公开(公告)号：US20160305946A1

公开(公告)日：2016-10-20

申请号：US15197105

申请日：2016-06-29

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold S. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y302/01001 ,  C12Y304/2107 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

公开(公告)号：US20230272482A1

公开(公告)日：2023-08-31

申请号：US18062419

申请日：2022-12-06

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold R. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  C12Y302/01001 ,  C12Y304/2107 ,  C12Q2600/156 ,  C12Q2600/154 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00 ,  C12Q2600/158

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

公开(公告)号：US20210095350A1

公开(公告)日：2021-04-01

申请号：US17101904

申请日：2020-11-23

Applicant: Exact Sciences Development Company, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  Hongzhi Zou ,  Graham P. Lidgard

IPC: C12Q1/6886 ,  C12Q1/6858 ,  C12Q1/6827

Abstract: The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.

公开(公告)号：US10519510B2

公开(公告)日：2019-12-31

申请号：US15278697

申请日：2016-09-28

Applicant: EXACT SCIENCES DEVELOPMENT COMPANY, LLC ,  MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： David A. Ahlquist ,  William R. Taylor ,  Hongzhi Zou ,  Graham P. Lidgard

IPC: C12Q1/68 ,  C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6858

Abstract: The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.

公开(公告)号：US20170198361A1

公开(公告)日：2017-07-13

申请号：US15467739

申请日：2017-03-23

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold S. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y302/01001 ,  C12Y304/2107 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

公开(公告)号：US20240417807A1

公开(公告)日：2024-12-19

申请号：US18746198

申请日：2024-06-18

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold R. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  G01N33/574

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

公开(公告)号：US20240344140A1

公开(公告)日：2024-10-17

申请号：US18594650

申请日：2024-03-04

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： Hongzhi Zou ,  David Ahlquist ,  Jonathan J. Harrington

IPC: C12Q1/6886 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  G01N33/57419 ,  C12Q2600/154 ,  C12Q2600/156 ,  G01N2333/805 ,  G01N2800/50 ,  G01N2800/7028

Abstract: The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals having a colorectal neoplasm by detecting the presence of exfoliated epithelial markers (e.g., human DNA, tumor associated gene alterations, tumor associated proteins) and blood markers (e.g., hemoglobin, serum proteins) in a stool sample obtained from the mammal.

公开(公告)号：US11530449B2

公开(公告)日：2022-12-20

申请号：US16738706

申请日：2020-01-09

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold R. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  G01N33/574

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

公开(公告)号：US10590489B2

公开(公告)日：2020-03-17

申请号：US15724890

申请日：2017-10-04

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold R. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: C12Q1/37 ,  C12Q1/6886 ,  C12Q1/40 ,  G01N33/574

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

公开(公告)号：US20190390286A1

公开(公告)日：2019-12-26

申请号：US16565022

申请日：2019-09-09

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Hongzhi Zou ,  David Ahlquist ,  Jonathan J. Harrington

IPC: C12Q1/6886 ,  G01N33/574

Abstract: The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals having a colorectal neoplasm by detecting the presence of exfoliated epithelial markers (e.g., human DNA, tumor assoicated gene alterations, tumor associated proteins) and blood markers (e.g., homoglobin, serum proteins) in a stool sample obtained from the mammal.