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26 条记录 (耗时 0.025 秒)

    NONWOVEN FABRIC AND PROCESS FOR PRODUCING THE SAME
    12.
    发明申请
    NONWOVEN FABRIC AND PROCESS FOR PRODUCING THE SAME 失效
    非织造织物及其制造方法

    公开(公告)号：US20080272520A1

    公开(公告)日：2008-11-06

    申请号：US12168720

    申请日：2008-07-07

    申请人： Shinya Komura ,  Takanori Miyoshi ,  Yoshihiko Sumi ,  Hiroyoshi Minematsu

    发明人： Shinya Komura ,  Takanori Miyoshi ,  Yoshihiko Sumi ,  Hiroyoshi Minematsu

    IPC分类号： B29C47/00

    CPC分类号： D04H3/02 ,  D01D5/0038 ,  D01D5/247 ,  D01D5/253 ,  D01F1/08 ,  D01F6/625 ,  D04H1/4382 ,  D04H1/4391 ,  Y10T442/608 ,  Y10T442/614

    摘要： A process for production of a nonwoven fabric, which comprises a step wherein a thermoplastic polymer is dissolved in a mixed solvent composed of a volatile good solvent and a volatile poor solvent, a step wherein the resulting solution is spun by an electrospinning method and a step wherein a nonwoven fabric accumulated on a collecting sheet is obtained, is employed to provide a nonwoven fabric having a surface area sufficiently large as a matrix for cell culturing in the field of regenerative medicine, with large gaps between filaments and a low apparent density suitable for cell culturing.

    摘要翻译： 一种无纺布的制造方法，其特征在于，包括将热塑性聚合物溶解在由挥发性良溶剂和挥发性不良溶剂组成的混合溶剂中的工序，其中所得溶液通过静电纺丝法和步骤 其中收集在收集片上的无纺织物用于提供表面积足够大的无纺织物作为再生医学领域的细胞培养基质，细丝间隙大，表观密度低 细胞培养。

    Pharmaceutical composition having inhibitory effect on overproduction and accumulation of extracellular matrix
    16.
    发明申请
    Pharmaceutical composition having inhibitory effect on overproduction and accumulation of extracellular matrix 审中-公开
    对细胞外基质过量产生和积累具有抑制作用的药物组合物

    公开(公告)号：US20050032675A1

    公开(公告)日：2005-02-10

    申请号：US10928407

    申请日：2004-08-30

    申请人： Satoshi Sasaki ,  Yoshihiko Sumi ,  Reginald Hughes

    发明人： Satoshi Sasaki ,  Yoshihiko Sumi ,  Reginald Hughes

    IPC分类号： A61K31/739 ,  A61K38/17 ,  A61K38/39 ,  A61K38/40 ,  A61K38/16

    CPC分类号： A61K31/739 ,  A61K38/1741

    摘要： A pharmaceutical composition having an inhibitory effect on the overproduction and the accumulation of extracellular matrix, said composition comprising as an active ingredient a compound that inhibits the biological activity of galectin-3, which pharmaceutical composition can serve as a therapeutic or preventive agent for glomerular nephritis, diabetic nephropathy or tissue fibrosis, as well as the use of said compound for the production of pharmaceuticals for the above-mentioned use, and a method for inhibition of the overproduction and accumulation of the extracellular matrix.

    摘要翻译： 一种药物组合物，其对细胞外基质的过度产生和积累具有抑制作用，所述组合物包含抑制半乳凝素-3生物活性的化合物作为活性成分，该组合物可用作肾小球性肾炎的治疗或预防剂 ，糖尿病性肾病或组织纤维化，以及所述化合物用于制备上述用途的药物的用途，以及抑制细胞外基质过量产生和积累的方法。

    Pharmaceutical Composition Having Inhibitory Effect on Overproduction and Accumulation of Extracellular Matrix
    18.
    发明申请
    Pharmaceutical Composition Having Inhibitory Effect on Overproduction and Accumulation of Extracellular Matrix 审中-公开
    对细胞外基质过量产生和积累具有抑制作用的药物组合物

    公开(公告)号：US20080219973A1

    公开(公告)日：2008-09-11

    申请号：US12123265

    申请日：2008-05-19

    申请人： Satoshi Sasaki ,  Yoshihiko Sumi ,  Reginald Colin Hughes

    发明人： Satoshi Sasaki ,  Yoshihiko Sumi ,  Reginald Colin Hughes

    IPC分类号： A61K39/395 ,  A61P43/00 ,  A61P3/00

    CPC分类号： A61K31/739 ,  A61K38/1741

    摘要： A pharmaceutical composition having an inhibitory effect on the overproduction and the accumulation of extracellular matrix, said composition comprising as an active ingredient a compound that inhibits the biological activity of galectin-3, which pharmaceutical composition can serve as a therapeutic or preventive agent for glomerular nephritis, diabetic nephropathy or tissue fibrosis, as well as the use of said compound for the production of pharmaceuticals for the above-mentioned use, and a method for inhibition of the overproduction and accumulation of the extracellular matrix.

    摘要翻译： 一种药物组合物，其对细胞外基质的过度产生和积累具有抑制作用，所述组合物包含抑制半乳凝素-3生物活性的化合物作为活性成分，该组合物可用作肾小球性肾炎的治疗或预防剂 ，糖尿病性肾病或组织纤维化，以及所述化合物用于制备上述用途的药物的用途，以及抑制细胞外基质过量产生和积累的方法。

    Chemical compounds containing a superoxide scavenger and an organic nitrate or nitrite moiety
    19.
    发明申请
    Chemical compounds containing a superoxide scavenger and an organic nitrate or nitrite moiety 审中-公开
    含有超氧化物清除剂和有机硝酸盐或亚硝酸盐部分的化合物

    公开(公告)号：US20050165094A1

    公开(公告)日：2005-07-28

    申请号：US09859463

    申请日：2001-05-18

    申请人： Zhi Zhang ,  Declan Naughton ,  Yoshihiko Sumi ,  Atsushi Imaizumi

    发明人： Zhi Zhang ,  Declan Naughton ,  Yoshihiko Sumi ,  Atsushi Imaizumi

    IPC分类号： A61K47/48 ,  A61P9/00 ,  A61K31/21 ,  C07C23/04

    CPC分类号： A61K47/52

    摘要： Compounds for use in the treatment of heart disease include a superoxide scavenger and an organic nitrate or nitrite moiety. The compounds can be represented by the formula (A)n(B)m, in which A is a superoxide scavenger, B is an organic nitrate or organic nitrite moiety, and n and m are values between 1 and 8. These compounds do not suffer from the problem of patient tolerance that is associated with the use of conventional agents such as organic nitrates.

    摘要翻译： 用于治疗心脏病的化合物包括超氧化物清除剂和有机硝酸盐或亚硝酸盐部分。 化合物可以由式（A）n（B）m表示，其中A是超氧化物清除剂，B是有机硝酸盐或有机亚硝酸盐部分，n和m是1和8之间的值。这些化合物不 患有与使用常规药剂如有机硝酸盐有关的患者耐受性的问题。

    cDNA and genomic DNA encoding the amino acid sequence of human .alpha..sub.2 -plasmin inhibition
    20.
    发明授权
    cDNA and genomic DNA encoding the amino acid sequence of human .alpha..sub.2 -plasmin inhibition 失效
    编码人α2-纤溶酶抑制的氨基酸序列的cDNA和基因组DNA

    公开(公告)号：US5221738A

    公开(公告)日：1993-06-22

    申请号：US803896

    申请日：1991-12-09

    申请人： Yoshihiko Sumi ,  Yataro Ichikawa ,  Masami Murakami ,  Nobuo Aoki

    发明人： Yoshihiko Sumi ,  Yataro Ichikawa ,  Masami Murakami ,  Nobuo Aoki

    IPC分类号： C07K14/81 ,  C12N15/55

    CPC分类号： C07K14/8121

    摘要： cDNA encoding a human .alpha..sub.2 -plasmin inhibitor precursor protein represented by an amino acid sequence from the -39th Met to the 452nd Lys in FIG. 1 of the accompanying drawings; an amino acid sequence of a human .alpha..sub.2 -plasmin inhibitor precursor represented by an amino acid sequence from the -39th Met to the 452nd Lys in FIG. 1 of the accompanying drawings; and genomic DNA encoding a human .alpha..sub.2 -plasmin inhibitor protein which is composed of exons II, III, IV, V, VI, VII, VIII, IX and X in FIG. 4 of the accompanying drawings, said exons being bonded to one another via introns.

    摘要翻译： 编码人α2-纤溶酶原抑制物前体蛋白的cDNA，由图3中的第39位Met至第452位Lys的氨基酸序列表示。 附图1; 由图3中的第39位Met至第452位Lys的氨基酸序列表示的人α2-纤溶酶抑制剂前体的氨基酸序列。 附图1; 以及编码图2中由外显子II，III，IV，V，VI，VII，VIII，IX和X组成的人α2-纤溶酶抑制蛋白的基因组DNA。 附图4中，所述外显子通过内含子彼此结合。