公开(公告)号：US20210330676A1

公开(公告)日：2021-10-28

申请号：US17268995

申请日：2019-08-16

申请人： Merck Sharp & Dohme Corp.

发明人： Dane Clausen ,  Xavier Fradera ,  Liangqin Guo ,  Yongxin Han ,  Shuwen He ,  Xianhai Huang ,  Joseph Kozlowski ,  Guoqing Li ,  Jongwon Lim ,  Theodore A. Martinot ,  Alexander Pasternak ,  Nunzio Sciammetta ,  Andreas Verras ,  Li Xiao ,  Wensheng Yu ,  Rui Zhang

IPC分类号： A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D401/06 ,  C07D413/14 ,  C07D451/06 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/454 ,  A61K31/46

摘要： Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US10995085B2

公开(公告)日：2021-05-04

申请号：US16819325

申请日：2020-03-16

申请人： Merck Sharp & Dohme Corp.

发明人： Yongxin Han ,  Abdelghani Achab ,  Yongqi Deng ,  Xavier Fradera ,  Craig Gibeau ,  Brett A. Hopkins ,  Derun Li ,  Kun Liu ,  Meredeth A. McGowan ,  Nunzio Sciammetta ,  David Sloman ,  Catherine White ,  Hongjun Zhang ,  Hua Zhou

IPC分类号： C07D405/10 ,  A61K31/4523 ,  A61K45/06 ,  C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/4155 ,  C07D305/08 ,  A61K31/337 ,  C07D417/10 ,  A61K31/427 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/4184 ,  C07D405/14 ,  A61K31/444 ,  A61K31/513 ,  C07D413/04 ,  C07D401/04 ,  C07D213/56 ,  A61K31/4418 ,  C07D417/14 ,  A61K31/501 ,  C07D241/12 ,  A61K31/4965 ,  A61K31/4427 ,  C07D263/32 ,  A61P37/00 ,  C07D231/12 ,  A61P35/00 ,  C07D413/10 ,  C07D401/12 ,  C07D405/04 ,  A61P31/00 ,  C07D209/46 ,  C07D413/14

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US20200231606A1

公开(公告)日：2020-07-23

申请号：US16326408

申请日：2017-08-24

申请人： Merck Sharp & Dohme Corp.

发明人： Kun Liu ,  Abdelghani Achab ,  Purakkattle Biju ,  Timothy A. Cernak ,  Yongqi Deng ,  Xavier Fradera ,  Liangqin Guo ,  Yongxin Han ,  Shuwen He ,  Joseph Kozlowski ,  Derun Li ,  Guoqing Li ,  Qinglin Pu ,  Zhi-Cai Shi ,  Wensheng Yu ,  Hongjun Zhang

IPC分类号： C07F5/02 ,  C07D271/08 ,  C07D413/12

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Formula (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US20200215042A1

公开(公告)日：2020-07-09

申请号：US16631192

申请日：2018-07-30

申请人： Merck Sharp & Dohme Corp.

发明人： Hua Zhou ,  Xavier Fradera ,  Yongxin Han ,  Meredeth A. McGowan ,  Nunzio Sciammetta ,  Catherine White ,  Wensheng Yu

IPC分类号： A61K31/444 ,  A61K45/06 ,  C07D471/04 ,  C07D401/08 ,  C07D401/14 ,  A61K31/4439

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US10647705B2

公开(公告)日：2020-05-12

申请号：US16186769

申请日：2018-11-12

申请人： Merck Sharp & Dohme Corp.

发明人： Yongxin Han ,  Abdelghani Achab ,  Yongqi Deng ,  Xavier Fradera ,  Craig Gibeau ,  Brett A. Hopkins ,  Derun Li ,  Kun Liu ,  Meredeth A. McGowan ,  Nunzio Sciammetta ,  David Sloman ,  Catherine White ,  Hongjun Zhang ,  Hua Zhou

IPC分类号： C07D405/10 ,  A61K31/4523 ,  A61K45/06 ,  C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/4155 ,  C07D305/08 ,  A61K31/337 ,  C07D417/10 ,  A61K31/427 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/4184 ,  C07D405/14 ,  A61K31/444 ,  A61K31/513 ,  C07D413/04 ,  C07D401/04 ,  C07D213/56 ,  A61K31/4418 ,  C07D417/14 ,  A61K31/501 ,  C07D241/12 ,  A61K31/4965 ,  A61K31/4427 ,  C07D263/32 ,  A61P37/00 ,  C07D231/12 ,  A61P35/00 ,  C07D413/10 ,  C07D401/12 ,  C07D405/04 ,  A61P31/00 ,  C07D209/46 ,  C07D413/14

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US11230547B2

公开(公告)日：2022-01-25

申请号：US16764448

申请日：2018-12-12

申请人： Merck Sharp & Dohme Corp.

发明人： Meredeth A. McGowan ,  Jason D. Katz ,  Matthew Christopher ,  Hua Zhou ,  David James Witter ,  Chaomin Li ,  John Lampe ,  Joey L. Methot ,  Abdelghani A. Achab ,  Xavier Fradera ,  Shimin Xu

IPC分类号： C07D487/08 ,  C07D519/00 ,  C07D403/14

摘要： The instant invention provides compounds of formulas Ia and Ib which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.

公开(公告)号：US11208407B2

公开(公告)日：2021-12-28

申请号：US16631191

申请日：2018-07-30

申请人： Merck Sharp & Dohme Corp.

发明人： Hua Zhou ,  Abdelghani Achab ,  Xavier Fradera ,  Yongxin Han ,  Derun Li ,  Meredeth A. McGowan ,  Nunzio Sciammetta ,  David L. Sloman ,  Wensheng Yu

IPC分类号： C07D471/04 ,  C07D235/14

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (I) Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US20210317091A1

公开(公告)日：2021-10-14

申请号：US16761855

申请日：2018-11-09

申请人： MERCK SHARP & DOHME CORP.

发明人： Yongxin Han ,  Abdelghani Achab ,  Indu Bharathan ,  Xavier Fradera ,  Derun Li ,  Nunzio Sciammetta ,  Wensheng Yu

IPC分类号： C07D241/12 ,  C07D213/64 ,  C07D213/56 ,  C07D239/26 ,  C07D413/04 ,  C07D241/18 ,  C07D237/08 ,  C07D213/76 ,  C07D401/04 ,  C07D405/10 ,  A61K45/06

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an 1DO-associated disease or disorder.

公开(公告)号：US11111232B2

公开(公告)日：2021-09-07

申请号：US16753050

申请日：2018-10-04

申请人： MERCK SHARP & DOHME CORP.

发明人： Catherine M. White ,  Abdelghani Achab ,  Indu T. Bharathan ,  Xavier Fradera ,  Yongxin Han ,  Derun Li ,  Jongwon Lim ,  Kun Liu ,  Meredeth Ann McGowan ,  Nunzio Sciammetta ,  Wensheng Yu ,  Hongjun Zhang ,  Hua Zhou

IPC分类号： A61K31/4418 ,  C07D401/14 ,  C07D213/74 ,  C07D401/12 ,  C07D405/12 ,  C07D413/14 ,  C07D417/14

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US11103493B2

公开(公告)日：2021-08-31

申请号：US16631192

申请日：2018-07-30

申请人： Merck Sharp & Dohme Corp.

发明人： Hua Zhou ,  Xavier Fradera ,  Yongxin Han ,  Meredeth A. McGowan ,  Nunzio Sciammetta ,  Catherine White ,  Wensheng Yu

IPC分类号： A61K31/444 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/08 ,  C07D401/14 ,  C07D471/04

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.