公开(公告)号：US06809113B2

公开(公告)日：2004-10-26

申请号：US10087208

申请日：2002-02-27

申请人： Edgardo Laborde ,  Louise Robinson ,  Fanying Meng ,  Brian T. Peterson ,  Hugo O. Villar ,  Steven E. Anuskiewicz ,  Yoshiro Ishiwata ,  Shoji Yokochi ,  Yukiharu Matsumoto ,  Takuji Kakigami ,  Hideaki Inagaki ,  Takahito Jomori ,  Kouji Matsushima

发明人： Edgardo Laborde ,  Louise Robinson ,  Fanying Meng ,  Brian T. Peterson ,  Hugo O. Villar ,  Steven E. Anuskiewicz ,  Yoshiro Ishiwata ,  Shoji Yokochi ,  Yukiharu Matsumoto ,  Takuji Kakigami ,  Hideaki Inagaki ,  Takahito Jomori ,  Kouji Matsushima

IPC分类号： A61K3135

CPC分类号： C07D401/12 ,  C07D215/48 ,  C07D241/42 ,  C07D265/36 ,  C07D319/18 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12

摘要： Compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection; pharmaceutical compositions comprising these compounds; and the use of these compounds and compositions in the prevention or treatment of such diseases.

摘要翻译： 作为MCP-1拮抗剂的化合物起作用，可用于预防或治疗慢性或急性炎性或自身免疫性疾病，特别是与异常淋巴细胞或单核细胞积累相关的疾病如关节炎，哮喘，动脉粥样硬化，糖尿病性肾病，炎性肠病， 克罗恩病，多发性硬化，肾炎，胰腺炎，肺纤维化，牛皮癣，再狭窄和移植排斥反应; 包含这些化合物的药物组合物; 以及这些化合物和组合物在预防或治疗这些疾病中的用途。

公开(公告)号：US06998407B2

公开(公告)日：2006-02-14

申请号：US10716652

申请日：2003-11-18

申请人： Edgardo Laborde ,  Louise Robinson ,  Fanying Meng ,  Brian T. Peterson ,  Hugo O. Villar ,  Steven E. Anuskiewicz ,  Yoshiro Ishiwata ,  Shoji Yokochi ,  Yukiharu Matsumoto ,  Takuji Kakigami ,  Hideaki Inagaki ,  Takahito Jomori ,  Kouji Matsushima

发明人： Edgardo Laborde ,  Louise Robinson ,  Fanying Meng ,  Brian T. Peterson ,  Hugo O. Villar ,  Steven E. Anuskiewicz ,  Yoshiro Ishiwata ,  Shoji Yokochi ,  Yukiharu Matsumoto ,  Takuji Kakigami ,  Hideaki Inagaki ,  Takahito Jomori ,  Kouji Matsushima

IPC分类号： A61K31/36 ,  A61K31/343 ,  C07D307/79 ,  C07D317/60

CPC分类号： C07D235/06 ,  C07D209/08 ,  C07D249/18 ,  C07D263/56 ,  C07D307/79 ,  C07D317/68 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12

摘要： Chemical compounds which are antagonists of Monocyte Chemoattractant Protein-1 (MCP-1) function, pharmaceutical compositions comprising these compounds, methods of treatment employing these compounds and compositions, and processes for preparing these compounds. The compounds are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection.

摘要翻译： 作为单核细胞趋化蛋白-1（MCP-1）功能拮抗剂的化合物，包含这些化合物的药物组合物，使用这些化合物和组合物的治疗方法，以及制备这些化合物的方法。 该化合物可用于预防或治疗慢性或急性炎性或自身免疫疾病，特别是与异常淋巴细胞或单核细胞积累相关的疾病，如关节炎，哮喘，动脉粥样硬化，糖尿病性肾病，炎性肠病，克罗恩病，多发性硬化，肾炎， 胰腺炎，肺纤维化，牛皮癣，再狭窄和移植排斥。

公开(公告)号：US06992086B2

公开(公告)日：2006-01-31

申请号：US10716363

申请日：2003-11-17

申请人： Edgardo Laborde ,  Louise Robinson ,  Fanying Meng ,  Brian T. Peterson ,  Hugo O. Villar ,  Steven E. Anuskiewicz ,  Yoshiro Ishiwata ,  Shoji Yokochi ,  Yukiharu Matsumoto ,  Takuji Kakigami ,  Hideaki Inagaki ,  Takahito Jomori ,  Kouji Matsushima

发明人： Edgardo Laborde ,  Louise Robinson ,  Fanying Meng ,  Brian T. Peterson ,  Hugo O. Villar ,  Steven E. Anuskiewicz ,  Yoshiro Ishiwata ,  Shoji Yokochi ,  Yukiharu Matsumoto ,  Takuji Kakigami ,  Hideaki Inagaki ,  Takahito Jomori ,  Kouji Matsushima

IPC分类号： A61K31/496 ,  A61K31/437 ,  C07D498/04 ,  C07D471/04 ,  A61P37/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5513 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to chemical compounds, pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, methods of treatment employing said compounds and compositions, and processes for preparing said compounds. Specifically, this invention relates to novel compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection. More specifically, the invention is related to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases.

公开(公告)号：US06677365B2

公开(公告)日：2004-01-13

申请号：US10106881

申请日：2002-03-25

申请人： Edgardo Laborde ,  Louise Robinson ,  Fanying Meng ,  Brian T. Peterson ,  Hugo O. Villar ,  Steven E. Anuskiewicz ,  Yoshiro Ishiwata ,  Shoji Yokochi ,  Yukiharu Matsumoto ,  Takuji Kakigami ,  Hideaki Inagaki ,  Takahito Jomori ,  Kouji Matsushima

发明人： Edgardo Laborde ,  Louise Robinson ,  Fanying Meng ,  Brian T. Peterson ,  Hugo O. Villar ,  Steven E. Anuskiewicz ,  Yoshiro Ishiwata ,  Shoji Yokochi ,  Yukiharu Matsumoto ,  Takuji Kakigami ,  Hideaki Inagaki ,  Takahito Jomori ,  Kouji Matsushima

IPC分类号： A61K3142

CPC分类号： C07D235/06 ,  C07D209/08 ,  C07D249/18 ,  C07D263/56 ,  C07D307/79 ,  C07D317/68 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12

摘要： Chemical compounds which are antagonists of Monocyte Chemoattractant Protein-1 (MCP-1) function, pharmaceutical compositions comprising these compounds, methods of treatment employing these compounds and compositions, and processes for preparing these compounds. The compounds are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection.

公开(公告)号：US07297696B2

公开(公告)日：2007-11-20

申请号：US10969440

申请日：2004-10-19

申请人： Edgardo Laborde ,  Louise Robinson ,  Fanying Meng ,  Brian T. Peterson ,  Hugo O. Villar ,  Steven E. Anuskiewicz ,  Yoshiro Ishiwata ,  Shoji Yokochi ,  Yukiharu Matsumoto ,  Takuji Kakigami ,  Hideaki Inagaki ,  Takahito Jomori ,  Kouji Matsushima

发明人： Edgardo Laborde ,  Louise Robinson ,  Fanying Meng ,  Brian T. Peterson ,  Hugo O. Villar ,  Steven E. Anuskiewicz ,  Yoshiro Ishiwata ,  Shoji Yokochi ,  Yukiharu Matsumoto ,  Takuji Kakigami ,  Hideaki Inagaki ,  Takahito Jomori ,  Kouji Matsushima

IPC分类号： A61K31/498 ,  C07D241/36

CPC分类号： C07D401/12 ,  C07D215/48 ,  C07D241/42 ,  C07D265/36 ,  C07D319/18 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12

摘要： Compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephrtitis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection; pharmaceutical compositions comprising these compounds; and the use of these compounds and compositions in the prevention or treatment of such diseases.

摘要翻译： 作为MCP-1拮抗剂的化合物起作用，可用于预防或治疗慢性或急性炎性或自身免疫性疾病，特别是与异常淋巴细胞或单核细胞积累相关的疾病如关节炎，哮喘，动脉粥样硬化，糖尿病性肾病，炎性肠病， 克罗恩病，多发性硬化，肾炎，胰腺炎，肺纤维化，牛皮癣，再狭窄和移植排斥反应; 包含这些化合物的药物组合物; 以及这些化合物和组合物在预防或治疗这些疾病中的用途。

公开(公告)号：US20050054668A1

公开(公告)日：2005-03-10

申请号：US10969440

申请日：2004-10-19

申请人： Edgardo Laborde ,  Louise Robinson ,  Fanying Meng ,  Brian Peterson ,  Hugo Villar ,  Steven Anuskiewicz ,  Yoshiro Ishiwata ,  Shoji Yokochi ,  Yukiharu Matsumoto ,  Takuji Kakigami ,  Hideaki Inagaki ,  Takahito Jomori ,  Kouji Matsushima

发明人： Edgardo Laborde ,  Louise Robinson ,  Fanying Meng ,  Brian Peterson ,  Hugo Villar ,  Steven Anuskiewicz ,  Yoshiro Ishiwata ,  Shoji Yokochi ,  Yukiharu Matsumoto ,  Takuji Kakigami ,  Hideaki Inagaki ,  Takahito Jomori ,  Kouji Matsushima

IPC分类号： A61K31/357 ,  A61K31/41 ,  A61K31/427 ,  A61K31/4433 ,  A61K31/47 ,  A61K31/498 ,  A61K31/538 ,  A61K45/00 ,  A61P1/04 ,  A61P1/18 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P29/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07D215/48 ,  C07D241/42 ,  C07D241/44 ,  C07D265/36 ,  C07D319/18 ,  C07D401/12 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12 ,  C07D491/02 ,  A61K31/4745 ,  C07D471/02 ,  C07D498/02

CPC分类号： C07D401/12 ,  C07D215/48 ,  C07D241/42 ,  C07D265/36 ,  C07D319/18 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D417/12

摘要： Compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephrtitis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection; pharmaceutical compositions comprising these compounds; and the use of these compounds and compositions in the prevention or treatment of such diseases.

摘要翻译： 作为MCP-1拮抗剂的化合物起作用，可用于预防或治疗慢性或急性炎性或自身免疫性疾病，特别是与异常淋巴细胞或单核细胞积累相关的疾病如关节炎，哮喘，动脉粥样硬化，糖尿病性肾病，炎性肠病， 克罗恩病，多发性硬化，肾炎，胰腺炎，肺纤维化，牛皮癣，再狭窄和移植排斥反应; 包含这些化合物的药物组合物; 以及这些化合物和组合物在预防或治疗这些疾病中的用途。

公开(公告)号：US06670364B2

公开(公告)日：2003-12-30

申请号：US10060967

申请日：2002-01-29

申请人： Edgardo Laborde ,  Louise Robinson ,  Fanying Meng ,  Brian T. Peterson ,  Hugo O. Villar ,  Steven E. Anuskiewicz ,  Yoshiro Ishiwata ,  Shoji Yokochi ,  Yukiharu Matsumoto ,  Takuji Kakigami ,  Hideaki Inagaki ,  Takahito Jomori ,  Kouji Matsushima

发明人： Edgardo Laborde ,  Louise Robinson ,  Fanying Meng ,  Brian T. Peterson ,  Hugo O. Villar ,  Steven E. Anuskiewicz ,  Yoshiro Ishiwata ,  Shoji Yokochi ,  Yukiharu Matsumoto ,  Takuji Kakigami ,  Hideaki Inagaki ,  Takahito Jomori ,  Kouji Matsushima

IPC分类号： A61P2900

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5513 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to chemical compounds, pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, methods of treatment employing said compounds and compositions, and processes for preparing said compounds. Specifically, this invention relates to novel compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection. More specifically, the invention is related to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases.

摘要翻译： 本发明涉及化合物，包含所述化合物的药物组合物，所述化合物和组合物的用途，使用所述化合物和组合物的治疗方法，以及制备所述化合物的方法。 具体而言，本发明涉及作为MCP-1功能的拮抗剂的新化合物，其可用于预防或治疗慢性或急性炎性或自身免疫性疾病，特别是与异常淋巴细胞或单核细胞积累相关的疾病，例如关节炎，哮喘，动脉粥样硬化， 糖尿病肾病，炎性肠病，克罗恩病，多发性硬化，肾炎，胰腺炎，肺纤维化，牛皮癣，再狭窄和移植排斥反应。 更具体地，本发明涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗这些疾病中的用途。