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    Microfluidic system
    11.
    发明授权
    Microfluidic system 有权
    微流体系统

    公开(公告)号：US08454811B2

    公开(公告)日：2013-06-04

    申请号：US12172740

    申请日：2008-07-14

    申请人： Rene Gerrit Heideman

    发明人： Rene Gerrit Heideman

    IPC分类号： B81B7/00 ,  B81B1/00 ,  G01N27/453

    CPC分类号： G01N27/44752 ,  B01L3/502707 ,  B01L3/569 ,  B01L2300/12 ,  B01L2400/0415 ,  C03C17/02

    摘要： A method for forming a microfluidic channel with improved flow characteristics for one or more analytes is disclosed. A microfluidic channel having modified surfaces is formed in fused silica. The fused silica surfaces are modified by the addition of a layer of borophosphosilicate glass. The addition of the borophosphosilicate glass results in an improved flow velocity profile of the analyte. As a result, control over the position and movement of analytes within the solution is improved.

    摘要翻译： 公开了一种用于形成具有改善的一种或多种分析物的流动特性的微流体通道的方法。 在熔融二氧化硅中形成具有改性表面的微流体通道。 熔融二氧化硅表面通过添加一层硼磷硅酸盐玻璃来改性。 硼磷硅酸盐玻璃的添加导致分析物的改进的流速分布。 因此，提高了溶液中分析物的位置和运动的控制。

    Waveguide-based sensor
    12.
    发明授权
    Waveguide-based sensor 有权
    基于波导的传感器

    公开(公告)号：US08154716B2

    公开(公告)日：2012-04-10

    申请号：US12554721

    申请日：2009-09-04

    申请人： Rene Gerrit Heideman

    发明人： Rene Gerrit Heideman

    IPC分类号： G01J1/44

    CPC分类号： G01N21/7703 ,  G01N21/6428 ,  G01N21/7746 ,  G01N2021/7716 ,  G01N2021/7786

    摘要： A sensor for sensing a target chemical with high signal-to-noise ratio is disclosed. In some embodiments, the sensor comprises a sensing region that is optically coupled with an attenuation region. The sensing region receives optical stimulation that comprises light characterized by an excitation wavelength. In response to exposure to the target chemical, the sensing region fluoresces at a fluorescence wavelength. The attenuation region receives light from the fluorescing sensing region that includes light characterized by the fluorescence wavelength (i.e., signal) and light characterized by the excitation wavelength (i.e., noise). The attenuation region conveys the light to a detector that provides an electrical output signal based on the target chemical. While conveying the light, however, the attenuation region improves the signal-to-noise ratio by attenuating light characterized by the excitation wavelength more than light characterized by the fluorescence region.

    摘要翻译： 公开了一种用于感测具有高信噪比的目标化学物质的传感器。 在一些实施例中，传感器包括与衰减区域光学耦合的感测区域。 感测区域接收包含以激发波长为特征的光的光学刺激。 响应于暴露于目标化学物质，感测区域以荧光波长发荧光。 衰减区域接收来自荧光检测区域的光，其包括由荧光波长（即，信号）表征的光和由激发波长（即，噪声）表征的光。 衰减区域将光传送到基于目标化学品提供电输出信号的检测器。 然而，在传送光的同时，衰减区域通过将特征在于激发波长的光多于由荧光区域表征的光来改善信噪比。

    Microfluidic System
    13.
    发明申请
    Microfluidic System 有权
    微流体系统

    公开(公告)号：US20100006435A1

    公开(公告)日：2010-01-14

    申请号：US12172740

    申请日：2008-07-14

    申请人： Rene Gerrit Heideman

    发明人： Rene Gerrit Heideman

    IPC分类号： C07K1/26 ,  G01N27/00

    CPC分类号： G01N27/44752 ,  B01L3/502707 ,  B01L3/569 ,  B01L2300/12 ,  B01L2400/0415 ,  C03C17/02

    摘要： A method for forming a microfluidic channel with improved flow characteristics for one or more analytes is disclosed. A microfluidic channel having modified surfaces is formed in fused silica. The fused silica surfaces are modified by the addition of a layer of borophosphosilicate glass. The addition of the borophosphosilicate glass results in an improved flow velocity profile of the analyte. As a result, control over the position and movement of analytes within the solution is improved.

    摘要翻译： 公开了一种用于形成具有改善的一种或多种分析物的流动特性的微流体通道的方法。 在熔融二氧化硅中形成具有改性表面的微流体通道。 熔融二氧化硅表面通过添加一层硼磷硅酸盐玻璃来改性。 硼磷硅酸盐玻璃的添加导致分析物的改进的流速分布。 因此，提高了溶液中分析物的位置和运动的控制。

    Waveguide-based Sensor
    18.
    发明申请
    Waveguide-based Sensor 有权
    基于波导的传感器

    公开(公告)号：US20120181451A1

    公开(公告)日：2012-07-19

    申请号：US13363031

    申请日：2012-01-31

    申请人： Rene Gerrit Heideman

    发明人： Rene Gerrit Heideman

    IPC分类号： G01N21/64

    CPC分类号： G01N21/7703 ,  G01N21/6428 ,  G01N21/7746 ,  G01N2021/7716 ,  G01N2021/7786

    摘要： A sensor for sensing a target chemical with high signal-to-noise ratio is disclosed. In some embodiments, the sensor comprises a sensing region that is optically coupled with an attenuation region. The sensing region receives optical stimulation that comprises light characterized by an excitation wavelength. In response to exposure to the target chemical, the sensing region fluoresces at a fluorescence wavelength. The attenuation region receives light from the fluorescing sensing region that includes light characterized by the fluorescence wavelength (i.e., signal) and light characterized by the excitation wavelength (i.e., noise). The attenuation region conveys the light to a detector that provides an electrical output signal based on the target chemical. While conveying the light, however, the attenuation region improves the signal-to-noise ratio by attenuating light characterized by the excitation wavelength more than light characterized by the fluorescence region.

    摘要翻译： 公开了一种用于感测具有高信噪比的目标化学物质的传感器。 在一些实施例中，传感器包括与衰减区域光学耦合的感测区域。 感测区域接收包含以激发波长为特征的光的光学刺激。 响应于暴露于目标化学品，感测区域以荧光波长发荧光。 衰减区域接收来自荧光检测区域的光，其包括由荧光波长（即，信号）表征的光和由激发波长（即，噪声）表征的光。 衰减区域将光传送到基于目标化学品提供电输出信号的检测器。 然而，在传送光的同时，衰减区域通过将特征在于激发波长的光多于由荧光区域表征的光来改善信噪比。

    Waveguide-based Sensor
    19.
    发明申请
    Waveguide-based Sensor 有权
    基于波导的传感器

    公开(公告)号：US20110058158A1

    公开(公告)日：2011-03-10

    申请号：US12554721

    申请日：2009-09-04

    申请人： Rene Gerrit Heideman

    发明人： Rene Gerrit Heideman

    IPC分类号： G01J1/44

    CPC分类号： G01N21/7703 ,  G01N21/6428 ,  G01N21/7746 ,  G01N2021/7716 ,  G01N2021/7786

    摘要： A sensor for sensing a target chemical with high signal-to-noise ratio is disclosed. In some embodiments, the sensor comprises a sensing region that is optically coupled with an attenuation region. The sensing region receives optical stimulation that comprises light characterized by an excitation wavelength. In response to exposure to the target chemical, the sensing region fluoresces at a fluorescence wavelength. The attenuation region receives light from the fluorescing sensing region that includes light characterized by the fluorescence wavelength (i.e., signal) and light characterized by the excitation wavelength (i.e., noise). The attenuation region conveys the light to a detector that provides an electrical output signal based on the target chemical. While conveying the light, however, the attenuation region improves the signal-to-noise ratio by attenuating light characterized by the excitation wavelength more than light characterized by the fluorescence region.

    摘要翻译： 公开了一种用于感测具有高信噪比的目标化学物质的传感器。 在一些实施例中，传感器包括与衰减区域光学耦合的感测区域。 感测区域接收包含以激发波长为特征的光的光学刺激。 响应于暴露于目标化学品，感测区域以荧光波长发荧光。 衰减区域接收来自荧光检测区域的光，其包括由荧光波长（即，信号）表征的光和由激发波长（即，噪声）表征的光。 衰减区域将光传送到基于目标化学品提供电输出信号的检测器。 然而，在传送光的同时，衰减区域通过将特征在于激发波长的光多于由荧光区域表征的光来改善信噪比。