公开(公告)号：US20210309521A1

公开(公告)日：2021-10-07

申请号：US17130536

申请日：2020-12-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hojeong JEON ,  Seung Hoon UM ,  Yu Chan KIM ,  Hyung-Seop HAN ,  Myoung-Ryul OK ,  Hyunseon SEO ,  Hyun Kwang SEOK

IPC: C01B25/32 ,  B23K26/122

Abstract: Provided is a method of synthesizing apatite powder by emitting a laser beam to a surface of a substrate immersed in a precursor solution. The method is including immersing a substrate in an apatite-forming precursor solution, emitting a laser beam to a region on a surface of the substrate immersed in the precursor solution, and obtaining apatite powder generated in the precursor solution.

公开(公告)号：US20200208254A1

公开(公告)日：2020-07-02

申请号：US16691613

申请日：2019-11-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yu Chan KIM ,  Hyun Kwang SEOK ,  SEUNG HEE HAN ,  Hojeong JEON ,  Myoung-Ryul OK ,  Hyunseon SEO ,  Kyoung Won PARK ,  Yeon Wook JUNG ,  Pil Ryung CHA

IPC: C23C14/16 ,  C23C14/48 ,  C23C14/35 ,  C23C14/34 ,  C23C14/32

Abstract: Provided is a method of increasing corrosion resistance of a magnesium (Mg) member. The method includes preparing a Mg member, and ion-implanting a doping element into a surface of the Mg member. Herein, the doping element includes an element capable of increasing a Fermi energy level of magnesium oxide (MgO) when doped on MgO.

公开(公告)号：US20150198532A1

公开(公告)日：2015-07-16

申请号：US14292197

申请日：2014-05-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwan Hyi LEE ,  Minhong JEUN ,  Yu Chan KIM ,  Seok LEE ,  Hyun Kwang SEOK

IPC: G01N21/64 ,  C07K16/08

CPC classification number: G01N33/54326 ,  C07K16/082 ,  G01N33/588 ,  G01N33/90 ,  G01N2021/6439

Abstract: The invention relates to a biomarker detecting probe which is capable of early detection of a biomarker and precise quantification thereof at the same time, and a method of detecting a biomarker using the same. More particularly, it relates to a biomarker detecting probe comprising a ferritin protein, and a targeting antibody linked with a fluorescent material, superparamagnetic nano particle, and conductive particle, and a method of detecting a biomarker using the same.

Abstract translation: 本发明涉及能够同时早期检测生物标志物和精确定量的生物标志物检测探针，以及使用其的生物标志物的检测方法。 更具体地，本发明涉及包含铁蛋白的生物标志物检测探针和与荧光材料，超顺磁性纳米颗粒和导电性粒子连接的靶向抗体，以及使用其的生物标志物的检测方法。

公开(公告)号：US20140170767A1

公开(公告)日：2014-06-19

申请号：US14093305

申请日：2013-11-29

Applicant: Korea Institute of Science and Technology

Inventor： Kwan Hyi LEE ,  Ho Young PARK ,  Yu Chan KIM ,  Hyun Kwang SEOK ,  Seok LEE

IPC: G01N33/543

CPC classification number: G01N33/54326

Abstract: A method for diagnosing a biomarker using magnetic particles and quantum dots for quantitative analysis and a biomarker diagnosis kit are provided. The method for diagnosing a biomarker includes: ii) providing magnetic particles having surfaces to which a primary antibody capable of collecting a biomarker using a linker is fixed; ii) providing quantum dots having surfaces to which a secondary antibody capable of detecting the biomarker is fixed; iii) sandwich-targeting the biomarker by the magnetic particles and the quantum dots; iv) selectively separating quantum dots sandwich-targeting the biomarker among the quantum dots; and v) quantifying the concentration of the biomarker by measuring absorbance or intensity of fluorescence of separated quantum dots.

Abstract translation: 提供了使用磁性粒子和量子点进行定量分析的生物标志物的诊断方法以及生物标志物诊断试剂盒。 用于诊断生物标志物的方法包括：ii）提供具有表面的磁性颗粒，所述表面能够使用接头固定生物标志物的一级抗体; ii）提供具有能够检测生物标志物的二级抗体固定的表面的量子点; iii）通过磁性颗粒和量子点夹心靶向生物标志物; iv）选择性地分离量子点之间的夹心靶向生物标志物的量子点; 和v）通过测量分离的量子点的荧光的吸光度或强度来量化生物标志物的浓度。