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公开(公告)号：US08580797B2
公开(公告)日：2013-11-12
申请号：US12768777
申请日：2010-04-28
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
IPC分类号： A61K31/497 , C07D413/14
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
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公开(公告)号：US20100280045A1
公开(公告)日：2010-11-04
申请号：US12768777
申请日：2010-04-28
申请人： Julie Nicole HAMBLIN , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
发明人： Julie Nicole HAMBLIN , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
IPC分类号： A61K31/497 , C07D413/14 , A61P11/00 , A61P31/12 , A61P37/00 , A61P29/00 , A61P9/00 , A61P7/00 , A61P1/18 , A61P13/12 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular Pl3-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是激酶活性抑制剂，特别是PI3激酶活性。
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13.发明授权公开(公告)号：US09326987B2
公开(公告)日：2016-05-03
申请号：US13821594
申请日：2011-09-06
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
IPC分类号： A61K31/535 , A61K31/497 , A61K31/445 , A61K31/55 , A61K31/5377 , C07D413/14 , A61K31/416 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5386
CPC分类号： A61K31/5377 , A61K31/416 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5386 , C07D413/14
摘要： The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.
摘要翻译： 本发明涉及用于治疗或预防流感病毒感染的化合物。
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公开(公告)号：US08586583B2
公开(公告)日：2013-11-19
申请号：US13633348
申请日：2012-10-02
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
IPC分类号： A61K31/497 , A61K31/535 , C07D413/14
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): And salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是激酶活性的抑制剂，特别是PI3-激酶活性。
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公开(公告)号：US08575162B2
公开(公告)日：2013-11-05
申请号：US12768775
申请日：2010-04-28
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
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公开(公告)号：US08524751B2
公开(公告)日：2013-09-03
申请号：US13254034
申请日：2010-03-05
申请人： Julie Nicole Hamblin , Zoe Alicia Harrison , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Christopher James Lunniss , Nigel James Parr
发明人： Julie Nicole Hamblin , Zoe Alicia Harrison , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Christopher James Lunniss , Nigel James Parr
IPC分类号： A61K31/4245 , A61K31/416 , C07D271/10 , C07D231/56
CPC分类号： C07D413/14 , C07D487/04 , C07D487/08
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是激酶活性的抑制剂，特别是PI3-激酶活性。
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公开(公告)号：US20120046286A1
公开(公告)日：2012-02-23
申请号：US13266254
申请日：2010-04-28
申请人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
发明人： Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
IPC分类号： A61K31/5377 , A61K31/496 , A61P11/00 , A61P31/12 , A61P37/08 , A61P29/00 , A61P9/00 , A61P7/00 , A61P25/00 , A61P1/18 , A61P13/12 , A61P11/06 , A61P33/02 , A61P31/10 , A61P19/02 , A61P9/10 , A61P7/02 , A61P35/00 , A61P25/04 , C07D413/14
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): And salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是激酶活性的抑制剂，特别是PI3-激酶活性。
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公开(公告)号：US20100280029A1
公开(公告)日：2010-11-04
申请号：US12768775
申请日：2010-04-28
申请人： Julie Nicole HAMBLIN , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
发明人： Julie Nicole HAMBLIN , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr
IPC分类号： A61K31/5377 , C07D413/14 , A61P11/00 , A61P31/12 , A61P37/08 , A61P37/00 , A61P29/00 , A61P9/00 , A61P25/00 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是激酶活性的抑制剂，特别是PI3-激酶活性。
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公开(公告)号：US20090136448A1
公开(公告)日：2009-05-28
申请号：US12097840
申请日：2006-12-20
申请人： John Andrew Corfield , Richard Martin Grimes , David Harrison , Charles David Hartley , Peter David Howes , Joelle Le , Malcolm Lees Meeson , Jacqueline Elizabeth Mordaunt , Pritom Shah , Martin John Slater , Gemma Victoria White
发明人： John Andrew Corfield , Richard Martin Grimes , David Harrison , Charles David Hartley , Peter David Howes , Joelle Le , Malcolm Lees Meeson , Jacqueline Elizabeth Mordaunt , Pritom Shah , Martin John Slater , Gemma Victoria White
IPC分类号： A61K38/21 , C07D491/02 , A61K31/4355 , C07D487/02 , A61K31/519 , C07D471/02 , A61K31/437 , C07D513/02 , A61P31/12 , A61K31/7056 , A61K31/429 , C07D263/54 , A61K31/423 , A61K31/5025 , C07D209/04 , A61K31/404
CPC分类号： C07D409/10 , C07D333/70 , C07D413/10 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D513/04
摘要： Anti-viral agents of compounds of Formula (I): wherein A, R1, R2 and R3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
摘要翻译： 式（I）化合物的抗病毒剂：其中A，R1，R2和R3如说明书中所定义，提供其制备方法及其在HCV治疗中的用途。
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公开(公告)号：US08765743B2
公开(公告)日：2014-07-01
申请号：US12994253
申请日：2009-06-03
申请人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
发明人： Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Joelle Le , Christopher James Lunniss , Nigel James Parr , Timothy John Ritchie , Juliet Kay Simpson , Christian Alan Paul Smethurst
IPC分类号： A61K31/4439 , A61K31/5377 , A61K31/4545 , A61K31/496 , C07D401/14 , C07D413/14 , C07D405/14 , C07D471/04
CPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04
摘要： The invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
摘要翻译： 本发明涉及式（I）的化合物及其盐。 本发明的化合物是PI3-激酶活性的抑制剂。
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