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11.发明申请NOVEL METALLOPROTEIN AND PROCESS FOR PRODUCING SAME, AND PROPHYLACTIC OR THERAPEUTIC AGENT FOR CORNEAL AND CONJUNCTIVAL DISEASES COMPRISING SAID METALLOPROTEIN 审中-公开新型金属蛋白酶及其生产方法，以及含有金属蛋白酶的正常和连续性疾病的预防或治疗药物公开(公告)号：US20140080765A1
公开(公告)日：2014-03-20
申请号：US14118879
申请日：2012-05-18
申请人： Akihiro Higuchi , Hiroyoshi Inoue , Kazuo Tsubota
发明人： Akihiro Higuchi , Hiroyoshi Inoue , Kazuo Tsubota
IPC分类号： C07K14/79
CPC分类号： C07K14/79 , A61K9/0048 , A61K38/40
摘要： The present invention provides: a novel metalloprotein, i.e., selenium-lactoferrin; and a process for producing the metalloprotein. Selenium-lactoferrin according to the present invention can be produced suitably by adding a selenium salt to a solution containing lactoferrin and/or apolactoferrin and then subjecting the resultant mixed solution to dialysis or ultrafiltration.Selenium-lactoferrin according to the present invention has an excellent therapeutic effect on corneal and conjunctival diseases, and is suitable for mass production on an industrial scale.
摘要翻译： 本发明提供：新型金属蛋白，即硒 - 乳铁蛋白; 和金属蛋白酶的制造方法。 根据本发明的硒 - 乳铁蛋白可以适当地通过向含有乳铁蛋白和/或脱铁乳铁蛋白的溶液中加入硒盐然后将所得混合溶液进行透析或超滤来制备。 根据本发明的硒 - 乳铁蛋白对角膜和结膜疾病具有优异的治疗作用，适用于工业规模的批量生产。
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12.发明申请THERAPEUTIC AGENT FOR CORNEAL SENSORY NERVE DAMAGE CONTAINING SEMAPHORIN INHIBITOR AS ACTIVE INGREDIENT 审中-公开含有作为活性成分的印度尼西亚抑制剂的角膜感觉神经损伤的治疗剂公开(公告)号：US20140018416A1
公开(公告)日：2014-01-16
申请号：US14001333
申请日：2012-02-23
申请人： Hideyuki Okano , Kazuo Tsubota , Shigeto Shimmura , Masahiro Omoto , Akiyoshi Kishino , Miho Maeda
发明人： Hideyuki Okano , Kazuo Tsubota , Shigeto Shimmura , Masahiro Omoto , Akiyoshi Kishino , Miho Maeda
IPC分类号： C07D311/86
CPC分类号： C07D311/86 , A61K31/352
摘要： A compound represented by formula (1), or a pharmaceutically acceptable salt thereof is effective as a therapeutic agent or a prophylactic agent for a corneal disease or sensory nerve damage due to corneal surgery, and as a regeneration accelerator for corneal sensory nerves: wherein R1 represents a hydrogen atom or a carboxyl group, R2 represents a hydrogen atom or a hydroxy group, R3 represents a hydrogen atom or a carboxyl group, and R4 represents a hydrogen atom or a hydroxy group.
摘要翻译： 由式（1）表示的化合物或其药学上可接受的盐作为用于角膜手术的角膜疾病或感觉神经损伤的治疗剂或预防剂，作为角膜感觉神经的再生促进剂是有效的：其中R1 表示氢原子或羧基，R2表示氢原子或羟基，R3表示氢原子或羧基，R4表示氢原子或羟基。
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公开(公告)号：US20090047738A1
公开(公告)日：2009-02-19
申请号：US12162905
申请日：2007-01-17
CPC分类号： A61K35/28 , A61K35/12 , A61K35/36 , A61K35/44 , C12N5/0621 , C12N5/0623 , C12N5/0656 , C12N2500/25 , C12N2501/11 , C12N2501/39 , C12N2501/81 , C12N2502/03 , C12N2502/08 , C12N2506/08 , C12N2509/00 , C12N2533/56
摘要： It is an object of the present invention to provide a feeder cell with less variation in quality. The present invention relates to a feeder cell derived from a tissue stem and/or progenitor cell. A method of preparation of the feeder cell, a method of preparation of a cultured cell using the feeder cell, and a cell culturing kit are also provided.
摘要翻译： 本发明的目的是提供一种质量变化较小的饲养池。 本发明涉及源于组织干和/或祖细胞的饲养细胞。 还提供了饲养细胞的制备方法，使用饲养细胞的培养细胞的制备方法和细胞培养试剂盒。
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公开(公告)号：US07470026B2
公开(公告)日：2008-12-30
申请号：US11482845
申请日：2006-07-07
申请人： Minako Kaido , Kazuo Tsubota
发明人： Minako Kaido , Kazuo Tsubota
摘要： The present invention provides a method and apparatus for measuring operating vision. An optotype mark is displayed (step 103). A subject's response to the optotype mark is accepted via an input device (step 104). A determination is made as to whether or not the response is correct (step 105). When the current response of the subject is correct and the previous response or one of the previous response and the last-but-one response is incorrect, an optotype mark corresponding to the same visual acuity is presented (step 112). When the previous response is correct or both the previous response and the last-but-one response are correct, an optotype mark corresponding to a visual acuity one level higher is presented (step 110). When the current response is incorrect, an optotype mark corresponding to a visual acuity one level lower is presented (step 111).
摘要翻译： 本发明提供了一种用于测量操作视觉的方法和装置。 显示视标标记（步骤103）。 受试者对视标标记的响应通过输入装置被接受（步骤104）。 确定响应是否正确（步骤105）。 当对象的当前响应是正确的，并且先前的响应或先前响应和最后一个响应中的一个不正确时，呈现对应于相同视力的视标（步骤112）。 当先前的响应是正确的或者先前的响应和最后一个响应都是正确的时，呈现对应于一个级别更高的视敏度的视标标记（步骤110）。 当电流响应不正确时，呈现对应于一级视觉敏锐度的视标标记（步骤111）。
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公开(公告)号：US07134998B2
公开(公告)日：2006-11-14
申请号：US10770443
申请日：2004-02-04
申请人： Koji Endo , Kazuo Tsubota , Eiki Goto
发明人： Koji Endo , Kazuo Tsubota , Eiki Goto
IPC分类号： A61B5/00
CPC分类号： A61B3/101
摘要： A tear secretion quantity examination system for evaluating simply and non-invasively the tear secretion quantity has: a moisture evaporation quantity detection unit for detecting the moisture evaporation quantity from a subject's eye with a humidity sensor; and an operation unit for computing evaluation parameters of the tear secretion quantity based on a detection signal of the moisture evaporation quantity detection unit. The operation means approximates an attenuation portion of saw-tooth responses appearing for each blink in a tear evaporation profile in which the detection value obtained with the humidity sensor is plotted against the time.
摘要翻译： 用于简单地和非侵入地评估泪液分泌量的泪液分泌量检查系统具有：湿度蒸发量检测单元，用于利用湿度传感器检测来自被检眼的水分蒸发量; 以及操作单元，用于基于水分蒸发量检测单元的检测信号来计算泪液分泌量的评价参数。 操作装置近似于泪液蒸发曲线中每次眨眼出现的锯齿响应的衰减部分，其中用湿度传感器获得的检测值相对于时间作图。
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公开(公告)号：US06852687B2
公开(公告)日：2005-02-08
申请号：US10132567
申请日：2002-04-26
申请人： Kazuo Tsubota , Akihiro Higuchi
发明人： Kazuo Tsubota , Akihiro Higuchi
CPC分类号： A61K38/38 , A61K2300/00
摘要： The present invention relates to a method for treating a subject having a condition or disease involving apoptosis, which comprises administering an effective amount of albumin to the subject. The apoptosis inhibiting activity of albumin can be increased by administering a cell growth factor such as epidermal growth factor, transforming growth factor, fibroblast growth factor, hepatocyte growth factor, insulin-like growth factor, platelet-derived growth factor and nerve growth factor and/or vitamin A together with albumin.
摘要翻译： 本发明涉及一种治疗患有涉及细胞凋亡的病症或疾病的受试者的方法，其包括对受试者施用有效量的白蛋白。 可以通过施用细胞生长因子如表皮生长因子，转化生长因子，成纤维细胞生长因子，肝细胞生长因子，胰岛素样生长因子，血小板衍生生长因子和神经生长因子和/ 或维生素A以及白蛋白。
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公开(公告)号：US6043213A
公开(公告)日：2000-03-28
申请号：US981229
申请日：1997-12-19
申请人： Kazuo Tsubota
发明人： Kazuo Tsubota
CPC分类号： A61K38/38 , Y10S514/912
摘要： The present invention provides a pharmaceutical composition for treatment of corneal and conjunctival lesion, and dry eye comprising albumin as an active ingredient. The pharmaceutical composition is also useful for increase of eye surface epithelium mucin secretion. The present invention further provides a method for treatment of corneal and conjunctival lesion, and dry eye, which comprises administering, to a subject in need of such treatment, albumin in an amount effective. In addition, the present invention provides a use of albumin for manufacture of a pharmaceutical composition of the present invention.
摘要翻译： PCT No.PCT / JP97 / 01329 Sec。 371 1997年12月19日第 102（e）1997年12月19日PCT PCT 1997年4月17日PCT公布。 第WO97 / 39769号公报 日期：1997年10月30日本发明提供了用于治疗角膜和结膜病变的药物组合物和包含白蛋白作为活性成分的干眼症。 该药物组合物也可用于增加眼表上皮粘蛋白分泌。 本发明还提供了一种治疗角膜和结膜病变以及干眼症的方法，其包括向需要这种治疗的受试者施用有效量的白蛋白。 另外，本发明提供白蛋白用于制造本发明的药物组合物的用途。
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18.发明授权Image processing apparatus which provides an indication of whether an odd or an even field is displayed 失效提供是否显示奇数或偶数场的指示的图像处理装置
公开(公告)号：US5479604A
公开(公告)日：1995-12-26
申请号：US112334
申请日：1993-08-27
申请人： Kazuo Tsubota
发明人： Kazuo Tsubota
IPC分类号： G09G1/16 , G09G5/00 , G09G5/06 , G09G5/12 , G09G5/18 , G09G5/36 , H04N5/765 , H04N9/82 , G06F15/00
CPC分类号： G09G5/363 , G09G5/06 , H04N5/765 , H04N9/8216 , H04N9/8233 , G09G1/16 , G09G2310/0224
摘要： An ODD/EVEN signal, showing whether odd fields or even fields of the image are displayed on a screen, is supplied to each unit operating for data transmission. In accordance with the ODD/EVEN signal, a CPU monitors a current condition of the display image so that data transmission and processing, and use of a data bus, are controlled with exact timing. Consequently, each unit in the apparatus may operate effectively.
摘要翻译： 一个ODD / EVEN信号，显示图像的奇数场或偶数场是否显示在屏幕上，被提供给操作数据传输的每个单元。 根据ODD / EVEN信号，CPU监视显示图像的当前状态，使得数据传输和处理以及数据总线的使用以精确的时序被控制。 因此，设备中的每个单元可以有效地操作。
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公开(公告)号：US20100113338A1
公开(公告)日：2010-05-06
申请号：US11993580
申请日：2006-06-21
CPC分类号： A61K38/1761 , A61K9/0048
摘要： Disclosed is a novel composition for the treatment of a corneal/conjunctival disease. A prophylactic or therapeutic agent for a corneal/conjunctival disease comprising selenoprotein P as an active ingredient, more specifically a prophylactic or therapeutic agent for a corneal/conjunctival disease such as dry eye, keratoconjunctivitis sicca, superficial punctate keratopathy, corneal erosion or corneal ulcer comprising selenoprotein P as an active ingredient, particularly a prophylactic or therapeutic agent for a corneal/conjuncrtival disease such as dry eye, keratoconjunctivitis sicca, superficial punctate keratopathy, corneal erosion or corneal ulcer accompanied by a corneal/conjunctival epithelial discorder.
摘要翻译： 公开了用于治疗角膜/结膜疾病的新型组合物。 一种用于角膜/结膜疾病的预防或治疗剂，其包含硒蛋白P作为活性成分，更具体地，涉及用于角膜/结膜疾病如干眼症，圆锥形结膜炎丝氨酸，浅表性点状角膜病，角膜侵蚀或角膜溃疡的预防或治疗剂，其包括 硒蛋白P作为活性成分，特别是用于角膜/结膜性疾病例如干眼症，透角圆锥形结膜炎，浅表性点状角膜病变，伴随角膜/结膜上皮发生器的角膜侵蚀或角膜溃疡的预防或治疗剂。
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公开(公告)号：US6159930A
公开(公告)日：2000-12-12
申请号：US450008
申请日：1999-11-29
申请人： Kazuo Tsubota
发明人： Kazuo Tsubota
CPC分类号： A61K38/38 , Y10S514/912
摘要： The present invention provides a pharmaceutical composition for treatment of corneal and conjunctival lesion, and dry eye comprising albumin as an active ingredient. The pharmaceutical composition is also useful for increase of eye surface epithelium mucin secretion. The present invention further provides a method for treatment of corneal and conjunctival lesion and dry eye, which comprises administering, to a subject in need of such treatment, albumin in an amount effective. In addition, the present invention provides a use of albumin for manufacture of a pharmaceutical composition of the present invention.
摘要翻译： 本发明提供了用于治疗角膜和结膜病变的药物组合物，以及包含白蛋白作为活性成分的干眼症。 该药物组合物也可用于增加眼表上皮粘蛋白分泌。 本发明还提供了一种治疗角膜和结膜病变和干眼症的方法，其包括向需要这种治疗的受试者施用有效量的白蛋白。 另外，本发明提供白蛋白用于制造本发明的药物组合物的用途。
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