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公开(公告)号：US20180237851A1
公开(公告)日：2018-08-23
申请号：US15953822
申请日：2018-04-16
申请人： Karius, Inc.
发明人： Fred C. Christians , Igor D. Vilfan , Michael Kertesz , Timothy A. Blauwkamp , Shivkumar Venkatasubrahmanyam , Michael Rosen , Rene Sit
IPC分类号： C12Q1/6874 , C12Q1/689 , C12N15/10 , G06F19/22
CPC分类号： C12Q1/6874 , C12N15/1065 , C12Q1/6869 , C12Q1/689 , C12Q2600/166 , G16B30/00 , C12Q2545/101
摘要： This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.
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公开(公告)号：US20170016048A1
公开(公告)日：2017-01-19
申请号：US15157374
申请日：2016-05-17
申请人： Karius, Inc.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6804 , C12Q1/6809 , C12Q1/6888 , C12Q2525/155 , C12Q2525/161 , C12Q2537/159
摘要： This disclosure provides methods and compositions that are useful for enriching a particular population of nucleic acids (a “population of interest”) within a complex mixture of nucleic acids. The population of interest may make up a minor portion of a complex mixture of nucleic acids. The methods and compositions provided herein are useful for detecting, predicting, diagnosing, or monitoring a disease or disorder, particularly a disease or disorder caused by a foreign microbe or pathogen.
摘要翻译： 本公开提供了可用于在核酸的复杂混合物中富集特定的核酸群体（“感兴趣群体”）的方法和组合物。 感兴趣的群体可能构成复杂的核酸混合物的一小部分。 本文提供的方法和组合物可用于检测，预测，诊断或监测疾病或病症，特别是由外来微生物或病原体引起的疾病或病症。
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公开(公告)号：US20240294979A1
公开(公告)日：2024-09-05
申请号：US18486005
申请日：2023-10-12
申请人： Karius, Inc.
发明人： Timothy A. Blauwkamp , Rene Sit , Igor D. Vilfan
IPC分类号： C12Q1/6869 , C12N9/00 , C12N9/12 , C12Q1/6806 , C12Q1/6855 , C12Q1/686 , C12Q1/6876
CPC分类号： C12Q1/6869 , C12N9/1247 , C12N9/93 , C12Q1/6806 , C12Q1/6855 , C12Q1/686 , C12Q1/6876 , C12Q2521/107 , C12Q2533/101 , C12Y207/07006 , C12Y207/07049 , C12Y605/01001 , C12Y605/01003
摘要： The disclosure provides methods, compositions, systems, and kits for the concurrent detection and analysis of different structural and chemical forms of nucleic acids in a sample.
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公开(公告)号：US11180800B2
公开(公告)日：2021-11-23
申请号：US15930488
申请日：2020-05-13
申请人： Karius, Inc.
发明人： Timothy A. Blauwkamp , Rene Sit , Igor D. Vilfan
IPC分类号： C12Q1/6869 , C12Q1/6806 , C12Q1/6855 , C12Q1/686 , C12N9/12 , C12N9/00 , C12Q1/6876
摘要： The disclosure provides methods, compositions, systems, and kits for the concurrent detection and analysis of different structural and chemical forms of nucleic acids in a sample.
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公开(公告)号：US20170275691A1
公开(公告)日：2017-09-28
申请号：US15469474
申请日：2017-03-24
申请人： Karius, Inc.
发明人： Fred C. Christians , Igor D. Vilfan , Michael Kertesz , Timothy A. Blauwkamp , Shivkumar Venkatasubrahmanyam , Michael Rosen , Rene Sit
CPC分类号： C12Q1/6874 , C12N15/1065 , C12Q1/6869 , C12Q1/689 , C12Q2600/166 , G06F19/22 , C12Q2545/101
摘要： This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.
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公开(公告)号：US20240309427A1
公开(公告)日：2024-09-19
申请号：US18674513
申请日：2024-05-24
申请人： Karius, Inc.
IPC分类号： C12Q1/6806 , C12N15/10 , C12Q1/6848 , C12Q1/6869 , C12Q1/6876
CPC分类号： C12Q1/6806 , C12N15/10 , C12N15/1003 , C12Q1/6848 , C12Q1/6869 , C12Q1/6876 , C12Q2523/313
摘要： This disclosure provides methods that are useful for reducing or inactivating contaminant nucleic acids.
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公开(公告)号：US20210324467A1
公开(公告)日：2021-10-21
申请号：US17355882
申请日：2021-06-23
申请人： Karius, Inc.
发明人： Fred C. Christians , Igor D. Vilfan , Michael Kertesz , Timothy A. Blauwkamp , Shivkumar Venkatasubrahmanyam , Michael Rosen , Rene Sit
IPC分类号： C12Q1/6874 , G16B30/00 , C12Q1/6869 , G16B30/10 , C12N15/10 , C12Q1/689
摘要： This disclosure provides methods for determining relative abundance of one or more non-host species in a sample from a host. Also provided are methods involving addition of known concentrations of synthetic nucleic acids to a sample and performing sequencing assays to identify non-host species such as pathogens. Also provided are methods of tracking samples, tracking reagents, and tracking diversity loss in sequencing assays.
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公开(公告)号：US10697008B2
公开(公告)日：2020-06-30
申请号：US15952203
申请日：2018-04-12
申请人： Karius, Inc.
发明人： Timothy A. Blauwkamp , Rene Sit , Igor D. Vilfan
IPC分类号： C12Q1/6869 , C12Q1/6806 , C12N9/12 , C12N9/00 , C12Q1/6855 , C12Q1/686 , C12Q1/6876 , C12N1/00
摘要： The disclosure provides methods, compositions, systems, and kits for the concurrent detection and analysis of different structural and chemical forms of nucleic acids in a sample.
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公开(公告)号：US20180371538A1
公开(公告)日：2018-12-27
申请号：US15952203
申请日：2018-04-12
申请人： Karius, Inc.
发明人： Timothy A. Blauwkamp , Rene Sit , Igor D. Vilfan
IPC分类号： C12Q1/6869 , C12Q1/6855 , C12Q1/6876 , C12Q1/6806 , C12N9/12 , C12N9/00 , C12Q1/686
摘要： The disclosure provides methods, compositions, systems, and kits for the concurrent detection and analysis of different structural and chemical forms of nucleic acids in a sample.
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公开(公告)号：US20240344111A1
公开(公告)日：2024-10-17
申请号：US18527138
申请日：2023-12-01
申请人： Karius, Inc.
IPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q1/6895 , G06F17/18
CPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q1/6895 , G06F17/18 , C12Q2565/102
摘要： This disclosure provides methods, compositions and kits for determining if nucleic acids detected in a sample such as a clinical sample are derived from contaminant pathogens or clinically-relevant pathogens.
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