公开(公告)号：US09205111B2

公开(公告)日：2015-12-08

申请号：US10583860

申请日：2004-12-22

申请人： Takashi Nishimura ,  Masaki Yasukawa

发明人： Takashi Nishimura ,  Masaki Yasukawa

IPC分类号： C12N5/00 ,  C12N5/08 ,  C12N15/63 ,  C07H21/04 ,  A01N63/00 ,  A61K39/395 ,  A61K48/00 ,  A61K35/26 ,  A61K39/00 ,  C12N5/0783 ,  C12N15/85 ,  C12N5/16

CPC分类号： A61K35/26 ,  A61K39/0011 ,  A61K39/395 ,  A61K2039/5156 ,  C07H21/04 ,  C12N5/0636 ,  C12N5/16 ,  C12N15/63 ,  C12N15/85

摘要： A novel process for preparing tumor-specific T cells is disclosed. According to the invention, antitumor-active, tumor-specific T cells are prepared by transducing a TCR gene from a tumor-specific CTL into antitumor-active T cells that have been nonspecifically activated, thus enabling tumor-specific cellular immunotherapy to be carried out from even small amounts of blood. MHC class I-restricted, tumor-specific Th cells are obtained by the method, allowing for the production of cells that react with tumor cells expressing an MHC class I molecule and show a helper activity and an antitumor activity.

摘要翻译： 公开了一种制备肿瘤特异性T细胞的新方法。 根据本发明，通过将来自肿瘤特异性CTL的TCR基因转导至非特异性激活的抗肿瘤活性T细胞来制备抗肿瘤活性的肿瘤特异性T细胞，从而能够进行肿瘤特异性细胞免疫治疗 从少量的血液。 通过该方法获得MHC I类限制性肿瘤特异性Th细胞，允许产生与表达MHC I类分子的肿瘤细胞反应并显示辅助活性和抗肿瘤活性的细胞。

公开(公告)号：US20130202588A1

公开(公告)日：2013-08-08

申请号：US13700355

申请日：2011-05-27

申请人： Takashi Nishimura

发明人： Takashi Nishimura

IPC分类号： A61K39/395 ,  A61K31/7068

CPC分类号： A61K39/3955 ,  A61K31/7068 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2815 ,  C07K16/2866 ,  A61K2300/00

摘要： An objective of the present invention is to provide novel therapeutic agents for cancer, which have an excellent antitumor effect in cancer patients by enhancing their immune function. The present inventors discovered that the administration of at IL-6 inhibitor and/or gemcitabine or a salt thereof to tumor-bearing organisms yields an excellent antitumor T cell response-enhancing effect, and completed the present invention. In addition, the present inventors discovered that the T cell response-enhancing effect produces an excellent antitumor effect.

摘要翻译： 本发明的目的是提供新的癌症治疗剂，其通过增强其免疫功能在癌症患者中具有优异的抗肿瘤作用。 本发明人发现IL-6抑制剂和/或吉西他滨或其盐对荷瘤生物的产生产生优异的抗肿瘤T细胞应答增强作用，并完成了本发明。 此外，本发明人发现，T细胞应答增强效果产生优异的抗肿瘤效果。

公开(公告)号：US20120100961A1

公开(公告)日：2012-04-26

申请号：US13321510

申请日：2010-05-17

申请人： Takashi Nishimura

发明人： Takashi Nishimura

IPC分类号： A63B21/005 ,  A63B21/062

CPC分类号： A63B21/062 ,  A63B21/0628 ,  A63B21/063 ,  A63B24/00

摘要： An electromechanical system for selecting weights in fitness station weight towers, wherein a vertical hollow rod, fixed to the cursor which fastens to the steel cable, which lifts the plates of unit weight, extends traversing central holes of these plates, traversing the upper wall of the base of the tower, which is hollow, this rod having a rotating shaft or screw that moves the weight selector upwards and downwards, mounted on the rod by bearings, and projecting below this bearing where it has at the end radial teeth that incase between protrusions existing in a circular low relief of a pulley, which is mounted on a bearing whose shaft is collinear to the rod and fixed to the lower face of the base, this pulley having a channel for a belt, driven by an electric motor fixed to the base.

摘要翻译： 一种用于在健身站重量塔中选择重量的机电系统，其中固定到光标上的垂直中空杆，其固定到钢缆上，该钢丝绳提升单元重量的板，延伸穿过这些板的中心孔，穿过上述 塔的底部是中空的，该杆具有通过轴承将重量选择器向上和向下移动的旋转轴或螺钉，并且在该轴承的下方突出，在该轴承处具有位于其之间的径向齿 存在于滑轮的圆形低浮雕中的突起，其安装在轴与杆共线并固定到基座的下表面的轴承上，该滑轮具有用于固定到 的基地。

公开(公告)号：US20120094809A1

公开(公告)日：2012-04-19

申请号：US13262138

申请日：2010-03-30

申请人： Takashi Nishimura

发明人： Takashi Nishimura

IPC分类号： A63B21/06

CPC分类号： A63B23/12 ,  A63B21/062 ,  A63B21/0628 ,  A63B21/063 ,  A63B21/4047 ,  A63B23/03525 ,  A63B23/0494 ,  A63B24/0087 ,  A63B2225/107

摘要： A floor of a gym's weight room is configured to encompass the installation of weight stations with weight towers controlled remotely from a control panel, with said weight station assembled atop a weight room floor. The floor of the gym, for each station-tower combination, includes two reinforced boxes embedded in the floor, each having an opening at floor level, wherein one box is located below the base of the weight station and one box is located in front of the respective weight tower, preferably positioned far from the station, the two boxes being connected by at least two parallel tubes located beneath the level of the gym's floor, and wherein the interior of each box is affixed with a cable pulley and bearing, each cable pulley being at a level so that the horizontal section of a steel cable runs toward a center of one of the tubes.

摘要翻译： 健身房的重量室的地板被配置为包括重量台的安装，其具有从控制面板远程控制的重量塔，所述重量站组装在重量室的地板上。 健身房的地板，对于每个站 - 塔组合，包括两个加强箱嵌入地板，每个在地面上具有开口，其中一个箱位于重量站的底部下方，一个箱位于 相应的重量塔，优选地位于远离工位的两个箱体通过位于健身房地板的水平面下方的至少两个平行管连接，并且其中每个箱体的内部固定有电缆滑轮和轴承，每个电缆 滑轮处于水平面，使钢缆的水平段朝向其中一个管的中心延伸。

公开(公告)号：US07938762B2

公开(公告)日：2011-05-10

申请号：US12304404

申请日：2006-11-10

申请人： Takashi Nishimura

发明人： Takashi Nishimura

IPC分类号： A63B21/008 ,  A63B21/005 ,  A63B21/062

CPC分类号： A63B21/0628 ,  A63B21/063 ,  A63B24/00

摘要： An automatic weight stack controller for fitness units adapted to a frame provided with weights piled up is disclosed, wherein the weights are provided with central vertical holes having inner circular grooves and a tube fit into said central holes, said tube being provided with radial holes disposed at the level of each weight wherein balls are housed, so that said balls can be pushed towards the grooves by a piston that slides vertically inside the tube, having conical ends and threaded on a vertical threaded bar centrally to the tube, where there is an eyelet for the steel cable designed to raise the weights, the selection of weights being carried out through a panel of instruments, with a digital display, and buttons to increase or decrease the number of weights.

摘要翻译： 公开了一种用于健身器具的自动重量堆叠控制器，其适用于装有堆重物的框架，其中重物设置有具有内圆形凹槽的中心垂直孔和配合到所述中心孔中的管，所述管设置有径向孔， 在其中容纳球的每个重量的水平面上，使得所述球可以通过在管内垂直滑动的活塞而被推向凹槽，该活塞具有锥形端并且在垂直螺纹杆上螺纹连接到管的中心，其中存在 设计用于提高重量的钢丝绳的孔眼，通过一组仪器进行的重量选择，具有数字显示器，以及用于增加或减少重量的按钮。

公开(公告)号：US20110095100A1

公开(公告)日：2011-04-28

申请号：US12996353

申请日：2008-10-20

申请人： Takashi Nishimura

发明人： Takashi Nishimura

IPC分类号： F23D14/28

CPC分类号： B05B7/2472 ,  A01C23/047 ,  B05B7/2416 ,  B05B7/2467 ,  B05B7/2475 ,  B05B7/2481 ,  B05B7/32 ,  B05B9/0877

摘要： Safe handling spraying device, which comprises a reservoir where is assembled an actuating lever or, manually or automatically actuating air pumps, that perform the internal reservoir pressurization. Inside of it, there is a pressure chamber where is stored water and the Chemical Concentrated product that is inside a pliable tightly closed bag. The reservoir (10) is designed for supplying water (Ag), the chemical concentrated product (CCP) is stored separately in a pliable container (12). The pliable container (12) is disposed inside of a pressure chamber or water reservoir (10), so that the same pressure defined inside the reservoir (10) is applied to the pliable container (12) simultaneously. The output end of the pliable container (12) is connected to the inlet of a mixing device (20) which doses the CCP continuously. After the CCP had been mixed with water, it communicates with a hose provided with an actuating trigger (30) and spraying nozzle (27) at the free end.

摘要翻译： 安全处理喷涂装置，其包括储存器，其中组装有执行内部储存器加压的致动杆或手动或自动致动空气泵。 在它的内部，有一个压力室，储存的水和化学浓缩产品在一个柔软的密闭袋子里面。 蓄水池（10）设计用于供水（Ag），化学浓缩产品（CCP）分别存储在柔性容器（12）中。 柔性容器（12）设置在压力室或储水器（10）的内部，使得限定在储存器（10）内的相同压力同时施加到柔性容器（12）。 柔性容器（12）的输出端连接到连续对CCP施加剂量的混合装置（20）的入口。 在CCP与水混合之后，它与一个带有致动触发器（30）的软管和自由端的喷嘴（27）连通。

公开(公告)号：US07534517B2

公开(公告)日：2009-05-19

申请号：US10973401

申请日：2004-10-27

申请人： Osamu Hiroi ,  Hisatoshi Fukumoto ,  Shoji Yoshioka ,  Hideo Maeda ,  Hiroaki Urushibata ,  Hironori Kuriki ,  Takashi Nishimura

发明人： Osamu Hiroi ,  Hisatoshi Fukumoto ,  Shoji Yoshioka ,  Hideo Maeda ,  Hiroaki Urushibata ,  Hironori Kuriki ,  Takashi Nishimura

IPC分类号： H01M2/08

CPC分类号： H01M8/0273 ,  H01M8/0258 ,  H01M8/0267 ,  H01M8/0271 ,  H01M8/1007 ,  H01M2008/1095 ,  Y02P70/56

摘要： A fuel cell includes a solid polymer electrolyte membrane and cathode and anode catalyst layers held between a fuel electrode substrate having a surface area larger than that of the cathode catalyst layer and an oxidizer electrode substrate having a surface area larger than that of the anode catalyst layer. The fuel electrode substrate includes a fuel-sealing support portion surrounding the cathode catalyst layer. The oxidizer electrode substrate includes an oxidizer-sealing support portion surrounding the anode catalyst layer. The fuel-sealing and oxidizer-sealing support portions each include pores partially or wholly filled with a resin. The fuel-sealing support portion is bonded to the membrane by the resin at a position closer to an outer edge of the membrane than is the cathode catalyst. The oxidizer-sealing support portion is bonded to the membrane by the resin at a position closer to the outer edge of the membrane than is the anode catalyst.

摘要翻译： 燃料电池包括固体聚合物电解质膜和保持在具有比阴极催化剂层的表面积大的表面积的燃料电极基板之间的阴极和阳极催化剂层以及表面积大于阳极催化剂层的表面积的氧化剂电极基板 。 燃料电极基板包括围绕阴极催化剂层的燃料密封支撑部。 氧化剂电极基板包括围绕阳极催化剂层的氧化剂密封支撑部。 燃料密封和氧化剂密封支撑部分各自包括部分或全部填充有树脂的孔。 燃料密封支撑部分通过树脂在比阴极催化剂更靠近膜外边缘的位置处与膜结合。 氧化剂密封支撑部分通过树脂在比阳极催化剂更靠近膜外边缘的位置处与膜结合。

公开(公告)号：US07489018B2

公开(公告)日：2009-02-10

申请号：US11405672

申请日：2006-04-18

申请人： Mitsuhiko Kitagawa ,  Takashi Nishimura ,  Yusuke Kawaguchi ,  Syotaro Ono

发明人： Mitsuhiko Kitagawa ,  Takashi Nishimura ,  Yusuke Kawaguchi ,  Syotaro Ono

IPC分类号： H01L27/082 ,  H01L27/102 ,  H01L29/70 ,  H01L31/11

CPC分类号： H01L29/7813 ,  H01L29/0634 ,  H01L29/0696 ,  H01L29/4933 ,  H01L29/7397 ,  H01L29/7824 ,  H01L29/7831 ,  H01L29/78603 ,  H01L29/78624

摘要： A transistor comprises: an insulating layer; a semiconductor layer provided on a major surface of the insulating layer; a gate insulating layer provided on the base region; and a gate electrode provided on the gate insulating layer. The semiconductor layer has a source portion having a plurality of source regions of a first conductivity type and a plurality of base contact regions of a second conductivity type, the source regions being alternated with the base contact regions, a drain portion of the first conductivity type, and a base region of the second conductivity type provided between the source portion and the drain portion, the base region being in contact with the source regions and the base contact regions. A junction between the source regions and the base region is closer to the drain portion side than a junction between the base contact regions and the base region.

摘要翻译： 晶体管包括：绝缘层; 设置在所述绝缘层的主表面上的半导体层; 设置在所述基底区域上的栅极绝缘层; 以及设置在栅极绝缘层上的栅电极。 半导体层具有源极部分，具有多个第一导电类型的源极区域和多个第二导电类型的基极接触区域，源极区域与基极接触区域交替，第一导电类型的漏极部分 以及设置在源极部分和漏极部分之间的第二导电类型的基极区域，基极区域与源极区域和基极接触区域接触。 源极区域和基极区域之间的接合部比基极接触区域和基极区域之间的接合部更靠近漏极部分侧。

公开(公告)号：US07279846B2

公开(公告)日：2007-10-09

申请号：US11205050

申请日：2005-08-17

申请人： Ihachiro Gofuku ,  Masaru Kamio ,  Hisanori Tsuda ,  Yasue Sato ,  Yoshiyuki Shimada ,  Hiromasa Mitani ,  Kazuyuki Seino ,  Takashi Nishimura

发明人： Ihachiro Gofuku ,  Masaru Kamio ,  Hisanori Tsuda ,  Yasue Sato ,  Yoshiyuki Shimada ,  Hiromasa Mitani ,  Kazuyuki Seino ,  Takashi Nishimura

IPC分类号： H01J7/24 ,  G09G3/22

CPC分类号： H01J41/12 ,  H01J7/14 ,  H01J29/94

摘要： Provided is an image display apparatus including: a vacuum container having an electron source enclosed therein for displaying an image; an ion pump communicating with the vacuum container for discharging air therefrom and decreasing pressure therein; and a resistor connected in series with the ion pump with respect to a power supply for driving the ion pump. Even if internal resistance of the ion pump undergoes order-of-magnitude changes according to its operating state, current consumption can be suppressed and the ion pump can be driven efficiently.

摘要翻译： 本发明提供一种图像显示装置，包括：真空容器，其内装有用于显示图像的电子源; 离子泵与真空容器连通，用于从其中排出空气并减小其中的压力; 以及与离子泵相对于用于驱动离子泵的电源串联连接的电阻器。 即使离子泵的内部电阻根据其运行状态而发生数量级的变化，也可以抑制电流消耗，能够有效地驱动离子泵。

公开(公告)号：US07221085B2

公开(公告)日：2007-05-22

申请号：US11403863

申请日：2006-04-14

申请人： Hirotaka Murata ,  Hiroaki Ibuki ,  Takashi Nishimura

发明人： Hirotaka Murata ,  Hiroaki Ibuki ,  Takashi Nishimura

IPC分类号： H01J1/62 ,  H01J1/304

CPC分类号： H01J31/123 ,  H01J29/085 ,  H01J29/94

摘要： A front substrate of an image display device has a phosphor screen and a metal back layer superposed on the phosphor screen. A plurality of electron emitting elements which emit electrons toward the phosphor screen are located on a rear substrate opposed to the front substrate. The metal back layer has a region which corresponds to the phosphor screen and is divided by gaps g1 in a first direction and gaps g2 in a second direction perpendicular to the first direction such that there are relations g1

摘要翻译： 图像显示装置的前基板具有叠层在荧光屏上的荧光屏和金属背层。 向荧光屏发射电子的多个电子发射元件位于与前基板相对的后基板上。 金属背层具有对应于荧光屏的区域，并且在与第一方向垂直的第二方向上以间隙g 1在第一方向上分开间隙g 2，使得存在关系g 1