公开(公告)号：US20100280174A1

公开(公告)日：2010-11-04

申请号：US12832522

申请日：2010-07-08

申请人： Dana Craig Bookbinder ,  Edward John Fewkes, JR. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

发明人： Dana Craig Bookbinder ,  Edward John Fewkes, JR. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

IPC分类号： C08L67/00 ,  C08L71/02

CPC分类号： C07H21/00 ,  B01L3/50 ,  B01L3/5082 ,  B01L2200/12 ,  B01L2300/16 ,  B05D7/02 ,  C07B2200/11 ,  C08J7/047 ,  C08J7/065 ,  C08J2471/00 ,  C09D5/00 ,  G01N33/54393

摘要： Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and fault the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

摘要翻译： 蛋白质结合水平小于约50-80ng / cm 2的疏水性聚合物表面通过以下方式实现：（1）将由溶剂和HLB数小于5的非离子表面活性剂组成的涂布溶液施加到表面 ; 和（2）干燥表面以除去溶剂，从而使表面活性剂与疏水性聚合物直接接触。 已经发现低HLB值和干燥步骤的组合产生低结合表面，其可以经受水和/或蛋白质溶液的多次洗涤。或者，低结合表面可以通过将非离子表面活性剂施加到 与熔融聚合物接触并将聚合物断裂成所需形状的模具表面，例如多孔板，移液管尖端等。 此外，低粘合表面可以通过将HLB数小于或等于10的非可溶性非离子表面活性剂在模制制品之前加入到聚合物共混物中来制备。

公开(公告)号：US07776572B2

公开(公告)日：2010-08-17

申请号：US11707851

申请日：2007-02-16

申请人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

发明人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

IPC分类号： C12N9/00 ,  C12N11/00 ,  C12N5/00 ,  C12N1/00 ,  C12M1/00 ,  G01N33/53 ,  C07K17/00 ,  C07H21/00 ,  A61K38/00 ,  A01N1/02 ,  C12Q1/00

CPC分类号： C07H21/00 ,  B01L3/50 ,  B01L3/5082 ,  B01L2200/12 ,  B01L2300/16 ,  B05D7/02 ,  C07B2200/11 ,  C08J7/047 ,  C08J7/065 ,  C08J2471/00 ,  C09D5/00 ,  G01N33/54393

摘要： Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

摘要翻译： 蛋白质结合水平小于约50-80ng / cm 2的疏水性聚合物表面通过以下方式实现：（1）将由溶剂和HLB数小于5的非离子表面活性剂组成的涂布溶液施加到表面 ; 和（2）干燥表面以除去溶剂，从而使表面活性剂与疏水性聚合物直接接触。 已经发现低HLB值和干燥步骤的组合产生低结合表面，其可以经受水和/或蛋白质溶液的多次洗涤。或者，低结合表面可以通过将非离子表面活性剂施加到 接触熔融聚合物并将聚合物形成所需形状的模具表面，例如多孔板，移液管尖端等。 此外，低粘合表面可以通过将HLB数小于或等于10的非可溶性非离子表面活性剂在模制制品之前加入到聚合物共混物中来制备。

公开(公告)号：US07312057B2

公开(公告)日：2007-12-25

申请号：US10378974

申请日：2003-03-03

申请人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

发明人： Dana Craig Bookbinder ,  Edward John Fewkes, Jr. ,  James Arthur Griffin ,  Frances M. Smith ,  David L. Tennent

IPC分类号： C12N9/00 ,  G01N33/53 ,  C07K17/00 ,  C07H21/00

CPC分类号： C07H21/00 ,  B01L3/50 ,  B01L3/5082 ,  B01L2200/12 ,  B01L2300/16 ,  B05D7/02 ,  C07B2200/11 ,  C08J7/047 ,  C08J7/065 ,  C08J2471/00 ,  C09D5/00 ,  G01N33/54393

摘要： Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

摘要翻译： 蛋白质结合水平小于约50-80ng / cm 2的疏水性聚合物表面通过以下方式实现：（1）施加由溶剂和具有HLB的非离子表面活性剂组成的涂布溶液 数量小于5的表面; 和（2）干燥表面以除去溶剂，从而使表面活性剂与疏水性聚合物直接接触。 已经发现低HLB值和干燥步骤的组合产生低结合表面，其可以经受水和/或蛋白质溶液的多次洗涤。或者，低结合表面可以通过将非离子表面活性剂施加到 接触熔融聚合物并将聚合物形成所需形状的模具表面，例如多孔板，移液管尖端等。 此外，低粘合表面可以通过将HLB数小于或等于10的非可溶性非离子表面活性剂在模制制品之前加入到聚合物共混物中来制备。

公开(公告)号：US5853446A

公开(公告)日：1998-12-29

申请号：US820206

申请日：1997-03-18

申请人： Alain R.E. Carre ,  Bernard Eid ,  Mark S. Friske ,  Ronald E. Johnson ,  Candace J. Quinn ,  Frances M. Smith ,  Jean-Pierre Themont

发明人： Alain R.E. Carre ,  Bernard Eid ,  Mark S. Friske ,  Ronald E. Johnson ,  Candace J. Quinn ,  Frances M. Smith ,  Jean-Pierre Themont

IPC分类号： B81C1/00 ,  C03C17/04 ,  C03B21/00 ,  C03B19/01 ,  C03B19/09 ,  C03B23/00

CPC分类号： B81C1/00111 ,  C03C17/04 ,  B81C2201/036 ,  H01J2211/36

摘要： A method and apparatus for making formed glass structures. A glass frit containing material is deposited within a recessed pattern, hardened in the recessed pattern, and transferred to a substrate. The method and apparatus of the invention are particularly useful for forming barrier rib structures for use in plasma display panels.

摘要翻译： 制造成形玻璃结构的方法和装置。 含有玻璃料的材料沉积在凹陷图案中，以凹陷图案硬化并转移到基底。 本发明的方法和装置特别适用于形成用于等离子体显示面板的隔壁结构。