公开(公告)号：US20070049812A1

公开(公告)日：2007-03-01

申请号：US11511476

申请日：2006-08-29

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi

IPC分类号： A61B5/00

CPC分类号： A61B5/14551 ,  A61B5/7207

摘要： In order to measure an oxygen saturation in blood of a subject, a living tissue of the subject is irradiated with a first light beam having a first wavelength and a second light beam having a second wavelength different from the first wavelength. A first electrical signal is generated from the first light beam reflected from or transmitted through the living tissue. A second electrical signal is generated from the second light beam reflected from or transmitted through the living tissue. The first electrical signal is divided into a plurality of first segments each of which includes a part of the first electrical signal for a predetermined time period. The second electrical signal is divided into a plurality of second segments each of which includes a part of the second electrical signal for the predetermined time period. It is calculated a gradient of a regression line between every one of the first segments and an associated one of the second segments, thereby obtaining a plurality of gradients.

摘要翻译： 为了测量对象的血液中的氧饱和度，用具有第一波长的第一光束和具有不同于第一波长的第二波长的第二光束照射被检体的活体组织。 从从生物体组织反射或透过活体组织的第一光束产生第一电信号。 从通过活体组织反射或透过的第二光束产生第二电信号。 第一电信号被分成多个第一段，每个第一段在预定时间段内包括第一电信号的一部分。 第二电信号被分成多个第二段，每个第二段包括预定时间段的第二电信号的一部分。 计算出每个第一段和第二段之间的回归线的梯度，从而获得多个梯度。

公开(公告)号：US5666952A

公开(公告)日：1997-09-16

申请号：US643944

申请日：1996-05-07

申请人： Masayoshi Fuse ,  Takuo Aoyagi

发明人： Masayoshi Fuse ,  Takuo Aoyagi

IPC分类号： A61B5/145 ,  A61B5/024 ,  A61B5/1455 ,  A61B5/00

CPC分类号： A61B5/02416 ,  A61B5/6817

摘要： A supporting shaft stands on an external auditory canal arm holding an LED. An attaching portion holding a PD is rotatably connected to one end of a holding arm. A column having a through hole 11b into which the supporting shaft is slidably inserted is fixed to the other end of the holding arm. The external auditory canal arm and the holding arm are connected to each other by a coil spring.

摘要翻译： 支撑轴位于外部听管臂上，手持LED。 保持PD的安装部可旋转地连接到保持臂的一端。 具有可滑动地插入支撑轴的通孔11b的支柱固定到保持臂的另一端。 外耳道臂和保持臂通过螺旋弹簧彼此连接。

公开(公告)号：US5697371A

公开(公告)日：1997-12-16

申请号：US358381

申请日：1994-12-19

申请人： Takuo Aoyagi ,  Michio Kanemoto ,  Naoki Kobayashi

发明人： Takuo Aoyagi ,  Michio Kanemoto ,  Naoki Kobayashi

IPC分类号： A61B5/026 ,  A61B5/0275 ,  A61B5/00

CPC分类号： A61B5/0275

摘要： Using the principle of pulse oximetry, the relationship between the logarithm of dye density and the passage of time is obtained to determine a regression line for the linear portion of the relationship; an intial dye density in the blood is determined for the point of time that defines the mean transit time for the initial circulation of the injected dye on the regression line; and the circulating blood volume is calculated from the thus determined initial dye density.

摘要翻译： 使用脉搏血氧饱和度原理，获得染料密度对数与时间的关系，以确定关系的线性部分的回归线; 确定血液中的初始染料浓度的时间点，该时间点定义了注射染料在回归线上的初始循环的平均通过时间; 并根据如此确定的初始染料密度计算循环血液体积。

公开(公告)号：US5190040A

公开(公告)日：1993-03-02

申请号：US743618

申请日：1991-08-12

申请人： Takuo Aoyagi

发明人： Takuo Aoyagi

IPC分类号： A61B5/00 ,  A61B5/0275

CPC分类号： A61B5/14551 ,  A61B5/0059 ,  A61B5/0275

摘要： An apparatus for measuring the change in the concentration of a pigment in blood is disclosed which comprises: light quantity detecting units for continuously detecting the quantities of radiations of light having different wavelengths that have been transmitted or reflected by living tissue containing pulsating blood; first computing unit which, when the concentration or absorptivity coefficient of a light-absorbing component in the blood changes with respect to light having either one of said wavelengths, computes the quantities of radiations of transmitted or reflected light having the wavelengths when the living tissue is in a state of ischemia on the basis of the constant and pulsating components of the quantity of each radiation of light that has been detected by the light quantity detectors both before and after the change occurred; and second computing unit which continuously determines the concentration of a pigment of interest in the blood by performing calculations based on the results of computation by the first computing means and on the quantities of radiations of light detected by the light quantity detecting units.

摘要翻译： 公开了一种用于测量血液中颜料浓度变化的装置，其包括：用于连续地检测由具有脉动血液的活组织透射或反射的具有不同波长的光的辐射量的光量检测单元; 第一计算单元，当所述血液中的光吸收成分的浓度或吸收系数相对于具有所述波长中的任一个的光而变化时，计算当所述生物体组织为波长时具有波长的透射或反射光的辐射量 基于在变化发生之前和之后由光量检测器检测到的每种辐射光量的恒定和脉动分量的局部缺血状态; 以及第二计算单元，其通过基于第一计算装置的计算结果和由光量检测单元检测到的光的辐射量来执行计算，连续地确定血液中感兴趣的颜料的浓度。

公开(公告)号：US4832484A

公开(公告)日：1989-05-23

申请号：US113969

申请日：1987-10-29

申请人： Takuo Aoyagi ,  Nobutaka Kobayashi ,  Tadashi Sasaki

发明人： Takuo Aoyagi ,  Nobutaka Kobayashi ,  Tadashi Sasaki

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1495 ,  G01J1/44 ,  G01N21/31

CPC分类号： A61B5/14551 ,  G01N21/314 ,  G01J2001/4433 ,  G01N2021/3144

摘要： An apparatus for determining the concentration of a light-absorbing material contained in blood flowing through a tissue which minimizes the amount of error caused by noise and which ensures highly precise results at all times. The apparatus operates according the principle that light beams of different wavelengths are absorbed by different amounts when passing through the tissue at different portions of the blood pulsation cycle. A plurality of points are detected that fall in the vicinity of the peak and trough of a cycle of a light detection signal. For each wavelength of light, the values of the detection signals produced at each of these points in time is stored. The concentration of the light-absorbing material is computed in response to the stored detection signals.

摘要翻译： 一种用于确定流过组织的血液中所含的吸光材料的浓度的装置，其使由噪声引起的误差量最小化并且始终确保高度精确的结果。 该装置根据以下原理工作：当在血液脉动周期的不同部分通过组织时，不同波长的光束被不同的量吸收。 检测到落在光检测信号的周期的峰值和谷值附近的多个点。 对于每个波长的光，存储在这些时间点中的每一个处产生的检测信号的值。 响应于所存储的检测信号计算光吸收材料的浓度。

公开(公告)号：US4964010A

公开(公告)日：1990-10-16

申请号：US437301

申请日：1989-11-16

申请人： Katsuyuki Miyasaka ,  Takuo Aoyagi

发明人： Katsuyuki Miyasaka ,  Takuo Aoyagi

IPC分类号： A61B5/00 ,  A61B5/01 ,  A61B5/08 ,  A61B5/145 ,  H01L33/00 ,  H05B33/08

CPC分类号： H05B33/0818 ,  H05B33/0884

摘要： An electronic device including a circuit element to which a pulse current is applied, and a device for limiting the time integration value of current flowing in the circuit element, the device being connected in series to the circuit element, to prevent the circuit element from being overheated.

公开(公告)号：US5999841A

公开(公告)日：1999-12-07

申请号：US916295

申请日：1997-08-22

申请人： Takuo Aoyagi ,  Michio Kanemoto ,  Naoki Kobayashi

发明人： Takuo Aoyagi ,  Michio Kanemoto ,  Naoki Kobayashi

IPC分类号： A61B5/026 ,  A61B5/0275 ,  A61B6/00 ,  A61B5/02

CPC分类号： A61B5/0275

摘要： Using the principle of pulse oximetry, the relationship between the logarithm of dye density and the passage of time is obtained to determine a regression line for the linear portion of the relationship; an intial dye density in the blood is determined for the point of time that defines the mean transit time for the initial circulation of the injected dye on the regression line; and the circulating blood volume is calculated from the thus determined initial dye density.

摘要翻译： 使用脉搏血氧饱和度原理，获得染料密度对数与时间的关系，以确定关系的线性部分的回归线; 确定血液中的初始染料浓度的时间点，该时间点定义了注射染料在回归线上的初始循环的平均通过时间; 并根据如此确定的初始染料密度计算循环血液体积。

公开(公告)号：US5690104A

公开(公告)日：1997-11-25

申请号：US661169

申请日：1996-06-10

申请人： Michio Kanemoto ,  Naoki Kobayashi ,  Takuo Aoyagi

发明人： Michio Kanemoto ,  Naoki Kobayashi ,  Takuo Aoyagi

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455

CPC分类号： A61B5/6826 ,  A61B5/14551 ,  A61B5/6838 ,  A61B2560/0209

摘要： Intensities of light of two different wavelengths transmitted through a tissue of a living body are measured during a first time period. A data processor determines a first regression line using logarithmically processed data corresponding to the light intensities measured during the first time period. An operator injects a dye into the living body and measurements of intensities of light at the two different wavelengths are made during a later time period. The data processor determines a second regression line using logarithmically processed data corresponding to the light intensities measured during the later time period. The data processor finds an intersection of the two regression lines and uses the intersection to determine a bloodless level point. The processor then forms a dye dilution curve incorporating the bloodless level point data.

摘要翻译： 在第一时间段内测量透过活体组织的两种不同波长的光的强度。 数据处理器使用对应于在第一时间段期间测量的光强度的对数处理数据来确定第一回归线。 操作者将染料注入到生物体中，并且在稍后的时间段内测量两种不同波长的光的强度。 数据处理器使用对应于在稍后时间段内测量的光强度的对数处理的数据来确定第二回归线。 数据处理器找到两条回归线的交点，并使用交点确定无血性水平点。 然后处理器形成掺有无血型水平点数据的染料稀释曲线。

公开(公告)号：US5385143A

公开(公告)日：1995-01-31

申请号：US14269

申请日：1993-02-05

申请人： Takuo Aoyagi

发明人： Takuo Aoyagi

IPC分类号： A61B5/00

CPC分类号： A61B5/14551

摘要： Disclosed is an apparatus for measuring a predetermined data of a living tissue, such as an oxygen saturation, a dye dilution curve and level of hemoglobin. The apparatus has an illumination intensity computing and storing circuit that stores the intensities of light components emitted from a three-wavelength light source assembly, and a computing circuit that calculates the intensity ratios of illuminating light from the intensity data stored in the circuit. The circuit determines the predetermined data of blood on the basis of the calculated intensity ratios and the intensities of light transmitted through a living tissue under assay, and it displays the predetermined data on display unit. The apparatus is capable of measuring the predetermined data without relying upon pulsations that occur in the subject.

摘要翻译： 公开了一种用于测量活组织的预定数据的装置，例如氧饱和度，染料稀释曲线和血红蛋白水平。 该装置具有照射强度计算和存储电路，其存储从三波长光源组件发射的光分量的强度，以及计算电路，其根据存储在电路中的强度数据计算照明光的强度比。 该电路基于计算的强度比和通过测定的活体组织透射的光的强度来确定血液的预定数据，并且在显示单元上显示预定数据。 该装置能够测量预定数据而不依赖于在对象中发生的脉动。