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    Carbocyclic hydrazino inhibitors of copper-containing amine oxidases
    11.
    发明授权
    Carbocyclic hydrazino inhibitors of copper-containing amine oxidases 失效
    含铜胺氧化酶的碳环肼抑制剂

    公开(公告)号：US06982286B2

    公开(公告)日：2006-01-03

    申请号：US09902789

    申请日：2001-07-12

    申请人： David John Smith ,  Ferenc Fülöp ,  Marjo Pihlavisto ,  László Lázár ,  Sakari Alaranta ,  Petri Vainio ,  Zsolt Szakonyi

    发明人： David John Smith ,  Ferenc Fülöp ,  Marjo Pihlavisto ,  László Lázár ,  Sakari Alaranta ,  Petri Vainio ,  Zsolt Szakonyi

    IPC分类号： A61K31/135

    CPC分类号： C07D273/00 ,  A61K31/15 ,  C07C243/20 ,  C07C2602/08

    摘要： The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-I (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The novel compounds have the general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof wherein R1 to R11 are as defined herein.

    摘要翻译： 本发明涉及用作通常称为氨基脲敏感性胺氧化酶（SSAO）的含铜胺氧化酶的抑制剂的碳环肼化合物，包括称为血管粘附蛋白-1（VAP-1）的人SSAO。 这些SSAO抑制剂具有用于治疗病症和疾病的药物的治疗用途，包括但不限于许多炎性病症和疾病（特别是慢性炎症病症如慢性关节炎，炎性肠病和慢性皮肤皮肤病），相关疾病 到碳水化合物代谢和脂肪细胞分化或功能和平滑肌细胞功能异常以及血管疾病。 新化合物具有以下通式：或其药学上可接受的溶剂合物，水合物或盐，其中R 1至R 11如本文所定义。