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公开(公告)号：US10654849B2
公开(公告)日：2020-05-19
申请号：US16306941
申请日：2017-06-09
发明人： András Kotschy , Csaba Wéber , Attila Vasas , Balázs Molnár , árpád Kiss , Alba Macias , James Brooke Murray , Elodie Lewkowicz , Olivier Geneste , Mäia Chanrion , Didier Demarles , Lisa Ivanschitz
IPC分类号： C07D471/04 , C07D487/04 , C07D495/04 , A61P35/00 , A61K31/519 , A61K31/522
摘要： Compounds of formula (I): wherein R1, R2, J, K, L, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.
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12.发明授权公开(公告)号：US10414754B2
公开(公告)日：2019-09-17
申请号：US15906389
申请日：2018-02-27
发明人： Arnaud Le Tiran , Thierry Le Diguarher , Jérôme-Benoît Starck , Jean-Michel Henlin , Guillaume De Nanteuil , Olivier Geneste , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen
IPC分类号： C07D401/14 , C07D471/04 , A61K31/4725 , A61K31/4985 , C07D487/04 , C07D519/00 , A61K45/06 , A61K31/475 , A61K31/5377 , A61K9/20 , A61K31/4709 , A61N5/10
摘要： Compounds of formula (I) wherein Ra, Rb, Rc, Rd, T, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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13.发明申请公开(公告)号：US20190201404A1
公开(公告)日：2019-07-04
申请号：US16296766
申请日：2019-03-08
发明人： András KOTSCHY , Zoltán Szlávik , Márton Csékei , Attila Paczal , Zoltán Szabó , Szabolcs Sipos , Gábor Radics , Ágnes Proszenyák , Balázs Bálint , Alain Bruno , Olivier Geneste , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Françoise Perron-Sierra
IPC分类号： A61K31/519 , A61N5/10 , A61K45/06 , C07D495/04 , A61K31/538 , A61K31/5377 , A61K31/55
CPC分类号： A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K45/06 , A61N5/10 , C07D495/04
摘要： Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R12, X, A and n are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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14.发明申请公开(公告)号：US20190192528A1
公开(公告)日：2019-06-27
申请号：US16271171
申请日：2019-02-08
发明人： Arnaud LE TIRAN , Thierry Le Diguarher , Jérôme-Benoît Starck , Jean-Michel Henlin , Anne-Françoise Guillouzic , Guillaume De Nanteuil , Olivier Geneste , Imre Fejes , János Tatai , Miklós Nyerges , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Didier Durand
IPC分类号： A61K31/5383 , A61K31/5377 , A61K31/4725 , A61K45/06 , C07D491/107 , A61K9/20 , C07D498/04 , A61K31/506 , C07D471/04 , C07D401/10 , C07D405/14 , C07D401/14 , C07D498/14 , A61K31/496 , C07D491/10
摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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15.发明授权公开(公告)号：US10323041B2
公开(公告)日：2019-06-18
申请号：US15738186
申请日：2016-06-22
发明人： Balazs Balint , Márton Csékei , Zoltán Szabó , Zoltan Szlavik , András Kotschy , Maïa Chanrion , Olivier Geneste , I-Jen Chen , James Edward Paul Davidson , James Brooke Murray , Szabolcs Sipos , Levente Ondi , Ágnes Proszenyák
IPC分类号： C07D491/048 , A61K31/519 , C07D495/04 , C07D403/12 , C07D333/56 , C07D405/04 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D209/12 , C07D307/80 , C07D307/81 , A61P35/02 , A61K45/06
摘要： Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
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公开(公告)号：US09765056B2
公开(公告)日：2017-09-19
申请号：US14905877
申请日：2014-07-22
发明人： Patrick Casara , Thierry Le Diguarher , Jean-Michel Henlin , Jéröme-Benoit Starck , Arnaud Le Tiran , Guillaume De Nanteuil , Olivier Geneste , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Claire Walmsley , Christopher John Graham , Stuart Ray , Daniel Maddox , Simon Bedford
IPC分类号： A61K31/506 , C07D401/10 , C07D401/14 , C07D405/14 , A61K31/4709 , C07D471/04 , A61K45/06 , A61K31/4725 , A61K31/496 , A61K31/5377 , C07D409/14
CPC分类号： C07D401/10 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , A61K2300/00
摘要： Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R3, R4, R5, A1, A2, T and W are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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17.发明申请公开(公告)号：US20170202851A1
公开(公告)日：2017-07-20
申请号：US15419228
申请日：2017-01-30
发明人： Arnaud LE TIRAN , Thierry Le Diguarher , Jérôme-Benoît Starck , Jean-Michel Henlin , Anne-Françoise Guillouzic , Guillaume De Nanteuil , Olivier Geneste , Imre Fejes , János Tatai , Miklós Nyerges , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Didier Durand
IPC分类号： A61K31/5383 , A61K31/506 , A61K31/5377 , A61K31/4725 , A61K31/496
CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14 , A61K2300/00
摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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公开(公告)号：US11046681B2
公开(公告)日：2021-06-29
申请号：US16306933
申请日：2017-06-09
发明人： András Kotschy , Csaba Wéber , Attila Vasas , Balázs Molnár , Árpád Kiss , Alba Macias , James Brooke Murray , Elodie Lewkowicz , Olivier Geneste , Maïa Chanrion , Didier Demarles
IPC分类号： A61K31/4545 , C07D211/32 , C07D471/04 , C07D487/04 , C07D495/04 , A61P37/02 , A61P35/00 , A61K45/06
摘要： Compounds of formula (I): wherein R1, R2, R3, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.
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公开(公告)号：US11028070B2
公开(公告)日：2021-06-08
申请号：US16865799
申请日：2020-05-04
发明人： James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Claire Walmsley , Mark Dodsworth , Johannes W. G. Meissner , Paul Brough , Imre Fejes , János Tatai , Miklós Nyerges , András Kotschy , Zoltán Szlávik , Olivier Geneste , Arnaud Le Tiran , Thierry Le Diguarher , Jean-Michel Henlin , Jérôme-Benoît Starck , Anne-Françoise Guillouzic , Guillaume De Nanteuil
IPC分类号： C07D401/14 , C07D405/14 , A61K31/4725 , C07D409/14 , C07D471/04 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/675 , A61K45/06 , A61N5/10 , C07D417/14 , C07F9/6561
摘要： Compound of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, t, p, p′, q, and q′ are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic agent.
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20.发明授权公开(公告)号：US10457687B2
公开(公告)日：2019-10-29
申请号：US15737783
申请日：2016-06-22
发明人： Zoltán Szlávik , Zoltán Szabó , Márton Csékei , Attila Paczal , András Kotschy , Alain Bruno , Olivier Geneste , I-Jen Chen , James Edward Paul Davidson , James Brooke Murray , Levente Ondi , Gábor Radics , Szabolcs Sipos , Ágnes Proszenyák , Françoise Perron-Sierra , Balázs Bálint
IPC分类号： C07D495/04 , A61K31/519 , A61P37/00 , A61P35/00
摘要： Compounds of formula (I): wherein R1, R2, R5, R6, R7, R12, X, Y, A, E and n are as defined in the description. Medicinal products containing the same which are useful in treating a condition requiring a pro-apoptotic agent.
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