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47 条记录 (耗时 0.036 秒)

    Use of Neboglamine in the Treatment of Toxicodependency
    11.
    发明申请
    Use of Neboglamine in the Treatment of Toxicodependency 审中-公开
    使用三聚谷氨酰胺治疗毒性依赖性

    公开(公告)号：US20100197962A1

    公开(公告)日：2010-08-05

    申请号：US12067390

    申请日：2006-10-03

    申请人： Francesco Makovec ,  Gianfranco Caselli ,  Lucio Claudio Rovati ,  Antonio Giordani

    发明人： Francesco Makovec ,  Gianfranco Caselli ,  Lucio Claudio Rovati ,  Antonio Giordani

    IPC分类号： C07C237/24

    CPC分类号： A61K31/16

    摘要： Use of neboglamine, (S)-4-amino-N(4,4-dimethyl-cyclohexyl)glutamic acid (CR 2249) (CAS Registry Number 163000-63-3), the racemic mixture thereof or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in the treatment of toxicodependency induced by drugs such as CNS sedatives such as opiates, barbiturates, benzodiazepines, alcohol, stimulants such as amphetamines and cocaine, and hallucinogens such as LSD, mescalin, cannabis (marijuana) or fencyclidine.

    摘要翻译： 使用奈格列胺，（S）-4-氨基-N-（4,4-二甲基 - 环己基）谷氨酸（CR 2249）（CAS登记号163000-63-3），其外消旋混合物或其药学上可接受的盐， 用于制备用于治疗由诸如阿片类药物，巴比妥类，苯并二氮杂类，酒精，兴奋剂如苯丙胺和可卡因的CNS镇静剂等药物诱导的毒性依赖性药物，以及迷幻药如LSD，mescalin，大麻（大麻）或 芬太尼

    N-phenylbenzamide derivatives as drugs for the treatment of COPD
    17.
    发明授权
    N-phenylbenzamide derivatives as drugs for the treatment of COPD 有权
    N-苯基苯甲酰胺衍生物作为治疗COPD的药物

    公开(公告)号：US07482371B2

    公开(公告)日：2009-01-27

    申请号：US11206803

    申请日：2005-08-19

    申请人： Lucio Claudio Rovati ,  Antonio Giordani ,  Gianfranco Caselli

    发明人： Lucio Claudio Rovati ,  Antonio Giordani ,  Gianfranco Caselli

    IPC分类号： C11D3/00

    CPC分类号： A61K31/41

    摘要： The invention relates to the use of a pharmaceutically active derivative of N-phenylbenzamide of Formula (I) or of a pharmaceutically acceptable salt thereof, for preparing a medicament for the therapeutic treatment of Chronic Obstructive Pulmonary Disease (COPD).Compounds of Formula (I): wherein R1 is cyano, nitro, halogen, hydroxy, C1-C4 alkyl, methoxy or tetrazol-5-yl group, R2 is hydrogen, hydroxy or methoxy, R3 is a tetrazol-5-yl group or hydrogen, R4 and R5 are hydrogen if R3 is tetrazol-5-yl group, or R4 and R5 are independently selected from the group consisting of carboxy, methoxycarbonyl, ethoxycarbonyl and carbamoyl if R3 is hydrogen, and R6 is hydrogen or methyl.

    摘要翻译： 本发明涉及式（I）的N-苯基苯甲酰胺或其药学上可接受的盐的药学活性衍生物在制备用于治疗慢性阻塞性肺疾病（COPD）的药物中的用途。 式（I）化合物：其中R 1是氰基，硝基，卤素，羟基，C 1 -C 4烷基，甲氧基或四唑-5-基，R 2是氢，羟基或甲氧基，R 3是四唑-5-基或 如果R 3是氢或甲基，则R 3和R 4各自独立地选自羧基，甲氧基羰基，乙氧基羰基和氨基甲酰基，如果R 3是四唑-5-基，则R 4和R 5是氢。