公开(公告)号：US20070135526A1

公开(公告)日：2007-06-14

申请号：US11649558

申请日：2007-01-04

申请人： Lan Huang

发明人： Lan Huang

IPC分类号： A61K31/11 ,  A61K31/045 ,  A61K31/025 ,  A61K31/015

CPC分类号： C07F9/65848 ,  C07C1/324 ,  C07C13/19 ,  C07C17/16 ,  C07C33/14 ,  C07C35/18 ,  C07C45/298 ,  C07C45/30 ,  C07C47/21 ,  C07C49/557 ,  C07C49/647 ,  C07C2601/14 ,  C07C2601/16 ,  C07C22/00 ,  C07C47/225

摘要： The present invention provides convergent processes for preparing (−)-beta-elemene, (−)-beta-elemenal, (−)-beta-elemenol, and (−)-beta-elemene fluoride and analogues thereof. Also provided are intermediates useful for preparing (−)-beta-elemene. The present invention further provides novel compositions based on analogues of (−)-beta-elemene, (−)-beta-elemenal, (−)-beta-elemenol, (−)-beta-elemene fluoride and methods for the treatment of cancer, such as brain tumor, lung cancer, breast cancer, prostate cancer, ovarian cancer, colorectal cancer, gastric intestional cancer, and stomach cancer. The inventors propose a combination therapy using 1) one or more of the following anti-cancer agents: including, but not limited to, Cisplatin, 5-FU, Taxol, Taxol derivatives, and any anti-cancer agent, and 2) one or more of the following (−)-beta-elemene and its analogs, including (−)-beta-elemene, (−)-beta-elemenal, (−)-beta-elemenol, (−)-beta-elemene fluoride, and their analogs, and (−)-beta-elemene's intermediate in its chemical synthesis, for the treatment of cancer, especially for the treatment of brain tumor, lung cancer, ovarian cancer, bladder cancer, cervical cancer, colon cancer, breast cancer, and prostate cancer.

摘要翻译： 本发明提供（ - ） - β-榄香烯，（ - ） - β-元素，（ - ） - β-榄香烯和（ - ） - β-榄香烯氟化物及其类似物的收敛方法。 还提供了可用于制备（ - ） - β-榄香烯的中间体。 本发明还提供了基于（ - ） - β-榄香烯，（ - ） - β-元素，（ - ） - β-榄香烯，（ - ） - β-榄香烯氟化物类似物和治疗癌症的新方法 ，如脑肿瘤，肺癌，乳腺癌，前列腺癌，卵巢癌，结肠直肠癌，胃肠癌和胃癌。 本发明人提出了使用以下1种或多种抗癌药物的组合疗法：包括但不限于顺铂，5-FU，紫杉醇，紫杉醇衍生物和任何抗癌剂，以及2）一种或多种 （ - ） - β-榄香烯及其类似物，包括（ - ） - β-榄香烯，（ - ） - β-元素，（ - ） - β-榄香烯，（ - ） - 他们的类似物和（ - ） - β-榄香烯在其化学合成中的中间体，用于治疗癌症，特别是用于治疗脑肿瘤，肺癌，卵巢癌，膀胱癌，子宫颈癌，结肠癌，乳腺癌和 前列腺癌。

公开(公告)号：US20070081383A1

公开(公告)日：2007-04-12

申请号：US11248506

申请日：2005-10-12

申请人： Ling Yang ,  Chen Liu ,  Lan Huang ,  Po Wu

发明人： Ling Yang ,  Chen Liu ,  Lan Huang ,  Po Wu

IPC分类号： G11C11/34

CPC分类号： G11C7/18 ,  H01L27/105 ,  H01L29/4238

摘要： A BLT can include a different channel length, channel width, or both to compensate for bit line loading effects. The channel length and/or channel width of the transistor structure can be configured so as to achieve a desired loading. Thus, the bit line transistor structure can improve global metal bit line loading uniformity and provide greater uniformity in bit line bias. Additionally, the greater uniformity in bit line bias can improve reliability.

摘要翻译： BLT可以包括不同的通道长度，通道宽度或两者以补偿位线负载效应。 晶体管结构的沟道长度和/或沟道宽度可以被配置为实现期望的负载。 因此，位线晶体管结构可以改善全局金属位线负载均匀性，并提供更高的位线偏置均匀性。 此外，位线偏置的更大的均匀性可以提高可靠性。

公开(公告)号：US20070079146A1

公开(公告)日：2007-04-05

申请号：US11244269

申请日：2005-10-05

申请人： Windsor Hsu ,  Lan Huang

发明人： Windsor Hsu ,  Lan Huang

IPC分类号： G06F12/14

CPC分类号： G06F21/6218

摘要： A virtual binding system ensures that the WORM logic for protecting data immutability cannot be circumvented, effectively guaranteeing WORM property of a WORM storage system composed of rewritable magnetic hard disks. To close the security hole between the rewritable media and the WORM logic, virtual binding securely authenticates the legitimacy of a WORM logic controller before granting data access on a WORM storage media. Furthermore, the system verifies the legitimacy of the WORM logic controller during data access. This approach virtually binds together the WORM logic controller and the WORM storage media even though the WORM logic controller and the WORM storage media may be physically separate.

摘要翻译： 虚拟绑定系统确保不能避免用于保护数据不变性的WORM逻辑，有效地保证由可重写磁性硬盘组成的WORM存储系统的WORM属性。 要关闭可重写介质和WORM逻辑之间的安全漏洞，虚拟绑定安全地验证WORM逻辑控制器的合法性，然后授予WORM存储介质上的数据访问权限。 此外，系统在数据访问期间验证WORM逻辑控制器的合法性。 即使WORM逻辑控制器和WORM存储介质可能是物理上分离的，这种方式实际上将WORM逻辑控制器和WORM存储介质绑定在一起。

公开(公告)号：US07058763B2

公开(公告)日：2006-06-06

申请号：US09848826

申请日：2001-05-04

申请人： Eran Gabber ,  Elizabeth Shriver ,  Christopher Stein ,  Lan Huang

发明人： Eran Gabber ,  Elizabeth Shriver ,  Christopher Stein ,  Lan Huang

IPC分类号： G06F12/00

CPC分类号： G06F17/30902 ,  G06F17/30067

摘要： A special-purpose file system is provided which includes a combination of services and features which improve the performance of applications employing caches, such as caching web proxies. This file system also provides a file system cache which can be used as a general high-performance file system cache for file systems which need a cache. The services and features include collocating files together on a disk; keeping file meta-data in memory; compressing file names to hash values for reference; using a flat naming scheme for files; providing background daemons that pack files into clusters and clean disk and main memory space; and implementing a user-level library. The file system reduces access to related disk files, eliminates disk operations that are needed to maintain directory and meta-data information, and avoids multiple buffering of file data, and saves and efficiently manages disk and main memory space.

公开(公告)号：US20060101126A1

公开(公告)日：2006-05-11

申请号：US10984088

申请日：2004-11-09

申请人： Lan Huang

发明人： Lan Huang

IPC分类号： G06F15/16

CPC分类号： H04L51/26

摘要： A method, system and apparatus for processing multiple attention levels in an electronic message can include assigning different attention levels to corresponding different designated recipients for a single message. More specifically, the method can include the step of generating separate messages from the single message and specifying a different one of the attention levels for each of the separate messages. Moreover, each of the separate messages can be addressed to be received by recipients which correspond to the specified one of the attention levels. Finally, the separate messages can be forwarded to addressed ones of the designated recipients.

摘要翻译： 一种用于在电子消息中处理多个关注级别的方法，系统和装置可以包括为不同的指定接收者为单个消息分配不同的注意力级别。 更具体地，该方法可以包括从单个消息生成单独的消息并且为每个单独消息指定不同的注意力级别的步骤。 此外，每个单独的消息可以被寻址以由对应于指定的一个关注级别的接收者接收。 最后，单独的消息可以转发到指定的接收者中的已寻址的消息。

公开(公告)号：US20060008478A1

公开(公告)日：2006-01-12

申请号：US10510708

申请日：2003-04-15

申请人： Tadao Ohno ,  Eiji Uchimura ,  Lan Huang ,  Ming Kuang

发明人： Tadao Ohno ,  Eiji Uchimura ,  Lan Huang ,  Ming Kuang

IPC分类号： A61K39/00

CPC分类号： A61K39/39 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55516 ,  A61K2039/55583

摘要： An immunoadjuvant which can efficiently exhibit potent adjuvant activity and avoid conditions undesirable for living bodies, and comprises precipitates formed by coacervation of (a) a soluble protein (provided that a soluble protein contained in tuberculin is excluded), and (b) a mucopolysaccharide, and further comprises (c) a soluble protein contained in tuberculin wherein said (c) is coprecipitated with the precipitates.

摘要翻译： 一种免疫佐剂，其能够有效地显示出有效的佐剂活性并避免生物体不利的条件，并且包含通过凝集（a）可溶性蛋白质形成的沉淀物（条件是不包括结核菌素中所含的可溶性蛋白质），和（b）粘多糖， 并且还包含（c）结核菌素中所含的可溶性蛋白质，其中所述（c）与沉淀物共沉淀。

公开(公告)号：US5591259A

公开(公告)日：1997-01-07

申请号：US470870

申请日：1995-06-06

申请人： Lan Huang ,  Stephen A. Farrington

发明人： Lan Huang ,  Stephen A. Farrington

IPC分类号： C04B24/06 ,  C04B28/02 ,  C04B24/04

CPC分类号： C04B28/02 ,  C04B24/06 ,  C04B2103/12 ,  C04B2111/00155

摘要： Rapid setting cementitious compositions comprise hydraulic cement and at least 4% by weight based on the weight of the cement of a water-soluble malate or citramalate such as an alkali metal malate or alkali metal citramalate.

摘要翻译： 快速凝固水泥质组合物包含水硬性水泥，至少4重量％，基于水泥的水溶性苹果酸盐或柠檬酸盐如碱金属苹果酸盐或碱金属柠檬酸盐的重量。

公开(公告)号：US08637467B2

公开(公告)日：2014-01-28

申请号：US13123424

申请日：2009-09-21

申请人： Lan Huang ,  Hua Zhou ,  Shengtao Yuan

发明人： Lan Huang ,  Hua Zhou ,  Shengtao Yuan

IPC分类号： A61K38/16 ,  C07K14/00

CPC分类号： C07K14/49 ,  A61K38/00 ,  C07K2299/00

摘要： Provided is the composition of a peptide and its mutagenic version, or other derivatives with the same 3-D structure with activity to bind the extracellular domain of PDGFR-α, or -β, but does not dimerize by itself, wherein said peptide comprises the sequence shown as SEQ ID NO: 1, 2 or 3. Also provided is the composition of the nucleotide sequence encoding said peptide and its derivatives, and the usage of said peptide and derivatives of the peptide in preparation of medicine for the prevention and treatment of fibrosis diseases, such as liver, kidney, and lung fibrosis, primary cancer, and cancer metastasis, especially stomach cancer, liver cancer, breast cancer, and lung cancer.

摘要翻译： 提供了肽及其诱变型的组合物或具有相同3-D结构的其它衍生物，其具有结合PDGFR-α或β-的细胞外结构域的活性，但其本身不二聚，其中所述肽包含 序列如SEQ ID NO：1,2或3.还提供了编码所述肽及其衍生物的核苷酸序列的组成，以及所述肽和肽衍生物在制备药物中的用途，用于预防和治疗 纤维化疾病如肝，肾和肺纤维化，原发性癌症和癌症转移，特别是胃癌，肝癌，乳腺癌和肺癌。

公开(公告)号：US20130144541A1

公开(公告)日：2013-06-06

申请号：US13471365

申请日：2012-05-14

申请人： Scott Rychnovsky ,  Lan Huang

发明人： Scott Rychnovsky ,  Lan Huang

IPC分类号： G01N33/68 ,  H01J49/00

CPC分类号： G01N33/6848 ,  C07D207/46 ,  G06F19/12 ,  G06F19/16 ,  G06F19/24 ,  G06F19/26 ,  G06F19/705 ,  G06F19/706 ,  H01J49/0036 ,  H01J49/0081 ,  H01J49/4225

摘要： Novel cross-linking compounds that can be used in mass spectrometry, tandem mass spectrometry, and multi-stage tandem mass spectrometry to facilitate structural analysis of proteins and protein complexes are provided and have the formula: where X is an N-hydroxy-succinimidyl or similar heterocyclic group. Also provided is a method of mapping protein-protein interactions of protein complexes using various mass spectrometry techniques.

摘要翻译： 提供了可用于质谱法，串联质谱法和多级串联质谱法以促进蛋白质和蛋白质复合物的结构分析的新型交联化合物，其具有下式：其中X是N-羟基 - 琥珀酰亚胺基或 类似杂环基。 还提供了使用各种质谱技术测定蛋白质复合物的蛋白质 - 蛋白质相互作用的方法。

公开(公告)号：US20100095138A1

公开(公告)日：2010-04-15

申请号：US12401081

申请日：2009-03-10

申请人： Lan Huang ,  Shih-Hao Liu

发明人： Lan Huang ,  Shih-Hao Liu

IPC分类号： G06F1/00

CPC分类号： G06F1/26 ,  G06F1/24

摘要： A computer start-up timing control device and a method thereof are provided for generating a power supply signal to enable a power supply unit (PSU) to provide power. The device includes a chipset, a delay circuit, and a logic gate. The delay circuit delays a standby power ready signal of the computer to generate a standby power delay signal. The chipset generates a power supply signal. The standby power delay signal enables the logic gate to transmit the power supply signal to the PSU via the logic gate. The PSU provides a power to make the computer enter a start-up procedure. The standby power delay signal delays the time for the chipset to send a power supply signal, so that a baseboard management controller (BMC) has enough time to complete initialization. Therefore, the chipset is prevented from accessing the BMC and obtaining erroneous information before the BMC finishes initialization.

摘要翻译： 提供了一种计算机启动定时控制装置及其方法，用于产生电源信号以使得电源单元（PSU）能够提供电力。 该器件包括芯片组，延迟电路和逻辑门。 延迟电路延迟计算机的备用电源就绪信号以产生待机功率延迟信号。 芯片组产生电源信号。 待机功率延迟信号使逻辑门经由逻辑门将电源信号发送到PSU。 PSU提供使计算机进入启动过程的电源。 待机功率延迟信号延迟芯片组发送电源信号的时间，从而使基板管理控制器（BMC）有足够的时间来完成初始化。 因此，在BMC完成初始化之前，防止芯片组访问BMC并获取错误信息。