公开(公告)号：US11273192B2

公开(公告)日：2022-03-15

申请号：US16428626

申请日：2019-05-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Young Tae Park ,  Kyusun Kim ,  Pilju Choi ,  Seon-Jun Choi ,  Bong Geun Song ,  Jae Young Choi

IPC: A61K36/258 ,  A23L33/105 ,  A61K8/9789 ,  A61K31/704 ,  A61Q19/08 ,  A61K8/63

Abstract: Provided are a method of efficiently producing a ginseng leaf extract including rare ginsenosides Rg6, Rk3, and Rh4 in increased amounts, and use of a ginseng leaf extract produced by the method.

公开(公告)号：US10933033B2

公开(公告)日：2021-03-02

申请号：US16282203

申请日：2019-02-21

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Young Tae Park ,  Taejung Kim ,  Young seok Kim ,  Pilju Choi ,  Kyusun Kim ,  SeonJun Choi ,  BongGeun Song ,  Kisung Kang ,  Buyng Su Hwang ,  Dahae Lee ,  Jihoon Song

IPC: A61K31/122 ,  A61K33/243 ,  A61P13/12 ,  A61K36/062 ,  A61K31/05 ,  A61K31/09

Abstract: A composition for preventing or reducing nephrotoxicity, and use thereof are provided, the composition including a Hypoxylon truncatum extract or an active component thereof.

公开(公告)号：US10004776B2

公开(公告)日：2018-06-26

申请号：US15201819

申请日：2016-07-05

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Kwantae Kim ,  Pilju Choi ,  Buyng Su Hwang ,  Young Seok Kim

IPC: A61K36/00 ,  A61K36/258 ,  A61K9/00

CPC classification number: A61K36/258 ,  A61K9/00 ,  A61K2236/00

Abstract: Provided are a pharmaceutical composition for preventing or treating skin cancer and a method of preventing or treating skin cancer in a subject by using the pharmaceutical composition, wherein the pharmaceutical composition includes a Panax spp. plant extract as an active ingredient.

公开(公告)号：US09211278B2

公开(公告)日：2015-12-15

申请号：US14036810

申请日：2013-09-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  The Council for Scientific and Industrial Research

Inventor： Hyun Ok Yang ,  Sung-Kwon Chung ,  Hak Cheol Kwon ,  Jin Wook Cha ,  Young-Joo Kim ,  Gerda Fouche ,  Rudzani Nthambeleni ,  Dashnie Naidoo ,  Jeremiah Senabe ,  Vinesh Jaichand Maharaj ,  Eric Khorombi ,  Jungyeob Ham ,  Joon Ki Kim

IPC: A01N43/30 ,  A61K31/36 ,  A61K31/365 ,  A23L1/30 ,  A23L2/52 ,  A61K36/185

CPC classification number: A61K31/365 ,  A23L2/52 ,  A23L33/105 ,  A61K36/185

Abstract: Composition and method for preventing and/or treating dementia and ameliorating memory impairment and/or improving memory, comprising one or more arylnaphthalene lignan derivatives, namely Justicidin A, 5-methoxyjusticidin A, Chinensinaphthol, and a pharmaceutically-acceptable salt thereof, as active ingredient.

Abstract translation: 包含一种或多种芳基萘木酚素衍生物的组合物和方法，其中包括一种或多种芳基萘木酚素衍生物，即Justicidin A，5-甲氧基调节蛋白A，Chinininaphthol及其药学上可接受的盐作为活性成分 。

公开(公告)号：US20130178436A1

公开(公告)日：2013-07-11

申请号：US13737482

申请日：2013-01-09

Applicant: Korea Institute of Science and Technology

Inventor： Ki Sung Kang ,  Su-Nam Kim, I ,  Jungyeob Ham ,  Woojung Lee ,  Noriko Yamabe ,  Ji Hwan Lee

IPC: A61K31/704

CPC classification number: A61K31/704 ,  A23L33/105 ,  A61K9/0095 ,  A61K9/1623 ,  A61K9/1664 ,  A61K9/2018 ,  A61K9/2059 ,  A61K9/4858 ,  A61K9/4866

Abstract: A composition for preventing, improving, or treating renal diseases, the composition including as an active ingredient a Maillard browning reaction product obtained by reacting ginsenoside Re, an extract of Panax species plant including ginsenoside Re, or glucose with amino acid at a temperature of 100 to 130° C. for 0.5 to 12 hours.

Abstract translation: 用于预防，改善或治疗肾脏疾病的组合物，所述组合物包含作为活性成分的美拉德褐变反应产物，其通过使人参皂甙Re，人参皂甙Re的人参提取物或葡萄糖与氨基酸在100℃的温度下反应而获得 至130℃，保持0.5至12小时。

公开(公告)号：US11717474B2

公开(公告)日：2023-08-08

申请号：US17138312

申请日：2020-12-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Bong Chul Chung ,  Sungdo Ha ,  Seok Lee ,  Jin-Chul Kim ,  Pilju Choi ,  Bong Geun Song

IPC: A61K36/00 ,  A61K8/49 ,  C07D311/80 ,  A23L33/105 ,  A23L5/30

CPC classification number: A61K8/498 ,  A23L5/34 ,  A23L33/105 ,  C07D311/80 ,  A23V2002/00 ,  A61K2236/333 ,  A61K2236/37

Abstract: Provided are: a method of preparing a cannabis processed product having an increased CBN content in an efficient and economic manner, through cyclization of CBD and aromatization of THC by continuous microwave irradiation of a cannabis extract; and use of a processed product having an increased CBN content prepared by the method, a fraction thereof, and a single ingredient of CBN, in foods, drugs, and cosmetics.

公开(公告)号：US11058736B2

公开(公告)日：2021-07-13

申请号：US16549767

申请日：2019-08-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Jin-Chul Kim ,  Chang Geon Kim ,  Bong Geun Song ,  Taejung Kim ,  Pilju Choi ,  Seon-Jun Choi

IPC: A61K36/185 ,  A61P27/04 ,  A61K9/00

Abstract: Provided are a pharmaceutical composition for preventing or treating dry eye syndrome, including an extract of Terminalia chebula or a fraction thereof as an active ingredient, and a method of preventing or treating dry eye syndrome in an individual.

公开(公告)号：US10653732B2

公开(公告)日：2020-05-19

申请号：US15935634

申请日：2018-03-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Bong Chul Chung ,  Taejung Kim ,  Pilju Choi ,  Ki Sung Kang ,  Buyng Su Hwang ,  Kyu Sun Kim

IPC: A61K36/062 ,  A61P3/10 ,  A61K31/122 ,  A23L33/10 ,  A61K31/05 ,  C07C35/44 ,  C07C39/205 ,  C07C39/14

Abstract: Provided are a composition for stimulating insulin secretion from cells, the composition including a Hypoxylon truncatum extract or an active ingredient thereof, and a method of stimulating insulin secretion from cells.

公开(公告)号：US20200061137A1

公开(公告)日：2020-02-27

申请号：US16549767

申请日：2019-08-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Jin-Chul Kim ,  Chang Geon Kim ,  Bong Geun Song ,  Taejung Kim ,  Pilju Choi ,  Seon-Jun Choi

IPC: A61K36/185 ,  A61P27/04

Abstract: Provided are a pharmaceutical composition for preventing or treating dry eye syndrome, including an extract of Terminalia chebula or a fraction thereof as an active ingredient, and a method of preventing or treating dry eye syndrome in an individual.

公开(公告)号：US09265806B2

公开(公告)日：2016-02-23

申请号：US14038378

申请日：2013-09-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH (CSIR)

Inventor： Hyun Ok Yang ,  Sung-Kwon Chung ,  Hak Cheol Kwon ,  Jin Wook Cha ,  Vinesh Jaichand Maharaj ,  Rudzani Nthambeleni ,  Dashnie Naidoo ,  Young-Joo Kim ,  Jungyeob Ham ,  Jeremiah Senabe ,  Gerda Fouche ,  Eric Khorombi ,  Joon Ki Kim

IPC: A01N65/00 ,  A61K36/185 ,  A23L1/30 ,  A23L2/52

CPC classification number: A61K36/185 ,  A23L2/52 ,  A23L33/105 ,  A61K2236/39

Abstract: A pharmaceutical composition and a food composition including extracts of Monsonia sp. for treating dementia, which compositions inhibit the formation of β-amyloid, and a method of preparing the extracts.

Abstract translation: 一种药物组合物和包含Monsonia sp。 用于治疗痴呆，所述组合物抑制β-淀粉样蛋白的形成，以及制备提取物的方法。