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公开(公告)号：US09994814B2
公开(公告)日：2018-06-12
申请号：US14889942
申请日：2014-04-09
发明人： Vincent C. Giampapa
IPC分类号： C12N5/00 , C12N5/074 , A61K45/06 , A61K35/545 , A61K35/28
CPC分类号： C12N5/0607 , A61K35/28 , A61K35/545 , A61K45/06 , C12N2502/03 , A61K2300/00
摘要： A method comprising obtaining a donor composition from a donor subject wherein the donor composition comprises a plurality of adult stem cell types; obtaining a receiver composition from a receiver subject wherein the receiver composition comprises a plurality of adult stem cell types; and co-culturing the donor composition and receiver composition wherein co-culturing comprises contacting the receiver composition a cell-free portion of the donor composition to produce a restored composition. Pharmaceutical compositions comprising a restored composition.
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2.发明申请公开(公告)号：US20180085405A1
公开(公告)日：2018-03-29
申请号：US15717810
申请日：2017-09-27
发明人： Thomas Ichim , Amit Patel , Santosh Kesari
IPC分类号： A61K35/50
CPC分类号： A61K35/50 , A61K35/545 , C12N2502/03
摘要： Disclosed are compositions of matter useful for treatment of stroke derived from amniotic fluid stem cell produced factors. In one embodiment the invention teaches the use of products derived from amniotic fluid stem cells cultured under basal conditions. In another embodiment the invention teaches the utilization of amniotic stem cell derived products from said amniotic stem cells cultured under conditions of stress. Said amniotic stem cell derived products include small molecules, proteins, peptides, conditioned media, microvesicles, including exosomes and apoptotic bodies. In one embodiment, the invention teaches administration of amniotic fluid stem cells that have been exposed to a stress condition.
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公开(公告)号：US20170035812A1
公开(公告)日：2017-02-09
申请号：US15289362
申请日：2016-10-10
CPC分类号： A61K35/50 , A61K38/19 , C12N5/0605 , C12N2501/11 , C12N2501/998 , C12N2502/025 , C12N2502/03 , A61K2300/00
摘要： The invention is directed to a novel cell-derived composition having bone growth, regeneration, and repair promoting properties. In particular, the invention is directed to a novel cell-derived composition having bone growth, regeneration, and repair promoting properties termed Amnion-derived Cellular Cytokine Solution-B (ACCS-B). The invention is further directed to the use of this novel composition to promote bone growth and/or regeneration and/or repair.
摘要翻译： 本发明涉及具有骨生长，再生和修复促进特性的新型细胞衍生组合物。 特别地，本发明涉及一种具有骨生长，再生和修复促进性质的新型细胞衍生组合物，称为羊膜衍生的细胞因子溶液-B（ACCS-B）。 本发明还涉及这种新型组合物用于促进骨生长和/或再生和/或修复的用途。
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公开(公告)号：US20140134137A1
公开(公告)日：2014-05-15
申请号：US14070075
申请日：2013-11-01
申请人： Wouter Van't Hof
发明人： Wouter Van't Hof
IPC分类号： C12N5/078
CPC分类号： C12N5/0634 , A61K35/545 , C12N5/0607 , C12N2502/03 , C12N2502/11 , G01N33/5073
摘要： The invention is generally directed to reducing inflammation by means of cells that secrete factors that reduce leukocyte extravasation. Specifically, the invention is directed to methods using cells that secrete factors that downregulate the expression of cellular adhesion molecules in leukocytes. Downregulating expression of cellular adhesion molecules reduces leukocyte adhesion to endothelial cells such that extravasation is reduced. The end result is a reduction of inflammation. The cells are non-embryonic non-germ cells that have pluripotent characteristics. These may include expression of pluripotential markers and broad differentiation potential.
摘要翻译： 本发明一般涉及通过分泌能减少白血球外渗的因子的细胞减少炎症。 具体地，本发明涉及使用分泌下调白细胞中细胞粘附分子表达的因子的细胞的方法。 细胞粘附分子的下调表达降低白细胞对内皮细胞的粘附，从而降低外渗。 最终的结果是减少炎症。 细胞是具有多能特征的非胚胎非生殖细胞。 这些可能包括多能标记物的表达和广泛的分化潜能。
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公开(公告)号：US20170327794A1
公开(公告)日：2017-11-16
申请号：US15442991
申请日：2017-02-27
申请人： InCube Labs, LLC
发明人： Mir Imran
CPC分类号： A61K35/38 , A61K35/28 , C12N5/0679 , C12N2502/025 , C12N2502/03 , C12N2502/1352 , C12N2502/1358 , C12N2502/23 , C12N2506/1346 , C12N2506/03
摘要： Various embodiments of the invention provide methods of treating diabetes and other glucose regulation disorders. In one embodiment, the method comprises removing L-cells from a donor, obtaining stem cells from a patient, and culturing the L-cells in the presence of the stem cells under conditions such that the stem cells differentiate into stem cell-derived L-cells (SCDLC). An amount of the SCDLC is introduced into the patient sufficient to cause a lowering of the patient's blood glucose level after ingestion of food. In another embodiment, the method comprises removing K-cells from a donor, obtaining stem cells from a patient, and culturing the K-cells in the presence of the stem cells under conditions such that the stem cells differentiate into stem cell-derived K-cells (SCDKC). An amount of the SCDKC is introduced into the patient sufficient to cause a lowering of the patient's blood glucose level after ingestion of food.
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公开(公告)号：US09464272B2
公开(公告)日：2016-10-11
申请号：US14567457
申请日：2014-12-11
申请人： Stemnion, Inc.
CPC分类号： A61K35/50 , A61K38/19 , C12N5/0605 , C12N2501/11 , C12N2501/998 , C12N2502/025 , C12N2502/03 , A61K2300/00
摘要： The invention is directed to a cell-derived composition having bone growth, regeneration, and repair promoting properties. In particular, the invention is directed to a cell-derived composition having bone growth, regeneration, and repair promoting properties termed Amnion-derived Cellular Cytokine Solution-B (ACCS-B). The invention is further directed to the use of this composition to promote bone growth and/or regeneration and/or repair.
摘要翻译： 本发明涉及具有骨生长，再生和修复促进特性的细胞衍生组合物。 特别地，本发明涉及一种具有称为淀粉衍生的细胞因子溶液-B（ACCS-B）的骨生长，再生和修复促进特性的细胞衍生组合物。 本发明进一步涉及这种组合物用于促进骨生长和/或再生和/或修复的用途。
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7.发明申请公开(公告)号：US20160145571A1
公开(公告)日：2016-05-26
申请号：US14889942
申请日：2014-04-09
发明人： Vincent C. Giampapa
IPC分类号： C12N5/074 , A61K35/545
CPC分类号： C12N5/0607 , A61K35/28 , A61K35/545 , A61K45/06 , C12N2502/03 , A61K2300/00
摘要： A method comprising obtaining a donor composition from a donor subject wherein the donor composition comprises a plurality of adult stem cell types; obtaining a receiver composition from a receiver subject wherein the receiver composition comprises a plurality of adult stem cell types; and co-culturing the donor composition and receiver composition wherein co-culturing comprises contacting the receiver composition a cell-free portion of the donor composition to produce a restored composition. Pharmaceutical compositions comprising a restored composition.
摘要翻译： 一种方法，包括从供体受试者获得供体组合物，其中所述供体组合物包含多种成体干细胞类型; 从接收者对象获得接收器组合物，其中所述接收器组合物包括多个成体干细胞类型; 以及共培养供体组合物和接受组合物，其中共培养包括使接受组合物接触供体组合物的无细胞部分以产生恢复的组合物。 包含还原组合物的药物组合物。
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公开(公告)号：US20150166951A1
公开(公告)日：2015-06-18
申请号：US14567457
申请日：2014-12-11
申请人： Stemnion, Inc.
CPC分类号： A61K35/50 , A61K38/19 , C12N5/0605 , C12N2501/11 , C12N2501/998 , C12N2502/025 , C12N2502/03 , A61K2300/00
摘要： The invention is directed to a novel cell-derived composition having bone growth, regeneration, and repair promoting properties. In particular, the invention is directed to a novel cell-derived composition having bone growth, regeneration, and repair promoting properties termed Amnion-derived Cellular Cytokine Solution-B (ACCS-B). The invention is further directed to the use of this novel composition to promote bone growth and/or regeneration and/or repair.
摘要翻译： 本发明涉及具有骨生长，再生和修复促进特性的新型细胞衍生组合物。 特别地，本发明涉及一种具有骨生长，再生和修复促进性质的新型细胞衍生组合物，称为羊膜衍生的细胞因子溶液-B（ACCS-B）。 本发明还涉及这种新型组合物用于促进骨生长和/或再生和/或修复的用途。
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公开(公告)号：US20090047738A1
公开(公告)日：2009-02-19
申请号：US12162905
申请日：2007-01-17
CPC分类号： A61K35/28 , A61K35/12 , A61K35/36 , A61K35/44 , C12N5/0621 , C12N5/0623 , C12N5/0656 , C12N2500/25 , C12N2501/11 , C12N2501/39 , C12N2501/81 , C12N2502/03 , C12N2502/08 , C12N2506/08 , C12N2509/00 , C12N2533/56
摘要： It is an object of the present invention to provide a feeder cell with less variation in quality. The present invention relates to a feeder cell derived from a tissue stem and/or progenitor cell. A method of preparation of the feeder cell, a method of preparation of a cultured cell using the feeder cell, and a cell culturing kit are also provided.
摘要翻译： 本发明的目的是提供一种质量变化较小的饲养池。 本发明涉及源于组织干和/或祖细胞的饲养细胞。 还提供了饲养细胞的制备方法，使用饲养细胞的培养细胞的制备方法和细胞培养试剂盒。
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10.发明申请公开(公告)号：US20170260505A1
公开(公告)日：2017-09-14
申请号：US15454876
申请日：2017-03-09
发明人： Hui-Kang MA , Shih-Chieh MA
IPC分类号： C12N5/071
CPC分类号： C12N5/0632 , C12N2500/84 , C12N2500/90 , C12N2501/11 , C12N2501/33 , C12N2501/999 , C12N2502/03 , C12N2509/00
摘要： A method for the ex vivo cultivation of oral mucosal epithelial progenitor cells and oral mucosal epithelial cells includes: subjecting an oral mucosal tissue to an enzymatic digestion treatment with collagenase, so as to obtain cell aggregates which include oral mucosal epithelial progenitor cells and oral mucosal epithelial cells; cultivating the cell aggregates with an amniotic membrane in a serum-free platelet lysate-containing medium in the absence of feeder cells, so that the cell aggregates are adhered onto the amniotic membrane; and subsequently cultivating the cell aggregates adhered on the amniotic membrane in a serum-free proliferation-facilitating medium in the absence of feeder cells.
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