 carbon atoms wherein the alkoxy moiety or alkenyloxy moiety may substituted by alkoxy or phenyl, and including the non-toxic pharmacologically acceptable salts thereof. The products have utility as parasiticides.The products are obtained by either of two methods: (1) via the reaction of an N'-(4-aminophenyl)-N,N-dimethylacetamidine with an acylating agent or (2) via the reaction of a 4-acylaminoaniline with an N,N-dimethylacetamide or N,N-dimethylthioacetamide.

    摘要翻译： 新的具有3-8个碳原子的直链或支链烷氧基烷基或具有3-8个碳原子的直链或支链链烯氧基烷基的4-氨基苯基乙酰胺，其中R是具有3-8个碳原子的直链或支链烷氧基烷基，其中烷氧基部分或烯氧基部分可被烷氧基取代 或苯基，并且包括其无毒的药理学上可接受的盐。 该产品具有作为杀寄生虫剂的作用。

    Penicillin 1,1-dioxides
    5.
    发明授权
    Penicillin 1,1-dioxides 失效
    青霉素1,1-二氧化物

    公开(公告)号：US4344955A

    公开(公告)日：1982-08-17

    申请号：US158975

    申请日：1980-06-12

    申请人： Ekkehard Niemers ,  Hans-Bodo Konig ,  Wilfried Schrock ,  Karl G. Metzger

    发明人： Ekkehard Niemers ,  Hans-Bodo Konig ,  Wilfried Schrock ,  Karl G. Metzger

    IPC分类号： A61K31/43 ,  A61P31/04 ,  C07D499/00 ,  C07D499/04 ,  C07D499/44 ,  C07D499/46 ,  C07D499/56 ,  C07D499/60 ,  C07D499/64 ,  C07D499/68 ,  C07D499/70 ,  C07D499/72 ,  C07D499/74 ,  C07D499/76 ,  C07D499/78

    CPC分类号： C07D499/00 ,  A61K31/43

    摘要： Anti-bacterially active penicillin 1,1-dioxides of the formula ##STR1## or a salt thereof, in which R.sub.1 denotes a hydrogen atom or an ester-forming radical,R.sub.2 denotes a hydrogen atom or optionally substituted alkoxy group,R.sub.3 denotes a hydrogen atom, COR.sub.4, SO.sub.2 -alkyl, SO.sub.2 -aryl or an optionally substituted alkyl group, but R.sub.2 and R.sub.3 do not simultaneously denote hydrogen atoms, andR.sub.4 denotes a hydrogen atom or any of many possible organic radicals.The compounds are also inhibitors of .beta.-lactamases so they can be used in conjunction with .beta.-lactamase-susceptible antibiotics. They are useful in fighting bacterial infection, in promoting animal growth and in preserving various materials.

    摘要翻译： 其中R1表示氢原子或成酯基团的式为“IMAGE”或其盐的抗细菌活性青霉素1,1-二氧化物，R 2表示氢原子或任选取代的烷氧基，R 3表示氢 原子，COR 4，SO 2 - 烷基，SO 2 - 芳基或任选取代的烷基，但R 2和R 3不同时表示氢原子，R 4表示氢原子或许多可能的有机基团中的任何一种。 这些化合物也是β-内酰胺酶的抑制剂，因此它们可以与β-内酰胺酶敏感的抗生素联合使用。 它们有助于消灭细菌感染，促进动物生长和保存各种材料。

    Combating fungi with trisubstituted cyanoguanidines
    9.
    发明授权
    Combating fungi with trisubstituted cyanoguanidines 失效
    抗真菌与三取代的氰基胍

    公开(公告)号：US4491595A

    公开(公告)日：1985-01-01

    申请号：US249249

    申请日：1981-03-30

    申请人： Ekkehard Niemers ,  Winfried Lunkenheimer ,  Wilhelm Brandes

    发明人： Ekkehard Niemers ,  Winfried Lunkenheimer ,  Wilhelm Brandes

    IPC分类号： A01N47/44 ,  C07C67/00 ,  C07C279/28 ,  C07C301/00 ,  C07C303/40 ,  C07C311/39 ,  C07D295/215 ,  C07C129/12 ,  A01N37/52

    CPC分类号： C07D295/215 ,  C07C279/28

    摘要： Trisubstituted cyanoguanidines of the formula ##STR1## in which R.sup.1 represents an optionally substituted phenyl or phenylalkyl radical, an alkyl radical with more than 1 carbon atom, a substituted alkyl radical, an alkenyl or alkinyl radical or an optionally substituted cycloalkyl radical,R.sup.2 represents an optionally substituted alkyl radical or an alkenyl or alkinyl radical andR.sup.3 represents an optionally substituted alkyl radical, an alkenyl or alkinyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl or phenylalkyl radical, orR.sup.2 and R.sup.3, together with the nitrogen atom to which they are bonded, represent an optionally substituted heterocyclic radical, which optionally contains an oxygen atom as a further hetero-atom,or a physiologically acceptable acid addition salt thereof, which possess fungicidal properties. Processes for their preparation are also taught.

    摘要翻译： 其中R 1表示任选取代的苯基或苯基烷基，具有多于1个碳原子的烷基，取代的烷基，链烯基或炔基或任选取代的环烷基，其中R 3代表下式的三取代的氰基胍： 任选取代的烷基或烯基或炔基，R 3表示任选取代的烷基，烯基或炔基，任选取代的环烷基或任选取代的苯基或苯基烷基，或R 2和R 3与氮原子一起 它们是键合的，表示任选地含有氧原子作为另外的杂原子的任选取代的杂环基，或其生理上可接受的酸加成盐，其具有杀真菌性。 还介绍了其准备过程。