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    RNA INTERFERENCE MEDIATED INHIBITION OF STROMAL CELL-DERIVED FACTOR-1 (SDF-1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
    11.
    发明申请
    RNA INTERFERENCE MEDIATED INHIBITION OF STROMAL CELL-DERIVED FACTOR-1 (SDF-1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) 审中-公开
    使用短暂干细胞核（siNA）的RNA干扰介导的阻断细胞衍生因子-1（SDF-1）基因表达的抑制作用

    公开(公告)号：US20090156533A1

    公开(公告)日：2009-06-18

    申请号：US12169519

    申请日：2008-07-08

    申请人： James McSwiggen ,  Leonid Beigelman

    发明人： James McSwiggen ,  Leonid Beigelman

    IPC分类号： A61K31/7105 ,  C07H21/02

    CPC分类号： C07H21/02 ,  A61K48/00 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/318 ,  C12N2310/321 ,  C12N2310/53 ,  C12N2310/3521

    摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of stromal cell-derived factor-1 (SDF-1) gene expression and/or activity. The present invention is also directed to compounds, compositions, and methods relating to traits, diseases and conditions that respond to the modulation of expression and/or activity of genes involved in SDF-1 gene expression pathways or other cellular processes that mediate the maintenance or development of such traits, diseases and conditions. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating or that mediate RNA interference (RNAi) against SDF-1 gene expression. Such small nucleic acid molecules are useful, for example, in providing compositions for treatment of traits, diseases and conditions that can respond to modulation of SDF-1 expression in a subject, such as ocular disease, cancer and proliferative diseases and any other disease, condition, trait or indication that can respond to the level of SDF-1 in a cell or tissue.

    摘要翻译： 本发明涉及用于研究，诊断和治疗对基质细胞衍生因子-1（SDF-1）基因表达和/或活性的调节作用的性状，疾病和病症的化合物，组合物和方法。 本发明还涉及与涉及SDF-1基因表达途径的基因的表达和/或活性的调节作用的性状，疾病和病症相关的化合物，组合物和方法，或调节维持的其他细胞过程 发展这种性状，疾病和状况。 具体而言，本发明涉及小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） 能够介导或介导针对SDF-1基因表达的RNA干扰（RNAi）的分子。 这样的小核酸分子可用于例如提供用于治疗能够对受试者的SDF-1表达的调节作用的性状，疾病和病症的组合物，例如眼部疾病，癌症和增殖性疾病以及任何其它疾病， 条件，特征或指示，可以响应于细胞或组织中SDF-1的水平。

    RNA INTERFERENCE MEDIATED INHIBITION OF GRB2 ASSOCIATED BINDING PROTEIN (GAB2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
    13.
    发明申请
    RNA INTERFERENCE MEDIATED INHIBITION OF GRB2 ASSOCIATED BINDING PROTEIN (GAB2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) 有权
    RNA干扰介导的抑制GRB2相关蛋白（GAB2）的基因表达使用短暂的干扰核酸（siNA）

    公开(公告)号：US20090093435A1

    公开(公告)日：2009-04-09

    申请号：US12203029

    申请日：2008-09-02

    申请人： James McSwiggen ,  Leonid Beigelman

    发明人： James McSwiggen ,  Leonid Beigelman

    IPC分类号： A61K31/7088 ,  C07H21/04

    CPC分类号： C12N15/113 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3521

    摘要： This invention relates to compounds, compositions, and methods useful for modulating associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of associated binding protein (GAB2) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of GAB2 genes. The small nucleic acid molecules are useful in the treatment of cancer, malignant blood disease (leukemia), inflammatory diseases or conditions, allergic diseases or conditions, or proliferative diseases or conditions.

    摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节相关结合蛋白（GAB2）基因表达的化合物，组合物和方法。 本发明还涉及可用于通过使用小核酸分子调节参与相关结合蛋白（GAB2）基因表达和/或通过RNA干扰（RNAi）的活性的其他基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节GAB2基因表达的方法。 小核酸分子可用于治疗癌症，恶性血液病（白血病），炎性疾病或病症，过敏性疾病或病症，或增殖性疾病或病症。

    RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
    15.
    发明申请
    RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) 审中-公开
    RNA干扰介导使用短干扰核酸（siNA）抑制基因表达

    公开(公告)号：US20080161256A1

    公开(公告)日：2008-07-03

    申请号：US11205646

    申请日：2005-08-17

    申请人： David Morrisey ,  James McSwiggen ,  Leonid Beigelman

    发明人： David Morrisey ,  James McSwiggen ,  Leonid Beigelman

    IPC分类号： A61K31/70 ,  A61P43/00

    CPC分类号： C07H21/02 ,  A61K31/70 ,  A61K48/00

    摘要： This invention relates to compounds, compositions, and methods useful for modulating gene expression using short interfering nucleic acid (siNA) molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of genes, such as expressed pseudogenes associated with the maintenance or development of diseases, disorders, traits, and conditions in a subject or organism. The invention also provides small nucleic acid molecules with reduced or attenuated immunostimulatory properties and methods for designing and synthesizing such small nucleic acid molecules having improved toxicologic properties while retaining RNAi activity.

    摘要翻译： 本发明涉及可用于使用短干扰核酸（siNA）分子调节基因表达的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节基因表达的方法，例如与受试者或生物中的疾病，病症，性状和病症的维持或发展相关的表达的假基因。 本发明还提供具有降低或减弱的免疫刺激性质的小核酸分子以及用于设计和合成具有改善的毒理学特性同时保留RNAi活性的这种小核酸分子的方法。

    RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
    18.
    发明申请
    RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) 审中-公开
    RNA干扰介导的使用短干扰核酸（siNA）的蛋白酪氨酸磷酸酶-1B（PTP-1B）基因表达的抑制

    公开(公告)号：US20060025361A1

    公开(公告)日：2006-02-02

    申请号：US11035813

    申请日：2005-01-14

    申请人： James McSwiggen ,  Leonid Beigelman ,  Nassim Usman

    发明人： James McSwiggen ,  Leonid Beigelman ,  Nassim Usman

    IPC分类号： A61K48/00 ,  C07H21/04

    CPC分类号： C12N15/1137 ,  A61K38/00 ,  A61K49/0008 ,  C12N15/87 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/318 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/332 ,  C12N2310/346 ,  C12N2310/3515 ,  C12N2310/3519 ,  C12N2310/53 ,  C12Y301/03048 ,  C12N2310/3521

    摘要： This invention relates to compounds, compositions, and methods useful for modulating protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of PTP-1B gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of PTP-1B genes. Such small nucleic acid molecules are useful, for example, for treating, preventing, inhibiting, or reducing obesity, insulin resistance, diabetes (eg. type II and type I diabetes) in a subject or organism, and for any other disease, trait, or condition that is related to or will respond to the levels of PTP-1B in a cell or tissue, alone or in combination with other treatments or therapies.

    摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节蛋白酪氨酸磷酸酶-1B（PTP-1B）基因表达的化合物，组合物和方法。 本发明还涉及使用小核酸分子调节涉及PTP-1B基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的其他基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节PTP-1B基因表达的方法。 这样的小核酸分子可用于例如治疗，预防，抑制或减少受试者或生物体内的肥胖，胰岛素抵抗，糖尿病（例如II型和I型糖尿病）和任何其它疾病，性状， 或与细胞或组织中PTP-1B水平相关或将会对其单独或与其它治疗或疗法组合相关的病症。

    RNA interference mediated inhibition of MAP kinase gene expression using short interfering nucleic acid (siNA)
    19.
    发明申请
    RNA interference mediated inhibition of MAP kinase gene expression using short interfering nucleic acid (siNA) 审中-公开
    RNA干扰介导的使用短干扰核酸（siNA）的MAP激酶基因表达的抑制

    公开(公告)号：US20050239731A1

    公开(公告)日：2005-10-27

    申请号：US10923379

    申请日：2004-08-20

    申请人： James McSwiggen ,  Bharat Chowrira ,  Peter Haeberli ,  Leonid Beigelman ,  Nassim Usman

    发明人： James McSwiggen ,  Bharat Chowrira ,  Peter Haeberli ,  Leonid Beigelman ,  Nassim Usman

    IPC分类号： A01N43/04 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12P19/34

    CPC分类号： C12N15/113 ,  C12N2310/14

    摘要： This invention relates to compounds, compositions, and methods useful for modulating mitogen activated protein kinase (MAP kinase) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of MAP kinase gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of MAP kinase genes, such as Jun amino-terminal kinase (e.g., JNK-1, JNK-2), p38 (MAPK 14), ERK (e.g., ERK-1, ERK-2) and/or c-Jun.

    摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节有丝分裂原活化蛋白激酶（MAP激酶）基因表达的化合物，组合物和方法。 本发明还涉及可用于通过使用小核酸分子调节涉及MAP激酶基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的其它基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和方法用于调节MAP激酶基因的表达，如Jun氨基末端激酶（如JNK-1，JNK-2），p38（MAPK14），ERK（如ERK-1，ERK-2 ）和/或c-Jun。

    RNA interference mediated inhibition of checkpoint Kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)
    20.
    发明申请
    RNA interference mediated inhibition of checkpoint Kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA) 审中-公开
    RNA干扰介导使用短干扰核酸（siNA）抑制检测点激酶-1（CHK-1）基因表达

    公开(公告)号：US20050196765A1

    公开(公告)日：2005-09-08

    申请号：US10898660

    申请日：2004-07-23

    申请人： James McSwiggen ,  Leonid Beigelman

    发明人： James McSwiggen ,  Leonid Beigelman

    IPC分类号： A61K48/00 ,  C07H21/02 ,  C12Q1/68

    CPC分类号： A61K31/675 ,  C07F9/65586 ,  C07F9/65616 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y207/11001

    摘要： This invention relates to compounds, compositions, and methods useful for modulating checkpoint kinase (e.g., checkpoint kinase-1 or CHK-1) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of checkpoint kinase gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of checkpoint kinase genes.

    摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节检验点激酶（例如检验点激酶-1或CHK-1）基因表达的化合物，组合物和方法。 本发明还涉及可用于通过使用小核酸分子调节参与检测点激酶基因表达和/或通过RNA干扰（RNAi）的活性的其他基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节检查点激酶基因表达的方法。