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公开(公告)号：US11692224B2
公开(公告)日：2023-07-04
申请号：US17355882
申请日：2021-06-23
申请人： Karius, Inc.
发明人： Fred C. Christians , Igor D. Vilfan , Michael Kertesz , Timothy A. Blauwkamp , Shivkumar Venkatasubrahmanyam , Michael Rosen , Rene Sit
IPC分类号： C12Q1/68 , C12Q1/6874 , G16B30/00 , C12Q1/6869 , G16B30/10 , C12N15/10 , C12Q1/689
CPC分类号： C12Q1/6874 , C12N15/1065 , C12Q1/689 , C12Q1/6869 , G16B30/00 , G16B30/10 , C12Q2600/166 , C12Q1/6869 , C12Q2545/101
摘要： This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.
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公开(公告)号：US20220154246A1
公开(公告)日：2022-05-19
申请号：US17390550
申请日：2021-07-30
申请人： Karius, Inc.
IPC分类号： C12Q1/6806 , C12Q1/6888
摘要： This disclosure provides methods and compositions that are useful for enriching a particular population of nucleic acids (a “population of interest”) within a complex mixture of nucleic acids. The population of interest may make up a minor portion of a complex mixture of nucleic acids. The methods and compositions provided herein are useful for detecting, predicting, diagnosing, or monitoring a disease or disorder, particularly a disease or disorder caused by a foreign microbe or pathogen.
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公开(公告)号：US11078532B2
公开(公告)日：2021-08-03
申请号：US15953822
申请日：2018-04-16
申请人： Karius, Inc.
发明人： Fred C. Christians , Igor D. Vilfan , Michael Kertesz , Timothy A. Blauwkamp , Shivkumar Venkatasubrahmanyam , Michael Rosen , Rene Sit
IPC分类号： C12Q1/68 , C12Q1/6874 , G16B30/00 , C12Q1/6869 , C12N15/10 , C12Q1/689
摘要： This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.
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公开(公告)号：US20240043923A1
公开(公告)日：2024-02-08
申请号：US18313716
申请日：2023-05-08
申请人： Karius, Inc.
发明人： Fred C. Christians , Igor D. Vilfan , Michael Kertesz , Timothy A. Blauwkamp , Shivkumar Venkatasubrahmanyam , Michael Rosen , Rene Sit
IPC分类号： C12Q1/6874 , G16B30/00 , C12Q1/6869 , G16B30/10 , C12N15/10 , C12Q1/689
CPC分类号： C12Q1/6874 , G16B30/00 , C12Q1/6869 , G16B30/10 , C12N15/1065 , C12Q1/689 , C12Q2600/166
摘要： This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.
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公开(公告)号：US11834711B2
公开(公告)日：2023-12-05
申请号：US17484674
申请日：2021-09-24
申请人： Karius, Inc.
发明人： Timothy A Blauwkamp , Rene Sit , Igor D. Vilfan
IPC分类号： C12Q1/6869 , C12N9/00 , C12Q1/6855 , C12Q1/6806 , C12N9/12 , C12Q1/686 , C12Q1/6876
CPC分类号： C12Q1/6869 , C12N9/1247 , C12N9/93 , C12Q1/6806 , C12Q1/686 , C12Q1/6855 , C12Q1/6876 , C12Q2521/107 , C12Q2533/101 , C12Y207/07006 , C12Y207/07049 , C12Y605/01001 , C12Y605/01003 , C12Q1/6806 , C12Q2525/155 , C12Q2525/191 , C12Q2535/122
摘要： The disclosure provides methods, compositions, systems, and kits for the concurrent detection and analysis of different structural and chemical forms of nucleic acids in a sample.
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公开(公告)号：US11674167B2
公开(公告)日：2023-06-13
申请号：US16884343
申请日：2020-05-27
申请人： KARIUS, INC.
IPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q1/6895 , G06F17/18
CPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q1/6895 , G06F17/18 , C12Q2565/102
摘要： This disclosure provides methods, compositions and kits for determining if nucleic acids detected in a sample such as a clinical sample are derived from contaminant pathogens or clinically-relevant pathogens.
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公开(公告)号：US11111520B2
公开(公告)日：2021-09-07
申请号：US15157374
申请日：2016-05-17
申请人： Karius, Inc.
IPC分类号： C12Q1/68 , C12Q1/6806 , C12Q1/6888 , C12Q1/6809 , C12Q1/6804
摘要： This disclosure provides methods and compositions that are useful for enriching a particular population of nucleic acids (a “population of interest”) within a complex mixture of nucleic acids. The population of interest may make up a minor portion of a complex mixture of nucleic acids. The methods and compositions provided herein are useful for detecting, predicting, diagnosing, or monitoring a disease or disorder, particularly a disease or disorder caused by a foreign microbe or pathogen.
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公开(公告)号：US09976181B2
公开(公告)日：2018-05-22
申请号：US15469474
申请日：2017-03-24
申请人： Karius, Inc.
发明人： Fred C. Christians , Igor D. Vilfan , Michael Kertesz , Timothy A. Blauwkamp , Shivkumar Venkatasubrahmanyam , Michael Rosen , Rene Sit
CPC分类号： C12Q1/6874 , C12N15/1065 , C12Q1/6869 , C12Q1/689 , C12Q2600/166 , G06F19/22 , C12Q2545/101
摘要： This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.
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